U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Multifocal breast carcinoma

MedGen UID:
458888
•Concept ID:
C2986662
•
Neoplastic Process
Synonyms: Multifocal breast cancer; Multifocal Breast Carcinoma
 
HPO: HP:0006625

Definition

Breast carcinoma that is bilateral or otherwise multifocal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Multifocal breast carcinoma

Professional guidelines

PubMed

Global variations in the definition and management of multifocal and multicentric breast cancer: the MINIM international survey.
Masannat YA, Rocco N, Garreffa E, Gulluoglu BM, Kothari A, Maglia A, Nava MB, Omar OS, Potter S, Catanuto G
Br J Surg 2022 Jul 15;109(8):656-659. doi: 10.1093/bjs/znac080. PMID: 35352093
Management of thyroid cancer: United Kingdom National Multidisciplinary Guidelines.
Mitchell AL, Gandhi A, Scott-Coombes D, Perros P
J Laryngol Otol 2016 May;130(S2):S150-S160. doi: 10.1017/S0022215116000578. PMID: 27841128Free PMC Article
Multiple lesions of the spleen: differential diagnosis of cystic and solid lesions.
Kamaya A, Weinstein S, Desser TS
Semin Ultrasound CT MR 2006 Oct;27(5):389-403. doi: 10.1053/j.sult.2006.06.004. PMID: 17048454

Recent clinical studies

Etiology

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
Meißner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Müller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M
Cold Spring Harb Mol Case Stud 2017 Jul;3(4) Epub 2017 Jul 5 doi: 10.1101/mcs.a001677. PMID: 28679691Free PMC Article
Bilateral and multifocal breast carcinoma. A clinical and autopsy study with special emphasis on carcinoma in situ.
Ringberg A, Palmer B, Linell F, Rychterova V, Ljungberg O
Eur J Surg Oncol 1991 Feb;17(1):20-9. PMID: 1847343

Diagnosis

Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification.
Gröschel S, Bommer M, Hutter B, Budczies J, Bonekamp D, Heining C, Horak P, Fröhlich M, Uhrig S, Hübschmann D, Geörg C, Richter D, Pfarr N, Pfütze K, Wolf S, Schirmacher P, Jäger D, von Kalle C, Brors B, Glimm H, Weichert W, Stenzinger A, Fröhling S
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001180. doi: 10.1101/mcs.a001180. PMID: 27900363Free PMC Article
HER2 testing of multifocal invasive breast carcinoma: how many blocks are enough?
Bethune GC, Mullen JB, Chang MC
Am J Clin Pathol 2013 Oct;140(4):588-92. doi: 10.1309/AJCPZSV2W1CPGRJW. PMID: 24045558
Sentinel lymph node mapping and biopsy for ductal carcinoma in situ and other controversial indications.
Fuhrman GM
Am Surg 2004 May;70(5):403-6. PMID: 15156947
Bilateral and multifocal breast carcinoma. A clinical and autopsy study with special emphasis on carcinoma in situ.
Ringberg A, Palmer B, Linell F, Rychterova V, Ljungberg O
Eur J Surg Oncol 1991 Feb;17(1):20-9. PMID: 1847343
Multifocal breast carcinoma.
Westman-Naeser S, Bengtsson E, Eriksson O, Jarkrans T, Nordin B, Stenkvist B
Am J Surg 1981 Aug;142(2):255-7. doi: 10.1016/0002-9610(81)90288-9. PMID: 7258538

Therapy

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
Meißner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Müller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M
Cold Spring Harb Mol Case Stud 2017 Jul;3(4) Epub 2017 Jul 5 doi: 10.1101/mcs.a001677. PMID: 28679691Free PMC Article
Sentinel lymph node mapping and biopsy for ductal carcinoma in situ and other controversial indications.
Fuhrman GM
Am Surg 2004 May;70(5):403-6. PMID: 15156947
Bilateral and multifocal breast carcinoma. A clinical and autopsy study with special emphasis on carcinoma in situ.
Ringberg A, Palmer B, Linell F, Rychterova V, Ljungberg O
Eur J Surg Oncol 1991 Feb;17(1):20-9. PMID: 1847343

Prognosis

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
Meißner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Müller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M
Cold Spring Harb Mol Case Stud 2017 Jul;3(4) Epub 2017 Jul 5 doi: 10.1101/mcs.a001677. PMID: 28679691Free PMC Article
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification.
Gröschel S, Bommer M, Hutter B, Budczies J, Bonekamp D, Heining C, Horak P, Fröhlich M, Uhrig S, Hübschmann D, Geörg C, Richter D, Pfarr N, Pfütze K, Wolf S, Schirmacher P, Jäger D, von Kalle C, Brors B, Glimm H, Weichert W, Stenzinger A, Fröhling S
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001180. doi: 10.1101/mcs.a001180. PMID: 27900363Free PMC Article
What is new in our understanding of multifocal breast cancer.
Dawson PJ
Pathol Res Pract 1993 Feb;189(1):111-6. doi: 10.1016/S0344-0338(11)80130-5. PMID: 8516211
Bilateral and multifocal breast carcinoma. A clinical and autopsy study with special emphasis on carcinoma in situ.
Ringberg A, Palmer B, Linell F, Rychterova V, Ljungberg O
Eur J Surg Oncol 1991 Feb;17(1):20-9. PMID: 1847343

Clinical prediction guides

Metastatic triple-negative breast cancer patient with TP53 tumor mutation experienced 11 months progression-free survival on bortezomib monotherapy without adverse events after ending standard treatments with grade 3 adverse events.
Meißner T, Mark A, Williams C, Berdel WE, Wiebe S, Kerkhoff A, Wardelmann E, Gaiser T, Müller-Tidow C, Rosenstiel P, Arnold N, Leyland-Jones B, Franke A, Stanulla M, Forster M
Cold Spring Harb Mol Case Stud 2017 Jul;3(4) Epub 2017 Jul 5 doi: 10.1101/mcs.a001677. PMID: 28679691Free PMC Article
Integration of genomics and histology revises diagnosis and enables effective therapy of refractory cancer of unknown primary with PDL1 amplification.
Gröschel S, Bommer M, Hutter B, Budczies J, Bonekamp D, Heining C, Horak P, Fröhlich M, Uhrig S, Hübschmann D, Geörg C, Richter D, Pfarr N, Pfütze K, Wolf S, Schirmacher P, Jäger D, von Kalle C, Brors B, Glimm H, Weichert W, Stenzinger A, Fröhling S
Cold Spring Harb Mol Case Stud 2016 Nov;2(6):a001180. doi: 10.1101/mcs.a001180. PMID: 27900363Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • ClinVar
      Related medical variations
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...