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Dental fluorosis

MedGen UID:
44506
Concept ID:
C0026618
Disease or Syndrome
Synonyms: Dental Fluoroses; Dental Fluorosis; Fluoroses, Dental; Fluorosis, Dental
SNOMED CT: Mottled teeth (120541000119103); Dental fluorosis (30265004); Intrinsic enamel discoloration of fluorosis (30265004)
 
Monarch Initiative: MONDO:0006722

Definition

A condition that results from excessive fluoride ingestion during tooth development, resulting in tooth discoloration ranging from white streaks to brown stains and cracks or pits in the tooth enamel. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDental fluorosis

Professional guidelines

PubMed

Zotti F, Albertini L, Tomizioli N, Capocasale G, Albanese M
Medicina (Kaunas) 2020 Dec 29;57(1) doi: 10.3390/medicina57010022. PMID: 33383755Free PMC Article
Cury JA, Tenuta LM
Braz Oral Res 2014;28 Spec No:1-7. Epub 2014 Jan 24 doi: 10.1590/S1806-83242014.50000001. PMID: 24554097
Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL
Med Oral Patol Oral Cir Bucal 2009 Feb 1;14(2):E103-7. PMID: 19179949

Recent clinical studies

Etiology

Saldarriaga A, Rojas-Gualdrón D, Restrepo M, Santos-Pinto L, Jeremias F
Acta Odontol Latinoam 2021 Aug 1;34(2):156-165. doi: 10.54589/aol.34/2/156. PMID: 34570864Free PMC Article
Di Giovanni T, Eliades T, Papageorgiou SN
J Esthet Restor Dent 2018 Nov;30(6):502-508. Epub 2018 Sep 8 doi: 10.1111/jerd.12408. PMID: 30194793
Iheozor-Ejiofor Z, Worthington HV, Walsh T, O'Malley L, Clarkson JE, Macey R, Alam R, Tugwell P, Welch V, Glenny AM
Cochrane Database Syst Rev 2015 Jun 18;2015(6):CD010856. doi: 10.1002/14651858.CD010856.pub2. PMID: 26092033Free PMC Article
Cury JA, Tenuta LM
Braz Oral Res 2014;28 Spec No:1-7. Epub 2014 Jan 24 doi: 10.1590/S1806-83242014.50000001. PMID: 24554097
Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL
Med Oral Patol Oral Cir Bucal 2009 Feb 1;14(2):E103-7. PMID: 19179949

Diagnosis

Meena L, Gupta R
N Engl J Med 2021 Oct 14;385(16):1510. Epub 2021 Oct 9 doi: 10.1056/NEJMicm2103503. PMID: 34623787
Martignon S, Bartlett D, Manton DJ, Martinez-Mier EA, Splieth C, Avila V
Caries Res 2021;55(1):1-11. Epub 2021 Jan 13 doi: 10.1159/000512483. PMID: 33440378
Zotti F, Albertini L, Tomizioli N, Capocasale G, Albanese M
Medicina (Kaunas) 2020 Dec 29;57(1) doi: 10.3390/medicina57010022. PMID: 33383755Free PMC Article
Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL
Med Oral Patol Oral Cir Bucal 2009 Feb 1;14(2):E103-7. PMID: 19179949
Watts A, Addy M
Br Dent J 2001 Mar 24;190(6):309-16. doi: 10.1038/sj.bdj.4800959. PMID: 11325156

Therapy

Hung M, Hon ES, Mohajeri A, Moparthi H, Vu T, Jeon J, Lipsky MS
JAMA Netw Open 2023 Jun 1;6(6):e2318406. doi: 10.1001/jamanetworkopen.2023.18406. PMID: 37351888Free PMC Article
Solanki YS, Agarwal M, Gupta AB, Gupta S, Shukla P
Sci Total Environ 2022 Feb 10;807(Pt 1):150601. Epub 2021 Sep 28 doi: 10.1016/j.scitotenv.2021.150601. PMID: 34597567
Di Giovanni T, Eliades T, Papageorgiou SN
J Esthet Restor Dent 2018 Nov;30(6):502-508. Epub 2018 Sep 8 doi: 10.1111/jerd.12408. PMID: 30194793
Cury JA, Tenuta LM
Braz Oral Res 2014;28 Spec No:1-7. Epub 2014 Jan 24 doi: 10.1590/S1806-83242014.50000001. PMID: 24554097
Sampaio FC, Levy SM
Monogr Oral Sci 2011;22:133-145. Epub 2011 Jun 23 doi: 10.1159/000325161. PMID: 21701196

