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Neoplasm of mediastinum

MedGen UID:
44322
Concept ID:
C0025063
Neoplastic Process
Synonyms: Mediastinal Neoplasm; Mediastinal Neoplasms; Mediastinum Neoplasm; Mediastinum Neoplasms; Neoplasm, Mediastinal; Neoplasm, Mediastinum; Neoplasms, Mediastinal; Neoplasms, Mediastinum
SNOMED CT: Neoplasm of mediastinum (126725000); Tumor of mediastinum (126725000)
 
Monarch Initiative: MONDO:0021386

Definition

A benign or malignant neoplasm that affects the structures of the mediastinum. Representative examples include mediastinal lipoma, mediastinal schwannoma, thymoma, mediastinal germ cell tumor, and mediastinal lymphoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of mediastinum

Professional guidelines

PubMed

Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Paydary K, Seraj SM, Zadeh MZ, Emamzadehfard S, Shamchi SP, Gholami S, Werner TJ, Alavi A
Mol Imaging Biol 2019 Feb;21(1):1-10. doi: 10.1007/s11307-018-1181-3. PMID: 29516387
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Gerber TS, Porubsky S
Histopathology 2024 Jan;84(1):183-195. Epub 2023 Nov 21 doi: 10.1111/his.15088. PMID: 37988262
Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Carter BW, Betancourt SL, Benveniste MF
Top Magn Reson Imaging 2017 Aug;26(4):153-165. doi: 10.1097/RMR.0000000000000134. PMID: 28777164
Carter BW, Benveniste MF, Madan R, Godoy MC, de Groot PM, Truong MT, Rosado-de-Christenson ML, Marom EM
Radiographics 2017 Mar-Apr;37(2):413-436. Epub 2017 Jan 27 doi: 10.1148/rg.2017160095. PMID: 28129068
Cohen AJ, Sbaschnig RJ, Hochholzer L, Lough FC, Albus RA
Ann Thorac Surg 1987 Jun;43(6):656-9. doi: 10.1016/s0003-4975(10)60244-5. PMID: 3592837

Diagnosis

Suster D
Ann Diagn Pathol 2022 Oct;60:152018. Epub 2022 Jul 22 doi: 10.1016/j.anndiagpath.2022.152018. PMID: 35908333
Garrana SH, Rosado-de-Christenson ML
Radiol Clin North Am 2021 Mar;59(2):155-168. Epub 2021 Jan 11 doi: 10.1016/j.rcl.2020.10.003. PMID: 33551078
Carter BW, Marom EM, Detterbeck FC
J Thorac Oncol 2014 Sep;9(9 Suppl 2):S102-9. doi: 10.1097/JTO.0000000000000294. PMID: 25396306
Duwe BV, Sterman DH, Musani AI
Chest 2005 Oct;128(4):2893-909. doi: 10.1378/chest.128.4.2893. PMID: 16236967
Yoneda KY, Louie S, Shelton DK
Curr Opin Pulm Med 2001 Jul;7(4):226-33. doi: 10.1097/00063198-200107000-00011. PMID: 11470979

Therapy

Savage KJ
Blood 2022 Sep 1;140(9):955-970. doi: 10.1182/blood.2020008376. PMID: 34496020
Yu Y, Dong X, Tu M, Wang H
Thorac Cancer 2021 Nov;12(21):2831-2837. Epub 2021 Sep 29 doi: 10.1111/1759-7714.14155. PMID: 34590432Free PMC Article
Armand P, Rodig S, Melnichenko V, Thieblemont C, Bouabdallah K, Tumyan G, Özcan M, Portino S, Fogliatto L, Caballero MD, Walewski J, Gulbas Z, Ribrag V, Christian B, Perini GF, Salles G, Svoboda J, Zain J, Patel S, Chen PH, Ligon AH, Ouyang J, Neuberg D, Redd R, Chatterjee A, Balakumaran A, Orlowski R, Shipp M, Zinzani PL
J Clin Oncol 2019 Dec 1;37(34):3291-3299. Epub 2019 Oct 14 doi: 10.1200/JCO.19.01389. PMID: 31609651Free PMC Article
Martelli M, Ferreri A, Di Rocco A, Ansuinelli M, Johnson PWM
Crit Rev Oncol Hematol 2017 May;113:318-327. Epub 2017 Jan 21 doi: 10.1016/j.critrevonc.2017.01.009. PMID: 28318892
Bhatt VR, Mourya R, Shrestha R, Armitage JO
Cancer Treat Rev 2015 Jun;41(6):476-85. Epub 2015 Apr 21 doi: 10.1016/j.ctrv.2015.04.006. PMID: 25913715

