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Middle Ear Carcinoma In Situ

MedGen UID:
452459
•Concept ID:
C0349613
•
Neoplastic Process
Synonym: Carcinoma in situ of middle ear
SNOMED CT: Carcinoma in situ of middle ear (92657003)

Definition

An intraepithelial carcinoma of the middle ear without evidence of invasion. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMiddle Ear Carcinoma In Situ

Professional guidelines

PubMed

The usefulness of narrow-band imaging for the diagnosis and treatment of vocal fold leukoplakia.
Huang F, Yu J, Zhang F, He C, Li S, Shao J
Acta Otolaryngol 2017 Sep;137(9):1002-1006. Epub 2017 May 14 doi: 10.1080/00016489.2017.1324216. PMID: 28503988
Patient preferences in early glottic cancer treatment.
McNeil ML, Wilke DR, Taylor SM
Ear Nose Throat J 2016 Jul;95(7):281-3. PMID: 27434477
HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma.
Nichols AC, Faquin WC, Westra WH, Mroz EA, Begum S, Clark JR, Rocco JW
Otolaryngol Head Neck Surg 2009 Feb;140(2):228-34. doi: 10.1016/j.otohns.2008.11.025. PMID: 19201294

Recent clinical studies

Etiology

Hyperbaric Oxygen Therapy for Threatened Nipple-Sparing Mastectomy Flaps: An Adjunct for Flap Salvage.
Nasr HY, Rifkin WJ, Muller JN, Chiu ES
Ann Plast Surg 2023 May 1;90(5S Suppl 2):S125-S129. Epub 2023 Mar 8 doi: 10.1097/SAP.0000000000003441. PMID: 36913565
In Situ Preservation of Parathyroid Gland With Vasculature for Papillary Thyroid Carcinoma Is Associated With Higher PTH Levels After Total Thyroidectomy.
Yin C, Song B, Zheng W, Li X, Zhao H, Wang X
Ear Nose Throat J 2022 Feb;101(2):95-104. Epub 2021 Sep 2 doi: 10.1177/01455613211039807. PMID: 34472380
Radiotherapy for ductal carcinoma in situ and risk of second non-breast cancers.
Withrow DR, Morton LM, Curtis RE, Schonfeld SJ, Berrington de González A
Breast Cancer Res Treat 2017 Nov;166(1):299-306. Epub 2017 Jul 25 doi: 10.1007/s10549-017-4410-6. PMID: 28744752Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Gender differences in tumor and patient characteristics in those undergoing Mohs surgery.
Lee KC, Higgins HW 2nd, Linden O, Cruz AP
Dermatol Surg 2014 Jun;40(6):686-90. doi: 10.1111/dsu.0000000000000020. PMID: 24852474

Diagnosis

In Situ Preservation of Parathyroid Gland With Vasculature for Papillary Thyroid Carcinoma Is Associated With Higher PTH Levels After Total Thyroidectomy.
Yin C, Song B, Zheng W, Li X, Zhao H, Wang X
Ear Nose Throat J 2022 Feb;101(2):95-104. Epub 2021 Sep 2 doi: 10.1177/01455613211039807. PMID: 34472380
Radiotherapy for ductal carcinoma in situ and risk of second non-breast cancers.
Withrow DR, Morton LM, Curtis RE, Schonfeld SJ, Berrington de González A
Breast Cancer Res Treat 2017 Nov;166(1):299-306. Epub 2017 Jul 25 doi: 10.1007/s10549-017-4410-6. PMID: 28744752Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Gender differences in tumor and patient characteristics in those undergoing Mohs surgery.
Lee KC, Higgins HW 2nd, Linden O, Cruz AP
Dermatol Surg 2014 Jun;40(6):686-90. doi: 10.1111/dsu.0000000000000020. PMID: 24852474
Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases.
Yousef YA, Finger PT
Ophthalmology 2012 Feb;119(2):233-40. Epub 2011 Dec 20 doi: 10.1016/j.ophtha.2011.08.005. PMID: 22189448

