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Lower urinary tract symptoms

MedGen UID:
452620
•Concept ID:
C0574785
•
Sign or Symptom
Synonyms: Lower Urinary Tract Symptom; Lower Urinary Tract Symptoms
SNOMED CT: Lower urinary tract symptoms (307541003); LUTS - lower urinary tract symptoms (307541003)

Definition

Symptoms that result from pathologic processes affecting the urinary bladder and/or urethra. They include urinary frequency and urgency, dysuria, nocturia, incomplete voiding, and poor stream during urination. [from NCI]

Professional guidelines

PubMed

Current diagnosis and management of erectile dysfunction.
McMahon CG
Med J Aust 2019 Jun;210(10):469-476. Epub 2019 May 17 doi: 10.5694/mja2.50167. PMID: 31099420
Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.
Bhasin S, Brito JP, Cunningham GR, Hayes FJ, Hodis HN, Matsumoto AM, Snyder PJ, Swerdloff RS, Wu FC, Yialamas MA
J Clin Endocrinol Metab 2018 May 1;103(5):1715-1744. doi: 10.1210/jc.2018-00229. PMID: 29562364
Diagnosis and treatment of urinary tract infections across age groups.
Chu CM, Lowder JL
Am J Obstet Gynecol 2018 Jul;219(1):40-51. Epub 2018 Jan 2 doi: 10.1016/j.ajog.2017.12.231. PMID: 29305250

Recent clinical studies

Etiology

Benign Prostatic Hyperplasia: Rapid Evidence Review.
Arnold MJ, Gaillardetz A, Ohiokpehai J
Am Fam Physician 2023 Jun;107(6):613-622. PMID: 37327163
Lower Urinary Tract Symptoms in Young Men-Causes and Management.
Beland L, Martin C, Han JS
Curr Urol Rep 2022 Feb;23(2):29-37. Epub 2022 Feb 8 doi: 10.1007/s11934-022-01087-9. PMID: 35132519
Benign Prostatic Hyperplasia and Lower Urinary Tract Symptoms: What Is the Role and Significance of Inflammation?
Lloyd GL, Marks JM, Ricke WA
Curr Urol Rep 2019 Aug 3;20(9):54. doi: 10.1007/s11934-019-0917-1. PMID: 31377881Free PMC Article
Rezūm Water Vapor Thermal Therapy for Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia: 4-Year Results From Randomized Controlled Study.
McVary KT, Rogers T, Roehrborn CG
Urology 2019 Apr;126:171-179. Epub 2019 Jan 21 doi: 10.1016/j.urology.2018.12.041. PMID: 30677455
What's New in Rezūm?
Pathak P, Helo S, McVary KT
Eur Urol Focus 2018 Jan;4(1):32-35. Epub 2018 Mar 9 doi: 10.1016/j.euf.2018.02.011. PMID: 29530631

Diagnosis

Management of Lower Urinary Tract Symptoms Attributed to Benign Prostatic Hyperplasia: AUA GUIDELINE PART I-Initial Work-up and Medical Management.
Lerner LB, McVary KT, Barry MJ, Bixler BR, Dahm P, Das AK, Gandhi MC, Kaplan SA, Kohler TS, Martin L, Parsons JK, Roehrborn CG, Stoffel JT, Welliver C, Wilt TJ
J Urol 2021 Oct;206(4):806-817. Epub 2021 Aug 13 doi: 10.1097/JU.0000000000002183. PMID: 34384237
The rising worldwide impact of benign prostatic hyperplasia.
Launer BM, McVary KT, Ricke WA, Lloyd GL
BJU Int 2021 Jun;127(6):722-728. Epub 2020 Nov 21 doi: 10.1111/bju.15286. PMID: 33124118Free PMC Article
Benign Prostatic Hyperplasia.
Langan RC
Prim Care 2019 Jun;46(2):223-232. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.003. PMID: 31030823
The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates.
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

Therapy

Prostatic Artery Embolisation Versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: 2-yr Outcomes of a Randomised, Open-label, Single-centre Trial.
Abt D, Müllhaupt G, Hechelhammer L, Markart S, Güsewell S, Schmid HP, Mordasini L, Engeler DS
Eur Urol 2021 Jul;80(1):34-42. Epub 2021 Feb 19 doi: 10.1016/j.eururo.2021.02.008. PMID: 33612376
Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.
Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M
Curr Urol Rep 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544Free PMC Article
Non-pharmacological interventions for treating chronic prostatitis/chronic pelvic pain syndrome.
Franco JV, Turk T, Jung JH, Xiao YT, Iakhno S, Garrote V, Vietto V
Cochrane Database Syst Rev 2018 May 12;5(5):CD012551. doi: 10.1002/14651858.CD012551.pub3. PMID: 29757454Free PMC Article
A Systematic Review and Meta-analysis of Functional Outcomes and Complications Following Transurethral Procedures for Lower Urinary Tract Symptoms Resulting from Benign Prostatic Obstruction: An Update.
Cornu JN, Ahyai S, Bachmann A, de la Rosette J, Gilling P, Gratzke C, McVary K, Novara G, Woo H, Madersbacher S
Eur Urol 2015 Jun;67(6):1066-1096. Epub 2014 Jun 25 doi: 10.1016/j.eururo.2014.06.017. PMID: 24972732
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
Bhasin S, Cunningham GR, Hayes FJ, Matsumoto AM, Snyder PJ, Swerdloff RS, Montori VM; Task Force, Endocrine Society
J Clin Endocrinol Metab 2010 Jun;95(6):2536-59. doi: 10.1210/jc.2009-2354. PMID: 20525905

