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Relapsing polychondritis

MedGen UID:
45995
Concept ID:
C0032453
Disease or Syndrome
Synonyms: Chronic atrophic polychondritis; Recurrent polychondritis
SNOMED CT: Meyenburg's disease (72275000); Relapsing polychondritis (72275000); Chronic polychondritis (72275000); Systemic chondromalacia (72275000)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0019125
Orphanet: ORPHA728

Definition

A rare, clinically heterogeneous, multisystemic inflammatory disease characterized by inflammation of the cartilage and proteoglycan rich structures leading to cartilage damage along with joint, ocular and cardiovascular involvement. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRelapsing polychondritis
Follow this link to review classifications for Relapsing polychondritis in Orphanet.

Professional guidelines

PubMed

Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Mertz P, Sparks J, Kobrin D, Ogbonnaya SA, Sevim E, Michet C, Arnaud L, Ferrada M
Best Pract Res Clin Rheumatol 2023 Mar;37(1):101867. Epub 2023 Oct 14 doi: 10.1016/j.berh.2023.101867. PMID: 37839908
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756

Recent clinical studies

Etiology

Cardoneanu A, Rezus II, Burlui AM, Richter P, Bratoiu I, Mihai IR, Macovei LA, Rezus E
Int J Mol Sci 2024 Feb 13;25(4) doi: 10.3390/ijms25042261. PMID: 38396936Free PMC Article
Mertz P, Sparks J, Kobrin D, Ogbonnaya SA, Sevim E, Michet C, Arnaud L, Ferrada M
Best Pract Res Clin Rheumatol 2023 Mar;37(1):101867. Epub 2023 Oct 14 doi: 10.1016/j.berh.2023.101867. PMID: 37839908
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099
de Montmollin N, Dusser D, Lorut C, Dion J, Costedoat-Chalumeau N, Mouthon L, Chassagnon G, Revel MP, Puéchal X
Autoimmun Rev 2019 Sep;18(9):102353. Epub 2019 Jul 16 doi: 10.1016/j.autrev.2019.102353. PMID: 31323366
Sharma A, Dhooria A, Aggarwal A, Rathi M, Chandran V
Curr Rheumatol Rep 2016 Jun;18(6):31. doi: 10.1007/s11926-016-0584-x. PMID: 27097818

Diagnosis

Mertz P, Costedoat-Chalumeau N, Ferrada MA, Moulis G, Mekinian A, Grayson PC, Arnaud L
Nat Rev Rheumatol 2024 Jun;20(6):347-360. Epub 2024 May 2 doi: 10.1038/s41584-024-01113-9. PMID: 38698240
Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Mertz P, Sparks J, Kobrin D, Ogbonnaya SA, Sevim E, Michet C, Arnaud L, Ferrada M
Best Pract Res Clin Rheumatol 2023 Mar;37(1):101867. Epub 2023 Oct 14 doi: 10.1016/j.berh.2023.101867. PMID: 37839908
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Haslag-Minoff J, Regunath H
N Engl J Med 2018 May 3;378(18):1715. doi: 10.1056/NEJMicm1713302. PMID: 29719184

Therapy

Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756
Grygiel-Górniak B, Tariq H, Mitchell J, Mohammed A, Samborski W
Postgrad Med 2021 Nov;133(8):953-963. Epub 2021 Sep 30 doi: 10.1080/00325481.2021.1979873. PMID: 34533099
Haslag-Minoff J, Regunath H
N Engl J Med 2018 May 3;378(18):1715. doi: 10.1056/NEJMicm1713302. PMID: 29719184
Chopra R, Chaudhary N, Kay J
Rheum Dis Clin North Am 2013 May;39(2):263-76. doi: 10.1016/j.rdc.2013.03.002. PMID: 23597963

