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Malignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

MedGen UID:
457456
Concept ID:
C2985230
Neoplastic Process

Definition

A malignant peripheral nerve sheath tumor characterized by the presence of mesenchymal differentiation. Representative example is the malignant Triton tumor which contains a rhabdomyosarcomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Peripheral Nerve Sheath Tumor with Mesenchymal Differentiation

Professional guidelines

PubMed

Lai JP, Robbins PF, Raffeld M, Aung PP, Tsokos M, Rosenberg SA, Miettinen MM, Lee CC
Mod Pathol 2012 Jun;25(6):854-8. Epub 2012 Mar 2 doi: 10.1038/modpathol.2012.31. PMID: 22388761Free PMC Article

Recent clinical studies

Etiology

Bowman CJ, Medeiros F, Fadare O, Sangoi AR, Horvai AE, Devine WP, McCluggage WG, Rabban JT
Int J Gynecol Pathol 2023 Jan 1;42(1):1-10. Epub 2022 Feb 18 doi: 10.1097/PGP.0000000000000858. PMID: 35180768
Velez Torres JM, Duarte EM, Diaz-Perez JA, Leibowitz J, Weed DT, Thomas G, Sargi Z, Civantos FJ, Arnold DJ, Gomez-Fernandez C, Montgomery EA, Rosenberg AE
Head Neck Pathol 2022 Jun;16(2):353-365. Epub 2021 Jul 12 doi: 10.1007/s12105-021-01360-2. PMID: 34251596Free PMC Article
Agaimy A, Stachel KD, Jüngert J, Radkow T, Carbon R, Metzler M, Holter W
Appl Immunohistochem Mol Morphol 2014 Sep;22(8):627-33. doi: 10.1097/PAI.0b013e318224751f. PMID: 21768875
Sadikovic B, Graham C, Ho M, Zielenska M, Somers GR
Pediatr Dev Pathol 2011 Jul-Aug;14(4):259-72. Epub 2010 Dec 16 doi: 10.2350/10-08-0890-OA.1. PMID: 21162641
Policarpio-Nicolas ML, Abbott TE, Dalkin AC, Bennett-Wick J, Frierson HF Jr
Diagn Cytopathol 2008 Feb;36(2):115-9. doi: 10.1002/dc.20772. PMID: 18181193

Diagnosis

Weigelt MA, Franklin MJ, Patel MT, Bergfeld WF
J Cutan Pathol 2023 Apr;50(4):326-329. Epub 2022 Nov 4 doi: 10.1111/cup.14343. PMID: 36271750
Odeyemi OO, Ozawa MG, Charville GW
Histopathology 2022 May;80(6):995-1000. Epub 2022 Feb 28 doi: 10.1111/his.14626. PMID: 35122289Free PMC Article
Petracco G, Patriarca C, Spasciani R, Parafioriti A
Pathologica 2019 Dec;111(4):365-368. doi: 10.32074/1591-951X-33-19. PMID: 31965114Free PMC Article
Scheithauer BW, Amrami KK, Folpe AL, Silva AI, Edgar MA, Woodruff JM, Levi AD, Spinner RJ
Hum Pathol 2011 Apr;42(4):568-77. Epub 2011 Feb 4 doi: 10.1016/j.humpath.2010.08.019. PMID: 21295819
Stasik CJ, Tawfik O
Arch Pathol Lab Med 2006 Dec;130(12):1878-81. doi: 10.5858/2006-130-1878-MPNSTW. PMID: 17149968

Therapy

Rekhi B, Shetty O, Bapat P, Gurav M, Qureshi S
Int J Surg Pathol 2021 Feb;29(1):102-108. Epub 2020 Jun 3 doi: 10.1177/1066896920927467. PMID: 32489127
Miolo G, Ash A, Buonadonna A, Lo Re G, Torrisi E, Cervo S, Santeufemia DA, Tuzi A, Canzonieri V
Cancer Biol Ther 2014;15(11):1439-43. doi: 10.4161/15384047.2014.956642. PMID: 25482943Free PMC Article
Lai JP, Robbins PF, Raffeld M, Aung PP, Tsokos M, Rosenberg SA, Miettinen MM, Lee CC
Mod Pathol 2012 Jun;25(6):854-8. Epub 2012 Mar 2 doi: 10.1038/modpathol.2012.31. PMID: 22388761Free PMC Article

Prognosis

Carter CS, Patel RM
Mod Pathol 2020 Jan;33(Suppl 1):66-82. Epub 2019 Nov 4 doi: 10.1038/s41379-019-0387-5. PMID: 31685962
Folpe AL
Mod Pathol 2014 Jan;27 Suppl 1:S64-79. doi: 10.1038/modpathol.2013.175. PMID: 24384854
Scheithauer BW, Amrami KK, Folpe AL, Silva AI, Edgar MA, Woodruff JM, Levi AD, Spinner RJ
Hum Pathol 2011 Apr;42(4):568-77. Epub 2011 Feb 4 doi: 10.1016/j.humpath.2010.08.019. PMID: 21295819
Stasik CJ, Tawfik O
Arch Pathol Lab Med 2006 Dec;130(12):1878-81. doi: 10.5858/2006-130-1878-MPNSTW. PMID: 17149968
Papi G, Corrado S, LiVolsi VA
Am J Clin Pathol 2006 Jun;125 Suppl:S95-123. doi: 10.1309/4DQW6RQX3C6KRX1J. PMID: 16830961

Clinical prediction guides

Odeyemi OO, Ozawa MG, Charville GW
Histopathology 2022 May;80(6):995-1000. Epub 2022 Feb 28 doi: 10.1111/his.14626. PMID: 35122289Free PMC Article
Schaefer IM, Hornick JL
Semin Diagn Pathol 2021 May;38(3):222-231. Epub 2020 Jun 5 doi: 10.1053/j.semdp.2020.05.005. PMID: 32646614Free PMC Article
Carter CS, Patel RM
Mod Pathol 2020 Jan;33(Suppl 1):66-82. Epub 2019 Nov 4 doi: 10.1038/s41379-019-0387-5. PMID: 31685962
Folpe AL
Mod Pathol 2014 Jan;27 Suppl 1:S64-79. doi: 10.1038/modpathol.2013.175. PMID: 24384854
Nappi O, Ritter JH, Pettinato G, Wick MR
Semin Diagn Pathol 1995 Aug;12(3):221-32. PMID: 8545589

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