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Pancreatic small cell neuroendocrine carcinoma

MedGen UID:
459466
Concept ID:
C2987240
Neoplastic Process
Synonyms: endocrine pancreas small cell carcinoma; Pancreatic Small Cell Carcinoma; Pancreatic Small Cell NEC; pancreatic small cell NEC; Pancreatic Small Cell NEC G3; pancreatic small cell NEC G3; Pancreatic Small Cell Neuroendocrine Carcinoma; pancreatic small cell neuroendocrine carcinoma; small cell carcinoma of endocrine pancreas
 
Monarch Initiative: MONDO:0006348

Definition

An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the pancreas. It is characterized by the presence of malignant small cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreatic small cell neuroendocrine carcinoma

Professional guidelines

PubMed

Harris PE, Zhernosekov K
Front Endocrinol (Lausanne) 2022;13:941832. Epub 2022 Oct 31 doi: 10.3389/fendo.2022.941832. PMID: 36387893Free PMC Article
Buscail L, Bournet B, Cordelier P
Nat Rev Gastroenterol Hepatol 2020 Mar;17(3):153-168. Epub 2020 Jan 31 doi: 10.1038/s41575-019-0245-4. PMID: 32005945
Ciardiello F, Tortora G
N Engl J Med 2008 Mar 13;358(11):1160-74. doi: 10.1056/NEJMra0707704. PMID: 18337605

Recent clinical studies

Etiology

Kawasaki K, Rekhtman N, Quintanal-Villalonga Á, Rudin CM
Nat Rev Clin Oncol 2023 Jan;20(1):16-32. Epub 2022 Oct 28 doi: 10.1038/s41571-022-00696-0. PMID: 36307533
Nakamura K, Zhu Z, Roy S, Jun E, Han H, Munoz RM, Nishiwada S, Sharma G, Cridebring D, Zenhausern F, Kim S, Roe DJ, Darabi S, Han IW, Evans DB, Yamada S, Demeure MJ, Becerra C, Celinski SA, Borazanci E, Tsai S, Kodera Y, Park JO, Bolton JS, Wang X, Kim SC, Von Hoff D, Goel A
Gastroenterology 2022 Nov;163(5):1252-1266.e2. Epub 2022 Jul 16 doi: 10.1053/j.gastro.2022.06.090. PMID: 35850192Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Rüschoff J, Nagelmeier I, Jasani B, Stoss O
Pathologe 2021 Nov;42(Suppl 1):62-68. Epub 2020 Dec 21 doi: 10.1007/s00292-020-00878-6. PMID: 33346874
Aggarwal R, Huang J, Alumkal JJ, Zhang L, Feng FY, Thomas GV, Weinstein AS, Friedl V, Zhang C, Witte ON, Lloyd P, Gleave M, Evans CP, Youngren J, Beer TM, Rettig M, Wong CK, True L, Foye A, Playdle D, Ryan CJ, Lara P, Chi KN, Uzunangelov V, Sokolov A, Newton Y, Beltran H, Demichelis F, Rubin MA, Stuart JM, Small EJ
J Clin Oncol 2018 Aug 20;36(24):2492-2503. Epub 2018 Jul 9 doi: 10.1200/JCO.2017.77.6880. PMID: 29985747Free PMC Article

Diagnosis

Garcia-Carbonero R, Anton-Pascual B, Modrego A, Del Carmen Riesco-Martinez M, Lens-Pardo A, Carretero-Puche C, Rubio-Cuesta B, Soldevilla B
Endocr Rev 2023 Jul 11;44(4):724-736. doi: 10.1210/endrev/bnad006. PMID: 36879384Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
El Rassy E, Tabchi S, Kourie HR, Assi T, Chebib R, Farhat F, Kattan J
Clin Res Hepatol Gastroenterol 2016 Jun;40(3):276-280. Epub 2015 Nov 11 doi: 10.1016/j.clinre.2015.09.010. PMID: 26566245
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626
Pepe G, Moncayo R, Bombardieri E, Chiti A
Eur J Nucl Med Mol Imaging 2012 Feb;39 Suppl 1:S41-51. doi: 10.1007/s00259-011-2019-2. PMID: 22388628

