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Natural Killer Cell Lymphoblastic Leukemia/Lymphoma

MedGen UID:
443133
•Concept ID:
C2826059
•
Neoplastic Process
Synonyms: Natural killer lymphoblastic leukemia; Natural killer-lymphoblastic leukemia/lymphoma; NK Cell Lymphoblastic Leukemia/Lymphoma; NK Lymphoblastic Leukemia/Lymphoma; NK-Lymphoblastic Leukemia/Lymphoma; NK-lymphoblastic leukemia/lymphoma; Precursor Natural Killer Cell Lymphoblastic Leukemia/Lymphoma; Precursor NK Cell Lymphoblastic Leukemia/Lymphoma
SNOMED CT: NK-lymphoblastic leukemia/lymphoma (783414002); Natural killer-lymphoblastic leukemia/lymphoma (783414002); Natural killer lymphoblastic leukemia (1258932003); Natural killer-lymphoblastic leukemia/lymphoma (1258932003); NK-lymphoblastic leukemia/lymphoma (1258932003)

Definition

A precursor lymphoid neoplasm that expresses CD56 and immature T-cell markers, lacks B-lymphoid and myeloid markers, and has immunoglobulin and T-cell receptor genes in the germline configuration. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNatural Killer Cell Lymphoblastic Leukemia/Lymphoma

Professional guidelines

PubMed

CD7 targeted "off-the-shelf" CAR-T demonstrates robust in vivo expansion and high efficacy in the treatment of patients with relapsed and refractory T cell malignancies.
Li S, Wang X, Liu L, Liu J, Rao J, Yuan Z, Gao L, Li Y, Luo L, Li G, Li Z, Li S, He J, Zhang L, Chen L, Huang W, Yin P, Li C, Li X, Wang Y, Dong Y, Zhang D, Zang Q, Chen Y, Shen L, Li W, Cao W, Zhang X, Wang S
Leukemia 2023 Nov;37(11):2176-2186. Epub 2023 Sep 12 doi: 10.1038/s41375-023-02018-4. PMID: 37700087
Exploitation of natural killer cells for the treatment of acute leukemia.
Handgretinger R, Lang P, André MC
Blood 2016 Jun 30;127(26):3341-9. Epub 2016 May 20 doi: 10.1182/blood-2015-12-629055. PMID: 27207791
NK/T-cell lymphomas: pathobiology, prognosis and treatment paradigm.
Suzuki R
Curr Oncol Rep 2012 Oct;14(5):395-402. doi: 10.1007/s11912-012-0245-9. PMID: 22639106

Recent clinical studies

Etiology

Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia.
Tan Y, Shan L, Zhao L, Deng B, Ling Z, Zhang Y, Peng S, Xu J, Duan J, Wang Z, Yu X, Zheng Q, Xu X, Tian Z, Zhang Y, Zhang J, Chang AH, Feng X, Pan J
J Hematol Oncol 2023 Apr 5;16(1):34. doi: 10.1186/s13045-023-01427-3. PMID: 37020231Free PMC Article
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131
CD38 antibodies in multiple myeloma: back to the future.
van de Donk NWCJ, Richardson PG, Malavasi F
Blood 2018 Jan 4;131(1):13-29. Epub 2017 Nov 8 doi: 10.1182/blood-2017-06-740944. PMID: 29118010
CD7-edited T cells expressing a CD7-specific CAR for the therapy of T-cell malignancies.
Gomes-Silva D, Srinivasan M, Sharma S, Lee CM, Wagner DL, Davis TH, Rouce RH, Bao G, Brenner MK, Mamonkin M
Blood 2017 Jul 20;130(3):285-296. Epub 2017 May 24 doi: 10.1182/blood-2017-01-761320. PMID: 28539325Free PMC Article
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants.
Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A, Posati S, Rogaia D, Frassoni F, Aversa F, Martelli MF, Velardi A
Science 2002 Mar 15;295(5562):2097-100. doi: 10.1126/science.1068440. PMID: 11896281

