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Necrobiosis lipoidica

MedGen UID:
45021
Concept ID:
C0027538
Disease or Syndrome
Synonym: Necrobiosis Lipoidica
SNOMED CT: NLD - Necrobiosis lipoidica (9418005); Necrobiosis lipoidica (9418005)
 
Monarch Initiative: MONDO:0006583
Orphanet: ORPHA542592

Definition

A rare skin disease characterized by enlarging, annular plaques with red-brown edges and atrophic, yellow-brown, telangiectatic centers. The lesions are commonly asymptomatic, but affected skin areas may be fragile, and painful ulcerations develop in many cases. In rare cases, development of squamous cell carcinoma within longstanding lesions has been reported. The lower legs, especially the shins, are the most frequently involved site. The condition is often associated with diabetes mellitus. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNecrobiosis lipoidica

Professional guidelines

PubMed

Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E
Lasers Med Sci 2021 Apr;36(3):497-506. Epub 2020 Sep 24 doi: 10.1007/s10103-020-03147-3. PMID: 32970197
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312

Recent clinical studies

Etiology

Kök GF, Türsen Ü
Adv Exp Med Biol 2022;1367:349-368. doi: 10.1007/978-3-030-92616-8_13. PMID: 35286702
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Asai J
J Dermatol 2017 Mar;44(3):297-303. doi: 10.1111/1346-8138.13662. PMID: 28256762
Wick MR
Semin Diagn Pathol 2017 May;34(3):301-311. Epub 2016 Dec 14 doi: 10.1053/j.semdp.2016.12.003. PMID: 28094163
Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P
Aust Fam Physician 2014 Mar;43(3):129-30. PMID: 24600675

Diagnosis

Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Terziroli Beretta-Piccoli B, Mainetti C, Peeters MA, Laffitte E
Clin Rev Allergy Immunol 2018 Feb;54(1):131-146. doi: 10.1007/s12016-017-8666-8. PMID: 29352388
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Wick MR
Semin Diagn Pathol 2017 May;34(3):261-272. Epub 2016 Dec 27 doi: 10.1053/j.semdp.2016.12.004. PMID: 28129926
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418

Therapy

Rajabi-Estarabadi A, Aickara DJ, Hirsch M, Williams NM, Maranda EL, Van Badiavas E
Lasers Med Sci 2021 Apr;36(3):497-506. Epub 2020 Sep 24 doi: 10.1007/s10103-020-03147-3. PMID: 32970197
Lima AL, Illing T, Schliemann S, Elsner P
Am J Clin Dermatol 2017 Aug;18(4):541-553. doi: 10.1007/s40257-017-0275-z. PMID: 28374407
Peckruhn M, Tittelbach J, Elsner P
J Dtsch Dermatol Ges 2017 Feb;15(2):151-157. doi: 10.1111/ddg.13186. PMID: 28214312
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Grillo E, Rodriguez-Muñoz D, González-Garcia A, Jaén P
Aust Fam Physician 2014 Mar;43(3):129-30. PMID: 24600675

Prognosis

Sanches MM, Roda Â, Pimenta R, Filipe PL, Freitas JP
Acta Med Port 2019 Jun 28;32(6):459-465. doi: 10.20344/amp.10738. PMID: 31292028
Sibbald C, Reid S, Alavi A
Dermatol Clin 2015 Jul;33(3):343-60. doi: 10.1016/j.det.2015.03.003. PMID: 26143418
Serrao R, Zirwas M, English JC
Am J Clin Dermatol 2007;8(6):347-56. doi: 10.2165/00128071-200708060-00004. PMID: 18039017
Ahmed I, Goldstein B
Clin Dermatol 2006 Jul-Aug;24(4):237-46. doi: 10.1016/j.clindermatol.2006.04.009. PMID: 16828404
Sibbald RG, Landolt SJ, Toth D
Endocrinol Metab Clin North Am 1996 Jun;25(2):463-72. doi: 10.1016/s0889-8529(05)70334-0. PMID: 8799710

Clinical prediction guides

Kuraitis D, Murina A
Cutis 2024 Jan;113(1):29-34. doi: 10.12788/cutis.0914. PMID: 38478947
Johnson E, Patel MH, Brumfiel CM, Severson KJ, Bhullar P, Boudreaux B, Butterfield RJ, DiCaudo DJ, Nelson SA, Pittelkow MR, Mangold AR
J Cutan Pathol 2022 Aug;49(8):692-700. Epub 2022 Apr 25 doi: 10.1111/cup.14238. PMID: 35403265
Berman HS, Shabihkhani M, Hogeling M
Dermatol Online J 2021 Jul 15;27(7) doi: 10.5070/D327754363. PMID: 34391328
Schmitt A, Volz A
J Dtsch Dermatol Ges 2019 May;17(5):518-533. doi: 10.1111/ddg.13848. PMID: 31115996
Toyota T, Umezu M, Oikawa N, Sanoyama R, Suzuki S, Suzuki H, Nakajima Y, Goto Y
Tohoku J Exp Med 1983 Dec;141(4):457-61. doi: 10.1620/tjem.141.457. PMID: 6670101

Recent systematic reviews

Nihal A, Caplan AS, Rosenbach M, Damsky W, Mangold AR, Shields BE
Int J Dermatol 2023 Dec;62(12):1529-1537. Epub 2023 Sep 29 doi: 10.1111/ijd.16856. PMID: 37772666
Sood S, Heung M, Georgakopoulos JR, Mufti A, Prajapati VH, Yeung J
J Am Acad Dermatol 2023 Aug;89(2):357-359. Epub 2023 Mar 28 doi: 10.1016/j.jaad.2023.03.024. PMID: 36990321
Seivright JR, Villa NM, De DR, Hsiao JL, Shi VY
Dermatol Ther 2022 Feb;35(2):e15234. Epub 2021 Dec 8 doi: 10.1111/dth.15234. PMID: 34825744
Mistry BD, Alavi A, Ali S, Mistry N
Int J Dermatol 2017 Dec;56(12):1319-1327. Epub 2017 Jun 26 doi: 10.1111/ijd.13610. PMID: 28650076
Kroft EB, Berkhof NJ, van de Kerkhof PC, Gerritsen RM, de Jong EM
J Am Acad Dermatol 2008 Dec;59(6):1017-30. Epub 2008 Oct 2 doi: 10.1016/j.jaad.2008.07.042. PMID: 18835066

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