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Addictive nicotine use

MedGen UID:
45086
•Concept ID:
C0028043
•
Mental or Behavioral Dysfunction
Synonyms: Nicotine addiction; Nicotine dependence
SNOMED CT: Nicotine dependence (56294008)
 
Related genes: GABBR2, SLC6A3, CYP2A6, CHRNA4
 
HPO: HP:0033543
Monarch Initiative: MONDO:0008575

Definition

Nicotine addiction can be defined as a chronic, compulsive craving for nicotine and continued usage despite harmful consequences. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Transcranial magnetic stimulation, deep brain stimulation, and other forms of neuromodulation for substance use disorders: Review of modalities and implications for treatment.
Mahoney JJ 3rd, Hanlon CA, Marshalek PJ, Rezai AR, Krinke L
J Neurol Sci 2020 Nov 15;418:117149. Epub 2020 Sep 20 doi: 10.1016/j.jns.2020.117149. PMID: 33002757Free PMC Article
Current advances in research in treatment and recovery: Nicotine addiction.
Prochaska JJ, Benowitz NL
Sci Adv 2019 Oct;5(10):eaay9763. Epub 2019 Oct 16 doi: 10.1126/sciadv.aay9763. PMID: 31663029Free PMC Article
DSM-5 criteria for substance use disorders: recommendations and rationale.
Hasin DS, O'Brien CP, Auriacombe M, Borges G, Bucholz K, Budney A, Compton WM, Crowley T, Ling W, Petry NM, Schuckit M, Grant BF
Am J Psychiatry 2013 Aug;170(8):834-51. doi: 10.1176/appi.ajp.2013.12060782. PMID: 23903334Free PMC Article

Recent clinical studies

Etiology

Nicotine Gateway Effects on Adolescent Substance Use.
Ren M, Lotfipour S
West J Emerg Med 2019 Aug 20;20(5):696-709. doi: 10.5811/westjem.2019.7.41661. PMID: 31539325Free PMC Article
RESPIRATORY IMPACT OF ELECTRONIC CIGARETTES AND "LOW-RISK" TOBACCO.
Thirión-Romero I, Pérez-Padilla R, Zabert G, Barrientos-Gutiérrez I
Rev Invest Clin 2019;71(1):17-27. doi: 10.24875/RIC.18002616. PMID: 30810544
The neurobiology of addiction.
Uhl GR, Koob GF, Cable J
Ann N Y Acad Sci 2019 Sep;1451(1):5-28. Epub 2019 Jan 15 doi: 10.1111/nyas.13989. PMID: 30644552Free PMC Article
Electronic Cigarette Harm and Benefit Perceptions and Use Among Youth.
Bernat D, Gasquet N, Wilson KO, Porter L, Choi K
Am J Prev Med 2018 Sep;55(3):361-367. Epub 2018 Jul 19 doi: 10.1016/j.amepre.2018.04.043. PMID: 30031636Free PMC Article
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.
Benowitz NL
Annu Rev Pharmacol Toxicol 2009;49:57-71. doi: 10.1146/annurev.pharmtox.48.113006.094742. PMID: 18834313Free PMC Article

Diagnosis

Bipolar Disorder and Comorbid Use of Illicit Substances.
Preuss UW, Schaefer M, Born C, Grunze H
Medicina (Kaunas) 2021 Nov 17;57(11) doi: 10.3390/medicina57111256. PMID: 34833474Free PMC Article
Addiction-related neuroadaptations following chronic nicotine exposure.
Wills L, Kenny PJ
J Neurochem 2021 Jun;157(5):1652-1673. doi: 10.1111/jnc.15356. PMID: 33742685
Nicotine Gateway Effects on Adolescent Substance Use.
Ren M, Lotfipour S
West J Emerg Med 2019 Aug 20;20(5):696-709. doi: 10.5811/westjem.2019.7.41661. PMID: 31539325Free PMC Article
Targeting Nicotine Addiction.
Carr E
Clin J Oncol Nurs 2018 Jun 1;22(3):243-244. doi: 10.1188/18.CJON.243-244. PMID: 29781460
The dopamine theory of addiction: 40 years of highs and lows.
Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR
Nat Rev Neurosci 2015 May;16(5):305-12. Epub 2015 Apr 15 doi: 10.1038/nrn3939. PMID: 25873042

Therapy

Electronic cigarettes for smoking cessation.
Hartmann-Boyce J, Lindson N, Butler AR, McRobbie H, Bullen C, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Fanshawe TR, Hajek P
Cochrane Database Syst Rev 2022 Nov 17;11(11):CD010216. doi: 10.1002/14651858.CD010216.pub7. PMID: 36384212Free PMC Article
Vaping: The new wave of nicotine addiction.
Dinardo P, Rome ES
Cleve Clin J Med 2019 Dec;86(12):789-798. doi: 10.3949/ccjm.86a.19118. PMID: 31821136
Nicotine Gateway Effects on Adolescent Substance Use.
Ren M, Lotfipour S
West J Emerg Med 2019 Aug 20;20(5):696-709. doi: 10.5811/westjem.2019.7.41661. PMID: 31539325Free PMC Article
Nicotine and health.
Drug Ther Bull 2014 Jul;52(7):78-81. doi: 10.1136/dtb.2014.7.0264. PMID: 25012148
Pharmacology of nicotine: addiction, smoking-induced disease, and therapeutics.
Benowitz NL
Annu Rev Pharmacol Toxicol 2009;49:57-71. doi: 10.1146/annurev.pharmtox.48.113006.094742. PMID: 18834313Free PMC Article

