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Pancreatic Moderately Differentiated Ductal Adenocarcinoma

MedGen UID:
459366
•Concept ID:
C2987140
•
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of medium-sized duct-like structures and small malignant tubular glandular structures. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Moderately Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Establishment and Molecular Characterization of Two Patient-Derived Pancreatic Ductal Adenocarcinoma Cell Lines as Preclinical Models for Treatment Response.
Braun R, Lapshyna O, Watzelt J, Drenckhan M, Künstner A, Färber B, Hael AAM, Bolm L, Honselmann KC, Konukiewitz B, Castven D, Spielmann M, Gorantla SP, Busch H, Marquardt JU, Keck T, Wellner UF, Ungefroren H
Cells 2023 Feb 11;12(4) doi: 10.3390/cells12040587. PMID: 36831254Free PMC Article
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Differential diagnosis of pancreatic tumors using ultrasound contrast imaging.
Sofuni A, Iijima H, Moriyasu F, Nakayama D, Shimizu M, Nakamura K, Itokawa F, Itoi T
J Gastroenterol 2005 May;40(5):518-25. doi: 10.1007/s00535-005-1578-z. PMID: 15942718

Recent clinical studies

Etiology

Predicting Long-term Disease-free Survival After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Cohort Study.
van Goor IWJM, Schouten TJ, Verburg DN, Besselink MG, Bonsing BA, Bosscha K, Brosens LAA, Busch OR, Cirkel GA, van Dam RM, Festen S, Koerkamp BG, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Roos D, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, van Santvoort HC, Daamen LA, Molenaar IQ; Dutch Pancreatic Cancer Group
Ann Surg 2024 Jan 1;279(1):132-137. Epub 2023 Jul 17 doi: 10.1097/SLA.0000000000006004. PMID: 37450706Free PMC Article
Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
The differential effects of sarcopenia and cachexia on overall survival for pancreatic ductal adenocarcinoma patients following pancreatectomy: A retrospective study based on a large population.
Shen XD, Wang X, Zheng ZJ, Chen YH, Tan CL, Liu XB, Ke NW
Cancer Med 2023 May;12(9):10438-10448. Epub 2023 Mar 20 doi: 10.1002/cam4.5779. PMID: 36938648Free PMC Article
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169

Diagnosis

Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
The differential effects of sarcopenia and cachexia on overall survival for pancreatic ductal adenocarcinoma patients following pancreatectomy: A retrospective study based on a large population.
Shen XD, Wang X, Zheng ZJ, Chen YH, Tan CL, Liu XB, Ke NW
Cancer Med 2023 May;12(9):10438-10448. Epub 2023 Mar 20 doi: 10.1002/cam4.5779. PMID: 36938648Free PMC Article
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Therapy

Endoscopic Ultrasound Can Differentiate High-Grade Pancreatic Intraepithelial Neoplasia, Small Pancreatic Ductal Adenocarcinoma, and Benign Stenosis.
Sagami R, Yamao K, Minami R, Nakahodo J, Akiyama H, Nishikiori H, Mizukami K, Yamao K, Bhatia V, Amano Y, Murakami K
Gut Liver 2024 Mar 15;18(2):338-347. Epub 2023 May 11 doi: 10.5009/gnl220521. PMID: 37165770Free PMC Article
Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
The differential effects of sarcopenia and cachexia on overall survival for pancreatic ductal adenocarcinoma patients following pancreatectomy: A retrospective study based on a large population.
Shen XD, Wang X, Zheng ZJ, Chen YH, Tan CL, Liu XB, Ke NW
Cancer Med 2023 May;12(9):10438-10448. Epub 2023 Mar 20 doi: 10.1002/cam4.5779. PMID: 36938648Free PMC Article
Robotic pancreaticoduodenectomy for pancreatic ductal adenocarcinoma: Analysis of surgical outcomes and long-term prognosis in a high-volume center.
Zhang XP, Xu S, Zhao ZM, Liu Q, Zhao GD, Hu MG, Tan XL, Liu R
Hepatobiliary Pancreat Dis Int 2023 Apr;22(2):140-146. Epub 2022 Sep 20 doi: 10.1016/j.hbpd.2022.09.006. PMID: 36171169
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Prognosis

