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Monoclonal gammopathy of undetermined significance(MGUS)

MedGen UID:
44485
Concept ID:
C0026470
Neoplastic Process
Synonyms: MGUS; Monoclonal gammopathy of uncertain significance
SNOMED CT: Monoclonal gammopathy of undetermined significance (35601003); Monoclonal gammopathy of undetermined significance (277577000); Monoclonal gammopathy of uncertain significance (277577000); MGUS - monoclonal gammopathy of undetermined significance (35601003); MGUS - monoclonal gammopathy of uncertain significance (277577000); Benign monoclonal gammopathy (58648008); Asymptomatic monoclonal gammopathy (58648008)
 
Monarch Initiative: MONDO:0004225

Definition

A condition in which an abnormal amount of a single immunoglobulin is present in the serum. This category includes IgM monoclonal gammopathy of undetermined significance and non-IgM monoclonal gammopathy of undetermined significance. Up to 25% of cases of monoclonal gammopathy of undetermined significance progress to a B-cell malignancy or myeloma. [from NCI]

Term Hierarchy

Professional guidelines

PubMed

Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article

Recent clinical studies

Etiology

Kaur J, Valisekka SS, Hameed M, Bandi PS, Varma S, Onwughalu CJ, Ibrahim H, Mongia H
Clin Lymphoma Myeloma Leuk 2023 May;23(5):e195-e212. Epub 2023 Feb 23 doi: 10.1016/j.clml.2023.02.004. PMID: 36966041
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Diagnosis

Kaur J, Valisekka SS, Hameed M, Bandi PS, Varma S, Onwughalu CJ, Ibrahim H, Mongia H
Clin Lymphoma Myeloma Leuk 2023 May;23(5):e195-e212. Epub 2023 Feb 23 doi: 10.1016/j.clml.2023.02.004. PMID: 36966041
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Therapy

Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article

Prognosis

van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Kyle RA, Durie BG, Rajkumar SV, Landgren O, Blade J, Merlini G, Kröger N, Einsele H, Vesole DH, Dimopoulos M, San Miguel J, Avet-Loiseau H, Hajek R, Chen WM, Anderson KC, Ludwig H, Sonneveld P, Pavlovsky S, Palumbo A, Richardson PG, Barlogie B, Greipp P, Vescio R, Turesson I, Westin J, Boccadoro M; International Myeloma Working Group
Leukemia 2010 Jun;24(6):1121-7. Epub 2010 Apr 22 doi: 10.1038/leu.2010.60. PMID: 20410922Free PMC Article

Clinical prediction guides

Dang M, Wang R, Lee HC, Patel KK, Becnel MR, Han G, Thomas SK, Hao D, Chu Y, Weber DM, Lin P, Lutter-Berka Z, Berrios Nolasco DA, Huang M, Bansal H, Song X, Zhang J, Futreal A, Moreno Rueda LY, Symer DE, Green MR, Rojas Hernandez CM, Kroll M, Afshar-Khargan V, Ndacayisaba LJ, Kuhn P, Neelapu SS, Orlowski RZ, Wang L, Manasanch EE
Cancer Cell 2023 Jun 12;41(6):1032-1047.e4. doi: 10.1016/j.ccell.2023.05.007. PMID: 37311413Free PMC Article
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Steensma DP, Bejar R, Jaiswal S, Lindsley RC, Sekeres MA, Hasserjian RP, Ebert BL
Blood 2015 Jul 2;126(1):9-16. Epub 2015 Apr 30 doi: 10.1182/blood-2015-03-631747. PMID: 25931582Free PMC Article
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Castaneda-Avila MA, Ulbricht CM, Epstein MM
Ann Hematol 2021 Apr;100(4):855-863. Epub 2021 Jan 8 doi: 10.1007/s00277-021-04400-7. PMID: 33416902Free PMC Article
Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Veronese N, Luchini C, Solmi M, Sergi G, Manzato E, Stubbs B
J Bone Miner Metab 2018 Jan;36(1):128-132. Epub 2017 Feb 27 doi: 10.1007/s00774-017-0817-8. PMID: 28243796
McShane CM, Murray LJ, Landgren O, O'Rorke MA, Korde N, Kunzmann AT, Ismail MR, Anderson LA
Cancer Epidemiol Biomarkers Prev 2014 Feb;23(2):332-42. Epub 2014 Jan 22 doi: 10.1158/1055-9965.EPI-13-0695. PMID: 24451437
Wadhera RK, Rajkumar SV
Mayo Clin Proc 2010 Oct;85(10):933-42. Epub 2010 Aug 16 doi: 10.4065/mcp.2010.0337. PMID: 20713974Free PMC Article

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