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Myocardial Reperfusion Injury

MedGen UID:
44552
Concept ID:
C0027055
Pathologic Function
Synonyms: Injuries, Myocardial Reperfusion; Injury, Myocardial Reperfusion; Myocardial Ischemic Reperfusion Injury; Myocardial Reperfusion Injuries; Reperfusion Injuries, Myocardial; Reperfusion Injury, Myocardial

Definition

Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial Reperfusion Injury

Professional guidelines

PubMed

Goina CA, Goina DM, Farcas SS, Andreescu NI
Int J Mol Sci 2024 Mar 4;25(5) doi: 10.3390/ijms25052986. PMID: 38474233Free PMC Article
Zhang T, Deng W, Deng Y, Liu Y, Xiao S, Luo Y, Xiang W, He Q
Biomed Pharmacother 2023 Sep;165:114706. Epub 2023 Jul 1 doi: 10.1016/j.biopha.2023.114706. PMID: 37400352
Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P
J Mol Med (Berl) 2006 Jun;84(6):469-77. Epub 2006 May 6 doi: 10.1007/s00109-006-0051-7. PMID: 16733765

Recent clinical studies

Etiology

Zhao WK, Zhou Y, Xu TT, Wu Q
Oxid Med Cell Longev 2021;2021:9929687. Epub 2021 Oct 23 doi: 10.1155/2021/9929687. PMID: 34725566Free PMC Article
Russo I, Penna C, Musso T, Popara J, Alloatti G, Cavalot F, Pagliaro P
Cardiovasc Diabetol 2017 May 31;16(1):71. doi: 10.1186/s12933-017-0550-6. PMID: 28569217Free PMC Article
Pagliaro P, Penna C
J Cardiovasc Med (Hagerstown) 2017 Mar;18(3):131-135. doi: 10.2459/JCM.0000000000000435. PMID: 27606784
Kalogeris T, Baines CP, Krenz M, Korthuis RJ
Compr Physiol 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006. PMID: 28135002Free PMC Article
Kobashigawa J, Zuckermann A, Macdonald P, Leprince P, Esmailian F, Luu M, Mancini D, Patel J, Razi R, Reichenspurner H, Russell S, Segovia J, Smedira N, Stehlik J, Wagner F; Consensus Conference participants
J Heart Lung Transplant 2014 Apr;33(4):327-40. Epub 2014 Mar 5 doi: 10.1016/j.healun.2014.02.027. PMID: 24661451

Diagnosis

Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y, Chen C
Mol Med Rep 2021 May;23(5) Epub 2021 Mar 24 doi: 10.3892/mmr.2021.11991. PMID: 33760122Free PMC Article
Li Y, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL, Du J
Circulation 2019 Aug 27;140(9):751-764. Epub 2019 Jun 21 doi: 10.1161/CIRCULATIONAHA.118.039262. PMID: 31220942
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article
Kobashigawa J, Zuckermann A, Macdonald P, Leprince P, Esmailian F, Luu M, Mancini D, Patel J, Razi R, Reichenspurner H, Russell S, Segovia J, Smedira N, Stehlik J, Wagner F; Consensus Conference participants
J Heart Lung Transplant 2014 Apr;33(4):327-40. Epub 2014 Mar 5 doi: 10.1016/j.healun.2014.02.027. PMID: 24661451
Pagliaro P, Penna C
Antioxid Redox Signal 2011 Mar 1;14(5):777-9. Epub 2010 Dec 15 doi: 10.1089/ars.2010.3531. PMID: 20712411

Therapy

Griffiths K, Lee JJ, Frenneaux MP, Feelisch M, Madhani M
Pharmacol Ther 2021 Jul;223:107819. Epub 2021 Feb 15 doi: 10.1016/j.pharmthera.2021.107819. PMID: 33600852
Roth S, Torregroza C, Huhn R, Hollmann MW, Preckel B
Anesth Analg 2020 Dec;131(6):1751-1764. doi: 10.1213/ANE.0000000000005234. PMID: 33186162
Li Y, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL, Du J
Circulation 2019 Aug 27;140(9):751-764. Epub 2019 Jun 21 doi: 10.1161/CIRCULATIONAHA.118.039262. PMID: 31220942
Rossello X, Lobo-Gonzalez M, Ibanez B
Eur Heart J Acute Cardiovasc Care 2019 Aug;8(5):443-456. Epub 2019 Jun 7 doi: 10.1177/2048872619845283. PMID: 31172789
Ibáñez B, Heusch G, Ovize M, Van de Werf F
J Am Coll Cardiol 2015 Apr 14;65(14):1454-71. doi: 10.1016/j.jacc.2015.02.032. PMID: 25857912

