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Gemignani syndrome

MedGen UID:
444093
Concept ID:
C2931587
Disease or Syndrome
Synonym: Spinocerebellar ataxia associated amyotrophy of the hands and sensorineural deafness
SNOMED CT: Spinocerebellar ataxia, amyotrophy, deafness syndrome (782690007); Gemignani syndrome (782690007)
Modes of inheritance:
Autosomal recessive inheritance
MedGen UID:
141025
Concept ID:
C0441748
Intellectual Product
Source: Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygotes (two copies of the same mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
 
Monarch Initiative: MONDO:0016159
Orphanet: ORPHA2074

Definition

A rare neurodegenerative disease characterized by slowly progressive ataxia, amyotrophy of the hands and distal arms, spastic paraplegia, progressive sensorineural hearing loss, hypogonadism and short stature. Additional features include generalized cerebellar atrophy and peripheral nervous system anomalies. Small cervical spinal cord, intellectual/language disability and localized vitiligo have also been reported. There have been no further descriptions in the literature since 1989. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGemignani syndrome

Professional guidelines

PubMed

Conversano C, Poli A, Ciacchini R, Hitchcott P, Bazzichi L, Gemignani A
Clin Exp Rheumatol 2019 Jan-Feb;37 Suppl 116(1):98-104. Epub 2019 Feb 8 PMID: 30747101
Talarico R, Palagini L, d'Ascanio A, Elefante E, Ferrari C, Stagnaro C, Tani C, Gemignani A, Mauri M, Bombardieri S, Mosca M
CNS Drugs 2015 Mar;29(3):189-96. doi: 10.1007/s40263-015-0228-0. PMID: 25643894
Brindani F, Vitetta F, Gemignani F
Clin Interv Aging 2009;4:305-13. Epub 2009 Jun 29 doi: 10.2147/cia.s4143. PMID: 19750232Free PMC Article

Recent clinical studies

Etiology

Baldini A, Frumento S, Menicucci D, Gemignani A, Scilingo EP, Greco A
Annu Int Conf IEEE Eng Med Biol Soc 2022 Jul;2022:3451-3454. doi: 10.1109/EMBC48229.2022.9871557. PMID: 36086358
Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Hitchcott PK, Menicucci D, Frumento S, Zaccaro A, Gemignani A
Sleep Breath 2020 Mar;24(1):15-23. Epub 2019 May 28 doi: 10.1007/s11325-019-01865-9. PMID: 31140116
Gemignani F, Brindani F, Vitetta F, Marbini A
Pain Med 2009 Nov;10(8):1481-6. doi: 10.1111/j.1526-4637.2009.00732.x. PMID: 20021603
Gemignani G, Berrettini S, Bruschini P, Sellari-Franceschini S, Fusari P, Piragine F, Pasero G, Olivieri I
Ann Otol Rhinol Laryngol 1991 Jun;100(6):459-63. doi: 10.1177/000348949110000606. PMID: 2058986

Diagnosis

Gemignani F
Muscle Nerve 2022 Apr;65(4):369-370. Epub 2022 Jan 31 doi: 10.1002/mus.27495. PMID: 35014706
Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Hitchcott PK, Menicucci D, Frumento S, Zaccaro A, Gemignani A
Sleep Breath 2020 Mar;24(1):15-23. Epub 2019 May 28 doi: 10.1007/s11325-019-01865-9. PMID: 31140116
Gemignani F, Brindani F, Vitetta F, Marbini A
Pain Med 2009 Nov;10(8):1481-6. doi: 10.1111/j.1526-4637.2009.00732.x. PMID: 20021603
Gemignani G, Berrettini S, Bruschini P, Sellari-Franceschini S, Fusari P, Piragine F, Pasero G, Olivieri I
Ann Otol Rhinol Laryngol 1991 Jun;100(6):459-63. doi: 10.1177/000348949110000606. PMID: 2058986