Diagnosis

Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers.
Dufva O, Gandolfi S, Huuhtanen J, Dashevsky O, Duàn H, Saeed K, Klievink J, Nygren P, Bouhlal J, Lahtela J, Näätänen A, Ghimire BR, Hannunen T, Ellonen P, Lähteenmäki H, Rumm P, Theodoropoulos J, Laajala E, Härkönen J, Pölönen P, Heinäniemi M, Hollmén M, Yamano S, Shirasaki R, Barbie DA, Roth JA, Romee R, Sheffer M, Lähdesmäki H, Lee DA, De Matos Simoes R, Kankainen M, Mitsiades CS, Mustjoki S
Immunity 2023 Dec 12;56(12):2816-2835.e13. doi: 10.1016/j.immuni.2023.11.008. PMID: 38091953
Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type.
Nishimura A, Yokoyama K, Naruto T, Yamagishi C, Imamura T, Nakazono H, Kimura S, Ito M, Sagisaka M, Tanaka Y, Piao J, Namikawa Y, Yanagimachi M, Isoda T, Kanai A, Matsui H, Isobe T, Sato-Otsubo A, Higuchi N, Takada A, Okuno H, Saito S, Karakawa S, Kobayashi S, Hasegawa D, Fujisaki H, Hasegawa D, Koike K, Koike T, Rai S, Umeda K, Sano H, Sekinaka Y, Ogawa A, Kinoshita A, Shiba N, Miki M, Kimura F, Nakayama H, Nakazawa Y, Taga T, Taki T, Adachi S, Manabe A, Koh K, Ishida Y, Takita J, Ishikawa F, Goto H, Morio T, Mizutani S, Tojo A, Takagi M
Sci Adv 2023 Dec 15;9(50):eadj4407. Epub 2023 Dec 13 doi: 10.1126/sciadv.adj4407. PMID: 38091391Free PMC Article
Epstein-Barr virus-associated T- and NK-cell lymphoproliferative diseases: an update and diagnostic approach.
Hue SS, Oon ML, Wang S, Tan SY, Ng SB
Pathology 2020 Jan;52(1):111-127. Epub 2019 Nov 22 doi: 10.1016/j.pathol.2019.09.011. PMID: 31767131
CD38 antibodies in multiple myeloma: back to the future.
van de Donk NWCJ, Richardson PG, Malavasi F
Blood 2018 Jan 4;131(1):13-29. Epub 2017 Nov 8 doi: 10.1182/blood-2017-06-740944. PMID: 29118010
Diagnosis and classification of hematologic malignancies on the basis of genetics.
Taylor J, Xiao W, Abdel-Wahab O
Blood 2017 Jul 27;130(4):410-423. Epub 2017 Jun 9 doi: 10.1182/blood-2017-02-734541. PMID: 28600336Free PMC Article

Therapy

Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia.
Tan Y, Shan L, Zhao L, Deng B, Ling Z, Zhang Y, Peng S, Xu J, Duan J, Wang Z, Yu X, Zheng Q, Xu X, Tian Z, Zhang Y, Zhang J, Chang AH, Feng X, Pan J
J Hematol Oncol 2023 Apr 5;16(1):34. doi: 10.1186/s13045-023-01427-3. PMID: 37020231Free PMC Article
IL-15 in the Combination Immunotherapy of Cancer.
Waldmann TA, Dubois S, Miljkovic MD, Conlon KC
Front Immunol 2020;11:868. Epub 2020 May 19 doi: 10.3389/fimmu.2020.00868. PMID: 32508818Free PMC Article
Use of CAR-Transduced Natural Killer Cells in CD19-Positive Lymphoid Tumors.
Liu E, Marin D, Banerjee P, Macapinlac HA, Thompson P, Basar R, Nassif Kerbauy L, Overman B, Thall P, Kaplan M, Nandivada V, Kaur I, Nunez Cortes A, Cao K, Daher M, Hosing C, Cohen EN, Kebriaei P, Mehta R, Neelapu S, Nieto Y, Wang M, Wierda W, Keating M, Champlin R, Shpall EJ, Rezvani K
N Engl J Med 2020 Feb 6;382(6):545-553. doi: 10.1056/NEJMoa1910607. PMID: 32023374Free PMC Article
CD38 antibodies in multiple myeloma: back to the future.
van de Donk NWCJ, Richardson PG, Malavasi F
Blood 2018 Jan 4;131(1):13-29. Epub 2017 Nov 8 doi: 10.1182/blood-2017-06-740944. PMID: 29118010
Natural killer cells.
Kay NE
Crit Rev Clin Lab Sci 1986;22(4):343-59. doi: 10.3109/10408368509165790. PMID: 2419034

