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Transitory tachypnea of newborn

MedGen UID:
452136
Concept ID:
C0158940
Disease or Syndrome
Synonyms: Newborn Transient Tachypnea; Newborn Transient Tachypneas; Transient Tachypnea of Newborn; Transient Tachypnea of the Newborn
SNOMED CT: Newborn transitory tachypnea (7550008); TTN - Transient tachypnea of newborn (7550008); Transient tachypnea of newborn (7550008); Wet lung syndrome in newborn (7550008); Transitory tachypnea of newborn (7550008); Tachypnea resolving about 6 hours postnatally (7550008); Idiopathic tachypnea of newborn (7550008)

Definition

A respiratory disorder characterized by higher than normal respiratory rates among premature and cesarean section delivered neonates whose lungs have not fully matured. The cause is often excess fluid in the lungs, and resolution is aided by supplemental oxygen and sometimes, antibiotics. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTransitory tachypnea of newborn

Professional guidelines

PubMed

Saji S, Hasegawa J, Oyelese Y, Furuya N, Homma C, Nishimura Y, Nakamura M, Suzuki N
J Obstet Gynaecol Res 2023 Nov;49(11):2680-2685. Epub 2023 Aug 24 doi: 10.1111/jog.15775. PMID: 37621145
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM
J Perinatol 2021 Jan;41(1):6-16. Epub 2020 Aug 4 doi: 10.1038/s41372-020-0757-3. PMID: 32753712

Recent clinical studies

Etiology

Yenuberi H, Ross B, Sasmita Tirkey R, Benjamin SJ, Rathore S, Karuppusami R, Lal A, Thomas N, Mathew JE
Obstet Gynecol 2024 Apr 1;143(4):468-474. Epub 2024 Feb 8 doi: 10.1097/AOG.0000000000005520. PMID: 38330411
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network
N Engl J Med 2016 Apr 7;374(14):1311-20. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1516783. PMID: 26842679Free PMC Article
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Diagnosis

Saji S, Hasegawa J, Oyelese Y, Furuya N, Homma C, Nishimura Y, Nakamura M, Suzuki N
J Obstet Gynaecol Res 2023 Nov;49(11):2680-2685. Epub 2023 Aug 24 doi: 10.1111/jog.15775. PMID: 37621145
Alhassen Z, Vali P, Guglani L, Lakshminrusimha S, Ryan RM
J Perinatol 2021 Jan;41(1):6-16. Epub 2020 Aug 4 doi: 10.1038/s41372-020-0757-3. PMID: 32753712
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article
Hermansen CL, Lorah KN
Am Fam Physician 2007 Oct 1;76(7):987-94. PMID: 17956068

Therapy

Yenuberi H, Ross B, Sasmita Tirkey R, Benjamin SJ, Rathore S, Karuppusami R, Lal A, Thomas N, Mathew JE
Obstet Gynecol 2024 Apr 1;143(4):468-474. Epub 2024 Feb 8 doi: 10.1097/AOG.0000000000005520. PMID: 38330411
Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Gyamfi-Bannerman C, Thom EA, Blackwell SC, Tita AT, Reddy UM, Saade GR, Rouse DJ, McKenna DS, Clark EA, Thorp JM Jr, Chien EK, Peaceman AM, Gibbs RS, Swamy GK, Norton ME, Casey BM, Caritis SN, Tolosa JE, Sorokin Y, VanDorsten JP, Jain L; NICHD Maternal–Fetal Medicine Units Network
N Engl J Med 2016 Apr 7;374(14):1311-20. Epub 2016 Feb 4 doi: 10.1056/NEJMoa1516783. PMID: 26842679Free PMC Article
Hermansen CL, Mahajan A
Am Fam Physician 2015 Dec 1;92(11):994-1002. PMID: 26760414
Reuter S, Moser C, Baack M
Pediatr Rev 2014 Oct;35(10):417-28; quiz 429. doi: 10.1542/pir.35-10-417. PMID: 25274969Free PMC Article

