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Monoclonal gammopathy of undetermined significance(MGUS)

MedGen UID:
44485
•Concept ID:
C0026470
•
Neoplastic Process
Synonyms: MGUS; Monoclonal gammopathy of uncertain significance
SNOMED CT: MGUS (35601003); Monoclonal gammopathy of undetermined significance (35601003); Monoclonal gammopathy of undetermined significance (277577000); Monoclonal gammopathy of uncertain significance (277577000); MGUS - Monoclonal gammopathy of uncertain significance (277577000); Benign monoclonal gammopathy (58648008); Asymptomatic monoclonal gammopathy (58648008)
 
Monarch Initiative: MONDO:0004225

Definition

A condition in which an abnormal amount of a single immunoglobulin is present in the serum. This category includes IgM monoclonal gammopathy of undetermined significance and non-IgM monoclonal gammopathy of undetermined significance. Up to 25% of cases of monoclonal gammopathy of undetermined significance progress to a B-cell malignancy or myeloma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMonoclonal gammopathy of undetermined significance

Professional guidelines

PubMed

IgM monoclonal gammopathies of clinical significance: diagnosis and management.
Khwaja J, D'Sa S, Minnema MC, Kersten MJ, Wechalekar A, Vos JM
Haematologica 2022 Sep 1;107(9):2037-2050. doi: 10.3324/haematol.2022.280953. PMID: 35770530Free PMC Article
Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment.
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Epidemiology, Staging, and Management of Multiple Myeloma.
Padala SA, Barsouk A, Barsouk A, Rawla P, Vakiti A, Kolhe R, Kota V, Ajebo GH
Med Sci (Basel) 2021 Jan 20;9(1) doi: 10.3390/medsci9010003. PMID: 33498356Free PMC Article

Recent clinical studies

Etiology

Monoclonal Gammopathy of Undetermined Significance.
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Multiple myeloma.
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Monoclonal gammopathy of renal significance (MGRS) histopathologic classification, diagnostic workup, and therapeutic options.
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Monoclonal gammopathy of undetermined significance.
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848
Diagnosis of monoclonal gammopathy of renal significance.
Bridoux F, Leung N, Hutchison CA, Touchard G, Sethi S, Fermand JP, Picken MM, Herrera GA, Kastritis E, Merlini G, Roussel M, Fervenza FC, Dispenzieri A, Kyle RA, Nasr SH; International Kidney and Monoclonal Gammopathy Research Group
Kidney Int 2015 Apr;87(4):698-711. Epub 2015 Jan 21 doi: 10.1038/ki.2014.408. PMID: 25607108

Diagnosis

Monoclonal Gammopathy of Undetermined Significance.
Gonsalves WI, Rajkumar SV
Ann Intern Med 2022 Dec;175(12):ITC177-ITC192. Epub 2022 Dec 13 doi: 10.7326/AITC202212200. PMID: 36508741
Cutaneous manifestations of monoclonal gammopathy.
Claveau JS, Wetter DA, Kumar S
Blood Cancer J 2022 Apr 11;12(4):58. doi: 10.1038/s41408-022-00661-1. PMID: 35411042Free PMC Article
Multiple myeloma.
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Monoclonal gammopathy of renal significance (MGRS) histopathologic classification, diagnostic workup, and therapeutic options.
Amaador K, Peeters H, Minnema MC, Nguyen TQ, Dendooven A, Vos JMI, Croockewit AJ, van de Donk NWCJ, Jacobs JFM, Wetzels JFM, Sprangers B, Abrahams AC
Neth J Med 2019 Sep;77(7):243-254. PMID: 31582582
Monoclonal gammopathy of undetermined significance.
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848

Therapy

Immunoglobulin light chain amyloidosis: 2022 update on diagnosis, prognosis, and treatment.
Gertz MA
Am J Hematol 2022 Jun 1;97(6):818-829. Epub 2022 Apr 25 doi: 10.1002/ajh.26569. PMID: 35429180
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021.
Hasib Sidiqi M, Gertz MA
Blood Cancer J 2021 May 15;11(5):90. doi: 10.1038/s41408-021-00483-7. PMID: 33993188Free PMC Article
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management.
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant.
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA; International Kidney and Monoclonal Gammopathy Research Group
Blood 2012 Nov 22;120(22):4292-5. Epub 2012 Oct 9 doi: 10.1182/blood-2012-07-445304. PMID: 23047823

