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Gastric Poorly Cohesive Adenocarcinoma

MedGen UID:
459619
Concept ID:
C2987393
Neoplastic Process
Synonyms: Gastric Poorly Cohesive Carcinoma; Poorly Cohesive Gastric Adenocarcinoma; Poorly Cohesive Gastric Carcinoma

Definition

An adenocarcinoma that arises from the gastric mucosa and is characterized by the presence of isolated malignant cells or malignant cells that form small aggregates. This category includes signet ring cell adenocarcinomas, adenocarcinomas that are composed of malignant cells resembling lymphocytes and histiocytes, and adenocarcinomas that are composed of malignant cells with deeply eosinophilic cytoplasm. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Poorly Cohesive Adenocarcinoma

Professional guidelines

PubMed

Bouriez D, Gronnier C, Najah H, Collet D
Dig Dis Sci 2022 Jun;67(6):2005-2009. Epub 2022 Apr 16 doi: 10.1007/s10620-022-07437-4. PMID: 35430699
Huang Q, Li R, Xu GF, Zhou D, Fan XS, Zou XP
J Dig Dis 2018 Dec;19(12):730-736. Epub 2018 Nov 14 doi: 10.1111/1751-2980.12674. PMID: 30270559
Ushiku T, Arnason T, Ban S, Hishima T, Shimizu M, Fukayama M, Lauwers GY
Mod Pathol 2013 Dec;26(12):1620-31. Epub 2013 May 31 doi: 10.1038/modpathol.2013.98. PMID: 23723017

Recent clinical studies

Etiology

Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Baek JH, Kang BW, Kang H, Cho M, Kwon OK, Park JY, Park KB, Seo AN, Kim JG
Cancer Chemother Pharmacol 2023 Oct;92(4):279-290. Epub 2023 Jul 22 doi: 10.1007/s00280-023-04564-1. PMID: 37480406
Simbolo M, Silvestris N, Malleo G, Mafficini A, Maggino L, Cocomazzi A, Veghini L, Mombello A, Pezzini F, Sereni E, Martelli FM, Gkountakos A, Ciaparrone C, Piredda ML, Ingravallo G, Paolino G, Nappo F, Rapposelli IG, Frassinetti L, Saragoni L, Lonardi S, Pea A, Paiella S, Fassan M, Brunetti O, Cingarlini S, Salvia R, Milella M, Corbo V, Lawlor RT, Scarpa A, Luchini C
Mod Pathol 2023 Sep;36(9):100251. Epub 2023 Jun 22 doi: 10.1016/j.modpat.2023.100251. PMID: 37355152
Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article
Liu S, Qiao X, Ji C, Shi H, Wang Y, Li L, Zhou Z
Eur Radiol 2021 Aug;31(8):5768-5778. Epub 2021 Feb 10 doi: 10.1007/s00330-021-07697-0. PMID: 33569616

Diagnosis

Baek JH, Kang BW, Kang H, Cho M, Kwon OK, Park JY, Park KB, Seo AN, Kim JG
Cancer Chemother Pharmacol 2023 Oct;92(4):279-290. Epub 2023 Jul 22 doi: 10.1007/s00280-023-04564-1. PMID: 37480406
Ieni A, Pizzimenti C, Giuffrè G, Caruso RA, Tuccari G
Curr Mol Med 2022;22(9):809-818. doi: 10.2174/1566524021666211123093532. PMID: 34814818
Kushima R
Pathologe 2022 Feb;43(1):8-15. Epub 2021 Nov 22 doi: 10.1007/s00292-021-01023-7. PMID: 34807275
Liu S, Qiao X, Ji C, Shi H, Wang Y, Li L, Zhou Z
Eur Radiol 2021 Aug;31(8):5768-5778. Epub 2021 Feb 10 doi: 10.1007/s00330-021-07697-0. PMID: 33569616
van der Post RS, Oliveira C, Guilford P, Carneiro F
Fam Cancer 2019 Jul;18(3):363-367. doi: 10.1007/s10689-019-00127-7. PMID: 30989426

