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Paraneoplastic Endocrine Syndromes

MedGen UID:
45038
•Concept ID:
C0027670
•
Disease or Syndrome
Synonyms: Ectopic Hormone Syndrome; Ectopic Hormone Syndromes; Endocrine Syndrome, Paraneoplastic; Paraneoplastic Endocrine Syndrome; Syndrome, Ectopic Hormone; Syndrome, Paraneoplastic Endocrine; Syndromes, Ectopic Hormone; Syndromes, Paraneoplastic Endocrine

Definition

Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Endocrine Syndromes

Professional guidelines

PubMed

Updated Review and Treatment Recommendations on Paraneoplastic Neurologic Syndromes and Chronic Pain.
Blyakhman I, Chakravarthy K
Pain Physician 2019 Sep;22(5):433-445. PMID: 31561645
Paraneoplastic syndromes: an approach to diagnosis and treatment.
Pelosof LC, Gerber DE
Mayo Clin Proc 2010 Sep;85(9):838-54. doi: 10.4065/mcp.2010.0099. PMID: 20810794Free PMC Article

Recent clinical studies

Etiology

Paraneoplastic syndromes: the way to an early diagnosis of lung cancer.
Paraschiv B, Diaconu CC, Toma CL, Bogdan MA
Pneumologia 2015;64(2):14-9. PMID: 26506668
Pancreatic endocrine tumors.
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379
Paraneoplastic syndromes in patients with nasopharyngeal cancer.
Toro C, Rinaldo A, Silver CE, Politi M, Ferlito A
Auris Nasus Larynx 2009 Oct;36(5):513-20. Epub 2008 Dec 27 doi: 10.1016/j.anl.2008.10.006. PMID: 19111998
Imaging in the investigation of paraneoplastic syndromes.
Rutherford GC, Dineen RA, O'Connor A
Clin Radiol 2007 Nov;62(11):1021-35. Epub 2007 Sep 12 doi: 10.1016/j.crad.2007.06.005. PMID: 17920860
Multiple endocrine neoplasia.
Caruso DR, O'Dorisio TM, Mazzaferri EL
Curr Opin Oncol 1991 Feb;3(1):103-8. doi: 10.1097/00001622-199102000-00015. PMID: 1675123

Diagnosis

Endocrine paraneoplastic syndromes in lung cancer: a respiratory physician's perspective.
Upadhya P, Ananthraju A, Vadala R, Mohanty Mohapatra M
Adv Respir Med 2021;89(4):403-412. doi: 10.5603/ARM.a2021.0075. PMID: 34494243
Endocrine paraneoplastic syndromes in lung cancer.
Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Paraneoplastic endocrine syndromes.
Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2017 Jun;24(6):R173-R190. Epub 2017 Mar 24 doi: 10.1530/ERC-17-0036. PMID: 28341725
Paraneoplastic syndromes: the way to an early diagnosis of lung cancer.
Paraschiv B, Diaconu CC, Toma CL, Bogdan MA
Pneumologia 2015;64(2):14-9. PMID: 26506668
Pancreatic endocrine tumors.
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379

Therapy

Metastatic pheochromocytoma and paraganglioma: Management of endocrine manifestations, surgery and ablative procedures, and systemic therapies.
Jasim S, Jimenez C
Best Pract Res Clin Endocrinol Metab 2020 Mar;34(2):101354. Epub 2019 Oct 24 doi: 10.1016/j.beem.2019.101354. PMID: 31685417
Medical management of secretory syndromes related to gastroenteropancreatic neuroendocrine tumours.
Dimitriadis GK, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2016 Sep;23(9):R423-36. Epub 2016 Jul 26 doi: 10.1530/ERC-16-0200. PMID: 27461388
Pancreatic endocrine tumors.
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379
Carcinoid tumours.
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Pituitary tumors: diagnosis and therapy.
Cook DM
CA Cancer J Clin 1983 Jul-Aug;33(4):215-36. doi: 10.3322/canjclin.33.4.215. PMID: 6407726

Prognosis

Endocrine paraneoplastic syndromes in lung cancer: a respiratory physician's perspective.
Upadhya P, Ananthraju A, Vadala R, Mohanty Mohapatra M
Adv Respir Med 2021;89(4):403-412. doi: 10.5603/ARM.a2021.0075. PMID: 34494243
Endocrine paraneoplastic syndromes in lung cancer.
Efthymiou C, Spyratos D, Kontakiotis T
Hormones (Athens) 2018 Sep;17(3):351-358. Epub 2018 Jul 2 doi: 10.1007/s42000-018-0046-0. PMID: 29968234
Paraneoplastic endocrine syndromes.
Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A
Endocr Relat Cancer 2017 Jun;24(6):R173-R190. Epub 2017 Mar 24 doi: 10.1530/ERC-17-0036. PMID: 28341725
Syndromes that Link the Endocrine System and Genitourinary Tract.
Özlük Y, Kılıçaslan I
Turk Patoloji Derg 2015;31 Suppl 1:155-71. doi: 10.5146/tjpath.2015.01322. PMID: 26177325
Pancreatic endocrine tumors.
Oberg K
Semin Oncol 2010 Dec;37(6):594-618. doi: 10.1053/j.seminoncol.2010.10.014. PMID: 21167379

Clinical prediction guides

Functionality is not an independent prognostic factor for pancreatic neuroendocrine tumors.
Chen HY, Zhou YL, Chen YH, Wang X, Zhang H, Ke NW, Liu XB, Tan CL
World J Gastroenterol 2020 Jul 7;26(25):3638-3649. doi: 10.3748/wjg.v26.i25.3638. PMID: 32742132Free PMC Article
Syndromes that Link the Endocrine System and Genitourinary Tract.
Özlük Y, Kılıçaslan I
Turk Patoloji Derg 2015;31 Suppl 1:155-71. doi: 10.5146/tjpath.2015.01322. PMID: 26177325
Proliferation parameters for pituitary adenomas.
Buchfelder M, Fahlbusch R, Adams EF, Kiesewetter F, Thierauf P
Acta Neurochir Suppl 1996;65:18-21. doi: 10.1007/978-3-7091-9450-8_7. PMID: 8738487
The value of cytometric DNA analysis as a prognostic tool in neuroendocrine neoplastic diseases.
Falkmer UG, Falkmer S
Pathol Res Pract 1995 May;191(4):281-303. doi: 10.1016/S0344-0338(11)80883-6. PMID: 7479346
Aberrant hormone activity by tumors of gynecologic importance.
Shane JM, Naftolin F
Am J Obstet Gynecol 1975 Jan 1;121(1):133-43. doi: 10.1016/0002-9378(75)90991-6. PMID: 163584

Recent systematic reviews

Paraneoplastic syndromes associated with gynecological cancers: A systematic review.
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M
Gynecol Oncol 2017 Sep;146(3):661-671. Epub 2017 Jun 24 doi: 10.1016/j.ygyno.2017.06.025. PMID: 28655412
Paraneoplastic humorally mediated hypercalcemia induced by parathyroid hormone-related protein in gynecologic malignancies: a systematic review.
Savvari P, Peitsidis P, Alevizaki M, Dimopoulos MA, Antsaklis A, Papadimitriou CA
Onkologie 2009 Sep;32(8-9):517-23. Epub 2009 Aug 12 doi: 10.1159/000226209. PMID: 19745599

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