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Gastric Adenoma, Gastric-Type

MedGen UID:
459641
•Concept ID:
C2987415
•
Neoplastic Process

Definition

A neoplastic polyp that arises from the stomach. It is characterized by the presence of gastric epithelial differentiation. It includes pyloric gland adenomas and foveolar-type adenomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGastric Adenoma, Gastric-Type

Professional guidelines

PubMed

Endoscopic differential diagnosis between foveolar-type gastric adenoma and gastric hyperplastic polyps in Helicobacter pylori-naïve patients.
Shibagaki K, Ishimura N, Kotani S, Fukuyama C, Takahashi Y, Kishimoto K, Yazaki T, Kataoka M, Omachi T, Kinoshita Y, Hasegawa N, Oka A, Mishima Y, Mishiro T, Oshima N, Kawashima K, Nagase M, Araki A, Kadota K, Ishihara S
Gastric Cancer 2023 Nov;26(6):1002-1011. Epub 2023 Aug 6 doi: 10.1007/s10120-023-01420-2. PMID: 37543537
Differential diagnosis of gastric adenoma and type IIa early gastric cancer.
Tsuchigame T, Ogata Y, Sumi M, Fukui K, Saito R, Nakashima K, Urata J, Arakawa A, Saito Y, Takahashi M
Acta Radiol 1991 Jan;32(1):37-41. PMID: 2012727

Recent clinical studies

Etiology

Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Ehmann S, Sassine D, Straubhar AM, Praiss AM, Aghajanian C, Alektiar KM, Broach V, Cadoo KA, Jewell EL, Boroujeni AM, Kyi C, Leitao MM, Mueller JJ, Murali R, Bhaloo SI, O'Cearbhaill RE, Park KJ, Sonoda Y, Weigelt B, Zamarin D, Abu-Rustum N, Friedman CF
Gynecol Oncol 2022 Dec;167(3):458-466. Epub 2022 Oct 15 doi: 10.1016/j.ygyno.2022.10.003. PMID: 36253302Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Extra-ampullary duodenal adenoma: a clinicopathological study.
Hijikata K, Nemoto T, Igarashi Y, Shibuya K
Histopathology 2017 Aug;71(2):200-207. Epub 2017 May 5 doi: 10.1111/his.13192. PMID: 28211946
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Diagnosis

Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging.
Kerwin CM, Markese M, Moroney MR, Smith LP, Patel NU
Abdom Radiol (NY) 2023 Feb;48(2):713-723. Epub 2022 Nov 5 doi: 10.1007/s00261-022-03724-w. PMID: 36334123
Gastric-type adenocarcinoma of the cervix: Clinical outcomes and genomic drivers.
Ehmann S, Sassine D, Straubhar AM, Praiss AM, Aghajanian C, Alektiar KM, Broach V, Cadoo KA, Jewell EL, Boroujeni AM, Kyi C, Leitao MM, Mueller JJ, Murali R, Bhaloo SI, O'Cearbhaill RE, Park KJ, Sonoda Y, Weigelt B, Zamarin D, Abu-Rustum N, Friedman CF
Gynecol Oncol 2022 Dec;167(3):458-466. Epub 2022 Oct 15 doi: 10.1016/j.ygyno.2022.10.003. PMID: 36253302Free PMC Article
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach.
Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T
Gastric Cancer 2006;9(3):177-84. doi: 10.1007/s10120-006-0381-8. PMID: 16952035

Therapy

Clinicopathological characteristics of patients with mucinous adenocarcinoma of the uterine cervix: A retrospective study of 21 cases.
Bonin L, Devouassoux-Shisheboran M, Golfier F
J Gynecol Obstet Hum Reprod 2019 May;48(5):319-327. Epub 2019 Feb 23 doi: 10.1016/j.jogoh.2019.02.002. PMID: 30807852
Intraductal papillary-mucinous tumours represent a distinct group of pancreatic neoplasms: an investigation of tumour cell differentiation and K-ras, p53 and c-erbB-2 abnormalities in 26 patients.
Sessa F, Solcia E, Capella C, Bonato M, Scarpa A, Zamboni G, Pellegata NS, Ranzani GN, Rickaert F, Klöppel G
Virchows Arch 1994;425(4):357-67. doi: 10.1007/BF00189573. PMID: 7820300

