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Placental insufficiency

MedGen UID:
45942
Concept ID:
C0032051
Disease or Syndrome
Synonyms: Insufficiency, Placental; Placental Insufficiency
SNOMED CT: Placental insufficiency (237292005)
Modes of inheritance:
 
Monarch Initiative: MONDO:0005919
Orphanet: ORPHA439167

Definition

A rare obstetric disease characterized by inadequate blood flow to the placenta during pregnancy, resulting in a decrease in trans-placental transfer of oxygen and nutrients to the fetus, potentially leading to fetal growth retardation, distress, or death. Maternal risk factors include preeclampsia, gestational diabetes, and smoking, among others. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlacental insufficiency

Professional guidelines

PubMed

Vasi İ, Kardaş RC, Ekici M, Yıldırım D, Kaya B, Duran R, Karadeniz H, Güler AA, Küçük H, Göker B, Bilgen ŞA, Tufan A, Öztürk MA, Erden A
Int J Rheum Dis 2024 May;27(5):e15175. doi: 10.1111/1756-185X.15175. PMID: 38720575
McCowan LM, Figueras F, Anderson NH
Am J Obstet Gynecol 2018 Feb;218(2S):S855-S868. doi: 10.1016/j.ajog.2017.12.004. PMID: 29422214
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article

Recent clinical studies

Etiology

Andreoli L, Regola F, Caproli A, Crisafulli F, Fredi M, Lazzaroni MG, Nalli C, Piantoni S, Zatti S, Franceschini F, Tincani A
Rheumatology (Oxford) 2024 Feb 6;63(SI):SI86-SI95. doi: 10.1093/rheumatology/kead537. PMID: 38320595
Raymond Y, Fernando S, Menezes M, Mol BW, McLennan A, da Silva Costa F, Hardy T, Rolnik DL
Am J Obstet Gynecol 2024 Apr;230(4):381-389. Epub 2023 Nov 25 doi: 10.1016/j.ajog.2023.11.1240. PMID: 38008147
Damhuis SE, Ganzevoort W, Gordijn SJ
Obstet Gynecol Clin North Am 2021 Jun;48(2):267-279. doi: 10.1016/j.ogc.2021.02.002. PMID: 33972065
Soh MC, Nelson-Piercy C
Rheum Dis Clin North Am 2017 May;43(2):201-214. Epub 2017 Mar 14 doi: 10.1016/j.rdc.2016.12.008. PMID: 28390563
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426

Diagnosis

Zur RL, Kingdom JC, Parks WT, Hobson SR
Obstet Gynecol Clin North Am 2020 Mar;47(1):81-98. Epub 2019 Dec 18 doi: 10.1016/j.ogc.2019.10.008. PMID: 32008673
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426
Kutteh WH, Hinote CD
Obstet Gynecol Clin North Am 2014 Mar;41(1):113-32. doi: 10.1016/j.ogc.2013.10.004. PMID: 24491987
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Lebovitz HE
Exp Clin Endocrinol Diabetes 2001;109 Suppl 2:S135-48. doi: 10.1055/s-2001-18576. PMID: 11460565

Therapy

Rolnik DL, Nicolaides KH, Poon LC
Am J Obstet Gynecol 2022 Feb;226(2S):S1108-S1119. Epub 2020 Aug 21 doi: 10.1016/j.ajog.2020.08.045. PMID: 32835720
Schreiber K, Sciascia S, de Groot PG, Devreese K, Jacobsen S, Ruiz-Irastorza G, Salmon JE, Shoenfeld Y, Shovman O, Hunt BJ
Nat Rev Dis Primers 2018 Jan 11;4:17103. doi: 10.1038/nrdp.2017.103. PMID: 29321641
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article
Kutteh WH, Hinote CD
Obstet Gynecol Clin North Am 2014 Mar;41(1):113-32. doi: 10.1016/j.ogc.2013.10.004. PMID: 24491987
Roberts IA, Murray NA
Curr Hematol Rep 2006 Mar;5(1):55-63. PMID: 16537047

