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Pancreatic Acinar Cell Neoplasm

MedGen UID:
459444
Concept ID:
C2987218
Neoplastic Process

Definition

An epithelial neoplasm that arises from the exocrine pancreas. It is characterized by the presence of neoplastic cells that resemble acinar cells and produce pancreatic exocrine enzymes. The vast majority are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic Acinar Cell Neoplasm

Professional guidelines

PubMed

Garajová I, Peroni M, Gelsomino F, Leonardi F
Curr Oncol 2023 Oct 31;30(11):9587-9601. doi: 10.3390/curroncol30110694. PMID: 37999114Free PMC Article
Ramsey ML, Hart PA, Forsmark CE
Curr Opin Gastroenterol 2023 Sep 1;39(5):428-435. Epub 2023 May 11 doi: 10.1097/MOG.0000000000000951. PMID: 37530731Free PMC Article
Mortenson MM, Katz MH, Tamm EP, Bhutani MS, Wang H, Evans DB, Fleming JB
Am J Surg 2008 Jul;196(1):100-13. Epub 2008 May 7 doi: 10.1016/j.amjsurg.2008.02.005. PMID: 18466869

Recent clinical studies

Etiology

Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Alonso-Curbelo D, Ho YJ, Burdziak C, Maag JLV, Morris JP 4th, Chandwani R, Chen HA, Tsanov KM, Barriga FM, Luan W, Tasdemir N, Livshits G, Azizi E, Chun J, Wilkinson JE, Mazutis L, Leach SD, Koche R, Pe'er D, Lowe SW
Nature 2021 Feb;590(7847):642-648. Epub 2021 Feb 3 doi: 10.1038/s41586-020-03147-x. PMID: 33536616Free PMC Article
Lu W, Li X, Luo Y
Cancer Lett 2021 Feb 28;499:5-13. Epub 2020 Nov 29 doi: 10.1016/j.canlet.2020.11.026. PMID: 33264641Free PMC Article
Wang L, Xie D, Wei D
Methods Mol Biol 2019;1882:299-308. doi: 10.1007/978-1-4939-8879-2_26. PMID: 30378064
Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, Quertinmont E, Svrcek M, Elarouci N, Iovanna J, Franchimont D, Verset L, Galdon MG, Devière J, de Reyniès A, Laurent-Puig P, Van Laethem JL, Bachet JB, Maréchal R
Gastroenterology 2018 Dec;155(6):1999-2013.e3. Epub 2018 Aug 27 doi: 10.1053/j.gastro.2018.08.033. PMID: 30165049

Diagnosis

Zundler S, Strobel D, Manger B, Neurath MF, Wildner D
Curr Rheumatol Rep 2017 Aug 26;19(10):62. doi: 10.1007/s11926-017-0690-4. PMID: 28844095
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article
Jun SY, Hong SM
Surg Pathol Clin 2016 Dec;9(4):581-593. Epub 2016 Oct 12 doi: 10.1016/j.path.2016.05.005. PMID: 27926361
Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK
Nat Med 2015 Nov;21(11):1364-71. Epub 2015 Oct 26 doi: 10.1038/nm.3973. PMID: 26501191Free PMC Article
Wöll S, Schlitter AM, Dhaene K, Roller M, Esposito I, Sahin U, Türeci Ö
Int J Cancer 2014 Feb 1;134(3):731-9. Epub 2013 Sep 16 doi: 10.1002/ijc.28400. PMID: 23900716

Therapy

Xing L, Lv L, Ren J, Yu H, Zhao X, Kong X, Xiang H, Tao X, Dong D
Biomed Pharmacother 2023 Dec;168:115717. Epub 2023 Oct 18 doi: 10.1016/j.biopha.2023.115717. PMID: 37862965
Ramsey ML, Hart PA, Forsmark CE
Curr Opin Gastroenterol 2023 Sep 1;39(5):428-435. Epub 2023 May 11 doi: 10.1097/MOG.0000000000000951. PMID: 37530731Free PMC Article
Zhang Z, Cheng L, Li J, Qiao Q, Karki A, Allison DB, Shaker N, Li K, Utturkar SM, Atallah Lanman NM, Rao X, Rychahou P, He D, Konieczny SF, Wang C, Shao Q, Evers BM, Liu X
Cancer Res 2022 Oct 4;82(19):3532-3548. doi: 10.1158/0008-5472.CAN-22-0018. PMID: 35950917Free PMC Article
Neuhöfer P, Roake CM, Kim SJ, Lu RJ, West RB, Charville GW, Artandi SE
Nature 2021 Sep;597(7878):715-719. Epub 2021 Sep 15 doi: 10.1038/s41586-021-03916-2. PMID: 34526722Free PMC Article
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article

