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Labored breathing

MedGen UID:
452605
•Concept ID:
C0553668
•
Sign or Symptom
Synonyms: Labored Breathing; Labored respiration
SNOMED CT: Labored breathing (248549001); Labored respiration (248549001)

Definition

Breathing that requires observed effort or an increased amount of energy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLabored breathing

Professional guidelines

PubMed

Fan Therapy for the Treatment of Dyspnea in Adults: A Systematic Review.
Qian Y, Wu Y, Rozman de Moraes A, Yi X, Geng Y, Dibaj S, Liu D, Naberhuis J, Bruera E
J Pain Symptom Manage 2019 Sep;58(3):481-486. Epub 2019 Apr 18 doi: 10.1016/j.jpainsymman.2019.04.011. PMID: 31004769
Viral croup: current diagnosis and treatment.
Rosekrans JA
Mayo Clin Proc 1998 Nov;73(11):1102-6; discussion 1107. doi: 10.4065/73.11.1102. PMID: 9818047
Adult criteria for obstructive sleep apnea do not identify children with serious obstruction.
Rosen CL, D'Andrea L, Haddad GG
Am Rev Respir Dis 1992 Nov;146(5 Pt 1):1231-4. doi: 10.1164/ajrccm/146.5_Pt_1.1231. PMID: 1443876

Recent clinical studies

Etiology

Prevention of SARS-CoV-2 and respiratory viral infections in healthcare settings: current and emerging concepts.
Rhee C, Baker MA, Klompas M
Curr Opin Infect Dis 2022 Aug 1;35(4):353-362. Epub 2022 Jul 5 doi: 10.1097/QCO.0000000000000839. PMID: 35849526
New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses.
Klompas M
Semin Respir Crit Care Med 2022 Apr;43(2):295-303. Epub 2022 Jan 18 doi: 10.1055/s-0041-1740582. PMID: 35042261
Ultraviolet radiation, vitamin D, and COVID-19.
Megna M, Marasca C, Fabbrocini G, Monfrecola G
Ital J Dermatol Venerol 2021 Jun;156(3):366-373. Epub 2021 Apr 29 doi: 10.23736/S2784-8671.21.06833-4. PMID: 33913665
Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy.
Ryan L, Rahman T, Strang A, Heinle R, Shaffer TH
PLoS One 2020;15(1):e0226980. Epub 2020 Jan 10 doi: 10.1371/journal.pone.0226980. PMID: 31923192Free PMC Article
Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial.
Azoulay E, Lemiale V, Mokart D, Nseir S, Argaud L, Pène F, Kontar L, Bruneel F, Klouche K, Barbier F, Reignier J, Berrahil-Meksen L, Louis G, Constantin JM, Mayaux J, Wallet F, Kouatchet A, Peigne V, Théodose I, Perez P, Girault C, Jaber S, Oziel J, Nyunga M, Terzi N, Bouadma L, Lebert C, Lautrette A, Bigé N, Raphalen JH, Papazian L, Darmon M, Chevret S, Demoule A
JAMA 2018 Nov 27;320(20):2099-2107. doi: 10.1001/jama.2018.14282. PMID: 30357270Free PMC Article

Diagnosis

New Insights into the Prevention of Hospital-Acquired Pneumonia/Ventilator-Associated Pneumonia Caused by Viruses.
Klompas M
Semin Respir Crit Care Med 2022 Apr;43(2):295-303. Epub 2022 Jan 18 doi: 10.1055/s-0041-1740582. PMID: 35042261
Diagnostic differences in respiratory breathing patterns and work of breathing indices in children with Duchenne muscular dystrophy.
Ryan L, Rahman T, Strang A, Heinle R, Shaffer TH
PLoS One 2020;15(1):e0226980. Epub 2020 Jan 10 doi: 10.1371/journal.pone.0226980. PMID: 31923192Free PMC Article
Dyspnea.
Williams CM
Cancer J 2006 Sep-Oct;12(5):365-73. doi: 10.1097/00130404-200609000-00006. PMID: 17034673
Evaluation of dyspnea in the elderly.
Mahler DA, Fierro-Carrion G, Baird JC
Clin Geriatr Med 2003 Feb;19(1):19-33, v. doi: 10.1016/s0749-0690(02)00050-2. PMID: 12735113
Viral croup: current diagnosis and treatment.
Rosekrans JA
Mayo Clin Proc 1998 Nov;73(11):1102-6; discussion 1107. doi: 10.4065/73.11.1102. PMID: 9818047

Therapy

Objective Scoring of Physiologically Induced Dyspnea by Non-Invasive RF Sensors.
Zhang Z, Sharma P, Conroy T, Phongtankuel V, Kan EC
IEEE Trans Biomed Eng 2022 Jan;69(1):432-442. Epub 2021 Dec 23 doi: 10.1109/TBME.2021.3096462. PMID: 34255624Free PMC Article
Ultraviolet radiation, vitamin D, and COVID-19.
Megna M, Marasca C, Fabbrocini G, Monfrecola G
Ital J Dermatol Venerol 2021 Jun;156(3):366-373. Epub 2021 Apr 29 doi: 10.23736/S2784-8671.21.06833-4. PMID: 33913665
Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial.
Azoulay E, Lemiale V, Mokart D, Nseir S, Argaud L, Pène F, Kontar L, Bruneel F, Klouche K, Barbier F, Reignier J, Berrahil-Meksen L, Louis G, Constantin JM, Mayaux J, Wallet F, Kouatchet A, Peigne V, Théodose I, Perez P, Girault C, Jaber S, Oziel J, Nyunga M, Terzi N, Bouadma L, Lebert C, Lautrette A, Bigé N, Raphalen JH, Papazian L, Darmon M, Chevret S, Demoule A
JAMA 2018 Nov 27;320(20):2099-2107. doi: 10.1001/jama.2018.14282. PMID: 30357270Free PMC Article
Chronobiology and chronotherapy of allergic rhinitis and bronchial asthma.
Smolensky MH, Lemmer B, Reinberg AE
Adv Drug Deliv Rev 2007 Aug 31;59(9-10):852-82. Epub 2007 Aug 17 doi: 10.1016/j.addr.2007.08.016. PMID: 17900748
Dyspnea.
Williams CM
Cancer J 2006 Sep-Oct;12(5):365-73. doi: 10.1097/00130404-200609000-00006. PMID: 17034673

