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Pleomorphic adenoma

MedGen UID:
44467
•Concept ID:
C0026277
•
Neoplastic Process
Synonyms: Adenoma, Pleomorphic; Adenomas, Pleomorphic; Chondroid Syringoma; Chondroid Syringomas; Mixed Salivary Gland Tumor; Pleomorphic Adenoma; Pleomorphic Adenomas; Salivary Gland Tumor, Mixed; Syringoma, Chondroid; Syringomas, Chondroid
SNOMED CT: Mixed salivary gland tumor (8360001); Pleomorphic adenoma (8360001); Mixed tumor (8360001); Mixed tumor, salivary gland type (8360001)

Definition

A benign or malignant neoplasm that arises from the salivary glands. It is characterized by the presence of epithelial and mesenchymal elements. This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Pleomorphic adenoma of the head and neck in children: presentation and management.
Dombrowski ND, Wolter NE, Irace AL, Cunningham MJ, Vargas SO, Perez-Atayde AR, Robson CD, Rahbar R
Laryngoscope 2019 Nov;129(11):2603-2609. Epub 2018 Nov 15 doi: 10.1002/lary.27590. PMID: 30431646
Benign Parotid Tumors.
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Diagnosis

Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Pleomorphic adenoma: the great mimicker of malignancy.
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Pleomorphic adenoma of salivary glands: common and uncommon CT and MR imaging features.
Kato H, Kawaguchi M, Ando T, Mizuta K, Aoki M, Matsuo M
Jpn J Radiol 2018 Aug;36(8):463-471. Epub 2018 May 29 doi: 10.1007/s11604-018-0747-y. PMID: 29845358
Pleomorphic adenoma.
Wasylik K, Kim JC, Amedee RG
J La State Med Soc 2001 Jan;153(1):12-6. PMID: 11272444

Therapy

Current thinking about the management of recurrent pleomorphic adenoma of the parotid: a structured review.
Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Chronic administration of phenytoin and pleomorphic adenoma: A case report and review of literature.
Maharshi V, Nagar P
Indian J Pharmacol 2017 Jan-Feb;49(1):130-131. doi: 10.4103/0253-7613.201018. PMID: 28458439Free PMC Article
p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Postoperative radiation therapy for parotid pleomorphic adenoma with close or positive margins: treatment outcomes and toxicities.
Patel S, Mourad WF, Wang C, Dhanireddy B, Concert C, Ryniak M, Khorsandi AS, Shourbaji RA, Li Z, Culliney B, Patel R, Bakst RL, Tran T, Shasha D, Schantz S, Persky MS, Hu KS, Harrison LB
Anticancer Res 2014 Aug;34(8):4247-51. PMID: 25075054
Tracheobronchial gland tumors.
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Proliferation in pleomorphic adenoma: Lights and shadow on this parameter, in a neoplasm showing unpredictable behavior-An immunohistochemical study and review of the literature.
De Rosa F, Pignatiello S, Sibillo MC, Guadagno E
Pathol Res Pract 2022 Apr;232:153748. Epub 2021 Dec 23 doi: 10.1016/j.prp.2021.153748. PMID: 35094844
Myoepithelial Carcinoma.
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Etiology and management of recurrent parotid pleomorphic adenoma.
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Clinical prediction guides

Pediatric primary salivary gland tumors.
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Proliferation in pleomorphic adenoma: Lights and shadow on this parameter, in a neoplasm showing unpredictable behavior-An immunohistochemical study and review of the literature.
De Rosa F, Pignatiello S, Sibillo MC, Guadagno E
Pathol Res Pract 2022 Apr;232:153748. Epub 2021 Dec 23 doi: 10.1016/j.prp.2021.153748. PMID: 35094844
Parotid pleomorphic and non-pleomorphic adenomas: a mono-institutional series of 512 patients.
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
Molecular Pathology of Salivary Gland Neoplasms: Diagnostic, Prognostic, and Predictive Perspective.
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400

Recent systematic reviews

Systematic review of prognostic factors in carcinoma ex pleomorphic adenoma.
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Surgical treatment of pleomorphic adenoma of parotid gland in children: a systematic review.
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Multiparametric magnetic resonance imaging of parotid tumors: A systematic review.
Coudert H, Mirafzal S, Dissard A, Boyer L, Montoriol PF
Diagn Interv Imaging 2021 Mar;102(3):121-130. Epub 2020 Sep 14 doi: 10.1016/j.diii.2020.08.002. PMID: 32943368
p53 expression in pleomorphic adenoma of salivary glands: A systematic review and meta-analysis.
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Metastasising pleomorphic adenoma: Systematic review.
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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