Prognosis

Faraoni EY, Singh K, Chandra V, Le Roux O, Dai Y, Sahin I, O'Brien BJ, Strickland LN, Li L, Vucic E, Warner AN, Pruski M, Clark T, Van Buren G, Thosani NC, Bynon JS, Wray CJ, Bar-Sagi D, Poulsen KL, Vornik LA, Savage MI, Sei S, Mohammed A, Zhao Z, Brown PH, Mills T, Eltzschig HK, McAllister F, Bailey-Lundberg JM
Cancer Res 2023 Apr 4;83(7):1111-1127. doi: 10.1158/0008-5472.CAN-22-2553. PMID: 36720042Free PMC Article
Zhao X, Li H, Lyu S, Zhai J, Ji Z, Zhang Z, Zhang X, Liu Z, Wang H, Xu J, Fan H, Kou J, Li L, Lang R, He Q
Int J Biol Sci 2021;17(10):2590-2605. Epub 2021 Jun 22 doi: 10.7150/ijbs.58886. PMID: 34326696Free PMC Article
Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK
Gastroenterology 2021 Nov;161(5):1584-1600. Epub 2021 Jul 8 doi: 10.1053/j.gastro.2021.06.045. PMID: 34245764Free PMC Article
Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, Sidoli S, Parris JLD, Affronti HC, Sivanand S, Egolf S, Sela Y, Trizzino M, Gardini A, Garcia BA, Snyder NW, Stanger BZ, Wellen KE
Cancer Discov 2019 Mar;9(3):416-435. Epub 2019 Jan 9 doi: 10.1158/2159-8290.CD-18-0567. PMID: 30626590Free PMC Article
Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, Quertinmont E, Svrcek M, Elarouci N, Iovanna J, Franchimont D, Verset L, Galdon MG, Devière J, de Reyniès A, Laurent-Puig P, Van Laethem JL, Bachet JB, Maréchal R
Gastroenterology 2018 Dec;155(6):1999-2013.e3. Epub 2018 Aug 27 doi: 10.1053/j.gastro.2018.08.033. PMID: 30165049

Clinical prediction guides

Umetsu SE, Kakar S, Basturk O, Kim GE, Chatterjee D, Wen KW, Hale G, Shafizadeh N, Cho SJ, Whitman J, Gill RM, Jones KD, Navale P, Bergsland E, Klimstra D, Joseph NM
Mod Pathol 2023 Mar;36(3):100065. Epub 2023 Jan 10 doi: 10.1016/j.modpat.2022.100065. PMID: 36788102
Luchini C, Scarpa A
Hum Pathol 2023 Feb;132:176-182. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.009. PMID: 35714836
Thompson ED, Wood LD
Arch Pathol Lab Med 2020 Jul 1;144(7):808-815. doi: 10.5858/arpa.2019-0472-RA. PMID: 31869246
Puleo F, Nicolle R, Blum Y, Cros J, Marisa L, Demetter P, Quertinmont E, Svrcek M, Elarouci N, Iovanna J, Franchimont D, Verset L, Galdon MG, Devière J, de Reyniès A, Laurent-Puig P, Van Laethem JL, Bachet JB, Maréchal R
Gastroenterology 2018 Dec;155(6):1999-2013.e3. Epub 2018 Aug 27 doi: 10.1053/j.gastro.2018.08.033. PMID: 30165049
Ross JS, Wang K, Chmielecki J, Gay L, Johnson A, Chudnovsky J, Yelensky R, Lipson D, Ali SM, Elvin JA, Vergilio JA, Roels S, Miller VA, Nakamura BN, Gray A, Wong MK, Stephens PJ
Int J Cancer 2016 Feb 15;138(4):881-90. Epub 2015 Sep 8 doi: 10.1002/ijc.29825. PMID: 26314551Free PMC Article

Recent systematic reviews

Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, Pimiento JM, Springett GM, Malafa MP
Cancer Control 2016 Oct;23(4):446-454. doi: 10.1177/107327481602300417. PMID: 27842335

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