Prognosis

Yenuberi H, Ross B, Sasmita Tirkey R, Benjamin SJ, Rathore S, Karuppusami R, Lal A, Thomas N, Mathew JE
Obstet Gynecol 2024 Apr 1;143(4):468-474. Epub 2024 Feb 8 doi: 10.1097/AOG.0000000000005520. PMID: 38330411
Sitaula D, Timalsina S, Sharma B, Pokharel B, Thapa R
J Nepal Health Res Counc 2021 Sep 6;19(2):321-326. doi: 10.33314/jnhrc.v19i2.3455. PMID: 34601524
McKinzie AH, Yang Z, Teal E, Daggy JK, Tepper RS, Quinney SK, Rhoads E, Haneline LS, Haas DM
Am J Obstet Gynecol 2021 Nov;225(5):536.e1-536.e7. Epub 2021 May 3 doi: 10.1016/j.ajog.2021.04.251. PMID: 33957112Free PMC Article
Rocha GM, Flor-De-Lima FS, Guimaraes HA
Minerva Pediatr 2018 Jun;70(3):217-224. Epub 2016 Sep 8 doi: 10.23736/S0026-4946.16.04490-X. PMID: 27607482
Saigal S, Usher RH
Biol Neonate 1977;32(1-2):62-72. doi: 10.1159/000240996. PMID: 901882

Clinical prediction guides

Choi H, Lee EJ, Ahn YS, Yoo YM
BMC Pediatr 2022 Nov 3;22(1):625. doi: 10.1186/s12887-022-03690-8. PMID: 36324100Free PMC Article
Basiri B, Sadeghi N, Sabzehei MK, Ashari FE
Respir Care 2022 Apr;67(4):433-439. Epub 2021 Nov 9 doi: 10.4187/respcare.09284. PMID: 34753814
Sitaula D, Timalsina S, Sharma B, Pokharel B, Thapa R
J Nepal Health Res Counc 2021 Sep 6;19(2):321-326. doi: 10.33314/jnhrc.v19i2.3455. PMID: 34601524
McKinzie AH, Yang Z, Teal E, Daggy JK, Tepper RS, Quinney SK, Rhoads E, Haneline LS, Haas DM
Am J Obstet Gynecol 2021 Nov;225(5):536.e1-536.e7. Epub 2021 May 3 doi: 10.1016/j.ajog.2021.04.251. PMID: 33957112Free PMC Article
Brookfield KF, O'Malley K, El-Sayed YY, Blumenfeld YJ, Butwick AJ
Am J Perinatol 2016 Apr;33(5):502-9. Epub 2015 Nov 23 doi: 10.1055/s-0035-1567891. PMID: 26595143Free PMC Article

Recent systematic reviews

Bruschettini M, Hassan KO, Romantsik O, Banzi R, Calevo MG, Moresco L
Cochrane Database Syst Rev 2022 Feb 24;2(2):CD013563. doi: 10.1002/14651858.CD013563.pub2. PMID: 35199848Free PMC Article
Moresco L, Bruschettini M, Macchi M, Calevo MG
Cochrane Database Syst Rev 2021 Feb 5;2(2):CD011878. doi: 10.1002/14651858.CD011878.pub3. PMID: 33543473Free PMC Article
Moresco L, Calevo MG, Baldi F, Cohen A, Bruschettini M
Cochrane Database Syst Rev 2016 May 23;2016(5):CD011877. doi: 10.1002/14651858.CD011877.pub2. PMID: 27211231Free PMC Article
Moresco L, Bruschettini M, Cohen A, Gaiero A, Calevo MG
Cochrane Database Syst Rev 2016 May 23;(5):CD011878. doi: 10.1002/14651858.CD011878.pub2. PMID: 27210618
Kassab M, Khriesat WM, Anabrees J
Cochrane Database Syst Rev 2015 Nov 21;2015(11):CD003064. doi: 10.1002/14651858.CD003064.pub3. PMID: 26590358Free PMC Article

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