Prognosis

Foat A, Stevens C, George G, Massawe J, Mhina A, Gray WK, Mmbaga BT, Rwakatema DS, Sallis P, Jarvis H, Haule I, Benedict D, Walker R
Glob Health Sci Pract 2023 Dec 22;11(6) doi: 10.9745/GHSP-D-22-00342. PMID: 38135514Free PMC Article
Zotti F, Albertini L, Tomizioli N, Capocasale G, Albanese M
Medicina (Kaunas) 2020 Dec 29;57(1) doi: 10.3390/medicina57010022. PMID: 33383755Free PMC Article
Mondal P, Chattopadhyay A
J Appl Toxicol 2020 May;40(5):552-566. Epub 2019 Dec 22 doi: 10.1002/jat.3931. PMID: 31867774
Harriehausen CX, Dosani FZ, Chiquet BT, Barratt MS, Quock RL
J Clin Pediatr Dent 2019;43(1):34-41. Epub 2018 Oct 5 doi: 10.17796/1053-4625-43.1.7. PMID: 30289368
Do LG, Ha DH, Spencer AJ
Med J Aust 2016 Jan 18;204(1):25. doi: 10.5694/mja15.00703. PMID: 26763813

Clinical prediction guides

Saldarriaga A, Rojas-Gualdrón D, Restrepo M, Santos-Pinto L, Jeremias F
Acta Odontol Latinoam 2021 Aug 1;34(2):156-165. doi: 10.54589/aol.34/2/156. PMID: 34570864Free PMC Article
Zotti F, Albertini L, Tomizioli N, Capocasale G, Albanese M
Medicina (Kaunas) 2020 Dec 29;57(1) doi: 10.3390/medicina57010022. PMID: 33383755Free PMC Article
Cury JA, Ricomini-Filho AP, Berti FLP, Tabchoury CP
Braz Dent J 2019;30(5):421-428. Epub 2019 Oct 7 doi: 10.1590/0103-6440201903124. PMID: 31596325
Iheozor-Ejiofor Z, Worthington HV, Walsh T, O'Malley L, Clarkson JE, Macey R, Alam R, Tugwell P, Welch V, Glenny AM
Cochrane Database Syst Rev 2015 Jun 18;2015(6):CD010856. doi: 10.1002/14651858.CD010856.pub2. PMID: 26092033Free PMC Article
Buzalaf MAR, Pessan JP, Honório HM, Ten Cate JM
Monogr Oral Sci 2011;22:97-114. Epub 2011 Jun 23 doi: 10.1159/000325151. PMID: 21701194

Recent systematic reviews

Veneri F, Iamandii I, Vinceti M, Birnbaum LS, Generali L, Consolo U, Filippini T
Curr Environ Health Rep 2023 Dec;10(4):417-441. Epub 2023 Oct 20 doi: 10.1007/s40572-023-00412-9. PMID: 37861949
Bourouni S, Dritsas K, Kloukos D, Wierichs RJ
Clin Oral Investig 2021 Aug;25(8):4711-4719. Epub 2021 Jun 9 doi: 10.1007/s00784-021-03931-7. PMID: 34106348Free PMC Article
da Cunha Coelho ASE, Mata PCM, Lino CA, Macho VMP, Areias CMFGP, Norton APMAP, Augusto APCM
J Esthet Restor Dent 2019 Jan;31(1):26-39. Epub 2018 Oct 4 doi: 10.1111/jerd.12420. PMID: 30284749
Di Giovanni T, Eliades T, Papageorgiou SN
J Esthet Restor Dent 2018 Nov;30(6):502-508. Epub 2018 Sep 8 doi: 10.1111/jerd.12408. PMID: 30194793
Iheozor-Ejiofor Z, Worthington HV, Walsh T, O'Malley L, Clarkson JE, Macey R, Alam R, Tugwell P, Welch V, Glenny AM
Cochrane Database Syst Rev 2015 Jun 18;2015(6):CD010856. doi: 10.1002/14651858.CD010856.pub2. PMID: 26092033Free PMC Article

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