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ERG Gene Rearrangement

MedGen UID:
443151
•Concept ID:
C2826127
•
Cell or Molecular Dysfunction
Synonyms: ERG Rearrangement; Erg-3 Gene Rearrangement; ETS Transcription Factor ERG Gene Rearrangement; p55 Gene Rearrangement; v-Ets Erythroblastosis Virus E26 Oncogene Like Gene Rearrangement

Definition

A molecular abnormality indicating rearrangement of the ERG gene. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVERG Gene Rearrangement

Professional guidelines

PubMed

Ewing Sarcoma of the Female Genital Tract: Clinicopathologic Analysis of 21 Cases With an Emphasis on the Differential Diagnosis of Gynecologic Round Cell, Spindle, and Epithelioid Neoplasms.
Sharma AE, Wepy CB, Chapel DB, Maccio L, Irshaid L, Al-Ibraheemi A, Dickson BC, Nucci MR, Crum CP, Fletcher CDM, Kolin DL
Am J Surg Pathol 2024 Aug 1;48(8):972-984. Epub 2024 May 2 doi: 10.1097/PAS.0000000000002232. PMID: 38708674
Genomics in acute lymphoblastic leukaemia: insights and treatment implications.
Roberts KG, Mullighan CG
Nat Rev Clin Oncol 2015 Jun;12(6):344-57. Epub 2015 Mar 17 doi: 10.1038/nrclinonc.2015.38. PMID: 25781572
Clinical applications of novel ERG immunohistochemistry in prostate cancer diagnosis and management.
Shah RB
Adv Anat Pathol 2013 Mar;20(2):117-24. doi: 10.1097/PAP.0b013e3182862ac5. PMID: 23399797

Recent clinical studies

Etiology

Correlation of ERG immunohistochemistry with molecular detection of TMPRSS2-ERG gene fusion.
Sung JY, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Kang SY, Choi YL, Kwon GY
J Clin Pathol 2016 Jul;69(7):586-92. Epub 2015 Dec 15 doi: 10.1136/jclinpath-2015-203314. PMID: 26670747
PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas.
Morais CL, Herawi M, Toubaji A, Albadine R, Hicks J, Netto GJ, De Marzo AM, Epstein JI, Lotan TL
Prostate 2015 Oct;75(14):1610-9. Epub 2015 Jul 14 doi: 10.1002/pros.23042. PMID: 26178158Free PMC Article
Frequent discordance between ERG gene rearrangement and ERG protein expression in a rapid autopsy cohort of patients with lethal, metastatic, castration-resistant prostate cancer.
Udager AM, Shi Y, Tomlins SA, Alva A, Siddiqui J, Cao X, Pienta KJ, Jiang H, Chinnaiyan AM, Mehra R
Prostate 2014 Sep;74(12):1199-208. Epub 2014 Jul 7 doi: 10.1002/pros.22836. PMID: 25043157Free PMC Article
TMPRSS2-ERG rearrangement in dominant anterior prostatic tumours: incidence and correlation with ERG immunohistochemistry.
Gopalan A, Leversha MA, Dudas ME, Maschino AC, Chang J, Al-Ahmadie HA, Chen YB, Tickoo SK, Reuter VE, Fine SW
Histopathology 2013 Aug;63(2):279-86. Epub 2013 May 23 doi: 10.1111/his.12153. PMID: 23701505Free PMC Article
Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.
Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA
Arch Pathol Lab Med 2009 Jul;133(7):1033-40. doi: 10.5858/133.7.1033. PMID: 19642730

Diagnosis

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.
Dadhania V, Gonzalez D, Yousif M, Cheng J, Morgan TM, Spratt DE, Reichert ZR, Mannan R, Wang X, Chinnaiyan A, Cao X, Dhanasekaran SM, Chinnaiyan AM, Pantanowitz L, Mehra R
BMC Cancer 2022 May 5;22(1):494. doi: 10.1186/s12885-022-09559-4. PMID: 35513774Free PMC Article
Correlation of ERG immunohistochemistry with molecular detection of TMPRSS2-ERG gene fusion.
Sung JY, Jeon HG, Jeong BC, Seo SI, Jeon SS, Lee HM, Choi HY, Kang SY, Choi YL, Kwon GY
J Clin Pathol 2016 Jul;69(7):586-92. Epub 2015 Dec 15 doi: 10.1136/jclinpath-2015-203314. PMID: 26670747
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
TMPRSS2-ERG rearrangement in dominant anterior prostatic tumours: incidence and correlation with ERG immunohistochemistry.
Gopalan A, Leversha MA, Dudas ME, Maschino AC, Chang J, Al-Ahmadie HA, Chen YB, Tickoo SK, Reuter VE, Fine SW
Histopathology 2013 Aug;63(2):279-86. Epub 2013 May 23 doi: 10.1111/his.12153. PMID: 23701505Free PMC Article
ERG gene rearrangement status in prostate cancer detected by immunohistochemistry.
Falzarano SM, Zhou M, Carver P, Tsuzuki T, Simmerman K, He H, Magi-Galluzzi C
Virchows Arch 2011 Oct;459(4):441-7. Epub 2011 Jul 20 doi: 10.1007/s00428-011-1128-4. PMID: 21773753

