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Asymptomatic Diseases

MedGen UID:
445285
•Concept ID:
C2936329
•
Disease or Syndrome
Synonyms: Asymptomatic Condition; Asymptomatic Conditions; Asymptomatic Disease; Asymptomatic State; Asymptomatic States; Condition, Asymptomatic; Disease, Asymptomatic; Disease, Pre-Symptomatic; Disease, Presymptomatic; Pre-Symptomatic Disease; Pre-Symptomatic Diseases; Presymptomatic Disease; Presymptomatic Diseases

Definition

Diseases that do not exhibit symptoms. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAsymptomatic Diseases

Professional guidelines

PubMed

Antihypertensive treatment adherence in workers of a General Hospital.
Feriato KT, Gusmão JL, Silva A, Santos CAD, Pereira RSF, Amendola F
Rev Bras Enferm 2018 Jul-Aug;71(4):1875-1882. doi: 10.1590/0034-7167-2016-0469. PMID: 30156672
Timing of testing and treatment for asymptomatic diseases.
Kirkizlar E, Faissol DM, Griffin PM, Swann JL
Math Biosci 2010 Jul;226(1):28-37. Epub 2010 Mar 31 doi: 10.1016/j.mbs.2010.03.007. PMID: 20361985
Compliance with treatment regimens in chronic asymptomatic diseases.
Miller NH
Am J Med 1997 Feb 17;102(2A):43-9. doi: 10.1016/s0002-9343(97)00467-1. PMID: 9217586

Recent clinical studies

Etiology

The efficacy of muscle energy techniques in symptomatic and asymptomatic subjects: a systematic review.
Thomas E, Cavallaro AR, Mani D, Bianco A, Palma A
Chiropr Man Therap 2019;27:35. Epub 2019 Aug 27 doi: 10.1186/s12998-019-0258-7. PMID: 31462989Free PMC Article
Accidental Heart Murmurs.
Begic E, Begic Z
Med Arch 2017 Aug;71(4):284-287. doi: 10.5455/medarh.2017.71.284-287. PMID: 28974851Free PMC Article
Giardiasis.
Minetti C, Chalmers RM, Beeching NJ, Probert C, Lamden K
BMJ 2016 Oct 27;355:i5369. doi: 10.1136/bmj.i5369. PMID: 27789441
American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts.
Vege SS, Ziring B, Jain R, Moayyedi P; Clinical Guidelines Committee; American Gastroenterology Association
Gastroenterology 2015 Apr;148(4):819-22; quize12-3. doi: 10.1053/j.gastro.2015.01.015. PMID: 25805375
Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis.
Demoruelle MK, Deane KD
Curr Rheumatol Rep 2012 Oct;14(5):472-80. doi: 10.1007/s11926-012-0275-1. PMID: 22773387Free PMC Article

Diagnosis

Diagnosis and Management of Primary Hyperparathyroidism.
Zhu CY, Sturgeon C, Yeh MW
JAMA 2020 Mar 24;323(12):1186-1187. doi: 10.1001/jama.2020.0538. PMID: 32031566
Early Diagnosis and Treatment of Asymptomatic Vertical Enamel and Dentin Cracks.
Alassaad SS
Compend Contin Educ Dent 2017 Nov/Dec;38(10):656-661; quiz 662. PMID: 29140093
Aortic Stenosis: Pathophysiology, Diagnosis, and Therapy.
Joseph J, Naqvi SY, Giri J, Goldberg S
Am J Med 2017 Mar;130(3):253-263. Epub 2016 Nov 1 doi: 10.1016/j.amjmed.2016.10.005. PMID: 27810479
Giardiasis.
Minetti C, Chalmers RM, Beeching NJ, Probert C, Lamden K
BMJ 2016 Oct 27;355:i5369. doi: 10.1136/bmj.i5369. PMID: 27789441
Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis.
Demoruelle MK, Deane KD
Curr Rheumatol Rep 2012 Oct;14(5):472-80. doi: 10.1007/s11926-012-0275-1. PMID: 22773387Free PMC Article

Therapy

Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial.
Roman A, Zork N, Haeri S, Schoen CN, Saccone G, Colihan S, Zelig C, Gimovsky AC, Seligman NS, Zullo F, Berghella V
Am J Obstet Gynecol 2020 Dec;223(6):902.e1-902.e11. Epub 2020 Jun 25 doi: 10.1016/j.ajog.2020.06.047. PMID: 32592693
Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis.
Sandborn WJ, Peyrin-Biroulet L, Zhang J, Chiorean M, Vermeire S, Lee SD, Kühbacher T, Yacyshyn B, Cabell CH, Naik SU, Klassen P, Panés J
Gastroenterology 2020 Feb;158(3):550-561. Epub 2019 Nov 9 doi: 10.1053/j.gastro.2019.10.035. PMID: 31711921
Giardiasis: An Overview.
Leung AKC, Leung AAM, Wong AHC, Sergi CM, Kam JKM
Recent Pat Inflamm Allergy Drug Discov 2019;13(2):134-143. doi: 10.2174/1872213X13666190618124901. PMID: 31210116
Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.
Kimura K, Hosoya T, Uchida S, Inaba M, Makino H, Maruyama S, Ito S, Yamamoto T, Tomino Y, Ohno I, Shibagaki Y, Iimuro S, Imai N, Kuwabara M, Hayakawa H, Ohtsu H, Ohashi Y; FEATHER Study Investigators
Am J Kidney Dis 2018 Dec;72(6):798-810. Epub 2018 Sep 1 doi: 10.1053/j.ajkd.2018.06.028. PMID: 30177485
Treatment strategies in early rheumatoid arthritis and prevention of rheumatoid arthritis.
Demoruelle MK, Deane KD
Curr Rheumatol Rep 2012 Oct;14(5):472-80. doi: 10.1007/s11926-012-0275-1. PMID: 22773387Free PMC Article

