U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ring fibers

MedGen UID:
451039
•Concept ID:
C0333770
•
Cell Component; Finding
Synonym: Ring fibres
SNOMED CT: Ring fibers (47913008)
 
HPO: HP:0100305

Definition

Ring fibers are formed by a bundle of peripheral myofibrils which are circumferentially oriented such that they encircle the internal portion of the sarcoplasm which is normal in structure and orientation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRing fibers

Professional guidelines

PubMed

Awake Laser Ablation with Continuous Neuropsychological Testing During Treatment of Brain Tumors and Epilepsy.
Nielsen SH, Skjøth-Rasmussen J, Moldrup SD, Engelmann CM, Jespersen B, Rasmussen R
Neurosurg Clin N Am 2023 Apr;34(2):239-245. Epub 2023 Jan 31 doi: 10.1016/j.nec.2022.11.003. PMID: 36906330
Occurrence, distribution and risk assessment of microplastics and polycyclic aromatic hydrocarbons in East lake, Hubei, China.
Shi M, Zhu J, Hu T, Xu A, Mao Y, Liu L, Zhang Y, She Z, Li P, Qi S, Xing X
Chemosphere 2023 Mar;316:137864. Epub 2023 Jan 12 doi: 10.1016/j.chemosphere.2023.137864. PMID: 36642129
Potential airborne asbestos exposures in dentistry: a comprehensive review and risk assessment.
Ierardi AM, Mathis C, Urban A, Jacobs N, Finley B, Gaffney S
Crit Rev Toxicol 2021 Apr;51(4):301-327. Epub 2021 Jun 1 doi: 10.1080/10408444.2021.1910624. PMID: 34060417

Recent clinical studies

Etiology

Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol 2018 Jun;83(6):1105-1124. doi: 10.1002/ana.25241. PMID: 29691892Free PMC Article
Effects of variable courses of inguinal nerves on pain in patients undergoing Lichtenstein repair for inguinal hernia: preliminary results.
Emeksiz S, Ozden H, Guven G
Acta Chir Belg 2013 May-Jun;113(3):196-202. doi: 10.1080/00015458.2013.11680911. PMID: 24941716

Diagnosis

Novel Mutation in Anoctamin 5 Gene Causing Limb-Girdle Muscular Dystrophy 2L.
Peddareddygari LR, Oberoi K, Baisre-De Leon A, Grewal RP
J Clin Neuromuscul Dis 2018 Jun;19(4):228-231. doi: 10.1097/CND.0000000000000202. PMID: 29794579
Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol 2018 Jun;83(6):1105-1124. doi: 10.1002/ana.25241. PMID: 29691892Free PMC Article
An unusual case with myotonia.
Da YW, Wang M, Li Y, Lu Y, Jia JP
Kaohsiung J Med Sci 2013 Mar;29(3):172-5. Epub 2012 Nov 22 doi: 10.1016/j.kjms.2012.08.029. PMID: 23465422
Ring fibers visualized by electron microscopy in a Japanese patient with malignant hyperthermia.
Kitagawa Y, Sato J, Kuriyama M, Sano K, Hashimoto K
Odontology 2011 Jan;99(1):101-104. Epub 2011 Jan 27 doi: 10.1007/s10266-010-0141-4. PMID: 21271335
Skeletal muscle abnormalities in two patients with dystonia.
Niiyama T, Higuchi I, Uchida Y, Horikiri T, Arimura K, Osame M
Acta Neuropathol 2002 Dec;104(6):670-3. Epub 2002 Sep 11 doi: 10.1007/s00401-002-0603-z. PMID: 12410389

Therapy

Ring fibers visualized by electron microscopy in a Japanese patient with malignant hyperthermia.
Kitagawa Y, Sato J, Kuriyama M, Sano K, Hashimoto K
Odontology 2011 Jan;99(1):101-104. Epub 2011 Jan 27 doi: 10.1007/s10266-010-0141-4. PMID: 21271335