Therapy

Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Boubaddi M, Teixeira Farinha H, Lambert C, Pereira B, Piessen G, Gualtierotti M, Voron T, Mantziari S, Pezet D, Gronnier C; French Association of Surgery
Ann Surg Oncol 2024 Feb;31(2):744-752. Epub 2023 Nov 16 doi: 10.1245/s10434-023-14496-y. PMID: 37971616
Baek JH, Kang BW, Kang H, Cho M, Kwon OK, Park JY, Park KB, Seo AN, Kim JG
Cancer Chemother Pharmacol 2023 Oct;92(4):279-290. Epub 2023 Jul 22 doi: 10.1007/s00280-023-04564-1. PMID: 37480406
Park S, Ha S, Kwon HW, Kim WH, Kim TY, Oh DY, Cheon GJ, Bang YJ
J Nucl Med 2017 Jun;58(6):899-904. Epub 2016 Nov 10 doi: 10.2967/jnumed.116.182675. PMID: 28572288
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459

Prognosis

Yen HH, Chen PY, Huang RY, Jeng JM, Lai IR
J Pathol Clin Res 2024 Jul;10(4):e12387. doi: 10.1002/2056-4538.12387. PMID: 38860888Free PMC Article
Ieni A, Pizzimenti C, Giuffrè G, Caruso RA, Tuccari G
Curr Mol Med 2022;22(9):809-818. doi: 10.2174/1566524021666211123093532. PMID: 34814818
Sarriugarte Lasarte A, García Alberdi E, Martínez Indart L, Gutiérrez Grijalba O, Álvarez Abad I, Guerra Lerma M, Calle Baraja M, Colina Alonso A
Rev Esp Enferm Dig 2021 May;113(5):324-331. doi: 10.17235/reed.2020.7184/2020. PMID: 33228367
Mariette C, Carneiro F, Grabsch HI, van der Post RS, Allum W, de Manzoni G; European Chapter of International Gastric Cancer Association
Gastric Cancer 2019 Jan;22(1):1-9. Epub 2018 Aug 25 doi: 10.1007/s10120-018-0868-0. PMID: 30167905
Lynch HT, Grady W, Suriano G, Huntsman D
J Surg Oncol 2005 Jun 1;90(3):114-33; discussion 133. doi: 10.1002/jso.20214. PMID: 15895459

Clinical prediction guides

Rokutan H, Arai Y, Kunita A, Yamasaki S, Nakamura H, Hama N, Nakayama A, Hosoda F, Totoki Y, Fujishiro M, Seto Y, Shibata T, Ushiku T
Am J Surg Pathol 2024 Jun 1;48(6):652-661. Epub 2024 Apr 8 doi: 10.1097/PAS.0000000000002222. PMID: 38584451Free PMC Article
Huang SC, Ng KF, Yeh TS, Cheng CT, Chen MC, Chao YC, Chuang HC, Liu YJ, Chen TC
Histopathology 2020 Aug;77(2):250-261. Epub 2020 Jul 2 doi: 10.1111/his.14117. PMID: 32343857
Huang Q, Li R, Xu GF, Zhou D, Fan XS, Zou XP
J Dig Dis 2018 Dec;19(12):730-736. Epub 2018 Nov 14 doi: 10.1111/1751-2980.12674. PMID: 30270559
Park S, Ha S, Kwon HW, Kim WH, Kim TY, Oh DY, Cheon GJ, Bang YJ
J Nucl Med 2017 Jun;58(6):899-904. Epub 2016 Nov 10 doi: 10.2967/jnumed.116.182675. PMID: 28572288
Gurzu S, Kadar Z, Sugimura H, Orlowska J, Bara T, Bara T Jr, Szederjesi J, Jung I
Appl Immunohistochem Mol Morphol 2016 May-Jun;24(5):326-36. doi: 10.1097/PAI.0000000000000189. PMID: 26067133

Recent systematic reviews

Garcia-Pelaez J, Barbosa-Matos R, Gullo I, Carneiro F, Oliveira C
Mol Oncol 2021 Nov;15(11):2841-2867. Epub 2021 May 2 doi: 10.1002/1878-0261.12948. PMID: 33724653Free PMC Article

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