Prognosis

Adenocarcinoma of the uterine cervix, gastric-type (GAS): a review of the literature focused on pathology and multimodality imaging.
Kerwin CM, Markese M, Moroney MR, Smith LP, Patel NU
Abdom Radiol (NY) 2023 Feb;48(2):713-723. Epub 2022 Nov 5 doi: 10.1007/s00261-022-03724-w. PMID: 36334123
Clinicopathological characteristics of non-ampullary duodenal tumors and their phenotypic classification.
Yoshida M, Shimoda T, Abe M, Kakushima N, Kawata N, Takizawa K, Ono H, Sugino T
Pathol Int 2019 Jul;69(7):398-406. Epub 2019 Jul 21 doi: 10.1111/pin.12829. PMID: 31328367
The developing spectrum of gastric-type cervical glandular lesions.
Talia KL, McCluggage WG
Pathology 2018 Feb;50(2):122-133. Epub 2017 Dec 9 doi: 10.1016/j.pathol.2017.09.009. PMID: 29233547
Intraductal neoplasms of the pancreas.
Klöppel G, Basturk O, Schlitter AM, Konukiewitz B, Esposito I
Semin Diagn Pathol 2014 Nov;31(6):452-466. Epub 2014 Sep 2 doi: 10.1053/j.semdp.2014.08.005. PMID: 25282472
New developments in endocervical glandular lesions.
McCluggage WG
Histopathology 2013 Jan;62(1):138-60. Epub 2012 Nov 8 doi: 10.1111/his.12012. PMID: 23134447

Clinical prediction guides

APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum.
Ishizu K, Hashimoto T, Naka T, Yatabe Y, Kojima M, Kuwata T, Nonaka S, Oda I, Esaki M, Kudo M, Gotohda N, Yoshida T, Yoshikawa T, Sekine S
J Gastroenterol 2021 Nov;56(11):988-998. Epub 2021 Sep 12 doi: 10.1007/s00535-021-01823-x. PMID: 34514550
Small Bowel Epithelial Precursor Lesions: A Focus on Molecular Alterations.
Vanoli A, Grillo F, Furlan D, Arpa G, Grami O, Guerini C, Riboni R, Mastracci L, Di Sabatino A
Int J Mol Sci 2021 Apr 22;22(9) doi: 10.3390/ijms22094388. PMID: 33922305Free PMC Article
Clinicopathological characteristics of non-ampullary duodenal tumors and their phenotypic classification.
Yoshida M, Shimoda T, Abe M, Kakushima N, Kawata N, Takizawa K, Ono H, Sugino T
Pathol Int 2019 Jul;69(7):398-406. Epub 2019 Jul 21 doi: 10.1111/pin.12829. PMID: 31328367
A Detailed Immunohistochemical Analysis of a Large Series of Cervical and Vaginal Gastric-type Adenocarcinomas.
Carleton C, Hoang L, Sah S, Kiyokawa T, Karamurzin YS, Talia KL, Park KJ, McCluggage WG
Am J Surg Pathol 2016 May;40(5):636-44. doi: 10.1097/PAS.0000000000000578. PMID: 26685087Free PMC Article
Endocervical glandular lesions exhibiting gastric differentiation: an emerging spectrum of benign, premalignant, and malignant lesions.
Mikami Y, McCluggage WG
Adv Anat Pathol 2013 Jul;20(4):227-37. doi: 10.1097/PAP.0b013e31829c2d66. PMID: 23752085

Recent systematic reviews

Simple mucinous cyst: another potential cancer precursor in the pancreas? Case report with molecular characterization and systematic review of the literature.
Milanetto AC, Tonello AS, Valotto G, Munari G, Luchini C, Fassan M, Pasquali C
Virchows Arch 2021 Jul;479(1):179-189. Epub 2021 Jan 28 doi: 10.1007/s00428-021-03029-1. PMID: 33511431Free PMC Article

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