Prognosis

Filamentous tangles with nemaline rods in MYH2 myopathy: a novel phenotype.
Madigan NN, Polzin MJ, Cui G, Liewluck T, Alsharabati MH, Klein CJ, Windebank AJ, Mer G, Milone M
Acta Neuropathol Commun 2021 Apr 29;9(1):79. doi: 10.1186/s40478-021-01168-9. PMID: 33926564Free PMC Article
Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol 2018 Jun;83(6):1105-1124. doi: 10.1002/ana.25241. PMID: 29691892Free PMC Article
Effects of variable courses of inguinal nerves on pain in patients undergoing Lichtenstein repair for inguinal hernia: preliminary results.
Emeksiz S, Ozden H, Guven G
Acta Chir Belg 2013 May-Jun;113(3):196-202. doi: 10.1080/00015458.2013.11680911. PMID: 24941716
Origin of the ring muscle fibers in neuromuscular diseases.
Sawicka E
Neuropatol Pol 1991;29(1-2):29-40. PMID: 1839930

Clinical prediction guides

Immunolocalization of protease-activated receptors in endothelial cells of splenic sinuses.
Uehara K, Uehara A
Cell Tissue Res 2021 Dec;386(3):605-615. Epub 2021 Oct 6 doi: 10.1007/s00441-021-03535-3. PMID: 34613486
Filamentous tangles with nemaline rods in MYH2 myopathy: a novel phenotype.
Madigan NN, Polzin MJ, Cui G, Liewluck T, Alsharabati MH, Klein CJ, Windebank AJ, Mer G, Milone M
Acta Neuropathol Commun 2021 Apr 29;9(1):79. doi: 10.1186/s40478-021-01168-9. PMID: 33926564Free PMC Article
Congenital Titinopathy: Comprehensive characterization and pathogenic insights.
Oates EC, Jones KJ, Donkervoort S, Charlton A, Brammah S, Smith JE 3rd, Ware JS, Yau KS, Swanson LC, Whiffin N, Peduto AJ, Bournazos A, Waddell LB, Farrar MA, Sampaio HA, Teoh HL, Lamont PJ, Mowat D, Fitzsimons RB, Corbett AJ, Ryan MM, O'Grady GL, Sandaradura SA, Ghaoui R, Joshi H, Marshall JL, Nolan MA, Kaur S, Punetha J, Töpf A, Harris E, Bakshi M, Genetti CA, Marttila M, Werlauff U, Streichenberger N, Pestronk A, Mazanti I, Pinner JR, Vuillerot C, Grosmann C, Camacho A, Mohassel P, Leach ME, Foley AR, Bharucha-Goebel D, Collins J, Connolly AM, Gilbreath HR, Iannaccone ST, Castro D, Cummings BB, Webster RI, Lazaro L, Vissing J, Coppens S, Deconinck N, Luk HM, Thomas NH, Foulds NC, Illingworth MA, Ellard S, McLean CA, Phadke R, Ravenscroft G, Witting N, Hackman P, Richard I, Cooper ST, Kamsteeg EJ, Hoffman EP, Bushby K, Straub V, Udd B, Ferreiro A, North KN, Clarke NF, Lek M, Beggs AH, Bönnemann CG, MacArthur DG, Granzier H, Davis MR, Laing NG
Ann Neurol 2018 Jun;83(6):1105-1124. doi: 10.1002/ana.25241. PMID: 29691892Free PMC Article
Bcl-2 and Bax protein expression in human myopathies.
Olivé M, Ferrer I
J Neurol Sci 1999 Mar 15;164(1):76-81. doi: 10.1016/s0022-510x(99)00041-6. PMID: 10385052
Immunohistochemical localization of smooth muscle myosin in human spleen, lymph node, and other lymphoid tissues. Unique staining patterns in splenic white pulp and sinuses, lymphoid follicles, and certain vasculature, with ultrastructural correlations.
Pinkus GS, Warhol MJ, O'Connor EM, Etheridge CL, Fujiwara K
Am J Pathol 1986 Jun;123(3):440-53. PMID: 2424311Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...