U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Idiopathic growth hormone deficiency(IGHD)

MedGen UID:
450529
•Concept ID:
C0342381
•
Disease or Syndrome
Synonym: IGHD
SNOMED CT: Idiopathic growth hormone insufficiency (237688008); IGHD - Idiopathic growth hormone deficiency (237688008); Idiopathic growth hormone deficiency (237688008)
 
Related genes: GH1, BTK

Professional guidelines

PubMed

Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.
Grimberg A, DiVall SA, Polychronakos C, Allen DB, Cohen LE, Quintos JB, Rossi WC, Feudtner C, Murad MH; Drug and Therapeutics Committee and Ethics Committee of the Pediatric Endocrine Society
Horm Res Paediatr 2016;86(6):361-397. Epub 2016 Nov 25 doi: 10.1159/000452150. PMID: 27884013

Recent clinical studies

Etiology

Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Near final height in patients with idiopathic growth hormone deficiency: A single-centre experience.
Kurnaz E, Çetinkaya S, Aycan Z
J Paediatr Child Health 2018 Nov;54(11):1221-1226. Epub 2018 May 28 doi: 10.1111/jpc.14061. PMID: 29806866
Idiopathic growth hormone deficiency in the morphologically normal pituitary gland is associated with perfusion delay.
Wang CY, Chung HW, Cho NY, Liu HS, Chou MC, Kao HW, Juan CJ, Lee MS, Huang GS, Chen CY
Radiology 2011 Jan;258(1):213-21. Epub 2010 Sep 30 doi: 10.1148/radiol.10100504. PMID: 20884913
Differential growth and maturation in idiopathic growth-hormone-deficient children.
Cantu G, Buschang PH, Gonzalez JL
Eur J Orthod 1997 Apr;19(2):131-9. doi: 10.1093/ejo/19.2.131. PMID: 9183062

Diagnosis

Psychiatric Disorders and Peer-Victimization in Children and Adolescents With Growth Hormone Deficiency.
Gizli Çoban Ö, Bedel A, Önder A, Sürer Adanır A, Tuhan H, Parlak M
Clin Pediatr (Phila) 2022 Oct;61(10):684-691. Epub 2022 May 17 doi: 10.1177/00099228221096654. PMID: 35581721
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Issues and trends in pediatric growth hormone therapy--an update from the GHMonitor observational registry.
Pitukcheewanont P, Desrosiers P, Steelman J, Rapaport R, Fuqua JS, Kreher NC, Hamlett A
Pediatr Endocrinol Rev 2008 Feb;5 Suppl 2:702-7. PMID: 18317441
Early-onset idiopathic growth hormone deficiency within KIGS.
Ranke MB, Lindberg A; KIGS International Board
Horm Res 2003;60(Suppl 1):18-21. doi: 10.1159/000071221. PMID: 12955013
Idiopathic growth hormone deficiency: a vanishing diagnosis?
Pfäffle R, Blankenstein O, Wüller S, Heimann K, Heimann G
Horm Res 2000;53 Suppl 3:1-8. doi: 10.1159/000023524. PMID: 10971095

Therapy

Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Growth hormone treatment for growth hormone deficiency and idiopathic short stature: new guidelines shaped by the presence and absence of evidence.
Grimberg A, Allen DB
Curr Opin Pediatr 2017 Aug;29(4):466-471. doi: 10.1097/MOP.0000000000000505. PMID: 28525404Free PMC Article
Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency, Turner syndrome, short stature, born small for gestational age and idiopathic short stature: KIGS analysis and review.
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173
Issues and trends in pediatric growth hormone therapy--an update from the GHMonitor observational registry.
Pitukcheewanont P, Desrosiers P, Steelman J, Rapaport R, Fuqua JS, Kreher NC, Hamlett A
Pediatr Endocrinol Rev 2008 Feb;5 Suppl 2:702-7. PMID: 18317441
Early-onset idiopathic growth hormone deficiency within KIGS.
Ranke MB, Lindberg A; KIGS International Board
Horm Res 2003;60(Suppl 1):18-21. doi: 10.1159/000071221. PMID: 12955013

Prognosis

Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency, Turner syndrome, short stature, born small for gestational age and idiopathic short stature: KIGS analysis and review.
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173
Spontaneous growth and response to growth hormone treatment in children with growth hormone deficiency and idiopathic short stature.
Wit JM, Kamp GA, Rikken B
Pediatr Res 1996 Feb;39(2):295-302. doi: 10.1203/00006450-199602000-00018. PMID: 8825803

Clinical prediction guides

Growth hormone deficit: Influence of puberty on the response to treatment.
Sánchez Malo MJ, Hidalgo Sanz J, Hernández Tejedor C, García Ventura M, Ferrer Lozano M, Labarta Aizpún JI, de Arriba Muñoz A
An Pediatr (Engl Ed) 2022 Mar;96(3):221-229. Epub 2022 Feb 28 doi: 10.1016/j.anpede.2021.04.008. PMID: 35241406
Differential diagnosis between constitutional delay of growth and puberty, idiopathic growth hormone deficiency and congenital hypogonadotropic hypogonadism: a clinical challenge for the pediatric endocrinologist.
Galazzi E, Persani LG
Minerva Endocrinol 2020 Dec;45(4):354-375. Epub 2020 Jul 23 doi: 10.23736/S0391-1977.20.03228-9. PMID: 32720501
Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center.
Al Shaikh A, Daftardar H, Alghamdi AA, Jamjoom M, Awidah S, Ahmed ME, Soliman AT
Acta Biomed 2020 Mar 19;91(1):29-40. doi: 10.23750/abm.v91i1.9182. PMID: 32191651Free PMC Article
Observed and predicted total pubertal growth during treatment with growth hormone in adolescents with idiopathic growth hormone deficiency, Turner syndrome, short stature, born small for gestational age and idiopathic short stature: KIGS analysis and review.
Ranke MB, Lindberg A
Horm Res Paediatr 2011;75(6):423-32. Epub 2011 Feb 25 doi: 10.1159/000324117. PMID: 21358173
Idiopathic growth hormone deficiency: a vanishing diagnosis?
Pfäffle R, Blankenstein O, Wüller S, Heimann K, Heimann G
Horm Res 2000;53 Suppl 3:1-8. doi: 10.1159/000023524. PMID: 10971095

Recent systematic reviews

The landscape of retesting in childhood-onset idiopathic growth hormone deficiency and its reversibility: a systematic review and meta-analysis.
Laurer E, Sirovina A, Blaschitz A, Tischlinger K, Montero-Lopez R, Hörtenhuber T, Wimleitner M, Högler W
Eur J Endocrinol 2022 Aug 1;187(2):265-278. Epub 2022 Jun 29 doi: 10.1530/EJE-21-1179. PMID: 35670597

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • GTR
      Related information in GTR
    • GTR(Clinical)
      Clinical tests in GTR
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...