Prognosis

Yang K, Gao R, Chen H, Hu J, Zhang P, Wei X, Shi J, Chen Y, Zhang L, Chen J, Lyu Y, Dong Z, Wei W, Hu K, Guo Y, Ge J, Sun A
Eur Heart J 2024 May 13;45(18):1662-1680. doi: 10.1093/eurheartj/ehae205. PMID: 38666340Free PMC Article
Yang Y, Li X, Chen G, Xian Y, Zhang H, Wu Y, Yang Y, Wu J, Wang C, He S, Wang Z, Wang Y, Wang Z, Liu H, Wang X, Zhang M, Zhang J, Li J, An T, Guan H, Li L, Shang M, Yao C, Han Y, Zhang B, Gao R, Peterson ED; CTS-AMI Investigators
JAMA 2023 Oct 24;330(16):1534-1545. doi: 10.1001/jama.2023.19524. PMID: 37874574Free PMC Article
Liu C, Li Z, Li B, Liu W, Zhang S, Qiu K, Zhu W
PeerJ 2023;11:e14952. Epub 2023 Mar 13 doi: 10.7717/peerj.14952. PMID: 36935924Free PMC Article
Heusch G
Nat Rev Cardiol 2020 Dec;17(12):773-789. Epub 2020 Jul 3 doi: 10.1038/s41569-020-0403-y. PMID: 32620851
Bugger H, Pfeil K
Biochim Biophys Acta Mol Basis Dis 2020 Jul 1;1866(7):165768. Epub 2020 Mar 12 doi: 10.1016/j.bbadis.2020.165768. PMID: 32173461

Clinical prediction guides

Bei Y, Zhu Y, Zhou J, Ai S, Yao J, Yin M, Hu M, Qi W, Spanos M, Li L, Wei M, Huang Z, Gao J, Liu C, van der Kraak PH, Li G, Lei Z, Sluijter JPG, Xiao J
Circulation 2024 Sep 10;150(11):848-866. Epub 2024 May 6 doi: 10.1161/CIRCULATIONAHA.123.067592. PMID: 38708602
Yang K, Gao R, Chen H, Hu J, Zhang P, Wei X, Shi J, Chen Y, Zhang L, Chen J, Lyu Y, Dong Z, Wei W, Hu K, Guo Y, Ge J, Sun A
Eur Heart J 2024 May 13;45(18):1662-1680. doi: 10.1093/eurheartj/ehae205. PMID: 38666340Free PMC Article
Hu M, Zhang X, Hu C, Ma ZG, Wang SS, Teng T, Zeng XF, Tang QZ
Cardiovasc Res 2024 Jul 31;120(9):1051-1064. doi: 10.1093/cvr/cvae077. PMID: 38637328
Fan Q, Tao R, Zhang H, Xie H, Lu L, Wang T, Su M, Hu J, Zhang Q, Chen Q, Iwakura Y, Shen W, Zhang R, Yan X
Circulation 2019 Jan 29;139(5):663-678. doi: 10.1161/CIRCULATIONAHA.118.036044. PMID: 30586706
Wang ZY, Liu YY, Liu GH, Lu HB, Mao CY
Life Sci 2018 Feb 1;194:88-97. Epub 2017 Dec 11 doi: 10.1016/j.lfs.2017.12.015. PMID: 29241711

Recent systematic reviews

Song W, Tang Q, Teng L, Zhang M, Sha S, Li B, Zhu L
Microvasc Res 2023 May;147:104502. Epub 2023 Feb 4 doi: 10.1016/j.mvr.2023.104502. PMID: 36746363
Prem PN, Sivakumar B, Boovarahan SR, Kurian GA
Phytomedicine 2022 Jul;101:154123. Epub 2022 Apr 26 doi: 10.1016/j.phymed.2022.154123. PMID: 35533608
Huang F, Mai J, Chen J, He Y, Chen X
J Cardiothorac Surg 2021 May 22;16(1):140. doi: 10.1186/s13019-021-01524-9. PMID: 34022925Free PMC Article
Makkos A, Ágg B, Petrovich B, Varga ZV, Görbe A, Ferdinandy P
Free Radic Biol Med 2021 Aug 20;172:237-251. Epub 2021 Jun 19 doi: 10.1016/j.freeradbiomed.2021.04.034. PMID: 33965565
Le Page S, Bejan-Angoulvant T, Angoulvant D, Prunier F
Basic Res Cardiol 2015 Mar;110(2):11. Epub 2015 Feb 5 doi: 10.1007/s00395-015-0467-8. PMID: 25653117

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