Prognosis

Utilising pneuRIP device in determining the adequacy of respiratory support when weaning high-flow nasal cannula in paediatric patients with acute respiratory distress: A pilot study.
Murala DK, Levenbrown Y, Xiao W, Hossain J, Shaffer TH
J Paediatr Child Health 2022 Sep;58(9):1548-1553. Epub 2022 Jun 2 doi: 10.1111/jpc.16031. PMID: 35652438
Quantitative Analysis of Thoracoabdominal Asynchrony in Pediatric Polysomnography.
Bronstein JZ, Xie L, Shaffer TH, Chidekel A, Heinle R
J Clin Sleep Med 2018 Jul 15;14(7):1169-1176. doi: 10.5664/jcsm.7218. PMID: 29991414Free PMC Article
Respiratory muscle function in infants with spinal muscular atrophy type I.
Finkel RS, Weiner DJ, Mayer OH, McDonough JM, Panitch HB
Pediatr Pulmonol 2014 Dec;49(12):1234-42. Epub 2014 Apr 29 doi: 10.1002/ppul.22997. PMID: 24777943
A novel nonhuman primate model for influenza transmission.
Moncla LH, Ross TM, Dinis JM, Weinfurter JT, Mortimer TD, Schultz-Darken N, Brunner K, Capuano SV 3rd, Boettcher C, Post J, Johnson M, Bloom CE, Weiler AM, Friedrich TC
PLoS One 2013;8(11):e78750. Epub 2013 Nov 14 doi: 10.1371/journal.pone.0078750. PMID: 24244352Free PMC Article
Withdrawal of life support in the neurological intensive care unit.
Mayer SA, Kossoff SB
Neurology 1999 May 12;52(8):1602-9. doi: 10.1212/wnl.52.8.1602. PMID: 10331685

Clinical prediction guides

Alterations in deglutition in children with congenital Zika virus syndrome.
Rios D, Rios M, Nóbrega AC, Oliveira LB, Vaz D, Sales H, Almeida BL, Lopes LS, Siqueira IC, Lucena R
Codas 2023;35(1):e20210270. Epub 2023 Jan 6 doi: 10.1590/2317-1782/20212021270. PMID: 36629551Free PMC Article
Objective Scoring of Physiologically Induced Dyspnea by Non-Invasive RF Sensors.
Zhang Z, Sharma P, Conroy T, Phongtankuel V, Kan EC
IEEE Trans Biomed Eng 2022 Jan;69(1):432-442. Epub 2021 Dec 23 doi: 10.1109/TBME.2021.3096462. PMID: 34255624Free PMC Article
Effect of High-Flow Nasal Oxygen vs Standard Oxygen on 28-Day Mortality in Immunocompromised Patients With Acute Respiratory Failure: The HIGH Randomized Clinical Trial.
Azoulay E, Lemiale V, Mokart D, Nseir S, Argaud L, Pène F, Kontar L, Bruneel F, Klouche K, Barbier F, Reignier J, Berrahil-Meksen L, Louis G, Constantin JM, Mayaux J, Wallet F, Kouatchet A, Peigne V, Théodose I, Perez P, Girault C, Jaber S, Oziel J, Nyunga M, Terzi N, Bouadma L, Lebert C, Lautrette A, Bigé N, Raphalen JH, Papazian L, Darmon M, Chevret S, Demoule A
JAMA 2018 Nov 27;320(20):2099-2107. doi: 10.1001/jama.2018.14282. PMID: 30357270Free PMC Article
Quantitative Analysis of Thoracoabdominal Asynchrony in Pediatric Polysomnography.
Bronstein JZ, Xie L, Shaffer TH, Chidekel A, Heinle R
J Clin Sleep Med 2018 Jul 15;14(7):1169-1176. doi: 10.5664/jcsm.7218. PMID: 29991414Free PMC Article
Effects of gossypol and cottonseed products on reproduction of mammals.
Randel RD, Chase CC Jr, Wyse SJ
J Anim Sci 1992 May;70(5):1628-38. doi: 10.2527/1992.7051628x. PMID: 1526930

Recent systematic reviews

Fan Therapy for the Treatment of Dyspnea in Adults: A Systematic Review.
Qian Y, Wu Y, Rozman de Moraes A, Yi X, Geng Y, Dibaj S, Liu D, Naberhuis J, Bruera E
J Pain Symptom Manage 2019 Sep;58(3):481-486. Epub 2019 Apr 18 doi: 10.1016/j.jpainsymman.2019.04.011. PMID: 31004769

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