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Transitory tachypnea of newborn

MedGen UID:
452136
•Concept ID:
C0158940
•
Disease or Syndrome
Synonyms: Newborn Transient Tachypnea; Newborn Transient Tachypneas; Transient Tachypnea of Newborn; Transient Tachypnea of the Newborn
SNOMED CT: Newborn transitory tachypnea (7550008); TTN - Transient tachypnea of newborn (7550008); Transient tachypnea of newborn (7550008); Wet lung syndrome in newborn (7550008); Transitory tachypnea of newborn (7550008); Tachypnea resolving about 6 hours postnatally (7550008); Idiopathic tachypnea of newborn (7550008)

Definition

A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitory tachypnea of newborn

Professional guidelines

PubMed

Individualized management of vasa previa and neonatal outcomes.
Saji S, Hasegawa J, Oyelese Y, Furuya N, Homma C, Nishimura Y, Nakamura M, Suzuki N
J Obstet Gynaecol Res 2023 Nov;49(11):2680-2685. Epub 2023 Aug 24 doi: 10.1111/jog.15775. PMID: 37621145
Interventions for the management of transient tachypnoea of the newborn - an overview of systematic reviews.
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM
J Perinatol 2021 Jan;41(1):6-16. Epub 2020 Aug 4 doi: 10.1038/s41372-020-0757-3. PMID: 32753712

Recent clinical studies

Etiology

Disquiet concerning cesarean birth.
Cohen WR, Robson MS, Bedrick AD
J Perinat Med 2023 Jun 27;51(5):591-599. Epub 2022 Nov 16 doi: 10.1515/jpm-2022-0343. PMID: 36376060
Interventions for the management of transient tachypnoea of the newborn - an overview of systematic reviews.
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.
Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network
N Engl J Med 2016 Apr 7;374(14):1311-20. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1516783. PMID: 26842679Free PMC Article
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Respiratory distress in the newborn.
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Diagnosis

Salbutamol for transient tachypnea of the newborn.
Moresco L, Bruschettini M, Macchi M, Calevo MG
Cochrane Database Syst Rev 2021 Feb 5;2(2):CD011878. doi: 10.1002/14651858.CD011878.pub3. PMID: 33543473Free PMC Article
Recent Advances in Pathophysiology and Management of Transient Tachypnea of Newborn.
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM
J Perinatol 2021 Jan;41(1):6-16. Epub 2020 Aug 4 doi: 10.1038/s41372-020-0757-3. PMID: 32753712
Newborn Respiratory Distress.
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Respiratory distress in the newborn.
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Therapy

Disquiet concerning cesarean birth.
Cohen WR, Robson MS, Bedrick AD
J Perinat Med 2023 Jun 27;51(5):591-599. Epub 2022 Nov 16 doi: 10.1515/jpm-2022-0343. PMID: 36376060
Interventions for the management of transient tachypnoea of the newborn - an overview of systematic reviews.
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Antenatal Betamethasone for Women at Risk for Late Preterm Delivery.
Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network
N Engl J Med 2016 Apr 7;374(14):1311-20. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1516783. PMID: 26842679Free PMC Article
Newborn Respiratory Distress.
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Respiratory distress in the newborn.
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article

Prognosis

European guidelines on perinatal care: corticosteroids for women at risk of preterm birth.
Daskalakis G, Pergialiotis V, Domellöf M, Ehrhardt H, Di Renzo GC, Koç E, Malamitsi-Puchner A, Kacerovsky M, Modi N, Shennan A, Ayres-de-Campos D, Gliozheni E, Rull K, Braun T, Beke A, Kosińska-Kaczyńska K, Areia AL, Vladareanu S, Sršen TP, Schmitz T, Jacobsson B
J Matern Fetal Neonatal Med 2023 Dec;36(1):2160628. doi: 10.1080/14767058.2022.2160628. PMID: 36689999
New parameters on prediction of severity of transient tachypnea of the newborn.
Çelik Y, Kahvecioğlu D, Ece İ, Atik F, Çetinkaya AK, Taşar MA
Turk J Med Sci 2022 Aug;52(4):1006-1012. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5402. PMID: 36326372Free PMC Article
Prevalence and Pregnancy Outcomes of Intrahepatic Cholestasis of Pregnancy.
Sitaula D, Timalsina S, Sharma B, Pokharel B, Thapa R
J Nepal Health Res Counc 2021 Sep 6;19(2):321-326. doi: 10.33314/jnhrc.v19i2.3455. PMID: 34601524
Skin-to-Skin Contact and the Incidence of Transient Tachypnea of the Newborn.
Mihalik H, Young Smith H, Mullen C, George E, Cottrell C, Markovich R, Savitski J
J Obstet Gynecol Neonatal Nurs 2021 Nov;50(6):724-731. Epub 2021 Sep 21 doi: 10.1016/j.jogn.2021.09.001. PMID: 34555334
Prospective investigation of serial ultrasound for transient tachypnea of the newborn.
Li CS, Chu SM, Lien R, Mok TY, Hsu KH, Lai SH
Pediatr Neonatol 2021 Jan;62(1):64-69. Epub 2020 Sep 9 doi: 10.1016/j.pedneo.2020.09.002. PMID: 32972849

