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Malakoplakia

MedGen UID:
44257
•Concept ID:
C0024525
•
Pathologic Function
Synonym: Malacoplakia
SNOMED CT: Malakoplakia (264545007); Malakoplakia (716766007); Malakoplakia (50707001); Malacoplakia (50707001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018913
Orphanet: ORPHA556

Definition

A chronic multisystem granulomatous inflammatory disease with manifestation of single or multiple soft plaques on various organs of the body. Can occur in all ages, with a mean age at diagnosis of 50 years old and a female predominance. Cases in children are rare. It is most common in immunodeficient patients with a history of diabetes, transplantation, lymphoma, steroid therapy or alcoholism. Seems to be due to an impaired response to bacterial infection. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalakoplakia

Professional guidelines

PubMed

Re: Extensive pelvic malacoplakia: observations on management.
Bergman H
J Urol 1986 Oct;136(4):920. doi: 10.1016/s0022-5347(17)45129-9. PMID: 3761461
Malacoplakia: a study of the literature and current concepts of pathogenesis, diagnosis and treatment.
Stanton MJ, Maxted W
J Urol 1981 Feb;125(2):139-46. doi: 10.1016/s0022-5347(17)54940-x. PMID: 7009885

Recent clinical studies

Etiology

Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
Granulomatous & histiocytic dermatitides.
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Histiocytic disorders of the chest: imaging findings.
Ahuja J, Kanne JP, Meyer CA, Pipavath SN, Schmidt RA, Swanson JO, Godwin JD
Radiographics 2015 Mar-Apr;35(2):357-70. doi: 10.1148/rg.352140197. PMID: 25763722
Granulomatous prostatitis--an infrequent diagnosis.
Mohan H, Bal A, Punia RP, Bawa AS
Int J Urol 2005 May;12(5):474-8. doi: 10.1111/j.1442-2042.2005.01068.x. PMID: 15948747
Renal parenchymal malakoplakia--a case report and review of the literature.
Saleem MA, Milford DV, Raafat F, White RH
Pediatr Nephrol 1993 Jun;7(3):256-8. doi: 10.1007/BF00853212. PMID: 8518093

Diagnosis

Malakoplakia of the urinary bladder: A review of the literature.
Polisini G, Delle Fave RF, Capretti C, Marronaro A, Costa AM, Quaresima L, Mazzaferro D, Galosi AB
Arch Ital Urol Androl 2022 Sep 27;94(3):350-354. doi: 10.4081/aiua.2022.3.350. PMID: 36165484
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Malakoplakia.
Rubinson R, Mendes VS, Sanchez G, Costantini S
Pediatr Dermatol 2012 Jul-Aug;29(4):541-3. Epub 2011 Oct 4 doi: 10.1111/j.1525-1470.2011.01467.x. PMID: 21967602
Xanthogranulomatous pyelonephritis.
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966
Idiopathic granulomatous orchitis.
Roy S, Hooda S, Parwani AV
Pathol Res Pract 2011 May 15;207(5):275-8. Epub 2011 Apr 1 doi: 10.1016/j.prp.2011.02.005. PMID: 21458170

Therapy

Malakoplakia of the urinary bladder: A review of the literature.
Polisini G, Delle Fave RF, Capretti C, Marronaro A, Costa AM, Quaresima L, Mazzaferro D, Galosi AB
Arch Ital Urol Androl 2022 Sep 27;94(3):350-354. doi: 10.4081/aiua.2022.3.350. PMID: 36165484
Malakoplakia of the urinary system.
Cięszczyk K, Puderecki M, Wronecki L, Burdan F, Szumiło J
Folia Med Cracov 2019;59(2):67-74. PMID: 31659350
Rectosigmoid malakoplakia.
Yen JM, Soh NWY, Petersson F, Pandya G
BMJ Case Rep 2017 May 31;2017 doi: 10.1136/bcr-2017-219464. PMID: 28566412Free PMC Article
Xanthogranulomatous pyelonephritis.
Li L, Parwani AV
Arch Pathol Lab Med 2011 May;135(5):671-4. doi: 10.5858/2009-0769-RSR.1. PMID: 21526966
Cutaneous malakoplakia.
Kohl SK, Hans CP
Arch Pathol Lab Med 2008 Jan;132(1):113-7. doi: 10.5858/2008-132-113-CM. PMID: 18181662

Prognosis

Malakoplakia of the urinary system.
Cięszczyk K, Puderecki M, Wronecki L, Burdan F, Szumiło J
Folia Med Cracov 2019;59(2):67-74. PMID: 31659350
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
A Case of Cutaneous Malakoplakia in the Head and Neck Region and Review of the Literature.
Coates M, Del Pero MM, Nassif R
Head Neck Pathol 2016 Dec;10(4):444-450. Epub 2016 May 6 doi: 10.1007/s12105-016-0721-x. PMID: 27154024Free PMC Article
Cutaneous malakoplakia.
Kohl SK, Hans CP
Arch Pathol Lab Med 2008 Jan;132(1):113-7. doi: 10.5858/2008-132-113-CM. PMID: 18181662
Malakoplakia in association with colorectal carcinoma: a series of four cases.
Pillay K, Chetty R
Pathology 2002 Aug;34(4):332-5. doi: 10.1080/003130202760120481. PMID: 12190290

Clinical prediction guides

Malakoplakia Presenting as a Lung Mass in a Lung Transplant Recipient: Case Report.
Grewal HS, Virk RK, Carroll ME, Benvenuto LJ, Robbins H, Shah L, D'Ovidio F, Arcasoy SM
Transplant Proc 2022 Jan-Feb;54(1):173-175. Epub 2021 Dec 29 doi: 10.1016/j.transproceed.2021.11.013. PMID: 34973840
Ultrastructural evidence of the evolutional process in malakoplakia.
Jung YS, Chung DY, Kim EJ, Cho NH
Histol Histopathol 2020 Feb;35(2):177-184. Epub 2019 Jul 12 doi: 10.14670/HH-18-150. PMID: 31298302
Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders.
Fitzgibbons PL
Semin Diagn Pathol 2018 Nov;35(6):370-380. Epub 2018 Oct 16 doi: 10.1053/j.semdp.2018.10.002. PMID: 30366790
The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology.
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Malakoplakia of testis.
Paquin F, Schick E, Parent C
Urology 1983 Feb;21(2):194-8. doi: 10.1016/0090-4295(83)90026-2. PMID: 6297143

Recent systematic reviews

Malakoplakia after renal transplantation in the current era of immunosuppressive therapy: case report and literature review.
Leão CA, Duarte MI, Gamba C, Ramos JF, Rossi F, Galvão MM, David-Neto E, Nahas W, Shikanai-Yasuda MA, Pierrotti LC
Transpl Infect Dis 2012 Dec;14(6):E137-41. Epub 2012 Oct 2 doi: 10.1111/tid.12012. PMID: 23025504

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