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Pancreatic Poorly Differentiated Ductal Adenocarcinoma

MedGen UID:
459367
•Concept ID:
C2987141
•
Neoplastic Process

Definition

A pancreatic ductal adenocarcinoma characterized by the presence of small and irregular malignant glandular structures, solid sheets of malignant cells, and single malignant cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Poorly Differentiated Ductal Adenocarcinoma

Professional guidelines

PubMed

Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.
Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M
J Exp Clin Cancer Res 2022 Mar 10;41(1):89. doi: 10.1186/s13046-022-02301-9. PMID: 35272688Free PMC Article
Pancreatic ductal adenocarcinoma contains an effector and regulatory immune cell infiltrate that is altered by multimodal neoadjuvant treatment.
Shibuya KC, Goel VK, Xiong W, Sham JG, Pollack SM, Leahy AM, Whiting SH, Yeh MM, Yee C, Riddell SR, Pillarisetty VG
PLoS One 2014;9(5):e96565. Epub 2014 May 2 doi: 10.1371/journal.pone.0096565. PMID: 24794217Free PMC Article
Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors.
La Rosa S, Klersy C, Uccella S, Dainese L, Albarello L, Sonzogni A, Doglioni C, Capella C, Solcia E
Hum Pathol 2009 Jan;40(1):30-40. Epub 2008 Aug 20 doi: 10.1016/j.humpath.2008.06.005. PMID: 18715612

Recent clinical studies

Etiology

Resected pancreatic adenocarcinoma: An Asian institution's experience.
Ng KYY, Chow EWX, Jiang B, Lim C, Goh BKP, Lee SY, Teo JY, Tan DMY, Cheow PC, Ooi LLPJ, Chow PKH, Lee JJX, Kam JH, Koh YX, Jeyaraj PR, Tan EK, Choo SP, Chan CY, Chung AYF, Tai D
Cancer Rep (Hoboken) 2021 Oct;4(5):e1393. Epub 2021 May 3 doi: 10.1002/cnr2.1393. PMID: 33939335Free PMC Article
Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients.
Park JY, King J, Reber H, Joe Hines O, Mederos MA, Wang HL, Dawson D, Wainberg Z, Donahue T, Girgis M
J Surg Oncol 2021 Feb;123(2):389-398. Epub 2020 Nov 4 doi: 10.1002/jso.26279. PMID: 33146409
Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
SMAD4 and TGFβR2 expression in pancreatic ductal carcinoma.
Văduva IA, Mărgăritescu C, Georgescu CV, Enache AO, Pădureanu R, Săftoiu A, Pirici D
Rom J Morphol Embryol 2019;60(3):803-809. PMID: 31912090
Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer.
Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, Dang Y, Hou Z, Lin W, Lin X, Zhang Z, Pan M, Huang H
J Hematol Oncol 2019 Nov 27;12(1):124. doi: 10.1186/s13045-019-0822-6. PMID: 31771616Free PMC Article

Diagnosis

Non-Ductal Tumors of the Pancreas.
Dhillon J
Monogr Clin Cytol 2020;26:92-108. Epub 2020 Sep 28 doi: 10.1159/000455737. PMID: 32987393
Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations.
Mpilla GB, Philip PA, El-Rayes B, Azmi AS
World J Gastroenterol 2020 Jul 28;26(28):4036-4054. doi: 10.3748/wjg.v26.i28.4036. PMID: 32821069Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
SMAD4 and TGFβR2 expression in pancreatic ductal carcinoma.
Văduva IA, Mărgăritescu C, Georgescu CV, Enache AO, Pădureanu R, Săftoiu A, Pirici D
Rom J Morphol Embryol 2019;60(3):803-809. PMID: 31912090
Pancreatic endocrine tumors: radiologic-clinicopathologic correlation.
Lewis RB, Lattin GE Jr, Paal E
Radiographics 2010 Oct;30(6):1445-64. doi: 10.1148/rg.306105523. PMID: 21071369

Therapy

Resected pancreatic adenocarcinoma: An Asian institution's experience.
Ng KYY, Chow EWX, Jiang B, Lim C, Goh BKP, Lee SY, Teo JY, Tan DMY, Cheow PC, Ooi LLPJ, Chow PKH, Lee JJX, Kam JH, Koh YX, Jeyaraj PR, Tan EK, Choo SP, Chan CY, Chung AYF, Tai D
Cancer Rep (Hoboken) 2021 Oct;4(5):e1393. Epub 2021 May 3 doi: 10.1002/cnr2.1393. PMID: 33939335Free PMC Article
Molecular Targeting of a BRAF Mutation in Pancreatic Ductal Adenocarcinoma: Case Report and Literature Review.
Seghers AK, Cuyle PJ, Van Cutsem E
Target Oncol 2020 Jun;15(3):407-410. doi: 10.1007/s11523-020-00727-9. PMID: 32495162
Intestinal microbiota enhances pancreatic carcinogenesis in preclinical models.
Thomas RM, Gharaibeh RZ, Gauthier J, Beveridge M, Pope JL, Guijarro MV, Yu Q, He Z, Ohland C, Newsome R, Trevino J, Hughes SJ, Reinhard M, Winglee K, Fodor AA, Zajac-Kaye M, Jobin C
Carcinogenesis 2018 Jul 30;39(8):1068-1078. doi: 10.1093/carcin/bgy073. PMID: 29846515Free PMC Article
Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.
Janky R, Binda MM, Allemeersch J, Van den Broeck A, Govaere O, Swinnen JV, Roskams T, Aerts S, Topal B
BMC Cancer 2016 Aug 12;16:632. doi: 10.1186/s12885-016-2540-6. PMID: 27520560Free PMC Article
Poorly differentiated resectable pancreatic cancer: is upfront resection worthwhile?
Crippa S, Partelli S, Zamboni G, Barugola G, Capelli P, Inama M, Bassi C, Pederzoli P, Falconi M
Surgery 2012 Sep;152(3 Suppl 1):S112-9. Epub 2012 Jul 3 doi: 10.1016/j.surg.2012.05.017. PMID: 22766365

