U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Temporomandibular joint ankylosis

MedGen UID:
444041
Concept ID:
C2931375
Disease or Syndrome
Synonyms: Ankylosis of the temporomandibular joint (TMJ); Temporomandibular ankylosis; TMJ Ankylosis
SNOMED CT: TMJ (temporomandibular joint) ankylosis (50603008); Ankylosis of temporomandibular joint (50603008)
 
HPO: HP:0012478

Definition

Bony fusion of the mandibular condyle to the base of the skull, resulting in limitation of jaw opening. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTemporomandibular joint ankylosis

Conditions with this feature

Nager syndrome
MedGen UID:
120519
Concept ID:
C0265245
Disease or Syndrome
Nager syndrome is the prototype for a group of disorders collectively referred to as the acrofacial dysostoses (AFDs), which are characterized by malformation of the craniofacial skeleton and the limbs. The major facial features of Nager syndrome include downslanted palpebral fissures, midface retrusion, and micrognathia, the latter of which often requires the placement of a tracheostomy in early childhood. Limb defects typically involve the anterior (radial) elements of the upper limbs and manifest as small or absent thumbs, triphalangeal thumbs, radial hypoplasia or aplasia, and radioulnar synostosis. Phocomelia of the upper limbs and, occasionally, lower-limb defects have also been reported. The presence of anterior upper-limb defects and the typical lack of lower-limb involvement distinguishes Nager syndrome from Miller syndrome (263750), another rare AFD; however, distinguishing Nager syndrome from other AFDs, including Miller syndrome, can be challenging (summary by Bernier et al., 2012).
Ophthalmomandibulomelic dysplasia
MedGen UID:
331604
Concept ID:
C1833872
Disease or Syndrome
Complete blindness due to corneal opacities, difficult mastication due to temporomandibular fusion and anomalies of the arms. Micrognathia, shortening and bowing of the forearm, ulnar deviation and bowed radius, short fibula, genu valgum and coxa vara have been reported. Intelligence is normal. The causative gene has not yet been identified. Autosomal dominant inheritance has been suggested.
Auriculocondylar syndrome 2
MedGen UID:
766318
Concept ID:
C3553404
Disease or Syndrome
Auriculocondylar syndrome (ARCND), also known as 'question-mark ear syndrome' or 'dysgnathia complex,' is a craniofacial malformation syndrome characterized by highly variable mandibular anomalies, including mild to severe micrognathia, often with temporomandibular joint ankylosis, cleft palate, and a distinctive ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark. Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia (summary by Rieder et al., 2012). For a discussion of genetic heterogeneity of auriculocondylar syndrome, see ARCND1 (602483).
Restrictive dermopathy 1
MedGen UID:
1812447
Concept ID:
C5676878
Disease or Syndrome
A restrictive dermopathy that has material basis in homozygous or compound heterozygous mutation in the ZMPSTE24 gene on chromosome 1p34.

Professional guidelines

PubMed

Fariña R, Canto L, Gunckel R, Alister JP, Uribe F
J Craniofac Surg 2018 Mar;29(2):427-431. doi: 10.1097/SCS.0000000000004134. PMID: 29509170
Karamese M, Duymaz A, Seyhan N, Keskin M, Tosun Z
J Craniomaxillofac Surg 2013 Dec;41(8):789-93. Epub 2013 Mar 5 doi: 10.1016/j.jcms.2013.01.027. PMID: 23465639
Sporniak-Tutak K, Janiszewska-Olszowska J, Kowalczyk R
Med Sci Monit 2011 May;17(5):RA111-6. doi: 10.12659/msm.881755. PMID: 21525821Free PMC Article

Recent clinical studies

Etiology

Yadav P, Roychoudhury A, Bhutia O
Br J Oral Maxillofac Surg 2021 Sep;59(7):820-825. Epub 2021 Feb 20 doi: 10.1016/j.bjoms.2021.02.007. PMID: 34272105
Abreu Silva ML, Henriques de Castro W, Baires Campos FE
J Oral Maxillofac Surg 2021 Feb;79(2):473.e1-473.e7. Epub 2020 Oct 6 doi: 10.1016/j.joms.2020.09.042. PMID: 33137301
He L, Zhang Z, Xiao E, He Y, Zhang Y
J Int Med Res 2020 Nov;48(11):300060520972073. doi: 10.1177/0300060520972073. PMID: 33213251Free PMC Article
Sharma VK, Rattan V, Rai S, Sharma P
J Craniomaxillofac Surg 2020 Aug;48(8):779-785. Epub 2020 Jun 27 doi: 10.1016/j.jcms.2020.06.005. PMID: 32709503
Fariña R, Canto L, Gunckel R, Alister JP, Uribe F
J Craniofac Surg 2018 Mar;29(2):427-431. doi: 10.1097/SCS.0000000000004134. PMID: 29509170

Diagnosis

Parrino D, Val M, Lovato A, de Filippis C, Nardini LG
Am J Otolaryngol 2022 Sep-Oct;43(5):103599. Epub 2022 Aug 12 doi: 10.1016/j.amjoto.2022.103599. PMID: 35988366
Córdova LA, Reyes M, Soto R, Hernández M, Cortés JE
J Craniomaxillofac Surg 2021 Jul;49(7):592-597. Epub 2021 Feb 20 doi: 10.1016/j.jcms.2021.02.014. PMID: 33750637
Pasetti M, Mazzoleni F, Novelli G, Iascone M, Bozzetti A, Selicorni A
Am J Med Genet A 2016 Aug;170(8):2191-5. Epub 2016 May 27 doi: 10.1002/ajmg.a.37767. PMID: 27232676
Movahed R, Mercuri LG
Oral Maxillofac Surg Clin North Am 2015 Feb;27(1):27-35. doi: 10.1016/j.coms.2014.09.003. PMID: 25483442
Li JM, Zhang XW, Zhang Y, Li YH, An JG, Xiao E, Yan YB
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Dec;116(6):e478-84. Epub 2012 Aug 15 doi: 10.1016/j.oooo.2012.02.036. PMID: 22901645

