U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Plummer-Vinson syndrome

MedGen UID:
45967
•Concept ID:
C0032249
•
Disease or Syndrome
Synonyms: Dysphagia sideropenica; Kelly's syndrome; Paterson's syndrome; Paterson-Brown-Kelly syndrome; Paterson-Kelly syndrome
SNOMED CT: Brown-Kelly-Paterson syndrome (80126007); Plummer-Vinson-Patterson-Kelly syndrome (80126007); Plummer-Vinson syndrome (80126007); Paterson-Kelly syndrome (80126007); Sideropenic dysphagia (80126007)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0018895
Orphanet: ORPHA54028

Definition

Plummer-Vinson or Paterson-Kelly syndrome presents as a classical triad of dysphagia, iron-deficiency anemia and esophageal webs. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlummer-Vinson syndrome
Follow this link to review classifications for Plummer-Vinson syndrome in Orphanet.

Professional guidelines

PubMed

Koilonychia: an update on pathophysiology, differential diagnosis and clinical relevance.
Walker J, Baran R, Vélez N, Jellinek N
J Eur Acad Dermatol Venereol 2016 Nov;30(11):1985-1991. Epub 2016 Aug 17 doi: 10.1111/jdv.13610. PMID: 27531645
Screening diagnosis and staging of esophageal cancer.
Lightdale CJ, Winawer SJ
Semin Oncol 1984 Jun;11(2):101-12. PMID: 6729490

Recent clinical studies

Etiology

Plummer-Vinson Syndrome with Proximal Esophageal Web.
Changela K, Haeri NS, Krishnaiah M, Reddy M
J Gastrointest Surg 2016 May;20(5):1074-5. Epub 2015 Dec 9 doi: 10.1007/s11605-015-3051-5. PMID: 26658794
Plummer-Vinson syndrome.
Hefaiedh R, Boutreaa Y, Ouakaa-Kchaou A, Gargouri D, Elloumi H, Kochlef A, Romani M, Kilani A, Kharrat J, Ghorbel A
Tunis Med 2010 Oct;88(10):721-4. PMID: 20890819
Plummer-Vinson syndrome.
Novacek G
Orphanet J Rare Dis 2006 Sep 15;1:36. doi: 10.1186/1750-1172-1-36. PMID: 16978405Free PMC Article
Squamous cell cancer of the oesophagus.
Messmann H
Best Pract Res Clin Gastroenterol 2001 Apr;15(2):249-65. doi: 10.1053/bega.2000.0172. PMID: 11355914
Nutrition and cancer.
Wynder EL
Fed Proc 1976 May 1;35(6):1309-15. PMID: 770204

Diagnosis

Plummer-Vinson Syndrome.
Binet Q, Delorme A
N Engl J Med 2024 Feb 15;390(7):652. Epub 2024 Feb 10 doi: 10.1056/NEJMicm2309721. PMID: 38345572
Plummer-Vinson Syndrome.
Liu CC, Lin YS
Ear Nose Throat J 2019 Jun;98(5):259-260. doi: 10.1177/0145561319850412. PMID: 31208220
Plummer-Vinson Syndrome.
Bakshi SS
Mayo Clin Proc 2016 Mar;91(3):404. doi: 10.1016/j.mayocp.2015.11.002. PMID: 26944249
Plummer-Vinson syndrome.
Masri O, Sharara AI
Clin Gastroenterol Hepatol 2013 Dec;11(12):e85. Epub 2013 May 21 doi: 10.1016/j.cgh.2013.05.012. PMID: 23707464
Plummer-Vinson syndrome.
Phatak S, Redkar N, Patil MA, Kuwar A
BMJ Case Rep 2012 Jul 25;2012 doi: 10.1136/bcr-2012-006403. PMID: 22843759Free PMC Article

Therapy

Paterson-Brown-Kelly syndrome.
Bakshi SS
Gastroenterol Hepatol 2018 Dec;41(10):650-651. Epub 2018 Jun 6 doi: 10.1016/j.gastrohep.2018.05.010. PMID: 29884482
A Web Effect: Plummer-Vinson Syndrome.
Kuwabara M, Tanaka M
Am J Med 2018 May;131(5):504-505. Epub 2018 Jan 31 doi: 10.1016/j.amjmed.2018.01.005. PMID: 29374547
Plummer-Vinson Syndrome.
Bakshi SS
Mayo Clin Proc 2016 Mar;91(3):404. doi: 10.1016/j.mayocp.2015.11.002. PMID: 26944249
Plummer-Vinson syndrome.
Phatak S, Redkar N, Patil MA, Kuwar A
BMJ Case Rep 2012 Jul 25;2012 doi: 10.1136/bcr-2012-006403. PMID: 22843759Free PMC Article
Plummer-Vinson syndrome.
Novacek G
Orphanet J Rare Dis 2006 Sep 15;1:36. doi: 10.1186/1750-1172-1-36. PMID: 16978405Free PMC Article

Prognosis

Endoscopic treatment of 135 cases of Plummer-Vinson web: a pilot experience.
Bakari G, Benelbarhdadi I, Bahije L, El Feydi Essaid A
Gastrointest Endosc 2014 Oct;80(4):738-741. Epub 2014 Jul 29 doi: 10.1016/j.gie.2014.05.332. PMID: 25085338
Plummer-Vinson syndrome.
Novacek G
Orphanet J Rare Dis 2006 Sep 15;1:36. doi: 10.1186/1750-1172-1-36. PMID: 16978405Free PMC Article
Squamous cell cancer of the oesophagus.
Messmann H
Best Pract Res Clin Gastroenterol 2001 Apr;15(2):249-65. doi: 10.1053/bega.2000.0172. PMID: 11355914
Plummer-Vinson syndrome. A case report and literature review.
Hoffman RM, Jaffe PE
Arch Intern Med 1995 Oct 9;155(18):2008-11. doi: 10.1001/archinte.155.18.2008. PMID: 7575056
Rise and fall of the Plummer-Vinson syndrome.
Chen TS, Chen PS
J Gastroenterol Hepatol 1994 Nov-Dec;9(6):654-8. doi: 10.1111/j.1440-1746.1994.tb01581.x. PMID: 7865729

Clinical prediction guides

Plummer-Vinson Syndrome in Children.
Butori M, Mahmoudi S, Dugelay-Ecochard E, Belarbi N, Bellaïche M, Hugot JP, Viala J
J Pediatr Gastroenterol Nutr 2015 Nov;61(5):547-52. doi: 10.1097/MPG.0000000000000842. PMID: 26502163
Plummer-Vinson syndrome.
Hefaiedh R, Boutreaa Y, Ouakaa-Kchaou A, Gargouri D, Elloumi H, Kochlef A, Romani M, Kilani A, Kharrat J, Ghorbel A
Tunis Med 2010 Oct;88(10):721-4. PMID: 20890819
Plummer-Vinson syndrome.
Novacek G
Orphanet J Rare Dis 2006 Sep 15;1:36. doi: 10.1186/1750-1172-1-36. PMID: 16978405Free PMC Article
The Brown Kelly-Paterson or Plummer-Vinson syndrome: an old score finally settled.
Slater SD
J R Coll Physicians Lond 1991 Jul;25(3):257-8. PMID: 1801780Free PMC Article
Nutrition and cancer.
Wynder EL
Fed Proc 1976 May 1;35(6):1309-15. PMID: 770204

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...