Prognosis

Single-cell RNA-seq reveals the genesis and heterogeneity of tumor microenvironment in pancreatic undifferentiated carcinoma with osteoclast-like giant-cells.
Wang X, Miao J, Wang S, Shen R, Zhang S, Tian Y, Li M, Zhu D, Yao A, Bao W, Zhang Q, Tang X, Wang X, Li J
Mol Cancer 2022 Jun 22;21(1):133. doi: 10.1186/s12943-022-01596-8. PMID: 35733218Free PMC Article
Pancreatic Ductal Adenocarcinoma and Its Variants: Pearls and Perils.
Schawkat K, Manning MA, Glickman JN, Mortele KJ
Radiographics 2020 Sep-Oct;40(5):1219-1239. Epub 2020 Jul 17 doi: 10.1148/rg.2020190184. PMID: 32678699
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer.
Pan Y, Lu F, Fei Q, Yu X, Xiong P, Yu X, Dang Y, Hou Z, Lin W, Lin X, Zhang Z, Pan M, Huang H
J Hematol Oncol 2019 Nov 27;12(1):124. doi: 10.1186/s13045-019-0822-6. PMID: 31771616Free PMC Article
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M
Cancer Res 2019 Oct 15;79(20):5367-5381. Epub 2019 Aug 22 doi: 10.1158/0008-5472.CAN-19-0454. PMID: 31439548

Clinical prediction guides

Resected pancreatic adenocarcinoma: An Asian institution's experience.
Ng KYY, Chow EWX, Jiang B, Lim C, Goh BKP, Lee SY, Teo JY, Tan DMY, Cheow PC, Ooi LLPJ, Chow PKH, Lee JJX, Kam JH, Koh YX, Jeyaraj PR, Tan EK, Choo SP, Chan CY, Chung AYF, Tai D
Cancer Rep (Hoboken) 2021 Oct;4(5):e1393. Epub 2021 May 3 doi: 10.1002/cnr2.1393. PMID: 33939335Free PMC Article
Poorly differentiated histologic grade correlates with worse survival in SMAD4 negative pancreatic adenocarcinoma patients.
Park JY, King J, Reber H, Joe Hines O, Mederos MA, Wang HL, Dawson D, Wainberg Z, Donahue T, Girgis M
J Surg Oncol 2021 Feb;123(2):389-398. Epub 2020 Nov 4 doi: 10.1002/jso.26279. PMID: 33146409
Genetic and clinical correlates of entosis in pancreatic ductal adenocarcinoma.
Hayashi A, Yavas A, McIntyre CA, Ho YJ, Erakky A, Wong W, Varghese AM, Melchor JP, Overholtzer M, O'Reilly EM, Klimstra DS, Basturk O, Iacobuzio-Donahue CA
Mod Pathol 2020 Sep;33(9):1822-1831. Epub 2020 Apr 29 doi: 10.1038/s41379-020-0549-5. PMID: 32350415Free PMC Article
Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.
Mizutani Y, Kobayashi H, Iida T, Asai N, Masamune A, Hara A, Esaki N, Ushida K, Mii S, Shiraki Y, Ando K, Weng L, Ishihara S, Ponik SM, Conklin MW, Haga H, Nagasaka A, Miyata T, Matsuyama M, Kobayashi T, Fujii T, Yamada S, Yamaguchi J, Wang T, Woods SL, Worthley D, Shimamura T, Fujishiro M, Hirooka Y, Enomoto A, Takahashi M
Cancer Res 2019 Oct 15;79(20):5367-5381. Epub 2019 Aug 22 doi: 10.1158/0008-5472.CAN-19-0454. PMID: 31439548
Expression of urocortin in pancreatic ductal adenocarcinoma and pancreatic intraepithelial neoplasia.
Cheng MF, Tsai WC, Hsia KT, Yang YS, Jin JS
APMIS 2014 Feb;122(2):147-54. Epub 2013 Jun 12 doi: 10.1111/apm.12117. PMID: 23755913

Recent systematic reviews

Phenotypical and potential functional characteristics of different immune cells expressing CD28H/B7-H5 and their relationship with cancer prognosis.
Zhong C, Lang Q, Yu J, Wu S, Xu F, Tian Y
Clin Exp Immunol 2020 Apr;200(1):12-21. Epub 2020 Feb 4 doi: 10.1111/cei.13413. PMID: 31901178Free PMC Article
Differentiation therapy and the mechanisms that terminate cancer cell proliferation without harming normal cells.
Enane FO, Saunthararajah Y, Korc M
Cell Death Dis 2018 Sep 6;9(9):912. doi: 10.1038/s41419-018-0919-9. PMID: 30190481Free PMC Article

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