Therapy

Primary spinal multifocal intradural-extramedullary Ewing sarcoma in children: presentation of a case and review of the literature.
Müngen E, Kurucu N, Kutluk T, Oğuz KK, Söylemezoğlu F, Yalçın B
Turk J Pediatr 2021;63(6):1084-1090. doi: 10.24953/turkjped.2021.06.018. PMID: 35023660
Clinicopathologic features of metastatic small cell carcinoma of the prostate to the liver: a series of four cases.
Bell PD, Huber AR, Agostini-Vulaj D
Diagn Pathol 2021 Apr 23;16(1):35. doi: 10.1186/s13000-021-01096-1. PMID: 33892760Free PMC Article
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Attard G, Swennenhuis JF, Olmos D, Reid AH, Vickers E, A'Hern R, Levink R, Coumans F, Moreira J, Riisnaes R, Oommen NB, Hawche G, Jameson C, Thompson E, Sipkema R, Carden CP, Parker C, Dearnaley D, Kaye SB, Cooper CS, Molina A, Cox ME, Terstappen LW, de Bono JS
Cancer Res 2009 Apr 1;69(7):2912-8. doi: 10.1158/0008-5472.CAN-08-3667. PMID: 19339269

Prognosis

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.
Dadhania V, Gonzalez D, Yousif M, Cheng J, Morgan TM, Spratt DE, Reichert ZR, Mannan R, Wang X, Chinnaiyan A, Cao X, Dhanasekaran SM, Chinnaiyan AM, Pantanowitz L, Mehra R
BMC Cancer 2022 May 5;22(1):494. doi: 10.1186/s12885-022-09559-4. PMID: 35513774Free PMC Article
The spectrum of neuroendocrine tumors: histologic classification, unique features and areas of overlap.
Klimstra DS, Beltran H, Lilenbaum R, Bergsland E
Am Soc Clin Oncol Educ Book 2015:92-103. doi: 10.14694/EdBook_AM.2015.35.92. PMID: 25993147
ERG gene rearrangement status in prostate cancer detected by immunohistochemistry.
Falzarano SM, Zhou M, Carver P, Tsuzuki T, Simmerman K, He H, Magi-Galluzzi C
Virchows Arch 2011 Oct;459(4):441-7. Epub 2011 Jul 20 doi: 10.1007/s00428-011-1128-4. PMID: 21773753
TMPRSS2-ERG gene fusion is associated with low Gleason scores and not with high-grade morphological features.
Fine SW, Gopalan A, Leversha MA, Al-Ahmadie HA, Tickoo SK, Zhou Q, Satagopan JM, Scardino PT, Gerald WL, Reuter VE
Mod Pathol 2010 Oct;23(10):1325-33. Epub 2010 Jun 18 doi: 10.1038/modpathol.2010.120. PMID: 20562851Free PMC Article
Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.
Mackinnon AC, Yan BC, Joseph LJ, Al-Ahmadie HA
Arch Pathol Lab Med 2009 Jul;133(7):1033-40. doi: 10.5858/133.7.1033. PMID: 19642730

Clinical prediction guides

Leveraging artificial intelligence to predict ERG gene fusion status in prostate cancer.
Dadhania V, Gonzalez D, Yousif M, Cheng J, Morgan TM, Spratt DE, Reichert ZR, Mannan R, Wang X, Chinnaiyan A, Cao X, Dhanasekaran SM, Chinnaiyan AM, Pantanowitz L, Mehra R
BMC Cancer 2022 May 5;22(1):494. doi: 10.1186/s12885-022-09559-4. PMID: 35513774Free PMC Article
PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas.
Morais CL, Herawi M, Toubaji A, Albadine R, Hicks J, Netto GJ, De Marzo AM, Epstein JI, Lotan TL
Prostate 2015 Oct;75(14):1610-9. Epub 2015 Jul 14 doi: 10.1002/pros.23042. PMID: 26178158Free PMC Article
ERG expression and prostatic adenocarcinoma.
Verdu M, Trias I, Roman R, Rodon N, Garcia-Pelaez B, Calvo M, Dominguez A, Banus JM, Puig X
Virchows Arch 2013 Jun;462(6):639-44. Epub 2013 May 24 doi: 10.1007/s00428-013-1415-3. PMID: 23703293
The relationship of TMPRSS2-ERG gene fusion between primary and metastatic prostate cancers.
Guo CC, Wang Y, Xiao L, Troncoso P, Czerniak BA
Hum Pathol 2012 May;43(5):644-9. Epub 2011 Sep 19 doi: 10.1016/j.humpath.2011.06.018. PMID: 21937078Free PMC Article
ERG gene rearrangement status in prostate cancer detected by immunohistochemistry.
Falzarano SM, Zhou M, Carver P, Tsuzuki T, Simmerman K, He H, Magi-Galluzzi C
Virchows Arch 2011 Oct;459(4):441-7. Epub 2011 Jul 20 doi: 10.1007/s00428-011-1128-4. PMID: 21773753

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