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Pancreatic Moderately Differentiated Ductal Adenocarcinoma

MedGen UID:
459366
•Concept ID:
C2987140
•
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Moderately Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H
Cells 2023 Feb 11;12(4) doi: 10.3390/cells12040587. PMID: 36831254Free PMC Article
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Significance of SATB2 expression in colon cancer and its differential diagnosis in digestive tract adenocarcinoma and ovarian primary and metastatic carcinoma.
Liu F, Gao Z, Shen D, Zhao H, Wang C, Ye Y, Ma Y, Kong F
Pathol Res Pract 2019 Jul;215(7):152430. Epub 2019 May 7 doi: 10.1016/j.prp.2019.04.022. PMID: 31101576

Recent clinical studies

Etiology

Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Imaging features of intraductal tubulopapillary neoplasm of the pancreas and its differentiation from conventional pancreatic ductal adenocarcinoma.
Khristenko E, Hank T, Gaida MM, Kauczor HU, Hackert T, Klauß M, Mayer P
Sci Rep 2022 Sep 16;12(1):15557. doi: 10.1038/s41598-022-19517-6. PMID: 36114217Free PMC Article
PD-L1 and PD-L2 expression in pancreatic ductal adenocarcinoma and their correlation with immune infiltrates and DNA damage response molecules.
Zhang Y, Chen X, Mo S, Ma H, Lu Z, Yu S, Chen J
J Pathol Clin Res 2022 May;8(3):257-267. Epub 2022 Jan 17 doi: 10.1002/cjp2.259. PMID: 35037417Free PMC Article
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome.
N Kalimuthu S, Wilson GW, Grant RC, Seto M, O'Kane G, Vajpeyi R, Notta F, Gallinger S, Chetty R
Gut 2020 Feb;69(2):317-328. Epub 2019 Jun 14 doi: 10.1136/gutjnl-2019-318217. PMID: 31201285
Levels of HOXB7 and miR-337 in pancreatic ductal adenocarcinoma patients.
Zhang R, Zheng S, Du Y, Wang Y, Zang W, Zhao G
Diagn Pathol 2014 Mar 18;9:61. doi: 10.1186/1746-1596-9-61. PMID: 24641834Free PMC Article

Diagnosis

Imaging features of intraductal tubulopapillary neoplasm of the pancreas and its differentiation from conventional pancreatic ductal adenocarcinoma.
Khristenko E, Hank T, Gaida MM, Kauczor HU, Hackert T, Klauß M, Mayer P
Sci Rep 2022 Sep 16;12(1):15557. doi: 10.1038/s41598-022-19517-6. PMID: 36114217Free PMC Article
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Feasibility and safety of microforceps biopsy in the diagnosis of pancreatic cysts.
Basar O, Yuksel O, Yang DJ, Samarasena J, Forcione D, DiMaio CJ, Wagh MS, Chang K, Casey B, Fernandez-Del Castillo C, Pitman MB, Brugge WR
Gastrointest Endosc 2018 Jul;88(1):79-86. Epub 2018 Mar 3 doi: 10.1016/j.gie.2018.02.039. PMID: 29510146
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
The role of S100P and IMP3 in the cytologic diagnosis of pancreatic adenocarcinoma.
Ezzat NE, Tahoun NS, Ismail YM
J Egypt Natl Canc Inst 2016 Dec;28(4):229-234. Epub 2016 Nov 7 doi: 10.1016/j.jnci.2016.10.002. PMID: 27839709

Therapy

Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
The differential effects of sarcopenia and cachexia on overall survival for pancreatic ductal adenocarcinoma patients following pancreatectomy: A retrospective study based on a large population.
Shen XD, Wang X, Zheng ZJ, Chen YH, Tan CL, Liu XB, Ke NW
Cancer Med 2023 May;12(9):10438-10448. Epub 2023 Mar 20 doi: 10.1002/cam4.5779. PMID: 36938648Free PMC Article
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Role of adjuvant therapy in resected stage IA subcentimeter (T1a/T1b) pancreatic cancer.
Shaib WL, Narayan AS, Switchenko JM, Kane SR, Wu C, Akce M, Alese OB, Patel PR, Maithel SK, Sarmiento JM, Kooby DA, El-Rayes BF
Cancer 2019 Jan 1;125(1):57-67. Epub 2018 Nov 20 doi: 10.1002/cncr.31787. PMID: 30457666Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Prognosis

Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J
J Pathol Clin Res 2022 May;8(3):268-278. Epub 2022 Jan 27 doi: 10.1002/cjp2.260. PMID: 35083884Free PMC Article
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome.
N Kalimuthu S, Wilson GW, Grant RC, Seto M, O'Kane G, Vajpeyi R, Notta F, Gallinger S, Chetty R
Gut 2020 Feb;69(2):317-328. Epub 2019 Jun 14 doi: 10.1136/gutjnl-2019-318217. PMID: 31201285
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Clinical prediction guides

Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J
J Pathol Clin Res 2022 May;8(3):268-278. Epub 2022 Jan 27 doi: 10.1002/cjp2.260. PMID: 35083884Free PMC Article
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Morphological classification of pancreatic ductal adenocarcinoma that predicts molecular subtypes and correlates with clinical outcome.
N Kalimuthu S, Wilson GW, Grant RC, Seto M, O'Kane G, Vajpeyi R, Notta F, Gallinger S, Chetty R
Gut 2020 Feb;69(2):317-328. Epub 2019 Jun 14 doi: 10.1136/gutjnl-2019-318217. PMID: 31201285
Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article
Pancreatic adenocarcinoma: insights into patterns of recurrence and disease behavior.
Sahin IH, Elias H, Chou JF, Capanu M, O'Reilly EM
BMC Cancer 2018 Jul 28;18(1):769. doi: 10.1186/s12885-018-4679-9. PMID: 30055578Free PMC Article

Recent systematic reviews

Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Systematic review and meta-analysis: Diagnostic performance of DNA alterations in pancreatic juice for the detection of pancreatic cancer.
Visser IJ, Levink IJM, Peppelenbosch MP, Fuhler GM, Bruno MJ, Cahen DL
Pancreatology 2022 Nov;22(7):973-986. Epub 2022 Jul 7 doi: 10.1016/j.pan.2022.06.260. PMID: 35864067

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