U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Post-thrombotic syndrome

MedGen UID:
46043
Concept ID:
C0032807
Disease or Syndrome
Synonyms: Disease, Postphlebitic; Diseases, Postphlebitic; Postphlebitic Disease; Postphlebitic Diseases; Postphlebitic Syndrome; Postphlebitic Syndromes; Syndrome, Postphlebitic; Syndromes, Postphlebitic
SNOMED CT: Post-phlebitic syndrome (410013001); Postthrombotic syndrome (20427003); Postphlebitic syndrome (20427003)
 
Monarch Initiative: MONDO:0005928

Definition

A condition characterized by a chronically swollen limb, often a leg with stasis dermatitis and ulcerations. This syndrome can appear soon after phlebitis or years later. Postphlebitic syndrome is the result of damaged or incompetent venous valves in the limbs. Distended, tortuous varicose veins are usually present. Leg pain may occur after long period of standing. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-thrombotic syndrome

Professional guidelines

PubMed

Kruger PC, Eikelboom JW, Douketis JD, Hankey GJ
Med J Aust 2019 Jun;210(11):516-524. Epub 2019 Jun 2 doi: 10.5694/mja2.50201. PMID: 31155730
Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, Urbanek T, Huebner M, Gaillard S, Carpentier P
Phlebology 2018 Apr;33(3):163-184. Epub 2017 Feb 22 doi: 10.1177/0268355516689631. PMID: 28549402Free PMC Article
Baskin JL, Pui CH, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, Howard SC
Lancet 2009 Jul 11;374(9684):159-69. doi: 10.1016/S0140-6736(09)60220-8. PMID: 19595350Free PMC Article

Recent clinical studies

Etiology

Mazzolai L, Ageno W, Alatri A, Bauersachs R, Becattini C, Brodmann M, Emmerich J, Konstantinides S, Meyer G, Middeldorp S, Monreal M, Righini M, Aboyans V
Eur J Prev Cardiol 2022 May 27;29(8):1248-1263. doi: 10.1093/eurjpc/zwab088. PMID: 34254133
Goldhaber SZ, Magnuson EA, Chinnakondepalli KM, Cohen DJ, Vedantham S
Vasc Med 2021 Dec;26(6):662-669. Epub 2021 Oct 4 doi: 10.1177/1358863X211042930. PMID: 34606385Free PMC Article
Campello E, Spiezia L, Adamo A, Simioni P
Expert Rev Hematol 2019 Mar;12(3):147-158. Epub 2019 Feb 26 doi: 10.1080/17474086.2019.1583555. PMID: 30773075
Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators
N Engl J Med 2017 Dec 7;377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671Free PMC Article
Kahn SR
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):413-418. doi: 10.1182/asheducation-2016.1.413. PMID: 27913509Free PMC Article

Diagnosis

Visonà A, Quere I, Mazzolai L, Amitrano M, Lugli M, Madaric J, Prandoni P; European Society of Vascular Medicine (ESVM)
Vasa 2021 Sep;50(5):331-340. Epub 2021 Mar 15 doi: 10.1024/0301-1526/a000946. PMID: 33720757
Khan O, Marmaro A, Cohen DA
Postgrad Med 2021 Aug;133(sup1):3-10. Epub 2021 Mar 8 doi: 10.1080/00325481.2021.1892390. PMID: 33618595
Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Rafetto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T
J Vasc Surg Venous Lymphat Disord 2020 May;8(3):342-352. Epub 2020 Feb 27 doi: 10.1016/j.jvsv.2019.12.075. PMID: 32113854
Kruger PC, Eikelboom JW, Douketis JD, Hankey GJ
Med J Aust 2019 Jun;210(11):516-524. Epub 2019 Jun 2 doi: 10.5694/mja2.50201. PMID: 31155730
Wolberg AS, Rosendaal FR, Weitz JI, Jaffer IH, Agnelli G, Baglin T, Mackman N
Nat Rev Dis Primers 2015 May 7;1:15006. doi: 10.1038/nrdp.2015.6. PMID: 27189130

Therapy

Goldhaber SZ, Magnuson EA, Chinnakondepalli KM, Cohen DJ, Vedantham S
Vasc Med 2021 Dec;26(6):662-669. Epub 2021 Oct 4 doi: 10.1177/1358863X211042930. PMID: 34606385Free PMC Article
Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, Urbanek T, Huebner M, Gaillard S, Carpentier P
Phlebology 2018 Apr;33(3):163-184. Epub 2017 Feb 22 doi: 10.1177/0268355516689631. PMID: 28549402Free PMC Article
Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators
N Engl J Med 2017 Dec 7;377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671Free PMC Article
Goldhaber SZ, Bounameaux H
Lancet 2012 May 12;379(9828):1835-46. Epub 2012 Apr 10 doi: 10.1016/S0140-6736(11)61904-1. PMID: 22494827
Baskin JL, Pui CH, Reiss U, Wilimas JA, Metzger ML, Ribeiro RC, Howard SC
Lancet 2009 Jul 11;374(9684):159-69. doi: 10.1016/S0140-6736(09)60220-8. PMID: 19595350Free PMC Article

