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Paronychia

MedGen UID:
45334
Concept ID:
C0030578
Disease or Syndrome; Finding
Synonym: Paronychias
SNOMED CT: Paronychia (71906005); Perionychia (71906005)
 
HPO: HP:0001818
Monarch Initiative: MONDO:0005898

Definition

The nail disease paronychia is an often-tender bacterial or fungal hand infection or foot infection where the nail and skin meet at the side or the base of a finger or toenail. The infection can start suddenly (acute paronychia) or gradually (chronic paronychia). [from HPO]

Term Hierarchy

Conditions with this feature

Hereditary acrodermatitis enteropathica
MedGen UID:
66355
Concept ID:
C0221036
Disease or Syndrome
Acrodermatitis enteropathica of the zinc deficiency type (AEZ) is characterized by intermittent simultaneous occurrence of diarrhea and dermatitis with failure to thrive. Alopecia of the scalp, eyebrows, and eyelashes is a usual feature. The skin lesions are bullous. Noteworthy is the cure by diodoquin, or diiodohydroxyquinoline (Dillaha et al., 1953; Bloom and Sobel, 1955). Rodin and Goldman (1969) described autopsy findings, including pancreatic islet hyperplasia, absence of the thymus and of germinal centers, and plasmocytosis of lymph nodes and spleen.
Pelger-Huet-like anomaly and episodic fever with abdominal pain
MedGen UID:
376692
Concept ID:
C1850054
Disease or Syndrome
Immunodeficiency-108 with autoinflammation (IMD108) is an autosomal recessive disorder characterized mainly by features of autoinflammation, often manifest as onset of recurrent episodes of abdominal pain associated with fever and elevated inflammatory markers around adolescence. Affected individuals also have recurrent infections, particularly of the skin and nails; poor wound healing; and mild bleeding tendencies. Peripheral blood examination shows hypolobulated neutrophils, suggesting a defect in myeloid differentiation and function. However, neutrophil primary and secondary granules are normal (summary by Goos et al., 2019).
Neuropathy, hereditary sensory and autonomic, type 2A
MedGen UID:
416701
Concept ID:
C2752089
Disease or Syndrome
Hereditary sensory and autonomic neuropathy type II (HSAN2) is characterized by progressively reduced sensation to pain, temperature, and touch. Onset can be at birth and is often before puberty. The sensory deficit is predominantly distal with the lower limbs more severely affected than the upper limbs. Over time sensory function becomes severely reduced. Unnoticed injuries and neuropathic skin promote ulcerations and infections that result in spontaneous amputation of digits or the need for surgical amputation. Osteomyelitis is common. Painless fractures can complicate the disease. Autonomic disturbances are variable and can include hyperhidrosis, tonic pupils, and urinary incontinence in those with more advanced disease.
Inflammatory skin and bowel disease, neonatal, 1
MedGen UID:
482131
Concept ID:
C3280501
Disease or Syndrome
Any neonatal inflammatory skin and bowel disease in which the cause of the disease is a mutation in the ADAM17 gene.

Professional guidelines

PubMed

Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Hsu WH, Yang JC, Mok TS, Loong HH
Ann Oncol 2018 Jan 1;29(suppl_1):i3-i9. doi: 10.1093/annonc/mdx702. PMID: 29462253
Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB, Eaby-Sandy B, Murphy BA; MASCC Skin Toxicity Study Group
Support Care Cancer 2011 Aug;19(8):1079-95. Epub 2011 Jun 1 doi: 10.1007/s00520-011-1197-6. PMID: 21630130Free PMC Article

Recent clinical studies

Etiology

Au AS, Leung WY, Tran D
J Am Podiatr Med Assoc 2020 May 1;110(3) doi: 10.7547/17-155. PMID: 32730608
Lomax A, Thornton J, Singh D
Foot Ankle Surg 2016 Dec;22(4):219-223. Epub 2015 Sep 21 doi: 10.1016/j.fas.2015.09.003. PMID: 27810017
Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, Gorbunova V, Hirsh V, Bennouna J, Orlov S, Mok T, Boyer M, Su WC, Lee KH, Kato T, Massey D, Shahidi M, Zazulina V, Sequist LV
Lancet Oncol 2015 Feb;16(2):141-51. Epub 2015 Jan 12 doi: 10.1016/S1470-2045(14)71173-8. PMID: 25589191
Lacouture ME, Anadkat MJ, Bensadoun RJ, Bryce J, Chan A, Epstein JB, Eaby-Sandy B, Murphy BA; MASCC Skin Toxicity Study Group
Support Care Cancer 2011 Aug;19(8):1079-95. Epub 2011 Jun 1 doi: 10.1007/s00520-011-1197-6. PMID: 21630130Free PMC Article
Black JR
Clin Podiatr Med Surg 1995 Apr;12(2):183-7. PMID: 7600493

Diagnosis

Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Natsis NE, Cohen PR
Am J Clin Dermatol 2018 Oct;19(5):671-677. doi: 10.1007/s40257-018-0362-9. PMID: 29882122
Leggit JC
Am Fam Physician 2017 Jul 1;96(1):44-51. PMID: 28671378

