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Pleomorphic adenoma

MedGen UID:
44467
Concept ID:
C0026277
Neoplastic Process
Synonyms: Adenoma, Pleomorphic; Adenomas, Pleomorphic; Chondroid Syringoma; Chondroid Syringomas; Mixed Salivary Gland Tumor; Pleomorphic Adenoma; Pleomorphic Adenomas; Salivary Gland Tumor, Mixed; Syringoma, Chondroid; Syringomas, Chondroid
SNOMED CT: Mixed salivary gland tumor (8360001); Pleomorphic adenoma (8360001); Mixed tumor (8360001); Mixed tumor, salivary gland type (8360001)

Definition

A benign or malignant neoplasm that arises from the salivary glands. It is characterized by the presence of epithelial and mesenchymal elements. This category includes pleomorphic adenoma, carcinoma ex pleomorphic adenoma, and carcinosarcoma. [from NCI]

Professional guidelines

PubMed

Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
López F, Suárez C, Vander Poorten V, Mäkitie A, Nixon IJ, Strojan P, Hanna EY, Rodrigo JP, de Bree R, Quer M, Takes RP, Bradford CR, Shaha AR, Sanabria A, Rinaldo A, Ferlito A
Head Neck 2019 Feb;41(2):522-535. Epub 2018 Dec 14 doi: 10.1002/hed.25439. PMID: 30549361
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Recent clinical studies

Etiology

Reilly S, Ellard R, O'Sullivan M, Khan R, Kennedy S
Orbit 2023 Dec;42(6):635-640. Epub 2022 May 12 doi: 10.1080/01676830.2022.2064515. PMID: 35546531
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Diagnosis

Reilly S, Ellard R, O'Sullivan M, Khan R, Kennedy S
Orbit 2023 Dec;42(6):635-640. Epub 2022 May 12 doi: 10.1080/01676830.2022.2064515. PMID: 35546531
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Hernandez-Prera JC, Skálová A, Franchi A, Rinaldo A, Vander Poorten V, Zbären P, Ferlito A, Wenig BM
Histopathology 2021 Sep;79(3):279-290. Epub 2021 Apr 22 doi: 10.1111/his.14322. PMID: 33368685
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

Therapy

Kanatas A, Ho MWS, Mücke T
Br J Oral Maxillofac Surg 2018 May;56(4):243-248. Epub 2018 Mar 8 doi: 10.1016/j.bjoms.2018.01.021. PMID: 29526342
Maharshi V, Nagar P
Indian J Pharmacol 2017 Jan-Feb;49(1):130-131. doi: 10.4103/0253-7613.201018. PMID: 28458439Free PMC Article
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Patel S, Mourad WF, Wang C, Dhanireddy B, Concert C, Ryniak M, Khorsandi AS, Shourbaji RA, Li Z, Culliney B, Patel R, Bakst RL, Tran T, Shasha D, Schantz S, Persky MS, Hu KS, Harrison LB
Anticancer Res 2014 Aug;34(8):4247-51. PMID: 25075054
Gaissert HA, Mark EJ
Cancer Control 2006 Oct;13(4):286-94. doi: 10.1177/107327480601300406. PMID: 17075566

Prognosis

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Xu B, Katabi N
Surg Pathol Clin 2021 Mar;14(1):67-73. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.008. PMID: 33526224Free PMC Article
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295
Witt RL, Eisele DW, Morton RP, Nicolai P, Poorten VV, Zbären P
Laryngoscope 2015 Apr;125(4):888-93. Epub 2014 Oct 7 doi: 10.1002/lary.24964. PMID: 25289881

Clinical prediction guides

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Jesberg P, Monzon A, Gitomer SA, Herrmann BW
Am J Otolaryngol 2023 Sep-Oct;44(5):103948. Epub 2023 Jun 8 doi: 10.1016/j.amjoto.2023.103948. PMID: 37352681
Lombardi D, Tomasoni M, Nicolai A, Paderno A, Grammatica A, Arcuri M, Lancini D, Battocchio S, Ardighieri L, Bozzola A, Pittiani F, Farina D, Redaelli de Zinis LO, Nicolai P, Piazza C
Eur Arch Otorhinolaryngol 2022 May;279(5):2543-2551. Epub 2021 Aug 5 doi: 10.1007/s00405-021-07018-7. PMID: 34355271
Toper MH, Sarioglu S
Adv Anat Pathol 2021 Mar 1;28(2):81-93. doi: 10.1097/PAP.0000000000000291. PMID: 33405400
Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Recent systematic reviews

Key S, Chia C, Hasan Z, Sundaresan P, Riffat F, Dwivedi RC
Laryngoscope 2024 Mar;134(3):1042-1053. Epub 2023 Aug 23 doi: 10.1002/lary.30993. PMID: 37610148
Key S, Chia C, Hasan Z, Sundaresan P, Dwivedi RC, Riffat F
Oral Oncol 2022 Oct;133:106052. Epub 2022 Jul 31 doi: 10.1016/j.oraloncology.2022.106052. PMID: 35921695
Galluzzi F, Garavello W
Auris Nasus Larynx 2022 Aug;49(4):547-553. Epub 2022 Jan 31 doi: 10.1016/j.anl.2022.01.013. PMID: 35101285
Alaizari NA, Tarakji B, Al-Maweri SA, Al-Shamiri HM, Darwish S, Baba F
Arch Oral Biol 2015 Sep;60(9):1437-41. Epub 2015 Jun 23 doi: 10.1016/j.archoralbio.2015.06.019. PMID: 26163983
Knight J, Ratnasingham K
Int J Surg 2015 Jul;19:137-45. Epub 2015 May 6 doi: 10.1016/j.ijsu.2015.04.084. PMID: 25958295

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