Therapy

Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Gemignani F, Ferrari G, Vitetta F, Giovanelli M, Macaluso C, Marbini A
J Neurol Neurosurg Psychiatry 2010 Jul;81(7):731-3. doi: 10.1136/jnnp.2009.177303. PMID: 20581138
Gemignani F, Giovanelli M, Vitetta F, Santilli D, Bellanova MF, Brindani F, Marbini A
J Peripher Nerv Syst 2010 Mar;15(1):57-62. doi: 10.1111/j.1529-8027.2010.00252.x. PMID: 20433606
Gemignani F, Brindani F, Vitetta F, Marbini A
Pain Med 2009 Nov;10(8):1481-6. doi: 10.1111/j.1526-4637.2009.00732.x. PMID: 20021603
Di Cori A, Petronio AS, Gemignani C, Zucchelli G, Di Bello V, Mariani M
J Heart Lung Transplant 2005 Aug;24(8):1146-9. doi: 10.1016/j.healun.2004.07.003. PMID: 16102462

Prognosis

Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Orrù G, Conversano C, Malloggi E, Francesconi F, Ciacchini R, Gemignani A
Int J Environ Res Public Health 2020 Sep 14;17(18) doi: 10.3390/ijerph17186688. PMID: 32937949Free PMC Article
Gemignani F, Giovanelli M, Vitetta F, Santilli D, Bellanova MF, Brindani F, Marbini A
J Peripher Nerv Syst 2010 Mar;15(1):57-62. doi: 10.1111/j.1529-8027.2010.00252.x. PMID: 20433606
Gemignani F, Brindani F, Vitetta F, Marbini A, Calzetti S
J Peripher Nerv Syst 2007 Mar;12(1):50-3. doi: 10.1111/j.1529-8027.2007.00116.x. PMID: 17374101
Gemignani G, Berrettini S, Bruschini P, Sellari-Franceschini S, Fusari P, Piragine F, Pasero G, Olivieri I
Ann Otol Rhinol Laryngol 1991 Jun;100(6):459-63. doi: 10.1177/000348949110000606. PMID: 2058986

Clinical prediction guides

Baldini A, Frumento S, Menicucci D, Gemignani A, Scilingo EP, Greco A
Annu Int Conf IEEE Eng Med Biol Soc 2022 Jul;2022:3451-3454. doi: 10.1109/EMBC48229.2022.9871557. PMID: 36086358
Gentiluomo M, Canzian F, Nicolini A, Gemignani F, Landi S, Campa D
Semin Cancer Biol 2022 Feb;79:105-131. Epub 2020 Aug 18 doi: 10.1016/j.semcancer.2020.08.003. PMID: 32818625
Gemignani F, Ferrari G, Vitetta F, Giovanelli M, Macaluso C, Marbini A
J Neurol Neurosurg Psychiatry 2010 Jul;81(7):731-3. doi: 10.1136/jnnp.2009.177303. PMID: 20581138
Olivieri I, Gemignani G, Camerini E, Semeria R, Pasero G
Br J Rheumatol 1990 Aug;29(4):264-7. doi: 10.1093/rheumatology/29.4.264. PMID: 2379043
Olivieri I, Gemignani G, Busoni F, Pecori F, Camerini E, Trippi D, Pasero G
Ann Rheum Dis 1988 Sep;47(9):780-3. doi: 10.1136/ard.47.9.780. PMID: 3178318Free PMC Article

Recent systematic reviews

Conversano C, Ciacchini R, Orrù G, Bazzichi ML, Gemignani A, Miniati M
Clin Exp Rheumatol 2021 May-Jun;39 Suppl 130(3):174-185. Epub 2020 Dec 2 doi: 10.55563/clinexprheumatol/73g6np. PMID: 33337987
Orrù G, Conversano C, Malloggi E, Francesconi F, Ciacchini R, Gemignani A
Int J Environ Res Public Health 2020 Sep 14;17(18) doi: 10.3390/ijerph17186688. PMID: 32937949Free PMC Article

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