Therapy

In Situ Preservation of Parathyroid Gland With Vasculature for Papillary Thyroid Carcinoma Is Associated With Higher PTH Levels After Total Thyroidectomy.
Yin C, Song B, Zheng W, Li X, Zhao H, Wang X
Ear Nose Throat J 2022 Feb;101(2):95-104. Epub 2021 Sep 2 doi: 10.1177/01455613211039807. PMID: 34472380
Voice Outcomes After Radiation for Early-Stage Laryngeal Cancer.
Naunheim MR, Garneau J, Park C, Carroll L, Goldberg L, Woo P
J Voice 2020 May;34(3):460-464. Epub 2019 Jan 2 doi: 10.1016/j.jvoice.2018.11.007. PMID: 30611594
Squamous carcinoma and dysplasia of the conjunctiva and cornea: an analysis of 101 cases.
Yousef YA, Finger PT
Ophthalmology 2012 Feb;119(2):233-40. Epub 2011 Dec 20 doi: 10.1016/j.ophtha.2011.08.005. PMID: 22189448
Photodynamic therapy and the treatment of head and neck neoplasia.
Biel MA
Laryngoscope 1998 Sep;108(9):1259-68. doi: 10.1097/00005537-199809000-00001. PMID: 9738739
Photodynamic therapy and the treatment of head and neck cancers.
Biel MA
J Clin Laser Med Surg 1996 Oct;14(5):239-44. doi: 10.1089/clm.1996.14.239. PMID: 9612189

Prognosis

DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Epstein-Barr virus (EBV) and polyomaviruses are detectable in oropharyngeal cancer and EBV may have prognostic impact.
Carpén T, Syrjänen S, Jouhi L, Randen-Brady R, Haglund C, Mäkitie A, Mattila PS, Hagström J
Cancer Immunol Immunother 2020 Aug;69(8):1615-1626. Epub 2020 Apr 20 doi: 10.1007/s00262-020-02570-3. PMID: 32314041Free PMC Article
Radiotherapy for ductal carcinoma in situ and risk of second non-breast cancers.
Withrow DR, Morton LM, Curtis RE, Schonfeld SJ, Berrington de González A
Breast Cancer Res Treat 2017 Nov;166(1):299-306. Epub 2017 Jul 25 doi: 10.1007/s10549-017-4410-6. PMID: 28744752Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344
Photodynamic therapy and the treatment of head and neck neoplasia.
Biel MA
Laryngoscope 1998 Sep;108(9):1259-68. doi: 10.1097/00005537-199809000-00001. PMID: 9738739

Clinical prediction guides

Hyperbaric Oxygen Therapy for Threatened Nipple-Sparing Mastectomy Flaps: An Adjunct for Flap Salvage.
Nasr HY, Rifkin WJ, Muller JN, Chiu ES
Ann Plast Surg 2023 May 1;90(5S Suppl 2):S125-S129. Epub 2023 Mar 8 doi: 10.1097/SAP.0000000000003441. PMID: 36913565
Volatile organic compound breath testing detects in-situ squamous cell carcinoma of bronchial and laryngeal regions and shows distinct profiles of each tumour.
Fielding D, Hartel G, Pass D, Davis M, Brown M, Dent A, Agnew J, Dickie G, Ware RS, Hodge R
J Breath Res 2020 Oct 6;14(4):046013. doi: 10.1088/1752-7163/abb18a. PMID: 33021204
Voice Outcomes After Radiation for Early-Stage Laryngeal Cancer.
Naunheim MR, Garneau J, Park C, Carroll L, Goldberg L, Woo P
J Voice 2020 May;34(3):460-464. Epub 2019 Jan 2 doi: 10.1016/j.jvoice.2018.11.007. PMID: 30611594
Neuropilin 1 Receptor Is Up-Regulated in Dysplastic Epithelium and Oral Squamous Cell Carcinoma.
Shahrabi-Farahani S, Gallottini M, Martins F, Li E, Mudge DR, Nakayama H, Hida K, Panigrahy D, D'Amore PA, Bielenberg DR
Am J Pathol 2016 Apr;186(4):1055-64. Epub 2016 Feb 11 doi: 10.1016/j.ajpath.2015.11.021. PMID: 26877262Free PMC Article
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

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