U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pleomorphic adenoma

MedGen UID:
44467
•Concept ID:
C0026277
•
Neoplastic Process
Synonyms: Adenoma, Pleomorphic; Adenomas, Pleomorphic; Chondroid Syringoma; Chondroid Syringomas; Mixed Salivary Gland Tumor; Pleomorphic Adenoma; Pleomorphic Adenomas; Salivary Gland Tumor, Mixed; Syringoma, Chondroid; Syringomas, Chondroid
SNOMED CT: Mixed salivary gland tumor (8360001); Pleomorphic adenoma (8360001); Mixed tumor (8360001); Mixed tumor, salivary gland type (8360001)

Definition

A benign or malignant neoplasm that arises from the salivary glands. It is characterized by the presence of epithelial and mesenchymal elements. This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Recurrent lacrimal gland pleomorphic adenoma.
Reilly S, Ellard R, O'Sullivan M, Khan R, Kennedy S
Orbit 2023 Dec;42(6):635-640. Epub 2022 May 12 doi: 10.1080/01676830.2022.2064515. PMID: 35546531
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Diagnosis

Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features.
Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M
Jpn J Radiol 2018 Aug;36(8):463-471. Epub 2018 May 29 doi: 10.1007/s11604-018-0747-y. PMID: 29845358
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Therapy

Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature.
Maharshi V, Nagar P
Indian J Pharmacol 2017 Jan-Feb;49(1):130-131. doi: 10.4103/0253-7613.201018. PMID: 28458439Free PMC Article
p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Postoperative radiation therapy for parotid pleomorphic adenoma with close or positive margins: treatment outcomes and toxicities.
Patel S, Mourad WF, Wang C, Dhanireddy B, Concert C, Ryniak M, Khorsandi AS, Shourbaji RA, Li Z, Culliney B, Patel R, Bakst RL, Tran T, Shasha D, Schantz S, Persky MS, Hu KS, Harrison LB
Anticancer Res 2014 Aug;34(8):4247-51. PMID: 25075054
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Clinical prediction guides

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Estrogen, Progesterone and Androgen Receptor in Primary and Recurrent Pleomorphic Salivary Adenomas.
Tarakji B, Mehsen Alali F
Asian Pac J Cancer Prev 2023 May 1;24(5):1731-1735. doi: 10.31557/APJCP.2023.24.5.1731. PMID: 37247295Free PMC Article
Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients.
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400

Recent systematic reviews

Molecular Factors in Carcinoma Ex Pleomorphic Adenoma: Systematic Review and Meta-Analysis.
Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Elective neck dissection in salivary gland malignancies: Systematic review and meta-analysis.
Yan F, Lao WP, Nguyen SA, Sharma AK, Day TA
Head Neck 2022 Feb;44(2):505-517. Epub 2021 Dec 4 doi: 10.1002/hed.26923. PMID: 34862810
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...