Prognosis

Bladder Bowel Dysfunction.
Aguiar LM, Franco I
Urol Clin North Am 2018 Nov;45(4):633-640. Epub 2018 Sep 7 doi: 10.1016/j.ucl.2018.06.010. PMID: 30316317
Prostate Cancer in Primary Care.
Merriel SWD, Funston G, Hamilton W
Adv Ther 2018 Sep;35(9):1285-1294. Epub 2018 Aug 10 doi: 10.1007/s12325-018-0766-1. PMID: 30097885Free PMC Article
Frailty and Lower Urinary Tract Symptoms.
Suskind AM
Curr Urol Rep 2017 Sep;18(9):67. doi: 10.1007/s11934-017-0720-9. PMID: 28718161Free PMC Article
The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates.
Egan KB
Urol Clin North Am 2016 Aug;43(3):289-97. doi: 10.1016/j.ucl.2016.04.001. PMID: 27476122
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

Clinical prediction guides

The Reduction of Male Lower Urinary Tract Symptoms Is Associated With a Decreased Risk of Death.
Welk B, McClure JA
J Urol 2023 Oct;210(4):670-677. Epub 2023 Sep 8 doi: 10.1097/JU.0000000000003602. PMID: 37681541
Lower Urinary Tract Symptoms are Common After Artificial Urinary Sphincter Implantation.
Son HS, Kim JH
Urology 2022 Jul;165:343-350. Epub 2022 Jan 31 doi: 10.1016/j.urology.2022.01.031. PMID: 35108593
The Relationship Between Lower Urinary Tract Symptoms and Severity of Alzheimer's Disease.
Chang CW, Juan YS, Yang YH, Lee HY
Am J Alzheimers Dis Other Demen 2021 Jan-Dec;36:1533317521992657. doi: 10.1177/1533317521992657. PMID: 33635087Free PMC Article
Lower Urinary Tract Symptoms in a Chronic Pelvic Pain Population.
Sammarco AG, Kobernik EK, Haefner HK, Till SR, Berger MB
Female Pelvic Med Reconstr Surg 2020 Nov;26(11):712-716. doi: 10.1097/SPV.0000000000000689. PMID: 30628949
Lower urinary tract symptoms that predict microscopic pyuria.
Khasriya R, Barcella W, De Iorio M, Swamy S, Gill K, Kupelian A, Malone-Lee J
Int Urogynecol J 2018 Jul;29(7):1019-1028. Epub 2017 Oct 2 doi: 10.1007/s00192-017-3472-7. PMID: 28971220Free PMC Article

Recent systematic reviews

European Association of Urology Guidelines on the Diagnosis and Management of Female Non-neurogenic Lower Urinary Tract Symptoms. Part 1: Diagnostics, Overactive Bladder, Stress Urinary Incontinence, and Mixed Urinary Incontinence.
Nambiar AK, Arlandis S, Bø K, Cobussen-Boekhorst H, Costantini E, de Heide M, Farag F, Groen J, Karavitakis M, Lapitan MC, Manso M, Arteaga SM, Riogh ANA, O'Connor E, Omar MI, Peyronnet B, Phé V, Sakalis VI, Sihra N, Tzelves L, van Poelgeest-Pomfret ML, van den Bos TWL, van der Vaart H, Harding CK
Eur Urol 2022 Jul;82(1):49-59. Epub 2022 Feb 23 doi: 10.1016/j.eururo.2022.01.045. PMID: 35216856
Minimally invasive treatments for lower urinary tract symptoms in men with benign prostatic hyperplasia: a network meta-analysis.
Franco JV, Jung JH, Imamura M, Borofsky M, Omar MI, Escobar Liquitay CM, Young S, Golzarian J, Veroniki AA, Garegnani L, Dahm P
Cochrane Database Syst Rev 2021 Jul 15;7(7):CD013656. doi: 10.1002/14651858.CD013656.pub2. PMID: 34693990Free PMC Article
Pregnancy- and obstetric-related risk factors for urinary incontinence, fecal incontinence, or pelvic organ prolapse later in life: A systematic review and meta-analysis.
Hage-Fransen MAH, Wiezer M, Otto A, Wieffer-Platvoet MS, Slotman MH, Nijhuis-van der Sanden MWG, Pool-Goudzwaard AL
Acta Obstet Gynecol Scand 2021 Mar;100(3):373-382. Epub 2020 Nov 2 doi: 10.1111/aogs.14027. PMID: 33064839
Benign prostate hyperplasia and nutrition.
Das K, Buchholz N
Clin Nutr ESPEN 2019 Oct;33:5-11. Epub 2019 Aug 12 doi: 10.1016/j.clnesp.2019.07.015. PMID: 31451276
Benign prostatic hyperplasia: epidemiology, economics and evaluation.
Vuichoud C, Loughlin KR
Can J Urol 2015 Oct;22 Suppl 1:1-6. PMID: 26497338

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