Therapy

Khan S, Budamagunta V, Zhou D
Adv Cancer Res 2023;159:145-184. Epub 2023 Mar 9 doi: 10.1016/bs.acr.2023.02.004. PMID: 37268395
Goodwin CM, Waters AM, Klomp JE, Javaid S, Bryant KL, Stalnecker CA, Drizyte-Miller K, Papke B, Yang R, Amparo AM, Ozkan-Dagliyan I, Baldelli E, Calvert V, Pierobon M, Sorrentino JA, Beelen AP, Bublitz N, Lüthen M, Wood KC, Petricoin EF, Sers C, McRee AJ, Cox AD, Der CJ
Cancer Res 2023 Jan 4;83(1):141-157. doi: 10.1158/0008-5472.CAN-22-0391. PMID: 36346366Free PMC Article
Pandit B, Royzen M
Genes (Basel) 2022 Mar 5;13(3) doi: 10.3390/genes13030466. PMID: 35328020Free PMC Article
Li AY, McCusker MG, Russo A, Scilla KA, Gittens A, Arensmeyer K, Mehra R, Adamo V, Rolfo C
Cancer Treat Rev 2019 Dec;81:101911. Epub 2019 Oct 30 doi: 10.1016/j.ctrv.2019.101911. PMID: 31715421
Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, Drake CG, Camacho LH, Kauh J, Odunsi K, Pitot HC, Hamid O, Bhatia S, Martins R, Eaton K, Chen S, Salay TM, Alaparthy S, Grosso JF, Korman AJ, Parker SM, Agrawal S, Goldberg SM, Pardoll DM, Gupta A, Wigginton JM
N Engl J Med 2012 Jun 28;366(26):2455-65. Epub 2012 Jun 2 doi: 10.1056/NEJMoa1200694. PMID: 22658128Free PMC Article

Prognosis

Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue MTA, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, Linkov I, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T
Cancer Discov 2021 Dec 1;11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. PMID: 34155000Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Elosua-Bayes M, Nieto P, Mereu E, Gut I, Heyn H
Nucleic Acids Res 2021 May 21;49(9):e50. doi: 10.1093/nar/gkab043. PMID: 33544846Free PMC Article
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Steins M, Thomas M, Geissler M
Recent Results Cancer Res 2014;201:109-23. doi: 10.1007/978-3-642-54490-3_6. PMID: 24756788

Clinical prediction guides

Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Elosua-Bayes M, Nieto P, Mereu E, Gut I, Heyn H
Nucleic Acids Res 2021 May 21;49(9):e50. doi: 10.1093/nar/gkab043. PMID: 33544846Free PMC Article
Naito T, Mitsunaga S, Miura S, Tatematsu N, Inano T, Mouri T, Tsuji T, Higashiguchi T, Inui A, Okayama T, Yamaguchi T, Morikawa A, Mori N, Takahashi T, Strasser F, Omae K, Mori K, Takayama K
J Cachexia Sarcopenia Muscle 2019 Feb;10(1):73-83. Epub 2018 Oct 18 doi: 10.1002/jcsm.12351. PMID: 30334618Free PMC Article
Steins M, Thomas M, Geißler M
Recent Results Cancer Res 2018;211:1-17. doi: 10.1007/978-3-319-91442-8_1. PMID: 30069756
Chan JK
Int J Surg Pathol 2014 Feb;22(1):12-32. Epub 2014 Jan 9 doi: 10.1177/1066896913517939. PMID: 24406626

Recent systematic reviews

Bellefkih FZ, Benchakroun N, Lalya I, Amaoui B, El Kacemi H, Acharki A, El Hfid M, El Mazghi A, Chekrine T, Bouchbika Z, Jouhadi H, Sahraoui S, Tawfiq N, Michalet M
Cancer Radiother 2023 Sep;27(6-7):622-637. Epub 2023 Jul 25 doi: 10.1016/j.canrad.2023.06.010. PMID: 37500390
Pan B, Lai H, Ma N, Li D, Deng X, Wang X, Zhang Q, Yang Q, Wang Q, Zhu H, Li M, Cao X, Tian J, Ge L, Yang K
Int J Behav Nutr Phys Act 2023 May 15;20(1):58. doi: 10.1186/s12966-023-01459-5. PMID: 37189146Free PMC Article
Arman T, Nelson PS
Front Endocrinol (Lausanne) 2022;13:1012005. Epub 2022 Nov 11 doi: 10.3389/fendo.2022.1012005. PMID: 36440195Free PMC Article
Rodger FE, Brennan PT, Nair R, Holroyd DJ
Surg Oncol 2022 Sep;44:101819. Epub 2022 Jul 20 doi: 10.1016/j.suronc.2022.101819. PMID: 35940030
Isidori AM, Lenzi A
Arq Bras Endocrinol Metabol 2007 Nov;51(8):1217-25. doi: 10.1590/s0004-27302007000800007. PMID: 18209859

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