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Multifocal Glioblastomas

MedGen UID:
457396
•Concept ID:
C2985170
•
Neoplastic Process

Definition

The occurrence of multiple and independent glioblastomas that are unrelated to inherited neoplastic syndromes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMultifocal Glioblastomas

Professional guidelines

PubMed

Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R
J Neurosurg 2011 Mar;114(3):576-84. Epub 2010 Aug 6 doi: 10.3171/2010.6.JNS091326. PMID: 20690813

Recent clinical studies

Etiology

Noninvasive radiomics model reveals macrophage infiltration in glioma.
Fan X, Li J, Huang B, Lu H, Lu C, Pan M, Wang X, Zhang H, You Y, Wang X, Wang Q, Zhang J
Cancer Lett 2023 Oct 1;573:216380. Epub 2023 Sep 1 doi: 10.1016/j.canlet.2023.216380. PMID: 37660885
Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups.
Pérez-Beteta J, Molina-García D, Villena M, Rodríguez MJ, Velásquez C, Martino J, Meléndez-Asensio B, Rodríguez de Lope Á, Morcillo R, Sepúlveda JM, Hernández-Laín A, Ramos A, Barcia JA, Lara PC, Albillo D, Revert A, Arana E, Pérez-García VM
AJNR Am J Neuroradiol 2019 Apr;40(4):634-640. Epub 2019 Mar 28 doi: 10.3174/ajnr.A6019. PMID: 30923085Free PMC Article
Bevacizumab for Patients with Recurrent Multifocal Glioblastomas.
Burger MC, Breuer S, Cieplik HC, Harter PN, Franz K, Bähr O, Steinbach JP
Int J Mol Sci 2017 Nov 20;18(11) doi: 10.3390/ijms18112469. PMID: 29156610Free PMC Article
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R
J Neurosurg 2011 Mar;114(3):576-84. Epub 2010 Aug 6 doi: 10.3171/2010.6.JNS091326. PMID: 20690813
Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies.
Burger PC, Kleihues P
Cancer 1989 May 15;63(10):2014-23. doi: 10.1002/1097-0142(19890515)63:10<2014::aid-cncr2820631025>3.0.co;2-l. PMID: 2539242

Diagnosis

Noninvasive radiomics model reveals macrophage infiltration in glioma.
Fan X, Li J, Huang B, Lu H, Lu C, Pan M, Wang X, Zhang H, You Y, Wang X, Wang Q, Zhang J
Cancer Lett 2023 Oct 1;573:216380. Epub 2023 Sep 1 doi: 10.1016/j.canlet.2023.216380. PMID: 37660885
Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype.
Lv SQ, Fu Z, Yang L, Li QR, Zhu J, Gai QJ, Mao M, He J, Qin Y, Yao XX, Lan X, Wang YX, Lu HM, Xiang Y, Zhang ZX, Huang GH, Yang W, Kang P, Sun Z, Shi Y, Yao XH, Bian XW, Wang Y
Theranostics 2022;12(1):459-473. Epub 2022 Jan 1 doi: 10.7150/thno.65739. PMID: 34987659Free PMC Article
Genetic analysis of a multifocal glioblastoma multiforme: a suitable tool to gain new aspects in glioma development.
Krex D, Mohr B, Appelt H, Schackert HK, Schackert G
Neurosurgery 2003 Dec;53(6):1377-84; discussion 1384. doi: 10.1227/01.neu.0000093426.29236.86. PMID: 14633303
Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies.
Burger PC, Kleihues P
Cancer 1989 May 15;63(10):2014-23. doi: 10.1002/1097-0142(19890515)63:10<2014::aid-cncr2820631025>3.0.co;2-l. PMID: 2539242

Therapy

Bevacizumab for Patients with Recurrent Multifocal Glioblastomas.
Burger MC, Breuer S, Cieplik HC, Harter PN, Franz K, Bähr O, Steinbach JP
Int J Mol Sci 2017 Nov 20;18(11) doi: 10.3390/ijms18112469. PMID: 29156610Free PMC Article
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R
J Neurosurg 2011 Mar;114(3):576-84. Epub 2010 Aug 6 doi: 10.3171/2010.6.JNS091326. PMID: 20690813