Prognosis

Multiple myeloma.
van de Donk NWCJ, Pawlyn C, Yong KL
Lancet 2021 Jan 30;397(10272):410-427. doi: 10.1016/S0140-6736(21)00135-5. PMID: 33516340
Monoclonal gammopathy of undetermined significance.
Mouhieddine TH, Weeks LD, Ghobrial IM
Blood 2019 Jun 6;133(23):2484-2494. Epub 2019 Apr 22 doi: 10.1182/blood.2019846782. PMID: 31010848
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Monoclonal Gammopathy-Associated Peripheral Neuropathy: Diagnosis and Management.
Chaudhry HM, Mauermann ML, Rajkumar SV
Mayo Clin Proc 2017 May;92(5):838-850. doi: 10.1016/j.mayocp.2017.02.003. PMID: 28473042Free PMC Article
Understanding and interpreting serum protein electrophoresis.
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Clinical prediction guides

Smoldering multiple myeloma current treatment algorithms.
Rajkumar SV, Kumar S, Lonial S, Mateos MV
Blood Cancer J 2022 Sep 5;12(9):129. doi: 10.1038/s41408-022-00719-0. PMID: 36064707Free PMC Article
Monoclonal gammopathy of renal significance (MGRS): Real-world data on outcomes and prognostic factors.
Gozzetti A, Guarnieri A, Zamagni E, Zakharova E, Coriu D, Bittrich M, Pika T, Tovar N, Schutz N, Ciofini S, Peña C, Rocchi S, Rassner M, Avivi I, Waszczuk-Gajda A, Chhabra S, Usnarska-Zubkiewicz L, González-Calle V, Mateos MV, Bocchia M, Bigi F, Füllgraf H, Bhasin-Chhabra B, Gentile M, Davila J, Vesole DH, Cavo M, Thapa B, Crusoe E, Einsele H, Legiec W, Charliński G, Jurczyszyn A
Am J Hematol 2022 Jul;97(7):877-884. Epub 2022 Apr 20 doi: 10.1002/ajh.26566. PMID: 35389534Free PMC Article
Changing paradigms in diagnosis and treatment of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM).
Ho M, Patel A, Goh CY, Moscvin M, Zhang L, Bianchi G
Leukemia 2020 Dec;34(12):3111-3125. Epub 2020 Oct 12 doi: 10.1038/s41375-020-01051-x. PMID: 33046818
Multiple myeloma.
Kumar SK, Rajkumar V, Kyle RA, van Duin M, Sonneveld P, Mateos MV, Gay F, Anderson KC
Nat Rev Dis Primers 2017 Jul 20;3:17046. doi: 10.1038/nrdp.2017.46. PMID: 28726797
Understanding and interpreting serum protein electrophoresis.
O'Connell TX, Horita TJ, Kasravi B
Am Fam Physician 2005 Jan 1;71(1):105-12. PMID: 15663032

Recent systematic reviews

Risk factors for monoclonal gammopathy of undetermined significance: a systematic review.
Castaneda-Avila MA, Ulbricht CM, Epstein MM
Ann Hematol 2021 Apr;100(4):855-863. Epub 2021 Jan 8 doi: 10.1007/s00277-021-04400-7. PMID: 33416902Free PMC Article
Systemic Amyloidosis Recognition, Prognosis, and Therapy: A Systematic Review.
Gertz MA, Dispenzieri A
JAMA 2020 Jul 7;324(1):79-89. doi: 10.1001/jama.2020.5493. PMID: 32633805
Monoclonal gammopathy of undetermined significance and bone health outcomes: a systematic review and exploratory meta-analysis.
Veronese N, Luchini C, Solmi M, Sergi G, Manzato E, Stubbs B
J Bone Miner Metab 2018 Jan;36(1):128-132. Epub 2017 Feb 27 doi: 10.1007/s00774-017-0817-8. PMID: 28243796
Prior autoimmune disease and risk of monoclonal gammopathy of undetermined significance and multiple myeloma: a systematic review.
McShane CM, Murray LJ, Landgren O, O'Rorke MA, Korde N, Kunzmann AT, Ismail MR, Anderson LA
Cancer Epidemiol Biomarkers Prev 2014 Feb;23(2):332-42. Epub 2014 Jan 22 doi: 10.1158/1055-9965.EPI-13-0695. PMID: 24451437
Prevalence of monoclonal gammopathy of undetermined significance: a systematic review.
Wadhera RK, Rajkumar SV
Mayo Clin Proc 2010 Oct;85(10):933-42. Epub 2010 Aug 16 doi: 10.4065/mcp.2010.0337. PMID: 20713974Free PMC Article

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