Prognosis

Incidence of Ischemic Stroke in Patients With Asymptomatic Severe Carotid Stenosis Without Surgical Intervention.
Chang RW, Tucker LY, Rothenberg KA, Lancaster E, Faruqi RM, Kuang HC, Flint AC, Avins AL, Nguyen-Huynh MN
JAMA 2022 May 24;327(20):1974-1982. doi: 10.1001/jama.2022.4835. PMID: 35608581Free PMC Article
Determining the true burden of kidney stone disease.
Thongprayoon C, Krambeck AE, Rule AD
Nat Rev Nephrol 2020 Dec;16(12):736-746. Epub 2020 Aug 4 doi: 10.1038/s41581-020-0320-7. PMID: 32753740
Physical examination-indicated cerclage in twin pregnancy: a randomized controlled trial.
Roman A, Zork N, Haeri S, Schoen CN, Saccone G, Colihan S, Zelig C, Gimovsky AC, Seligman NS, Zullo F, Berghella V
Am J Obstet Gynecol 2020 Dec;223(6):902.e1-902.e11. Epub 2020 Jun 25 doi: 10.1016/j.ajog.2020.06.047. PMID: 32592693
Ocular demodicosis: A review.
Moris García V, Valenzuela Vargas G, Marín Cornuy M, Aguila Torres P
Arch Soc Esp Oftalmol (Engl Ed) 2019 Jul;94(7):316-322. Epub 2019 May 29 doi: 10.1016/j.oftal.2019.04.003. PMID: 31151686
Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors.
Fernández-Friera L, Fuster V, López-Melgar B, Oliva B, García-Ruiz JM, Mendiguren J, Bueno H, Pocock S, Ibáñez B, Fernández-Ortiz A, Sanz J
J Am Coll Cardiol 2017 Dec 19;70(24):2979-2991. doi: 10.1016/j.jacc.2017.10.024. PMID: 29241485

Clinical prediction guides

Asymptomatic peripheral artery disease: Silent but deadly.
Behroozian AA, Beckman JA
Prog Cardiovasc Dis 2021 Mar-Apr;65:2-8. Epub 2021 Feb 20 doi: 10.1016/j.pcad.2021.02.009. PMID: 33617896
High-risk carotid plaque: lessons learned from histopathology.
Kolodgie FD, Yahagi K, Mori H, Romero ME, Trout HH Rd, Finn AV, Virmani R
Semin Vasc Surg 2017 Mar;30(1):31-43. Epub 2017 Apr 27 doi: 10.1053/j.semvascsurg.2017.04.008. PMID: 28818257
EAU Guidelines on Diagnosis and Conservative Management of Urolithiasis.
Türk C, Petřík A, Sarica K, Seitz C, Skolarikos A, Straub M, Knoll T
Eur Urol 2016 Mar;69(3):468-74. Epub 2015 Aug 28 doi: 10.1016/j.eururo.2015.07.040. PMID: 26318710
Cardiovascular risk assessment in kidney transplantation.
Hart A, Weir MR, Kasiske BL
Kidney Int 2015 Mar;87(3):527-34. Epub 2014 Oct 8 doi: 10.1038/ki.2014.335. PMID: 25296093
Fortuitously discovered liver lesions.
Dietrich CF, Sharma M, Gibson RN, Schreiber-Dietrich D, Jenssen C
World J Gastroenterol 2013 Jun 7;19(21):3173-88. doi: 10.3748/wjg.v19.i21.3173. PMID: 23745019Free PMC Article

Recent systematic reviews

Subclinical hypothyroidism and thyroid autoimmunity in recurrent pregnancy loss: a systematic review and meta-analysis.
Dong AC, Morgan J, Kane M, Stagnaro-Green A, Stephenson MD
Fertil Steril 2020 Mar;113(3):587-600.e1. doi: 10.1016/j.fertnstert.2019.11.003. PMID: 32192591
The efficacy of muscle energy techniques in symptomatic and asymptomatic subjects: a systematic review.
Thomas E, Cavallaro AR, Mani D, Bianco A, Palma A
Chiropr Man Therap 2019;27:35. Epub 2019 Aug 27 doi: 10.1186/s12998-019-0258-7. PMID: 31462989Free PMC Article
Pulse oximetry screening for critical congenital heart defects.
Plana MN, Zamora J, Suresh G, Fernandez-Pineda L, Thangaratinam S, Ewer AK
Cochrane Database Syst Rev 2018 Mar 1;3(3):CD011912. doi: 10.1002/14651858.CD011912.pub2. PMID: 29494750Free PMC Article
Thyroid Function Within the Normal Range, Subclinical Hypothyroidism, and the Risk of Atrial Fibrillation.
Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen WPJ, Peeters RP, Luben R, Völzke H, Dörr M, Walsh JP, Bremner A, Iacoviello M, Macfarlane P, Heeringa J, Stott DJ, Westendorp RGJ, Khaw KT, Magnani JW, Aujesky D, Rodondi N; Thyroid Studies Collaboration
Circulation 2017 Nov 28;136(22):2100-2116. Epub 2017 Oct 23 doi: 10.1161/CIRCULATIONAHA.117.028753. PMID: 29061566Free PMC Article
Chiari Malformation Type 1: A Systematic Review of Natural History and Conservative Management.
Langridge B, Phillips E, Choi D
World Neurosurg 2017 Aug;104:213-219. Epub 2017 Apr 21 doi: 10.1016/j.wneu.2017.04.082. PMID: 28435116

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