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Pancreatic Moderately Differentiated Ductal Adenocarcinoma

MedGen UID:
459366
Concept ID:
C2987140
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Moderately Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Rompen IF, Levine J, Habib JR, Sereni E, Mughal N, Hewitt DB, Sacks GD, Welling TH, Simeone DM, Kaplan B, Berman RS, Cohen SM, Wolfgang CL, Javed AA
Ann Surg 2024 Aug 1;280(2):317-324. Epub 2023 Oct 23 doi: 10.1097/SLA.0000000000006142. PMID: 37870253Free PMC Article
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H
Cells 2023 Feb 11;12(4) doi: 10.3390/cells12040587. PMID: 36831254Free PMC Article
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article

Recent clinical studies

Etiology

Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Flick KF, Yip-Schneider MT, Sublette CM, Simpson RE, Colgate CL, Wu H, Soufi M, Dewitt JM, Mosley AL, Ceppa EP, Zhang J, Schmidt CM
Pancreas 2020 Sep;49(8):1044-1051. doi: 10.1097/MPA.0000000000001628. PMID: 32769857
Gaitanidis A, Alevizakos M, Tsaroucha A, Tsalikidis C, Simopoulos C, Pitiakoudis M
Eur J Surg Oncol 2018 May;44(5):693-699. Epub 2018 Jan 12 doi: 10.1016/j.ejso.2018.01.011. PMID: 29426780
DiMaio CJ, Weis-Garcia F, Bagiella E, Tang LH, Allen PJ
Gastrointest Endosc 2016 Jun;83(6):1205-9. Epub 2015 Sep 25 doi: 10.1016/j.gie.2015.09.020. PMID: 26408423Free PMC Article
Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ
Clin Cancer Res 2011 Mar 15;17(6):1502-8. Epub 2011 Jan 25 doi: 10.1158/1078-0432.CCR-10-1561. PMID: 21266527Free PMC Article

Diagnosis

Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Gurram KC, Czapla A, Thakkar S
BMJ Case Rep 2014 Oct 7;2014 doi: 10.1136/bcr-2014-205322. PMID: 25293684Free PMC Article
Kucera S, Centeno BA, Springett G, Malafa MP, Chen YA, Weber J, Klapman J
JOP 2012 Jul 10;13(4):409-13. doi: 10.6092/1590-8577/664. PMID: 22797397
Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ
Clin Cancer Res 2011 Mar 15;17(6):1502-8. Epub 2011 Jan 25 doi: 10.1158/1078-0432.CCR-10-1561. PMID: 21266527Free PMC Article

Therapy

Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Shen XD, Wang X, Zheng ZJ, Chen YH, Tan CL, Liu XB, Ke NW
Cancer Med 2023 May;12(9):10438-10448. Epub 2023 Mar 20 doi: 10.1002/cam4.5779. PMID: 36938648Free PMC Article
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article
Yamashita Y, Kato J, Ueda K, Nakamura Y, Kawaji Y, Abe H, Nuta J, Tamura T, Itonaga M, Yoshida T, Maeda H, Maekita T, Iguchi M, Tamai H, Ichinose M
Biomed Res Int 2015;2015:491782. Epub 2015 May 18 doi: 10.1155/2015/491782. PMID: 26090411Free PMC Article

Prognosis

Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Flick KF, Yip-Schneider MT, Sublette CM, Simpson RE, Colgate CL, Wu H, Soufi M, Dewitt JM, Mosley AL, Ceppa EP, Zhang J, Schmidt CM
Pancreas 2020 Sep;49(8):1044-1051. doi: 10.1097/MPA.0000000000001628. PMID: 32769857
Gaitanidis A, Alevizakos M, Tsaroucha A, Tsalikidis C, Simopoulos C, Pitiakoudis M
Eur J Surg Oncol 2018 May;44(5):693-699. Epub 2018 Jan 12 doi: 10.1016/j.ejso.2018.01.011. PMID: 29426780
Kucera S, Centeno BA, Springett G, Malafa MP, Chen YA, Weber J, Klapman J
JOP 2012 Jul 10;13(4):409-13. doi: 10.6092/1590-8577/664. PMID: 22797397
Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ
Clin Cancer Res 2011 Mar 15;17(6):1502-8. Epub 2011 Jan 25 doi: 10.1158/1078-0432.CCR-10-1561. PMID: 21266527Free PMC Article

Clinical prediction guides

Flick KF, Yip-Schneider MT, Sublette CM, Simpson RE, Colgate CL, Wu H, Soufi M, Dewitt JM, Mosley AL, Ceppa EP, Zhang J, Schmidt CM
Pancreas 2020 Sep;49(8):1044-1051. doi: 10.1097/MPA.0000000000001628. PMID: 32769857
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article
Kucera S, Centeno BA, Springett G, Malafa MP, Chen YA, Weber J, Klapman J
JOP 2012 Jul 10;13(4):409-13. doi: 10.6092/1590-8577/664. PMID: 22797397
Maker AV, Katabi N, Qin LX, Klimstra DS, Schattner M, Brennan MF, Jarnagin WR, Allen PJ
Clin Cancer Res 2011 Mar 15;17(6):1502-8. Epub 2011 Jan 25 doi: 10.1158/1078-0432.CCR-10-1561. PMID: 21266527Free PMC Article

Recent systematic reviews

Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Visser IJ, Levink IJM, Peppelenbosch MP, Fuhler GM, Bruno MJ, Cahen DL
Pancreatology 2022 Nov;22(7):973-986. Epub 2022 Jul 7 doi: 10.1016/j.pan.2022.06.260. PMID: 35864067

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