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Disorder of ovary

MedGen UID:
45256
•Concept ID:
C0029928
•
Disease or Syndrome
Synonyms: Disease, Ovarian; Diseases, Ovarian; Ovarian Disease; Ovarian Diseases
SNOMED CT: Ovarian disorder (5552004); Disorder of ovary (5552004)

Definition

A non-neoplastic or neoplastic disorder that affects the ovary. Representative examples of non-neoplastic disorders include endometriosis and polycystic ovarian disease. Representative examples of neoplastic disorders include ovarian surface epithelial-stromal tumors, germ cell tumors, and sex cord-stromal tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisorder of ovary

Professional guidelines

PubMed

Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome.
Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ; International PCOS Network
Fertil Steril 2018 Aug;110(3):364-379. Epub 2018 Jul 19 doi: 10.1016/j.fertnstert.2018.05.004. PMID: 30033227Free PMC Article
Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment.
Escobar-Morreale HF
Nat Rev Endocrinol 2018 May;14(5):270-284. Epub 2018 Mar 23 doi: 10.1038/nrendo.2018.24. PMID: 29569621
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R
Fertil Steril 2016 Jul;106(1):6-15. Epub 2016 May 24 doi: 10.1016/j.fertnstert.2016.05.003. PMID: 27233760

Recent clinical studies

Etiology

Adnexal torsion: a review of diagnosis and management strategies.
Chang-Patel EJ, Palacios-Helgeson LK, Gould CH
Curr Opin Obstet Gynecol 2022 Aug 1;34(4):196-203. doi: 10.1097/GCO.0000000000000787. PMID: 35895961
High risk and low prevalence diseases: Ovarian torsion.
Bridwell RE, Koyfman A, Long B
Am J Emerg Med 2022 Jun;56:145-150. Epub 2022 Mar 31 doi: 10.1016/j.ajem.2022.03.046. PMID: 35397355
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Ovarian torsion.
Cass DL
Semin Pediatr Surg 2005 May;14(2):86-92. doi: 10.1053/j.sempedsurg.2005.01.003. PMID: 15846564
Terms, definitions and measurements to describe the sonographic features of adnexal tumors: a consensus opinion from the International Ovarian Tumor Analysis (IOTA) Group.
Timmerman D, Valentin L, Bourne TH, Collins WP, Verrelst H, Vergote I; International Ovarian Tumor Analysis (IOTA) Group
Ultrasound Obstet Gynecol 2000 Oct;16(5):500-5. doi: 10.1046/j.1469-0705.2000.00287.x. PMID: 11169340

Diagnosis

Adnexal torsion: a review of diagnosis and management strategies.
Chang-Patel EJ, Palacios-Helgeson LK, Gould CH
Curr Opin Obstet Gynecol 2022 Aug 1;34(4):196-203. doi: 10.1097/GCO.0000000000000787. PMID: 35895961
High risk and low prevalence diseases: Ovarian torsion.
Bridwell RE, Koyfman A, Long B
Am J Emerg Med 2022 Jun;56:145-150. Epub 2022 Mar 31 doi: 10.1016/j.ajem.2022.03.046. PMID: 35397355
Managing poor ovarian response in the patient with diminished ovarian reserve.
Cedars MI
Fertil Steril 2022 Apr;117(4):655-656. doi: 10.1016/j.fertnstert.2022.02.026. PMID: 35367010
Reproductive ovarian testing and the alphabet soup of diagnoses: DOR, POI, POF, POR, and FOR.
Pastore LM, Christianson MS, Stelling J, Kearns WG, Segars JH
J Assist Reprod Genet 2018 Jan;35(1):17-23. Epub 2017 Oct 2 doi: 10.1007/s10815-017-1058-4. PMID: 28971280Free PMC Article
Ovarian torsion.
Cass DL
Semin Pediatr Surg 2005 May;14(2):86-92. doi: 10.1053/j.sempedsurg.2005.01.003. PMID: 15846564

Therapy

The Role of Androgen Supplementation in Women With Diminished Ovarian Reserve: Time to Randomize, Not Meta-Analyze.
Neves AR, Montoya-Botero P, Polyzos NP
Front Endocrinol (Lausanne) 2021;12:653857. Epub 2021 May 17 doi: 10.3389/fendo.2021.653857. PMID: 34079524Free PMC Article
Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial.
Xu Y, Nisenblat V, Lu C, Li R, Qiao J, Zhen X, Wang S
Reprod Biol Endocrinol 2018 Mar 27;16(1):29. doi: 10.1186/s12958-018-0343-0. PMID: 29587861Free PMC Article
Imaging modalities for the non-invasive diagnosis of endometriosis.
Nisenblat V, Bossuyt PM, Farquhar C, Johnson N, Hull ML
Cochrane Database Syst Rev 2016 Feb 26;2(2):CD009591. doi: 10.1002/14651858.CD009591.pub2. PMID: 26919512Free PMC Article