Prognosis

Noninvasive radiomics model reveals macrophage infiltration in glioma.
Fan X, Li J, Huang B, Lu H, Lu C, Pan M, Wang X, Zhang H, You Y, Wang X, Wang Q, Zhang J
Cancer Lett 2023 Oct 1;573:216380. Epub 2023 Sep 1 doi: 10.1016/j.canlet.2023.216380. PMID: 37660885
Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype.
Lv SQ, Fu Z, Yang L, Li QR, Zhu J, Gai QJ, Mao M, He J, Qin Y, Yao XX, Lan X, Wang YX, Lu HM, Xiang Y, Zhang ZX, Huang GH, Yang W, Kang P, Sun Z, Shi Y, Yao XH, Bian XW, Wang Y
Theranostics 2022;12(1):459-473. Epub 2022 Jan 1 doi: 10.7150/thno.65739. PMID: 34987659Free PMC Article
Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups.
Pérez-Beteta J, Molina-García D, Villena M, Rodríguez MJ, Velásquez C, Martino J, Meléndez-Asensio B, Rodríguez de Lope Á, Morcillo R, Sepúlveda JM, Hernández-Laín A, Ramos A, Barcia JA, Lara PC, Albillo D, Revert A, Arana E, Pérez-García VM
AJNR Am J Neuroradiol 2019 Apr;40(4):634-640. Epub 2019 Mar 28 doi: 10.3174/ajnr.A6019. PMID: 30923085Free PMC Article
Bevacizumab for Patients with Recurrent Multifocal Glioblastomas.
Burger MC, Breuer S, Cieplik HC, Harter PN, Franz K, Bähr O, Steinbach JP
Int J Mol Sci 2017 Nov 20;18(11) doi: 10.3390/ijms18112469. PMID: 29156610Free PMC Article
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R
J Neurosurg 2011 Mar;114(3):576-84. Epub 2010 Aug 6 doi: 10.3171/2010.6.JNS091326. PMID: 20690813

Clinical prediction guides

Noninvasive radiomics model reveals macrophage infiltration in glioma.
Fan X, Li J, Huang B, Lu H, Lu C, Pan M, Wang X, Zhang H, You Y, Wang X, Wang Q, Zhang J
Cancer Lett 2023 Oct 1;573:216380. Epub 2023 Sep 1 doi: 10.1016/j.canlet.2023.216380. PMID: 37660885
Comprehensive omics analyses profile genesets related with tumor heterogeneity of multifocal glioblastomas and reveal LIF/CCL2 as biomarkers for mesenchymal subtype.
Lv SQ, Fu Z, Yang L, Li QR, Zhu J, Gai QJ, Mao M, He J, Qin Y, Yao XX, Lan X, Wang YX, Lu HM, Xiang Y, Zhang ZX, Huang GH, Yang W, Kang P, Sun Z, Shi Y, Yao XH, Bian XW, Wang Y
Theranostics 2022;12(1):459-473. Epub 2022 Jan 1 doi: 10.7150/thno.65739. PMID: 34987659Free PMC Article
Murine models of IDH-wild-type glioblastoma exhibit spatial segregation of tumor initiation and manifestation during evolution.
Li Y, Li B, Li W, Wang Y, Akgül S, Treisman DM, Heist KA, Pierce BR, Hoff B, Ho CY, Ferguson DO, Rehemtulla A, Zheng S, Ross BD, Li JZ, Zhu Y
Nat Commun 2020 Jul 22;11(1):3669. doi: 10.1038/s41467-020-17382-3. PMID: 32699356Free PMC Article
Morphologic Features on MR Imaging Classify Multifocal Glioblastomas in Different Prognostic Groups.
Pérez-Beteta J, Molina-García D, Villena M, Rodríguez MJ, Velásquez C, Martino J, Meléndez-Asensio B, Rodríguez de Lope Á, Morcillo R, Sepúlveda JM, Hernández-Laín A, Ramos A, Barcia JA, Lara PC, Albillo D, Revert A, Arana E, Pérez-García VM
AJNR Am J Neuroradiol 2019 Apr;40(4):634-640. Epub 2019 Mar 28 doi: 10.3174/ajnr.A6019. PMID: 30923085Free PMC Article
Multiple craniotomies in the management of multifocal and multicentric glioblastoma. Clinical article.
Hassaneen W, Levine NB, Suki D, Salaskar AL, de Moura Lima A, McCutcheon IE, Prabhu SS, Lang FF, DeMonte F, Rao G, Weinberg JS, Wildrick DM, Aldape KD, Sawaya R
J Neurosurg 2011 Mar;114(3):576-84. Epub 2010 Aug 6 doi: 10.3171/2010.6.JNS091326. PMID: 20690813

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