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Pancreatic small cell neuroendocrine carcinoma

MedGen UID:
459466
Concept ID:
C2987240
Neoplastic Process
Synonyms: endocrine pancreas small cell carcinoma; Pancreatic Small Cell Carcinoma; Pancreatic Small Cell NEC; pancreatic small cell NEC; Pancreatic Small Cell NEC G3; pancreatic small cell NEC G3; Pancreatic Small Cell Neuroendocrine Carcinoma; pancreatic small cell neuroendocrine carcinoma; small cell carcinoma of endocrine pancreas
 
Monarch Initiative: MONDO:0006348

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Buscail L, Bournet B, Cordelier P
Nat Rev Gastroenterol Hepatol 2020 Mar;17(3):153-168. Epub 2020 Jan 31 doi: 10.1038/s41575-019-0245-4. PMID: 32005945
Ciardiello F, Tortora G
N Engl J Med 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704. PMID: 18337605

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

Recent clinical studies

Etiology

Kawasaki K, Rekhtman N, Quintanal-Villalonga Á, Rudin CM
Nat Rev Clin Oncol 2023 Jan;20(1):16-32. Epub 2022 Oct 28 doi: 10.1038/s41571-022-00696-0. PMID: 36307533
Nakamura K, Zhu Z, Roy S, Jun E, Han H, Munoz RM, Nishiwada S, Sharma G, Cridebring D, Zenhausern F, Kim S, Roe DJ, Darabi S, Han IW, Evans DB, Yamada S, Demeure MJ, Becerra C, Celinski SA, Borazanci E, Tsai S, Kodera Y, Park JO, Bolton JS, Wang X, Kim SC, Von Hoff D, Goel A
Gastroenterology 2022 Nov;163(5):1252-1266.e2. Epub 2022 Jul 16 doi: 10.1053/j.gastro.2022.06.090. PMID: 35850192Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Franciosi V, Maglietta G, Degli Esposti C, Caruso G, Cavanna L, Bertè R, Bacchini G, Bocchi L, Piva E, Monfredo M, Scafuri V, Di Cesare P, Melotti B, Sequino M, Rimanti A, Binovi C, Ghisoni F, Caminiti C
Ann Palliat Med 2019 Sep;8(4):381-389. Epub 2019 Mar 14 doi: 10.21037/apm.2019.02.07. PMID: 30943735

Diagnosis

Garcia-Carbonero R, Anton-Pascual B, Modrego A, Del Carmen Riesco-Martinez M, Lens-Pardo A, Carretero-Puche C, Rubio-Cuesta B, Soldevilla B
Endocr Rev 2023 Jul 11;44(4):724-736. doi: 10.1210/endrev/bnad006. PMID: 36879384Free PMC Article
Mondal P, Patel NS, Bailey K, Aravind S, Cartwright SB, Hollingsworth MA, Lazenby AJ, Carlson MA
Dis Model Mech 2023 Jan 1;16(1) Epub 2023 Jan 16 doi: 10.1242/dmm.049699. PMID: 36579622Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
D'Agosto S, Andreani S, Scarpa A, Corbo V
Int J Mol Sci 2019 Jun 5;20(11) doi: 10.3390/ijms20112766. PMID: 31195689Free PMC Article
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Therapy

Singhal A, Li BT, O'Reilly EM
Nat Med 2024 Apr;30(4):969-983. Epub 2024 Apr 18 doi: 10.1038/s41591-024-02903-0. PMID: 38637634
Wei D, Wang L, Zuo X, Maitra A, Bresalier RS
Clin Cancer Res 2024 Feb 16;30(4):655-662. doi: 10.1158/1078-0432.CCR-23-2098. PMID: 37831007Free PMC Article
Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Milano G, Innocenti F, Minami H
Cancer Sci 2022 Jul;113(7):2224-2231. Epub 2022 May 26 doi: 10.1111/cas.15377. PMID: 35445479Free PMC Article
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
Cancer Treat Rev 2019 Dec;81:101911. Epub 2019 Oct 30 doi: 10.1016/j.ctrv.2019.101911. PMID: 31715421

Prognosis

Venizelos A, Elvebakken H, Perren A, Nikolaienko O, Deng W, Lothe IMB, Couvelard A, Hjortland GO, Sundlöv A, Svensson J, Garresori H, Kersten C, Hofsli E, Detlefsen S, Krogh M, Sorbye H, Knappskog S
Endocr Relat Cancer 2021 Nov 11;29(1):1-14. doi: 10.1530/ERC-21-0152. PMID: 34647903Free PMC Article
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue MTA, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, Linkov I, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T
Cancer Discov 2021 Dec 1;11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. PMID: 34155000Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Steins M, Thomas M, Geissler M
Recent Results Cancer Res 2014;201:109-23. doi: 10.1007/978-3-642-54490-3_6. PMID: 24756788

Clinical prediction guides

Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue MTA, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, Linkov I, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T
Cancer Discov 2021 Dec 1;11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. PMID: 34155000Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Buscail L, Bournet B, Cordelier P
Nat Rev Gastroenterol Hepatol 2020 Mar;17(3):153-168. Epub 2020 Jan 31 doi: 10.1038/s41575-019-0245-4. PMID: 32005945
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Recent systematic reviews

Silva A, Cerqueira MC, Rosa B, Sobral C, Pinto-Ribeiro F, Costa MF, Baltazar F, Afonso J
Int J Mol Sci 2023 Mar 7;24(6) doi: 10.3390/ijms24065141. PMID: 36982217Free PMC Article
Gadducci A, Carinelli S, Aletti G
Gynecol Oncol 2017 Mar;144(3):637-646. Epub 2017 Jan 3 doi: 10.1016/j.ygyno.2016.12.003. PMID: 28057354
Mc Menamin ÚC, Murray LJ, Cantwell MM, Hughes CM
Cancer Causes Control 2012 Feb;23(2):221-30. Epub 2011 Nov 25 doi: 10.1007/s10552-011-9881-x. PMID: 22116540
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859
Barlési F, Villani P, Doddoli C, Gimenez C, Kleisbauer JP
Fundam Clin Pharmacol 2004 Feb;18(1):85-91. doi: 10.1046/j.0767-3981.2003.00206.x. PMID: 14748759

Supplemental Content

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    Clinical resources

    Practice guidelines

    • PubMed
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2023
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Neuroendocrine and Adrenal Tumors, 2023

    Consumer resources

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