Prognosis

Managing poor ovarian response in the patient with diminished ovarian reserve.
Cedars MI
Fertil Steril 2022 Apr;117(4):655-656. doi: 10.1016/j.fertnstert.2022.02.026. PMID: 35367010
Ovarian cancer today and tomorrow: A global assessment by world region and Human Development Index using GLOBOCAN 2020.
Cabasag CJ, Fagan PJ, Ferlay J, Vignat J, Laversanne M, Liu L, van der Aa MA, Bray F, Soerjomataram I
Int J Cancer 2022 Nov 1;151(9):1535-1541. Epub 2022 Mar 30 doi: 10.1002/ijc.34002. PMID: 35322413
Towards complication-free assisted reproduction technology.
Santos-Ribeiro S, Mackens S, Racca A, Blockeel C
Best Pract Res Clin Endocrinol Metab 2019 Feb;33(1):9-19. Epub 2018 Nov 3 doi: 10.1016/j.beem.2018.10.006. PMID: 30473208
Ovarian extracellular MicroRNAs as the potential non-invasive biomarkers: An update.
Montazerian M, Yasari F, Aghaalikhani N
Biomed Pharmacother 2018 Oct;106:1633-1640. Epub 2018 Jul 29 doi: 10.1016/j.biopha.2018.07.073. PMID: 30119239
Ultrasound Imaging for Ovarian and Deep Infiltrating Endometriosis.
Exacoustos C, Zupi E, Piccione E
Semin Reprod Med 2017 Jan;35(1):5-24. Epub 2017 Jan 11 doi: 10.1055/s-0036-1597127. PMID: 28076877

Clinical prediction guides

Ovarian inguinal hernia.
Prodromidou A, Machairas N, Garoufalia Z, Kostakis ID, Kyriakidis AV, Spartalis E, Sotiropoulos GC
Ann R Coll Surg Engl 2020 Feb;102(2):75-83. Epub 2019 Nov 7 doi: 10.1308/rcsann.2019.0137. PMID: 31696731Free PMC Article
Prediction of therapy response in ovarian cancer: Where are we now?
El Bairi K, Amrani M, Kandhro AH, Afqir S
Crit Rev Clin Lab Sci 2017 Jun;54(4):233-266. Epub 2017 Apr 26 doi: 10.1080/10408363.2017.1313190. PMID: 28443762
Imaging of Adnexal Masses.
Thakur M, Timmerman D
Clin Obstet Gynecol 2017 Mar;60(1):38-45. doi: 10.1097/GRF.0000000000000261. PMID: 28005597
Criteria, prevalence, and phenotypes of polycystic ovary syndrome.
Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R
Fertil Steril 2016 Jul;106(1):6-15. Epub 2016 May 24 doi: 10.1016/j.fertnstert.2016.05.003. PMID: 27233760
Ultrasound in gynecology.
Derchi LE, Serafini G, Gandolfo N, Gandolfo NG, Martinoli C
Eur Radiol 2001;11(11):2137-55. doi: 10.1007/s003300101080. PMID: 11702153

Recent systematic reviews

Polycystic ovaries and herbal remedies: A systematic review.
Manouchehri A, Abbaszadeh S, Ahmadi M, Nejad FK, Bahmani M, Dastyar N
JBRA Assist Reprod 2023 Mar 30;27(1):85-91. doi: 10.5935/1518-0557.20220024. PMID: 35916457Free PMC Article
Life Modifications and PCOS: Old Story But New Tales.
Gu Y, Zhou G, Zhou F, Wu Q, Ma C, Zhang Y, Ding J, Hua K
Front Endocrinol (Lausanne) 2022;13:808898. Epub 2022 Apr 13 doi: 10.3389/fendo.2022.808898. PMID: 35498415Free PMC Article
Clinical Practice Guidelines on the Diagnosis and Management of Polycystic Ovary Syndrome: A Systematic Review and Quality Assessment Study.
Al Wattar BH, Fisher M, Bevington L, Talaulikar V, Davies M, Conway G, Yasmin E
J Clin Endocrinol Metab 2021 Jul 13;106(8):2436-2446. doi: 10.1210/clinem/dgab232. PMID: 33839790Free PMC Article
Metabolic dysfunction in polycystic ovary syndrome: Pathogenic role of androgen excess and potential therapeutic strategies.
Sanchez-Garrido MA, Tena-Sempere M
Mol Metab 2020 May;35:100937. Epub 2020 Feb 5 doi: 10.1016/j.molmet.2020.01.001. PMID: 32244180Free PMC Article
The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis.
Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz BO
Hum Reprod 2016 Dec;31(12):2841-2855. Epub 2016 Sep 22 doi: 10.1093/humrep/dew218. PMID: 27664216

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