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Spindle cell oncocytoma

MedGen UID:
458787
Concept ID:
C2986561
Neoplastic Process
Synonyms: Spindle Cell Oncocytoma; spindle cell oncocytoma; Spindle Cell Oncocytoma/Oncocytic Pituicytoma
SNOMED CT: Spindle cell oncocytoma (703844007)
 
Monarch Initiative: MONDO:0858960

Definition

A very rare, WHO grade 1 neoplasm of the posterior pituitary. It is characterized by the presence of spindle cells with eosinophilic, granular cytoplasm forming fascicles. Electron microscopic studies demonstrate the accumulation of intracytoplasmic mitochondria and lack of secretory granules. Immunohistochemical studies are negative for pituitary hormones. Patients may present with pituitary hypofunction, visual disturbances, headache, nausea and vomiting. The clinical course is usually benign. [from NCI]

Professional guidelines

PubMed

Trifa A, Knafo S, Maatoug A, Militaru M, Copaciu R, Aghakhani N, Parker F
Acta Neurol Belg 2023 Jun;123(3):815-822. Epub 2022 Mar 17 doi: 10.1007/s13760-022-01917-0. PMID: 35301693
Kandregula S, Shashidhar A, Rao S, Beniwal M, Shukla D, Srinivas D, Saini J, Mahadevan A, Santosh V, Arimappamagan A
J Neurol Surg A Cent Eur Neurosurg 2022 Sep;83(5):442-450. Epub 2021 Dec 15 doi: 10.1055/s-0041-1740264. PMID: 34911085

Recent clinical studies

Etiology

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Giantini Larsen AM, Cote DJ, Zaidi HA, Bi WL, Schmitt PJ, Iorgulescu JB, Miller MB, Smith TR, Lopes MB, Jane JA, Laws ER
J Neurosurg 2018 Oct 19;131(2):517-525. doi: 10.3171/2018.4.JNS18211. PMID: 30485213Free PMC Article
Mete O, Lopes MB
Endocr Pathol 2017 Sep;28(3):228-243. doi: 10.1007/s12022-017-9498-z. PMID: 28766057
Manoranjan B, Koziarz A, Kameda-Smith MM, Provias JP
J Clin Neurosci 2017 Sep;43:134-146. Epub 2017 Jun 28 doi: 10.1016/j.jocn.2017.05.017. PMID: 28668473
Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P
Acta Neuropathol 2007 Aug;114(2):97-109. Epub 2007 Jul 6 doi: 10.1007/s00401-007-0243-4. PMID: 17618441Free PMC Article

Diagnosis

Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Kobalka PJ, Huntoon K, Becker AP
Neurosurgery 2021 Apr 15;88(5):900-918. doi: 10.1093/neuros/nyaa548. PMID: 33476394
Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C
Rev Endocr Metab Disord 2019 Jun;20(2):219-238. doi: 10.1007/s11154-019-09484-1. PMID: 30864049
Giantini Larsen AM, Cote DJ, Zaidi HA, Bi WL, Schmitt PJ, Iorgulescu JB, Miller MB, Smith TR, Lopes MB, Jane JA, Laws ER
J Neurosurg 2018 Oct 19;131(2):517-525. doi: 10.3171/2018.4.JNS18211. PMID: 30485213Free PMC Article
Kleinschmidt-DeMasters BK
Curr Opin Endocrinol Diabetes Obes 2016 Dec;23(6):476-484. doi: 10.1097/MED.0000000000000293. PMID: 27763894

Therapy

Yang YC, Liao WC
World Neurosurg 2021 Jul;151:21-22. Epub 2021 Apr 8 doi: 10.1016/j.wneu.2021.03.158. PMID: 33839335
Dawoud FM, Naylor RM, Giannini C, Swanson AA, Meyer FB, Uhm JH
Clin Neurol Neurosurg 2020 Sep;196:106059. Epub 2020 Jun 30 doi: 10.1016/j.clineuro.2020.106059. PMID: 32682222
Sollfrank L, Lettmaier S, Erdmann M, Uslu U
Anticancer Res 2019 Jul;39(7):3955-3959. doi: 10.21873/anticanres.13549. PMID: 31262927
Guerrero-Pérez F, Vidal N, Marengo AP, Pozo CD, Blanco C, Rivero-Celada D, Díez JJ, Iglesias P, Picó A, Villabona C
Endocrine 2019 Jan;63(1):36-43. Epub 2018 Oct 1 doi: 10.1007/s12020-018-1774-2. PMID: 30276594
Vajtai I, Beck J, Kappeler A, Hewer E
Acta Neuropathol 2011 Aug;122(2):253-8. Epub 2011 May 18 doi: 10.1007/s00401-011-0835-x. PMID: 21590491