Prognosis

Substance use during the COVID-19 pandemic: What is really happening?
Mellos E, Paparrigopoulos T
Psychiatriki 2022 Mar 28;33(1):17-20. Epub 2022 Feb 21 doi: 10.22365/jpsych.2022.072. PMID: 35255473
Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay to promote lymphatic metastasis of human esophageal cancer.
Wang M, Li Y, Xiao Y, Yang M, Chen J, Jian Y, Chen X, Shi D, Chen X, Ouyang Y, Kong L, Huang X, Bai J, Lin C, Song L
Nat Commun 2021 Dec 1;12(1):7006. doi: 10.1038/s41467-021-27348-8. PMID: 34853315Free PMC Article
An overview of alcohol and tobacco/nicotine interactions in the human laboratory.
Verplaetse TL, McKee SA
Am J Drug Alcohol Abuse 2017 Mar;43(2):186-196. Epub 2016 Jul 20 doi: 10.1080/00952990.2016.1189927. PMID: 27439453Free PMC Article
Nicotine withdrawal.
McLaughlin I, Dani JA, De Biasi M
Curr Top Behav Neurosci 2015;24:99-123. doi: 10.1007/978-3-319-13482-6_4. PMID: 25638335Free PMC Article
Nicotine addiction.
Benowitz NL
Prim Care 1999 Sep;26(3):611-31. doi: 10.1016/s0095-4543(05)70120-2. PMID: 10436290

Clinical prediction guides

Genetically determined metabolism of nicotine and its clinical significance.
Delijewski M, Bartoń A, Delijewska P, Balwierz R, Jakubiak G, Kośmider L, Pawlas N
Acta Biochim Pol 2019 Oct 4;66(4):375-381. doi: 10.18388/abp.2019_2645. PMID: 31584787
RESPIRATORY IMPACT OF ELECTRONIC CIGARETTES AND "LOW-RISK" TOBACCO.
Thirión-Romero I, Pérez-Padilla R, Zabert G, Barrientos-Gutiérrez I
Rev Invest Clin 2019;71(1):17-27. doi: 10.24875/RIC.18002616. PMID: 30810544
The dopamine theory of addiction: 40 years of highs and lows.
Nutt DJ, Lingford-Hughes A, Erritzoe D, Stokes PR
Nat Rev Neurosci 2015 May;16(5):305-12. Epub 2015 Apr 15 doi: 10.1038/nrn3939. PMID: 25873042
Pilot study of the 5-HT2AR agonist psilocybin in the treatment of tobacco addiction.
Johnson MW, Garcia-Romeu A, Cosimano MP, Griffiths RR
J Psychopharmacol 2014 Nov;28(11):983-92. Epub 2014 Sep 11 doi: 10.1177/0269881114548296. PMID: 25213996Free PMC Article
Nicotine chemistry, metabolism, kinetics and biomarkers.
Benowitz NL, Hukkanen J, Jacob P 3rd
Handb Exp Pharmacol 2009;(192):29-60. doi: 10.1007/978-3-540-69248-5_2. PMID: 19184645Free PMC Article

Recent systematic reviews

Electronic cigarettes for smoking cessation.
Hartmann-Boyce J, Lindson N, Butler AR, McRobbie H, Bullen C, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Fanshawe TR, Hajek P
Cochrane Database Syst Rev 2022 Nov 17;11(11):CD010216. doi: 10.1002/14651858.CD010216.pub7. PMID: 36384212Free PMC Article
Risk and protective factors of drug abuse among adolescents: a systematic review.
Nawi AM, Ismail R, Ibrahim F, Hassan MR, Manaf MRA, Amit N, Ibrahim N, Shafurdin NS
BMC Public Health 2021 Nov 13;21(1):2088. doi: 10.1186/s12889-021-11906-2. PMID: 34774013Free PMC Article
Electronic cigarettes for smoking cessation.
Hartmann-Boyce J, McRobbie H, Butler AR, Lindson N, Bullen C, Begh R, Theodoulou A, Notley C, Rigotti NA, Turner T, Fanshawe TR, Hajek P
Cochrane Database Syst Rev 2021 Sep 14;9(9):CD010216. doi: 10.1002/14651858.CD010216.pub6. PMID: 34519354Free PMC Article
Nicotine replacement therapy versus control for smoking cessation.
Hartmann-Boyce J, Chepkin SC, Ye W, Bullen C, Lancaster T
Cochrane Database Syst Rev 2018 May 31;5(5):CD000146. doi: 10.1002/14651858.CD000146.pub5. PMID: 29852054Free PMC Article
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review.
Deepmala, Slattery J, Kumar N, Delhey L, Berk M, Dean O, Spielholz C, Frye R
Neurosci Biobehav Rev 2015 Aug;55:294-321. Epub 2015 May 6 doi: 10.1016/j.neubiorev.2015.04.015. PMID: 25957927

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      Clinical tests in GTR
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