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Labile hypertension due to being in a clinical environment

MedGen UID:
452336
Concept ID:
C0262534
Disease or Syndrome
Synonyms: Clinic Hypertension, Isolated; Hypertension, Isolated Clinic; Hypertension, White Coat; Isolated Clinic Hypertension; Syndrome, White Coat; White Coat Hypertension; White Coat Syndrome
SNOMED CT: White coat hypertension (697930002); Labile hypertension due to being in a clinical environment (697930002)

Definition

Phenomenon where BLOOD PRESSURE readings are elevated only when taken in clinical settings. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLabile hypertension due to being in a clinical environment

Professional guidelines

PubMed

Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
Acelajado MC, Hughes ZH, Oparil S, Calhoun DA
Circ Res 2019 Mar 29;124(7):1061-1070. doi: 10.1161/CIRCRESAHA.118.312156. PMID: 30920924Free PMC Article
Carey RM, Calhoun DA, Bakris GL, Brook RD, Daugherty SL, Dennison-Himmelfarb CR, Egan BM, Flack JM, Gidding SS, Judd E, Lackland DT, Laffer CL, Newton-Cheh C, Smith SM, Taler SJ, Textor SC, Turan TN, White WB; American Heart Association Professional/Public Education and Publications Committee of the Council on Hypertension; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Genomic and Precision Medicine; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council
Hypertension 2018 Nov;72(5):e53-e90. doi: 10.1161/HYP.0000000000000084. PMID: 30354828Free PMC Article

Recent clinical studies

Etiology

Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
Mancia G, Facchetti R, Bombelli M, Cuspidi C, Grassi G
Hypertension 2021 Dec;78(6):1677-1688. Epub 2021 Nov 10 doi: 10.1161/HYPERTENSIONAHA.121.16489. PMID: 34757765Free PMC Article
Lamirault G, Artifoni M, Daniel M, Barber-Chamoux N, Nantes University Hospital Working Group On Hypertension
Curr Hypertens Rev 2020;16(1):61-72. doi: 10.2174/1573402115666191011111402. PMID: 31622203
Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR
Ann Intern Med 2019 Jun 18;170(12):853-862. Epub 2019 Jun 11 doi: 10.7326/M19-0223. PMID: 31181575Free PMC Article
Konukoglu D, Uzun H
Adv Exp Med Biol 2017;956:511-540. doi: 10.1007/5584_2016_90. PMID: 28035582

Diagnosis

Metoki H, Iwama N, Hamada H, Satoh M, Murakami T, Ishikuro M, Obara T
Hypertens Res 2022 Aug;45(8):1298-1309. Epub 2022 Jun 20 doi: 10.1038/s41440-022-00965-6. PMID: 35726086Free PMC Article
McFadden CB
Med Clin North Am 2022 Mar;106(2):259-267. Epub 2022 Feb 2 doi: 10.1016/j.mcna.2021.11.003. PMID: 35227429
Al Ghorani H, Kulenthiran S, Lauder L, Böhm M, Mahfoud F
J Hum Hypertens 2021 May;35(5):398-409. Epub 2021 Jan 12 doi: 10.1038/s41371-020-00477-1. PMID: 33437020Free PMC Article
Lamirault G, Artifoni M, Daniel M, Barber-Chamoux N, Nantes University Hospital Working Group On Hypertension
Curr Hypertens Rev 2020;16(1):61-72. doi: 10.2174/1573402115666191011111402. PMID: 31622203
Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR
Ann Intern Med 2019 Jun 18;170(12):853-862. Epub 2019 Jun 11 doi: 10.7326/M19-0223. PMID: 31181575Free PMC Article

Therapy

Huang QF, Yang WY, Asayama K, Zhang ZY, Thijs L, Li Y, O'Brien E, Staessen JA
Hypertension 2021 Feb;77(2):254-264. Epub 2021 Jan 4 doi: 10.1161/HYPERTENSIONAHA.120.14591. PMID: 33390042Free PMC Article
Lamirault G, Artifoni M, Daniel M, Barber-Chamoux N, Nantes University Hospital Working Group On Hypertension
Curr Hypertens Rev 2020;16(1):61-72. doi: 10.2174/1573402115666191011111402. PMID: 31622203
Song JJ, Ma Z, Wang J, Chen LX, Zhong JC
J Cardiovasc Transl Res 2020 Feb;13(1):47-54. Epub 2019 May 1 doi: 10.1007/s12265-019-09888-z. PMID: 31044374
Konukoglu D, Uzun H
Adv Exp Med Biol 2017;956:511-540. doi: 10.1007/5584_2016_90. PMID: 28035582
Hamrahian SM, Falkner B
Adv Exp Med Biol 2017;956:307-325. doi: 10.1007/5584_2016_84. PMID: 27873228