Prognosis

Mertz P, Costedoat-Chalumeau N, Ferrada MA, Moulis G, Mekinian A, Grayson PC, Arnaud L
Nat Rev Rheumatol 2024 Jun;20(6):347-360. Epub 2024 May 2 doi: 10.1038/s41584-024-01113-9. PMID: 38698240
Loeza-Uribe MP, Hinojosa-Azaola A, Sánchez-Hernández BE, Crispín JC, Apodaca-Chávez E, Ferrada MA, Martín-Nares E
Reumatol Clin (Engl Ed) 2024 Jan;20(1):47-56. Epub 2023 Dec 29 doi: 10.1016/j.reumae.2023.12.004. PMID: 38160120
Mertz P, Sparks J, Kobrin D, Ogbonnaya SA, Sevim E, Michet C, Arnaud L, Ferrada M
Best Pract Res Clin Rheumatol 2023 Mar;37(1):101867. Epub 2023 Oct 14 doi: 10.1016/j.berh.2023.101867. PMID: 37839908
Arnaud L, Costedoat-Chalumeau N, Mathian A, Sailler L, Belot A, Dion J, Morel N, Moulis G; Collaborators
Rev Med Interne 2023 Jun;44(6):282-294. Epub 2023 May 24 doi: 10.1016/j.revmed.2023.05.005. PMID: 37236870
Al-Hakim A, Savic S
Expert Rev Clin Immunol 2023 Feb;19(2):203-215. Epub 2022 Dec 26 doi: 10.1080/1744666X.2023.2157262. PMID: 36537591

Clinical prediction guides

Liu Y, Cheng L, Zhao M, Zhan H, Li X, Huang Y, Li H, Hou Y, Li Y
Front Immunol 2023;14:1274677. Epub 2023 Oct 3 doi: 10.3389/fimmu.2023.1274677. PMID: 37854592Free PMC Article
Liu Y, Li X, Cheng L, Zhan H, Huang Y, Li H, Li Y
Clin Exp Immunol 2023 Jun 5;212(3):199-211. doi: 10.1093/cei/uxad014. PMID: 36751132Free PMC Article
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756
Ferrada MA, Sikora KA, Luo Y, Wells KV, Patel B, Groarke EM, Ospina Cardona D, Rominger E, Hoffmann P, Le MT, Deng Z, Quinn KA, Rose E, Tsai WL, Wigerblad G, Goodspeed W, Jones A, Wilson L, Schnappauf O, Laird RS, Kim J, Allen C, Sirajuddin A, Chen M, Gadina M, Calvo KR, Kaplan MJ, Colbert RA, Aksentijevich I, Young NS, Savic S, Kastner DL, Ombrello AK, Beck DB, Grayson PC
Arthritis Rheumatol 2021 Oct;73(10):1886-1895. Epub 2021 Aug 31 doi: 10.1002/art.41743. PMID: 33779074
Longo L, Greco A, Rea A, Lo Vasco VR, De Virgilio A, De Vincentiis M
Autoimmun Rev 2016 Jun;15(6):539-43. Epub 2016 Feb 11 doi: 10.1016/j.autrev.2016.02.013. PMID: 26876384

Recent systematic reviews

Montero ML, Panda RM, Palacios VJ, Solis RN, Levi JR
Ann Otol Rhinol Laryngol 2024 Nov;133(11):933-939. Epub 2024 Aug 20 doi: 10.1177/00034894241275474. PMID: 39162098
Damian L, Pamfil C, Bucșa C, Nicula C, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Grapini L, Arnaud L, Rednic S
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):86-92. Epub 2022 Feb 24 doi: 10.55563/clinexprheumatol/27n7im. PMID: 35238768
Petitdemange A, Sztejkowski C, Damian L, Martin T, Mouthon L, Amoura Z, Cutolo M, Burmester GR, Fonseca JE, Rednic S, Arnaud L
Clin Exp Rheumatol 2022 May;40 Suppl 134(5):81-85. Epub 2022 Jan 28 doi: 10.55563/clinexprheumatol/h9gq1o. PMID: 35238756
Kemta Lekpa F, Kraus VB, Chevalier X
Semin Arthritis Rheum 2012 Apr;41(5):712-9. Epub 2011 Nov 8 doi: 10.1016/j.semarthrit.2011.08.006. PMID: 22071463
Belot A, Duquesne A, Job-Deslandre C, Costedoat-Chalumeau N, Boudjemaa S, Wechsler B, Cochat P, Piette JC, Cimaz R
J Pediatr 2010 Mar;156(3):484-9. Epub 2009 Nov 1 doi: 10.1016/j.jpeds.2009.09.045. PMID: 19880136

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