Prognosis

Borg A, Jaunmuktane Z, Dorward N
World Neurosurg 2020 Feb;134:e968-e978. Epub 2019 Nov 14 doi: 10.1016/j.wneu.2019.11.043. PMID: 31734425
Oushy S, Graffeo CS, Perry A, Stafford SL, Link MJ, Pollock BE
J Neurooncol 2019 Sep;144(2):325-332. Epub 2019 Jun 28 doi: 10.1007/s11060-019-03231-x. PMID: 31254265
Lopes MBS
Acta Neuropathol 2017 Oct;134(4):521-535. Epub 2017 Aug 18 doi: 10.1007/s00401-017-1769-8. PMID: 28821944
Manoranjan B, Koziarz A, Kameda-Smith MM, Provias JP
J Clin Neurosci 2017 Sep;43:134-146. Epub 2017 Jun 28 doi: 10.1016/j.jocn.2017.05.017. PMID: 28668473
Sali A, Epari S, Tampi C, Goel A
Neuropathology 2017 Dec;37(6):535-543. Epub 2017 Jun 19 doi: 10.1111/neup.12393. PMID: 28631277

Clinical prediction guides

Kim H, Lee K, Shim YM, Kim EE, Kim SK, Phi JH, Park CK, Choi SH, Park SH
Lab Invest 2023 Aug;103(8):100159. Epub 2023 Apr 22 doi: 10.1016/j.labinv.2023.100159. PMID: 37088465
Trifa A, Knafo S, Maatoug A, Militaru M, Copaciu R, Aghakhani N, Parker F
Acta Neurol Belg 2023 Jun;123(3):815-822. Epub 2022 Mar 17 doi: 10.1007/s13760-022-01917-0. PMID: 35301693
Schmid S, Solomon DA, Perez E, Thieme A, Kleinschmidt-DeMasters BK, Giannini C, Reinhardt A, Asa SL, Mete O, Stichel D, Siewert C, Dittmayer C, Hasselblatt M, Paulus W, Nagel C, Harter PN, Schittenhelm J, Honegger J, Rushing E, Coras R, Pfister SM, Buslei R, Koch A, Perry A, Jones DTW, von Deimling A, Capper D, Lopes MB
Acta Neuropathol 2021 Dec;142(6):1025-1043. Epub 2021 Oct 18 doi: 10.1007/s00401-021-02377-1. PMID: 34661724Free PMC Article
Saeger W, von Schöning J, Flitsch J, Jautzke G, Bergmann M, Hagel C, Knappe UJ
Endocr Pathol 2021 Dec;32(4):473-479. Epub 2021 Jun 15 doi: 10.1007/s12022-021-09677-y. PMID: 34129177
Oushy S, Graffeo CS, Perry A, Stafford SL, Link MJ, Pollock BE
J Neurooncol 2019 Sep;144(2):325-332. Epub 2019 Jun 28 doi: 10.1007/s11060-019-03231-x. PMID: 31254265

Recent systematic reviews

Hasegawa H, Van Gompel JJ, Oushy SH, Pollock BE, Link MJ, Meyer FB, Bancos I, Erickson D, Davidge-Pitts CJ, Little JT, Uhm JH, Swanson AA, Giannini C, Mahajan A, Atkinson JL
World Neurosurg 2021 May;149:e197-e216. Epub 2021 Feb 18 doi: 10.1016/j.wneu.2021.02.051. PMID: 33610869
Vuong HG, Nguyen TPX, Pham N, Dunn IF
Pituitary 2021 Jun;24(3):429-437. Epub 2020 Nov 18 doi: 10.1007/s11102-020-01110-7. PMID: 33205233
Whipple SG, Savardekar AR, Rao S, Mahadevan A, Guthikonda B, Kosty JA
World Neurosurg 2021 Jan;145:148-158. Epub 2020 Sep 8 doi: 10.1016/j.wneu.2020.09.023. PMID: 32916355
Oushy S, Graffeo CS, Perry A, Stafford SL, Link MJ, Pollock BE
J Neurooncol 2019 Sep;144(2):325-332. Epub 2019 Jun 28 doi: 10.1007/s11060-019-03231-x. PMID: 31254265
Guerrero-Pérez F, Marengo AP, Vidal N, Iglesias P, Villabona C
Rev Endocr Metab Disord 2019 Jun;20(2):219-238. doi: 10.1007/s11154-019-09484-1. PMID: 30864049

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