Prognosis

Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.
Kumar A, Taghi Khani A, Duault C, Aramburo S, Sanchez Ortiz A, Lee SJ, Chan A, McDonald T, Huang M, Lacayo NJ, Sakamoto KM, Yu J, Hurtz C, Carroll M, Tasian SK, Ghoda L, Marcucci G, Gu Z, Rosen ST, Armenian S, Izraeli S, Chen CW, Caligiuri MA, Forman SJ, Maecker HT, Swaminathan S
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006649. PMID: 37217248Free PMC Article
Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Long-term follow-up of donor-derived CD7 CAR T-cell therapy in patients with T-cell acute lymphoblastic leukemia.
Tan Y, Shan L, Zhao L, Deng B, Ling Z, Zhang Y, Peng S, Xu J, Duan J, Wang Z, Yu X, Zheng Q, Xu X, Tian Z, Zhang Y, Zhang J, Chang AH, Feng X, Pan J
J Hematol Oncol 2023 Apr 5;16(1):34. doi: 10.1186/s13045-023-01427-3. PMID: 37020231Free PMC Article
Central Nervous System Involvement of Natural Killer and T Cell Neoplasms.
Aaroe AE, Nevel KS
Curr Oncol Rep 2019 Mar 27;21(5):40. doi: 10.1007/s11912-019-0794-2. PMID: 30919085
Diagnosis and classification of hematologic malignancies on the basis of genetics.
Taylor J, Xiao W, Abdel-Wahab O
Blood 2017 Jul 27;130(4):410-423. Epub 2017 Jun 9 doi: 10.1182/blood-2017-02-734541. PMID: 28600336Free PMC Article

Clinical prediction guides

Tumor heterogeneity and immune-evasive T follicular cell lymphoma phenotypes at single-cell resolution.
Suma S, Suehara Y, Fujisawa M, Abe Y, Hattori K, Makishima K, Sakamoto T, Sawa A, Bando H, Kaji D, Sugio T, Kato K, Akashi K, Matsue K, Carreras J, Nakamura N, Suzuki A, Suzuki Y, Ito K, Shiiba H, Chiba S, Sakata-Yanagimoto M
Leukemia 2024 Feb;38(2):340-350. Epub 2023 Nov 27 doi: 10.1038/s41375-023-02093-7. PMID: 38012392Free PMC Article
Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type.
Nishimura A, Yokoyama K, Naruto T, Yamagishi C, Imamura T, Nakazono H, Kimura S, Ito M, Sagisaka M, Tanaka Y, Piao J, Namikawa Y, Yanagimachi M, Isoda T, Kanai A, Matsui H, Isobe T, Sato-Otsubo A, Higuchi N, Takada A, Okuno H, Saito S, Karakawa S, Kobayashi S, Hasegawa D, Fujisaki H, Hasegawa D, Koike K, Koike T, Rai S, Umeda K, Sano H, Sekinaka Y, Ogawa A, Kinoshita A, Shiba N, Miki M, Kimura F, Nakayama H, Nakazawa Y, Taga T, Taki T, Adachi S, Manabe A, Koh K, Ishida Y, Takita J, Ishikawa F, Goto H, Morio T, Mizutani S, Tojo A, Takagi M
Sci Adv 2023 Dec 15;9(50):eadj4407. Epub 2023 Dec 13 doi: 10.1126/sciadv.adj4407. PMID: 38091391Free PMC Article
Intrinsic suppression of type I interferon production underlies the therapeutic efficacy of IL-15-producing natural killer cells in B-cell acute lymphoblastic leukemia.
Kumar A, Taghi Khani A, Duault C, Aramburo S, Sanchez Ortiz A, Lee SJ, Chan A, McDonald T, Huang M, Lacayo NJ, Sakamoto KM, Yu J, Hurtz C, Carroll M, Tasian SK, Ghoda L, Marcucci G, Gu Z, Rosen ST, Armenian S, Izraeli S, Chen CW, Caligiuri MA, Forman SJ, Maecker HT, Swaminathan S
J Immunother Cancer 2023 May;11(5) doi: 10.1136/jitc-2022-006649. PMID: 37217248Free PMC Article
Allogeneic hematopoietic stem cell transplantation for NK/T-cell lymphoma: an international collaborative analysis.
Berning P, Schmitz N, Ngoya M, Finel H, Boumendil A, Wang F, Huang XJ, Hermine O, Philippe L, Couronné L, Jaccard A, Liu D, Wu D, Reinhardt HC, Chalandon Y, Wagner-Drouet E, Kwon M, Zhang X, Carpenter B, Yakoub-Agha I, Wulf G, López-Jiménez J, Sanz J, Labussière-Wallet H, Shimoni A, Dreger P, Sureda A, Kim WS, Glass B
Leukemia 2023 Jul;37(7):1511-1520. Epub 2023 May 8 doi: 10.1038/s41375-023-01924-x. PMID: 37157017Free PMC Article
Serpin B9 controls tumor cell killing by CAR T cells.
Kimman T, Slomp A, Martens A, Grabherr S, Li S, van Diest E, Meeldijk J, Kuball J, Minnema MC, Eldering E, Bovenschen N, Sebestyén Z, Peperzak V
J Immunother Cancer 2023 Mar;11(3) doi: 10.1136/jitc-2022-006364. PMID: 36931661Free PMC Article

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