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Myocardial Reperfusion Injury

MedGen UID:
44552
•Concept ID:
C0027055
•
Pathologic Function
Synonyms: Injuries, Myocardial Reperfusion; Injury, Myocardial Reperfusion; Myocardial Ischemic Reperfusion Injury; Myocardial Reperfusion Injuries; Reperfusion Injuries, Myocardial; Reperfusion Injury, Myocardial

Definition

Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial Reperfusion Injury

Professional guidelines

PubMed

A New Approach for the Prevention and Treatment of Cardiovascular Disorders. Molecular Hydrogen Significantly Reduces the Effects of Oxidative Stress.
LeBaron TW, Kura B, Kalocayova B, Tribulova N, Slezak J
Molecules 2019 May 31;24(11) doi: 10.3390/molecules24112076. PMID: 31159153Free PMC Article
The role of cyclosporine in the treatment of myocardial reperfusion injury.
Gill RS, Bigam DL, Cheung PY
Shock 2012 Apr;37(4):341-7. doi: 10.1097/SHK.0b013e31824bc9ab. PMID: 22293599
Fibrin(ogen) and its fragments in the pathophysiology and treatment of myocardial infarction.
Zacharowski K, Zacharowski P, Reingruber S, Petzelbauer P
J Mol Med (Berl) 2006 Jun;84(6):469-77. Epub 2006 May 6 doi: 10.1007/s00109-006-0051-7. PMID: 16733765

Recent clinical studies

Etiology

Ferroptosis: Opportunities and Challenges in Myocardial Ischemia-Reperfusion Injury.
Zhao WK, Zhou Y, Xu TT, Wu Q
Oxid Med Cell Longev 2021;2021:9929687. Epub 2021 Oct 23 doi: 10.1155/2021/9929687. PMID: 34725566Free PMC Article
Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction.
Rout A, Tantry US, Novakovic M, Sukhi A, Gurbel PA
Expert Opin Pharmacother 2020 Oct;21(15):1851-1865. Epub 2020 Jul 13 doi: 10.1080/14656566.2020.1787987. PMID: 32659185
The protective role of curcumin in myocardial ischemia-reperfusion injury.
Mokhtari-Zaer A, Marefati N, Atkin SL, Butler AE, Sahebkar A
J Cell Physiol 2018 Jan;234(1):214-222. Epub 2018 Jul 3 doi: 10.1002/jcp.26848. PMID: 29968913
l-Carnitine and heart disease.
Wang ZY, Liu YY, Liu GH, Lu HB, Mao CY
Life Sci 2018 Feb 1;194:88-97. Epub 2017 Dec 11 doi: 10.1016/j.lfs.2017.12.015. PMID: 29241711
Ischemia/Reperfusion.
Kalogeris T, Baines CP, Krenz M, Korthuis RJ
Compr Physiol 2016 Dec 6;7(1):113-170. doi: 10.1002/cphy.c160006. PMID: 28135002Free PMC Article

Diagnosis

Non-Coding RNAs: Prevention, Diagnosis, and Treatment in Myocardial Ischemia-Reperfusion Injury.
Marinescu MC, Lazar AL, Marta MM, Cozma A, Catana CS
Int J Mol Sci 2022 Mar 1;23(5) doi: 10.3390/ijms23052728. PMID: 35269870Free PMC Article
HIF‑1α in myocardial ischemia‑reperfusion injury (Review).
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y, Chen C
Mol Med Rep 2021 May;23(5) Epub 2021 Mar 24 doi: 10.3892/mmr.2021.11991. PMID: 33760122Free PMC Article
S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury.
Li Y, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL, Du J
Circulation 2019 Aug 27;140(9):751-764. Epub 2019 Jun 21 doi: 10.1161/CIRCULATIONAHA.118.039262. PMID: 31220942
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article
How is cardiac troponin released from injured myocardium?
Mair J, Lindahl B, Hammarsten O, Müller C, Giannitsis E, Huber K, Möckel M, Plebani M, Thygesen K, Jaffe AS
Eur Heart J Acute Cardiovasc Care 2018 Sep;7(6):553-560. Epub 2017 Dec 27 doi: 10.1177/2048872617748553. PMID: 29278915

Therapy

Cardioprotection of pharmacological postconditioning on myocardial ischemia/reperfusion injury.
Wu Y, Liu H, Wang X
Life Sci 2021 Jan 1;264:118628. Epub 2020 Oct 22 doi: 10.1016/j.lfs.2020.118628. PMID: 33131670
Dexmedetomidine pretreatment attenuates myocardial ischemia reperfusion induced acute kidney injury and endoplasmic reticulum stress in human and rat.
Tang C, Hu Y, Gao J, Jiang J, Shi S, Wang J, Geng Q, Liang X, Chai X
Life Sci 2020 Sep 15;257:118004. Epub 2020 Jul 2 doi: 10.1016/j.lfs.2020.118004. PMID: 32621918
S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocyte Death in Response to Ischemic/Reperfusion Injury.
Li Y, Chen B, Yang X, Zhang C, Jiao Y, Li P, Liu Y, Li Z, Qiao B, Bond Lau W, Ma XL, Du J
Circulation 2019 Aug 27;140(9):751-764. Epub 2019 Jun 21 doi: 10.1161/CIRCULATIONAHA.118.039262. PMID: 31220942
Ischaemic conditioning and reperfusion injury.
Hausenloy DJ, Yellon DM
Nat Rev Cardiol 2016 Apr;13(4):193-209. Epub 2016 Feb 4 doi: 10.1038/nrcardio.2016.5. PMID: 26843289
Evolving therapies for myocardial ischemia/reperfusion injury.
Ibáñez B, Heusch G, Ovize M, Van de Werf F
J Am Coll Cardiol 2015 Apr 14;65(14):1454-71. doi: 10.1016/j.jacc.2015.02.032. PMID: 25857912