Therapy

Park K, Haura EB, Leighl NB, Mitchell P, Shu CA, Girard N, Viteri S, Han JY, Kim SW, Lee CK, Sabari JK, Spira AI, Yang TY, Kim DW, Lee KH, Sanborn RE, Trigo J, Goto K, Lee JS, Yang JC, Govindan R, Bauml JM, Garrido P, Krebs MG, Reckamp KL, Xie J, Curtin JC, Haddish-Berhane N, Roshak A, Millington D, Lorenzini P, Thayu M, Knoblauch RE, Cho BC
J Clin Oncol 2021 Oct 20;39(30):3391-3402. Epub 2021 Aug 2 doi: 10.1200/JCO.21.00662. PMID: 34339292Free PMC Article
Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC
N Engl J Med 2020 Apr 9;382(15):1430-1442. Epub 2020 Mar 18 doi: 10.1056/NEJMoa1912735. PMID: 32187457Free PMC Article
Natsis NE, Cohen PR
Am J Clin Dermatol 2018 Oct;19(5):671-677. doi: 10.1007/s40257-018-0362-9. PMID: 29882122
Hsu WH, Yang JC, Mok TS, Loong HH
Ann Oncol 2018 Jan 1;29(suppl_1):i3-i9. doi: 10.1093/annonc/mdx702. PMID: 29462253
Hartmann JT, Haap M, Kopp HG, Lipp HP
Curr Drug Metab 2009 Jun;10(5):470-81. doi: 10.2174/138920009788897975. PMID: 19689244

Prognosis

Gurel MS, Tekin B, Uzun S
Clin Dermatol 2020 Mar-Apr;38(2):140-151. Epub 2019 Oct 24 doi: 10.1016/j.clindermatol.2019.10.008. PMID: 32513395
Lomax A, Thornton J, Singh D
Foot Ankle Surg 2016 Dec;22(4):219-223. Epub 2015 Sep 21 doi: 10.1016/j.fas.2015.09.003. PMID: 27810017
Yang JC, Wu YL, Schuler M, Sebastian M, Popat S, Yamamoto N, Zhou C, Hu CP, O'Byrne K, Feng J, Lu S, Huang Y, Geater SL, Lee KY, Tsai CM, Gorbunova V, Hirsh V, Bennouna J, Orlov S, Mok T, Boyer M, Su WC, Lee KH, Kato T, Massey D, Shahidi M, Zazulina V, Sequist LV
Lancet Oncol 2015 Feb;16(2):141-51. Epub 2015 Jan 12 doi: 10.1016/S1470-2045(14)71173-8. PMID: 25589191
Shafritz AB, Coppage JM
J Am Acad Orthop Surg 2014 Mar;22(3):165-74. doi: 10.5435/JAAOS-22-03-165. PMID: 24603826
Rigopoulos D, Larios G, Gregoriou S, Alevizos A
Am Fam Physician 2008 Feb 1;77(3):339-46. PMID: 18297959

Clinical prediction guides

Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC
N Engl J Med 2020 Apr 9;382(15):1430-1442. Epub 2020 Mar 18 doi: 10.1056/NEJMoa1912735. PMID: 32187457Free PMC Article
Lacouture M, Sibaud V
Am J Clin Dermatol 2018 Nov;19(Suppl 1):31-39. doi: 10.1007/s40257-018-0384-3. PMID: 30374901Free PMC Article
Natsis NE, Cohen PR
Am J Clin Dermatol 2018 Oct;19(5):671-677. doi: 10.1007/s40257-018-0362-9. PMID: 29882122
Macdonald JB, Macdonald B, Golitz LE, LoRusso P, Sekulic A
J Am Acad Dermatol 2015 Feb;72(2):203-18; quiz 219-20. doi: 10.1016/j.jaad.2014.07.032. PMID: 25592338
Hartmann JT, Haap M, Kopp HG, Lipp HP
Curr Drug Metab 2009 Jun;10(5):470-81. doi: 10.2174/138920009788897975. PMID: 19689244

Recent systematic reviews

Liu T, Jiang S, Teng X, Zhong L, Liu M, Jin Y, Dong M
Immunopharmacol Immunotoxicol 2023 Feb;45(1):1-9. Epub 2022 Aug 18 doi: 10.1080/08923973.2022.2112222. PMID: 35950851
Sechi A, Zengarini C, Piraccini BM, Alessandrini A, Bruni F, Patrizi A, Naldi L, Starace M
Dermatol Ther 2022 Feb;35(2):e15251. Epub 2021 Dec 23 doi: 10.1111/dth.15251. PMID: 34877747
Foley K, Gupta AK, Versteeg S, Mays R, Villanueva E, John D
Cochrane Database Syst Rev 2020 Jan 16;1(1):CD012093. doi: 10.1002/14651858.CD012093.pub2. PMID: 31978269Free PMC Article
Petrelli F, Ardito R, Ghidini A, Zaniboni A, Ghidini M, Barni S, Tomasello G
Oncology 2018;94(4):191-199. Epub 2018 Jan 23 doi: 10.1159/000486338. PMID: 29393280
Pinto C, Barone CA, Girolomoni G, Russi EG, Merlano MC, Ferrari D, Maiello E
Am J Clin Oncol 2016 Aug;39(4):407-15. doi: 10.1097/COC.0000000000000291. PMID: 27077276

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