Predicting Long-term Disease-free Survival After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Cohort Study.
van Goor IWJM, Schouten TJ, Verburg DN, Besselink MG, Bonsing BA, Bosscha K, Brosens LAA, Busch OR, Cirkel GA, van Dam RM, Festen S, Koerkamp BG, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Roos D, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, van Santvoort HC, Daamen LA, Molenaar IQ; Dutch Pancreatic Cancer Group
Ann Surg 2024 Jan 1;279(1):132-137. Epub 2023 Jul 17 doi: 10.1097/SLA.0000000000006004. PMID: 37450706Free PMC Article
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors.
Al-Hader A, Al-Rohil RN, Han H, Von Hoff D
World J Gastroenterol 2017 Dec 7;23(45):7945-7951. doi: 10.3748/wjg.v23.i45.7945. PMID: 29259370Free PMC Article

Clinical prediction guides

Predicting Long-term Disease-free Survival After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Cohort Study.
van Goor IWJM, Schouten TJ, Verburg DN, Besselink MG, Bonsing BA, Bosscha K, Brosens LAA, Busch OR, Cirkel GA, van Dam RM, Festen S, Koerkamp BG, van der Harst E, de Hingh IHJT, Intven MPW, Kazemier G, Los M, Meijer GJ, de Meijer VE, Nieuwenhuijs VB, Roos D, Schreinemakers JMJ, Stommel MWJ, Verdonk RC, van Santvoort HC, Daamen LA, Molenaar IQ; Dutch Pancreatic Cancer Group
Ann Surg 2024 Jan 1;279(1):132-137. Epub 2023 Jul 17 doi: 10.1097/SLA.0000000000006004. PMID: 37450706Free PMC Article
Evaluation and prognostic significance of tumor budding in pancreatic ductal adenocarcinomas.
Argon A, Öz Ö, Kebat TA
Indian J Pathol Microbiol 2023 Jan-Mar;66(1):38-43. doi: 10.4103/ijpm.ijpm_905_21. PMID: 36656208
Analysis of a novel immune checkpoint, Siglec-15, in pancreatic ductal adenocarcinoma.
Chen X, Mo S, Zhang Y, Ma H, Lu Z, Yu S, Chen J
J Pathol Clin Res 2022 May;8(3):268-278. Epub 2022 Jan 27 doi: 10.1002/cjp2.260. PMID: 35083884Free PMC Article
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway.
Ogawa K, Lin Q, Li L, Bai X, Chen X, Chen H, Kong R, Wang Y, Zhu H, He F, Xu Q, Liu L, Li M, Zhang S, Nagaoka K, Carlson R, Safran H, Charpentier K, Sun B, Wands J, Dong X
J Hematol Oncol 2019 Dec 30;12(1):144. doi: 10.1186/s13045-019-0837-z. PMID: 31888763Free PMC Article

Recent systematic reviews

Differentiation of autoimmune pancreatitis from pancreatic adenocarcinoma using CT characteristics: a systematic review and meta-analysis.
Yoon SB, Jeon TY, Moon SH, Shin DW, Lee SM, Choi MH, Min JH, Kim MJ
Eur Radiol 2023 Dec;33(12):9010-9021. Epub 2023 Jul 19 doi: 10.1007/s00330-023-09959-5. PMID: 37466708
Systematic review and meta-analysis: Diagnostic performance of DNA alterations in pancreatic juice for the detection of pancreatic cancer.
Visser IJ, Levink IJM, Peppelenbosch MP, Fuhler GM, Bruno MJ, Cahen DL
Pancreatology 2022 Nov;22(7):973-986. Epub 2022 Jul 7 doi: 10.1016/j.pan.2022.06.260. PMID: 35864067

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