Therapy

Mittal N, Goyal M, Sardana D
Br J Oral Maxillofac Surg 2022 Nov;60(9):1151-1158. Epub 2022 Jun 11 doi: 10.1016/j.bjoms.2022.05.012. PMID: 35811261
De Roo N, Van Doorne L, Troch A, Vermeersch H, Brusselaers N
J Craniomaxillofac Surg 2016 Jan;44(1):6-15. Epub 2015 Sep 10 doi: 10.1016/j.jcms.2015.08.019. PMID: 26433770
Ma J, Jiang H, Liang L
J Craniomaxillofac Surg 2015 Sep;43(7):1202-7. Epub 2015 May 8 doi: 10.1016/j.jcms.2015.04.017. PMID: 26054446
Katsnelson A, Markiewicz MR, Keith DA, Dodson TB
J Oral Maxillofac Surg 2012 Mar;70(3):531-6. Epub 2011 Dec 30 doi: 10.1016/j.joms.2011.10.003. PMID: 22209104
Bayat M, Badri A, Moharamnejad N
Oral Maxillofac Surg 2009 Dec;13(4):207-12. doi: 10.1007/s10006-009-0174-4. PMID: 19806372

Prognosis

Kolçakoğlu K, Doğan S, Zararsız G, Kütük N, Gönen ZB
J Oral Rehabil 2023 Oct;50(10):940-947. Epub 2023 Jun 7 doi: 10.1111/joor.13498. PMID: 37221976
Keyser B, Afzal Z, Warburton G
Atlas Oral Maxillofac Surg Clin North Am 2020 Sep;28(2):111-118. Epub 2020 Jul 4 doi: 10.1016/j.cxom.2020.05.005. PMID: 32741508
Fariña R, Canto L, Gunckel R, Alister JP, Uribe F
J Craniofac Surg 2018 Mar;29(2):427-431. doi: 10.1097/SCS.0000000000004134. PMID: 29509170
Li JM, Zhang XW, Zhang Y, Li YH, An JG, Xiao E, Yan YB
Oral Surg Oral Med Oral Pathol Oral Radiol 2013 Dec;116(6):e478-84. Epub 2012 Aug 15 doi: 10.1016/j.oooo.2012.02.036. PMID: 22901645
Katsnelson A, Markiewicz MR, Keith DA, Dodson TB
J Oral Maxillofac Surg 2012 Mar;70(3):531-6. Epub 2011 Dec 30 doi: 10.1016/j.joms.2011.10.003. PMID: 22209104

Clinical prediction guides

Kolçakoğlu K, Doğan S, Zararsız G, Kütük N, Gönen ZB
J Oral Rehabil 2023 Oct;50(10):940-947. Epub 2023 Jun 7 doi: 10.1111/joor.13498. PMID: 37221976
Yadav P, Roychoudhury A, Bhutia O
Br J Oral Maxillofac Surg 2021 Sep;59(7):820-825. Epub 2021 Feb 20 doi: 10.1016/j.bjoms.2021.02.007. PMID: 34272105
Keyser B, Afzal Z, Warburton G
Atlas Oral Maxillofac Surg Clin North Am 2020 Sep;28(2):111-118. Epub 2020 Jul 4 doi: 10.1016/j.cxom.2020.05.005. PMID: 32741508
Sharma VK, Rattan V, Rai S, Sharma P
J Craniomaxillofac Surg 2020 Aug;48(8):779-785. Epub 2020 Jun 27 doi: 10.1016/j.jcms.2020.06.005. PMID: 32709503
Katsnelson A, Markiewicz MR, Keith DA, Dodson TB
J Oral Maxillofac Surg 2012 Mar;70(3):531-6. Epub 2011 Dec 30 doi: 10.1016/j.joms.2011.10.003. PMID: 22209104

Recent systematic reviews

Mittal N, Goyal M, Sardana D
Br J Oral Maxillofac Surg 2022 Nov;60(9):1151-1158. Epub 2022 Jun 11 doi: 10.1016/j.bjoms.2022.05.012. PMID: 35811261
Kattimani VS, Jairaj A, Govindan NO, Mathai P, Sahu S, Patley A, Sultana PS
J Contemp Dent Pract 2020 Mar 1;21(3):337-349. PMID: 32434984
De Roo N, Van Doorne L, Troch A, Vermeersch H, Brusselaers N
J Craniomaxillofac Surg 2016 Jan;44(1):6-15. Epub 2015 Sep 10 doi: 10.1016/j.jcms.2015.08.019. PMID: 26433770
Ma J, Jiang H, Liang L
J Craniomaxillofac Surg 2015 Sep;43(7):1202-7. Epub 2015 May 8 doi: 10.1016/j.jcms.2015.04.017. PMID: 26054446
Katsnelson A, Markiewicz MR, Keith DA, Dodson TB
J Oral Maxillofac Surg 2012 Mar;70(3):531-6. Epub 2011 Dec 30 doi: 10.1016/j.joms.2011.10.003. PMID: 22209104

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...