Prognosis

Wang X, Ma Y, Hui X, Li M, Li J, Tian J, Wang Q, Yan P, Li J, Xie P, Yang K, Yao L
Cochrane Database Syst Rev 2023 Apr 14;4(4):CD010956. doi: 10.1002/14651858.CD010956.pub3. PMID: 37058421Free PMC Article
Zuo Z, Yue J, Dong BR, Wu T, Liu GJ, Hao Q
Cochrane Database Syst Rev 2021 Apr 15;4(4):CD004437. doi: 10.1002/14651858.CD004437.pub6. PMID: 33857326Free PMC Article
Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Rafetto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T
J Vasc Surg Venous Lymphat Disord 2020 May;8(3):342-352. Epub 2020 Feb 27 doi: 10.1016/j.jvsv.2019.12.075. PMID: 32113854
Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators
N Engl J Med 2017 Dec 7;377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671Free PMC Article
Goldhaber SZ, Bounameaux H
Lancet 2012 May 12;379(9828):1835-46. Epub 2012 Apr 10 doi: 10.1016/S0140-6736(11)61904-1. PMID: 22494827

Clinical prediction guides

Visonà A, Quere I, Mazzolai L, Amitrano M, Lugli M, Madaric J, Prandoni P; European Society of Vascular Medicine (ESVM)
Vasa 2021 Sep;50(5):331-340. Epub 2021 Mar 15 doi: 10.1024/0301-1526/a000946. PMID: 33720757
Khan O, Marmaro A, Cohen DA
Postgrad Med 2021 Aug;133(sup1):3-10. Epub 2021 Mar 8 doi: 10.1080/00325481.2021.1892390. PMID: 33618595
Lurie F, Passman M, Meisner M, Dalsing M, Masuda E, Welch H, Bush RL, Blebea J, Carpentier PH, De Maeseneer M, Gasparis A, Labropoulos N, Marston WA, Rafetto J, Santiago F, Shortell C, Uhl JF, Urbanek T, van Rij A, Eklof B, Gloviczki P, Kistner R, Lawrence P, Moneta G, Padberg F, Perrin M, Wakefield T
J Vasc Surg Venous Lymphat Disord 2020 May;8(3):342-352. Epub 2020 Feb 27 doi: 10.1016/j.jvsv.2019.12.075. PMID: 32113854
Vedantham S, Goldhaber SZ, Julian JA, Kahn SR, Jaff MR, Cohen DJ, Magnuson E, Razavi MK, Comerota AJ, Gornik HL, Murphy TP, Lewis L, Duncan JR, Nieters P, Derfler MC, Filion M, Gu CS, Kee S, Schneider J, Saad N, Blinder M, Moll S, Sacks D, Lin J, Rundback J, Garcia M, Razdan R, VanderWoude E, Marques V, Kearon C; ATTRACT Trial Investigators
N Engl J Med 2017 Dec 7;377(23):2240-2252. doi: 10.1056/NEJMoa1615066. PMID: 29211671Free PMC Article
Busuttil A, Lim CS, Davies AH
Adv Exp Med Biol 2017;906:363-375. doi: 10.1007/5584_2016_126. PMID: 27628001

Recent systematic reviews

Wang X, Ma Y, Hui X, Li M, Li J, Tian J, Wang Q, Yan P, Li J, Xie P, Yang K, Yao L
Cochrane Database Syst Rev 2023 Apr 14;4(4):CD010956. doi: 10.1002/14651858.CD010956.pub3. PMID: 37058421Free PMC Article
Zuo Z, Yue J, Dong BR, Wu T, Liu GJ, Hao Q
Cochrane Database Syst Rev 2021 Apr 15;4(4):CD004437. doi: 10.1002/14651858.CD004437.pub6. PMID: 33857326Free PMC Article
Broderick C, Watson L, Armon MP
Cochrane Database Syst Rev 2021 Jan 19;1(1):CD002783. doi: 10.1002/14651858.CD002783.pub5. PMID: 33464575Free PMC Article
Rabe E, Partsch H, Hafner J, Lattimer C, Mosti G, Neumann M, Urbanek T, Huebner M, Gaillard S, Carpentier P
Phlebology 2018 Apr;33(3):163-184. Epub 2017 Feb 22 doi: 10.1177/0268355516689631. PMID: 28549402Free PMC Article
Morling JR, Yeoh SE, Kolbach DN
Cochrane Database Syst Rev 2015 Sep 16;(9):CD005626. doi: 10.1002/14651858.CD005626.pub3. PMID: 26373375

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...