Prognosis

Disruption of Circadian Rhythms by Shift Work Exacerbates Reperfusion Injury in Myocardial Infarction.
Zhao Y, Lu X, Wan F, Gao L, Lin N, He J, Wei L, Dong J, Qin Z, Zhong F, Qiao Z, Wang W, Ge H, Ding S, Yang Y, Xiu J, Shan P, Yan F, Zhao S, Ji Y, Pu J
J Am Coll Cardiol 2022 May 31;79(21):2097-2115. doi: 10.1016/j.jacc.2022.03.370. PMID: 35618347Free PMC Article
Myocardial ischaemia-reperfusion injury and cardioprotection in perspective.
Heusch G
Nat Rev Cardiol 2020 Dec;17(12):773-789. Epub 2020 Jul 3 doi: 10.1038/s41569-020-0403-y. PMID: 32620851
Mitochondrial ROS in myocardial ischemia reperfusion and remodeling.
Bugger H, Pfeil K
Biochim Biophys Acta Mol Basis Dis 2020 Jul 1;1866(7):165768. Epub 2020 Mar 12 doi: 10.1016/j.bbadis.2020.165768. PMID: 32173461
The coronary circulation in acute myocardial ischaemia/reperfusion injury: a target for cardioprotection.
Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G
Cardiovasc Res 2019 Jun 1;115(7):1143-1155. doi: 10.1093/cvr/cvy286. PMID: 30428011Free PMC Article
l-Carnitine and heart disease.
Wang ZY, Liu YY, Liu GH, Lu HB, Mao CY
Life Sci 2018 Feb 1;194:88-97. Epub 2017 Dec 11 doi: 10.1016/j.lfs.2017.12.015. PMID: 29241711

Clinical prediction guides

Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury.
D'Ascenzo F, Femminò S, Ravera F, Angelini F, Caccioppo A, Franchin L, Grosso A, Comità S, Cavallari C, Penna C, De Ferrari GM, Camussi G, Pagliaro P, Brizzi MF
Pharmacol Res 2021 Aug;170:105715. Epub 2021 Jun 7 doi: 10.1016/j.phrs.2021.105715. PMID: 34111564
Targeted pharmacotherapy for ischemia reperfusion injury in acute myocardial infarction.
Rout A, Tantry US, Novakovic M, Sukhi A, Gurbel PA
Expert Opin Pharmacother 2020 Oct;21(15):1851-1865. Epub 2020 Jul 13 doi: 10.1080/14656566.2020.1787987. PMID: 32659185
Dectin-1 Contributes to Myocardial Ischemia/Reperfusion Injury by Regulating Macrophage Polarization and Neutrophil Infiltration.
Fan Q, Tao R, Zhang H, Xie H, Lu L, Wang T, Su M, Hu J, Zhang Q, Chen Q, Iwakura Y, Shen W, Zhang R, Yan X
Circulation 2019 Jan 29;139(5):663-678. doi: 10.1161/CIRCULATIONAHA.118.036044. PMID: 30586706
l-Carnitine and heart disease.
Wang ZY, Liu YY, Liu GH, Lu HB, Mao CY
Life Sci 2018 Feb 1;194:88-97. Epub 2017 Dec 11 doi: 10.1016/j.lfs.2017.12.015. PMID: 29241711
Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.
Montaigne D, Marechal X, Modine T, Coisne A, Mouton S, Fayad G, Ninni S, Klein C, Ortmans S, Seunes C, Potelle C, Berthier A, Gheeraert C, Piveteau C, Deprez R, Eeckhoute J, Duez H, Lacroix D, Deprez B, Jegou B, Koussa M, Edme JL, Lefebvre P, Staels B
Lancet 2018 Jan 6;391(10115):59-69. Epub 2017 Oct 26 doi: 10.1016/S0140-6736(17)32132-3. PMID: 29107324

Recent systematic reviews

Exercise for myocardial ischemia-reperfusion injury: A systematic review and meta-analysis based on preclinical studies.
Song W, Tang Q, Teng L, Zhang M, Sha S, Li B, Zhu L
Microvasc Res 2023 May;147:104502. Epub 2023 Feb 4 doi: 10.1016/j.mvr.2023.104502. PMID: 36746363
Recent advances in potential of Fisetin in the management of myocardial ischemia-reperfusion injury-A systematic review.
Prem PN, Sivakumar B, Boovarahan SR, Kurian GA
Phytomedicine 2022 Jul;101:154123. Epub 2022 Apr 26 doi: 10.1016/j.phymed.2022.154123. PMID: 35533608
Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review.
Huang F, Mai J, Chen J, He Y, Chen X
J Cardiothorac Surg 2021 May 22;16(1):140. doi: 10.1186/s13019-021-01524-9. PMID: 34022925Free PMC Article
Systematic review and network analysis of microRNAs involved in cardioprotection against myocardial ischemia/reperfusion injury and infarction: Involvement of redox signalling.
Makkos A, Ágg B, Petrovich B, Varga ZV, Görbe A, Ferdinandy P
Free Radic Biol Med 2021 Aug 20;172:237-251. Epub 2021 Jun 19 doi: 10.1016/j.freeradbiomed.2021.04.034. PMID: 33965565
Remote Ischemic Perconditioning to Reduce Reperfusion Injury During Acute ST-Segment-Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis.
McLeod SL, Iansavichene A, Cheskes S
J Am Heart Assoc 2017 May 17;6(5) doi: 10.1161/JAHA.117.005522. PMID: 28515120Free PMC Article

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