Prognosis

Staplin N, de la Sierra A, Ruilope LM, Emberson JR, Vinyoles E, Gorostidi M, Ruiz-Hurtado G, Segura J, Baigent C, Williams B
Lancet 2023 Jun 17;401(10393):2041-2050. Epub 2023 May 5 doi: 10.1016/S0140-6736(23)00733-X. PMID: 37156250
Mancia G, Facchetti R, Bombelli M, Cuspidi C, Grassi G
Hypertension 2021 Dec;78(6):1677-1688. Epub 2021 Nov 10 doi: 10.1161/HYPERTENSIONAHA.121.16489. PMID: 34757765Free PMC Article
Al Ghorani H, Kulenthiran S, Lauder L, Böhm M, Mahfoud F
J Hum Hypertens 2021 May;35(5):398-409. Epub 2021 Jan 12 doi: 10.1038/s41371-020-00477-1. PMID: 33437020Free PMC Article
Song JJ, Ma Z, Wang J, Chen LX, Zhong JC
J Cardiovasc Transl Res 2020 Feb;13(1):47-54. Epub 2019 May 1 doi: 10.1007/s12265-019-09888-z. PMID: 31044374
Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR
Ann Intern Med 2019 Jun 18;170(12):853-862. Epub 2019 Jun 11 doi: 10.7326/M19-0223. PMID: 31181575Free PMC Article

Clinical prediction guides

Staplin N, de la Sierra A, Ruilope LM, Emberson JR, Vinyoles E, Gorostidi M, Ruiz-Hurtado G, Segura J, Baigent C, Williams B
Lancet 2023 Jun 17;401(10393):2041-2050. Epub 2023 May 5 doi: 10.1016/S0140-6736(23)00733-X. PMID: 37156250
Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR
Ann Intern Med 2019 Jun 18;170(12):853-862. Epub 2019 Jun 11 doi: 10.7326/M19-0223. PMID: 31181575Free PMC Article
Muntner P, Shimbo D, Carey RM, Charleston JB, Gaillard T, Misra S, Myers MG, Ogedegbe G, Schwartz JE, Townsend RR, Urbina EM, Viera AJ, White WB, Wright JT Jr
Hypertension 2019 May;73(5):e35-e66. doi: 10.1161/HYP.0000000000000087. PMID: 30827125
Wagner S
Adv Exp Med Biol 2017;956:97-107. doi: 10.1007/5584_2016_151. PMID: 27757934

Recent systematic reviews

Scott G, Gillon TE, Pels A, von Dadelszen P, Magee LA
Am J Obstet Gynecol 2022 Feb;226(2S):S1222-S1236. Epub 2020 Aug 20 doi: 10.1016/j.ajog.2020.08.018. PMID: 32828743
Cohen JB, Lotito MJ, Trivedi UK, Denker MG, Cohen DL, Townsend RR
Ann Intern Med 2019 Jun 18;170(12):853-862. Epub 2019 Jun 11 doi: 10.7326/M19-0223. PMID: 31181575Free PMC Article
Cuspidi C, Sala C, Tadic M, Rescaldani M, Grassi G, Mancia G
Blood Press Monit 2015 Apr;20(2):57-63. doi: 10.1097/MBP.0000000000000094. PMID: 25405819
Achelrod D, Wenzel U, Frey S
Am J Hypertens 2015 Mar;28(3):355-61. Epub 2014 Aug 25 doi: 10.1093/ajh/hpu151. PMID: 25156625
Kikidis D, Tsioufis K, Papanikolaou V, Zerva K, Hantzakos A
Eur Arch Otorhinolaryngol 2014 Feb;271(2):237-43. Epub 2013 Mar 29 doi: 10.1007/s00405-013-2450-z. PMID: 23539411

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