Clinical prediction guides

European guidelines on perinatal care: corticosteroids for women at risk of preterm birth.
Daskalakis G, Pergialiotis V, Domellöf M, Ehrhardt H, Di Renzo GC, Koç E, Malamitsi-Puchner A, Kacerovsky M, Modi N, Shennan A, Ayres-de-Campos D, Gliozheni E, Rull K, Braun T, Beke A, Kosińska-Kaczyńska K, Areia AL, Vladareanu S, Sršen TP, Schmitz T, Jacobsson B
J Matern Fetal Neonatal Med 2023 Dec;36(1):2160628. doi: 10.1080/14767058.2022.2160628. PMID: 36689999
New parameters on prediction of severity of transient tachypnea of the newborn.
Çelik Y, Kahvecioğlu D, Ece İ, Atik F, Çetinkaya AK, Taşar MA
Turk J Med Sci 2022 Aug;52(4):1006-1012. Epub 2022 Aug 10 doi: 10.55730/1300-0144.5402. PMID: 36326372Free PMC Article
Comparison of neonatal outcomes with and without the administration of betamethasone in late preterm births.
Bulut AN, Cundubey CR, Ceyhan V, Aydin E
Int J Gynaecol Obstet 2022 Feb;156(2):349-354. Epub 2021 Nov 30 doi: 10.1002/ijgo.14028. PMID: 34787903
Effects of Inhaled Salbutamol on Transient Tachypnea of the Newborn.
Basiri B, Sadeghi N, Sabzehei MK, Ashari FE
Respir Care 2022 Apr;67(4):433-439. Epub 2021 Nov 9 doi: 10.4187/respcare.09284. PMID: 34753814
Prospective investigation of serial ultrasound for transient tachypnea of the newborn.
Li CS, Chu SM, Lien R, Mok TY, Hsu KH, Lai SH
Pediatr Neonatol 2021 Jan;62(1):64-69. Epub 2020 Sep 9 doi: 10.1016/j.pedneo.2020.09.002. PMID: 32972849

Recent systematic reviews

Interventions for the management of transient tachypnoea of the newborn - an overview of systematic reviews.
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Salbutamol for transient tachypnea of the newborn.
Moresco L, Bruschettini M, Macchi M, Calevo MG
Cochrane Database Syst Rev 2021 Feb 5;2(2):CD011878. doi: 10.1002/14651858.CD011878.pub3. PMID: 33543473Free PMC Article
Strategies for managing transient tachypnoea of the newborn - a systematic review.
Buchiboyina A, Jasani B, Deshmukh M, Patole S
J Matern Fetal Neonatal Med 2017 Jul;30(13):1524-1532. Epub 2016 Oct 20 doi: 10.1080/14767058.2016.1193143. PMID: 27762156
Epinephrine for transient tachypnea of the newborn.
Moresco L, Calevo MG, Baldi F, Cohen A, Bruschettini M
Cochrane Database Syst Rev 2016 May 23;2016(5):CD011877. doi: 10.1002/14651858.CD011877.pub2. PMID: 27211231Free PMC Article
Salbutamol for transient tachypnea of the newborn.
Moresco L, Bruschettini M, Cohen A, Gaiero A, Calevo MG
Cochrane Database Syst Rev 2016 May 23;(5):CD011878. doi: 10.1002/14651858.CD011878.pub2. PMID: 27210618

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