Prognosis

Zinzani PL, Broccoli A
Hematol Oncol Clin North Am 2016 Dec;30(6):1261-1275. doi: 10.1016/j.hoc.2016.07.011. PMID: 27888880
Cabral FC, Trotman-Dickenson B, Madan R
Eur J Radiol 2015 Mar;84(3):489-498. Epub 2014 Dec 15 doi: 10.1016/j.ejrad.2014.11.039. PMID: 25557510
Duwe BV, Sterman DH, Musani AI
Chest 2005 Oct;128(4):2893-909. doi: 10.1378/chest.128.4.2893. PMID: 16236967
Maher MM, Shepard JA
Semin Thorac Cardiovasc Surg 2005 Spring;17(1):12-9. doi: 10.1053/j.semtcvs.2004.12.003. PMID: 16104356
Cohen AJ, Sbaschnig RJ, Hochholzer L, Lough FC, Albus RA
Ann Thorac Surg 1987 Jun;43(6):656-9. doi: 10.1016/s0003-4975(10)60244-5. PMID: 3592837

Clinical prediction guides

Tan A, Nolan JA
Paediatr Anaesth 2022 Jan;32(1):4-9. Epub 2021 Nov 14 doi: 10.1111/pan.14319. PMID: 34714957
Bai Y, Zhao G, Tan Y
World J Surg Oncol 2019 Dec 4;17(1):205. doi: 10.1186/s12957-019-1742-1. PMID: 31801558Free PMC Article
Bhatt VR, Mourya R, Shrestha R, Armitage JO
Cancer Treat Rev 2015 Jun;41(6):476-85. Epub 2015 Apr 21 doi: 10.1016/j.ctrv.2015.04.006. PMID: 25913715
De Leyn P, Dooms C, Kuzdzal J, Lardinois D, Passlick B, Rami-Porta R, Turna A, Van Schil P, Venuta F, Waller D, Weder W, Zielinski M
Eur J Cardiothorac Surg 2014 May;45(5):787-98. Epub 2014 Feb 26 doi: 10.1093/ejcts/ezu028. PMID: 24578407
Thomas CR Jr, Bonomi PD
Curr Opin Oncol 1991 Apr;3(2):335-43. doi: 10.1097/00001622-199104000-00015. PMID: 1648973

Recent systematic reviews

Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Watanabe A, Miyajima M, Mishina T, Tsuruta K, Takahashi Y, Maki R, Tada M
Surg Today 2017 Dec;47(12):1419-1428. Epub 2017 Mar 11 doi: 10.1007/s00595-017-1494-x. PMID: 28285463
Fernández-Villar A, Mouronte-Roibás C, Botana-Rial M, Ruano-Raviña A
Arch Bronconeumol 2016 Feb;52(2):96-102. Epub 2015 Nov 10 doi: 10.1016/j.arbres.2015.08.007. PMID: 26565072
Wahidi MM, Herth F, Yasufuku K, Shepherd RW, Yarmus L, Chawla M, Lamb C, Casey KR, Patel S, Silvestri GA, Feller-Kopman DJ
Chest 2016 Mar;149(3):816-35. Epub 2016 Jan 12 doi: 10.1378/chest.15-1216. PMID: 26402427
Wang T, Liu L, Luo J, Liu T, Wei A
Urol J 2015 Apr 29;12(2):2057-64. PMID: 25923148

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