Prognosis

MacDonald TM, Walker SP, Hannan NJ, Tong S, Kaitu'u-Lino TJ
EBioMedicine 2022 Jan;75:103780. Epub 2021 Dec 23 doi: 10.1016/j.ebiom.2021.103780. PMID: 34954654Free PMC Article
Rolnik DL, Nicolaides KH, Poon LC
Am J Obstet Gynecol 2022 Feb;226(2S):S1108-S1119. Epub 2020 Aug 21 doi: 10.1016/j.ajog.2020.08.045. PMID: 32835720
Chaemsaithong P, Sahota DS, Poon LC
Am J Obstet Gynecol 2022 Feb;226(2S):S1071-S1097.e2. Epub 2020 Jul 16 doi: 10.1016/j.ajog.2020.07.020. PMID: 32682859
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807

Clinical prediction guides

MacDonald TM, Walker SP, Hannan NJ, Tong S, Kaitu'u-Lino TJ
EBioMedicine 2022 Jan;75:103780. Epub 2021 Dec 23 doi: 10.1016/j.ebiom.2021.103780. PMID: 34954654Free PMC Article
Nardozza LM, Caetano AC, Zamarian AC, Mazzola JB, Silva CP, Marçal VM, Lobo TF, Peixoto AB, Araujo Júnior E
Arch Gynecol Obstet 2017 May;295(5):1061-1077. Epub 2017 Mar 11 doi: 10.1007/s00404-017-4341-9. PMID: 28285426
Buyon JP, Kim MY, Guerra MM, Laskin CA, Petri M, Lockshin MD, Sammaritano L, Branch DW, Porter TF, Sawitzke A, Merrill JT, Stephenson MD, Cohn E, Garabet L, Salmon JE
Ann Intern Med 2015 Aug 4;163(3):153-63. doi: 10.7326/M14-2235. PMID: 26098843Free PMC Article
Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA
Lancet 2010 Oct 30;376(9751):1498-509. Epub 2010 Sep 6 doi: 10.1016/S0140-6736(10)60709-X. PMID: 20822807
Lagrew DC Jr
Clin Obstet Gynecol 1995 Mar;38(1):11-25. doi: 10.1097/00003081-199503000-00005. PMID: 7796539

Recent systematic reviews

Alcover N, Regiroli G, Benachi A, Vauloup-Fellous C, Vivanti AJ, De Luca D
Am J Obstet Gynecol 2023 Aug;229(2):118-128. Epub 2023 Jan 24 doi: 10.1016/j.ajog.2023.01.019. PMID: 36706855Free PMC Article
Mone F, Mellis R, Gabriel H, Baptiste C, Giordano J, Wapner R, Chitty LS
Am J Obstet Gynecol 2023 Apr;228(4):409-417.e4. Epub 2022 Oct 7 doi: 10.1016/j.ajog.2022.09.045. PMID: 36209938
Mazarico E, Molinet-Coll C, Martinez-Portilla RJ, Figueras F
Acta Obstet Gynecol Scand 2020 Feb;99(2):167-174. Epub 2019 Oct 8 doi: 10.1111/aogs.13730. PMID: 31519033
Horton J, Sterrenburg M, Lane S, Maheshwari A, Li TC, Cheong Y
Hum Reprod Update 2019 Sep 11;25(5):592-632. doi: 10.1093/humupd/dmz012. PMID: 31318420
Andreoli L, Bertsias GK, Agmon-Levin N, Brown S, Cervera R, Costedoat-Chalumeau N, Doria A, Fischer-Betz R, Forger F, Moraes-Fontes MF, Khamashta M, King J, Lojacono A, Marchiori F, Meroni PL, Mosca M, Motta M, Ostensen M, Pamfil C, Raio L, Schneider M, Svenungsson E, Tektonidou M, Yavuz S, Boumpas D, Tincani A
Ann Rheum Dis 2017 Mar;76(3):476-485. Epub 2016 Jul 25 doi: 10.1136/annrheumdis-2016-209770. PMID: 27457513Free PMC Article

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