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Esophagitis, eosinophilic, 2(EOE2)

MedGen UID:
462029
•Concept ID:
C3150679
•
Disease or Syndrome
Synonym: EOE2
 
Monarch Initiative: MONDO:0013260
OMIM®: 613412

Clinical features

From HPO
Epigastric pain
MedGen UID:
452270
•Concept ID:
C0232493
•
Sign or Symptom
Pain that is localized to the region of the upper abdomen immediately below the ribs.
See: Feature record | Search on this feature
Failure to thrive
MedGen UID:
746019
•Concept ID:
C2315100
•
Disease or Syndrome
Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
See: Feature record | Search on this feature
Dysphagia
MedGen UID:
41440
•Concept ID:
C0011168
•
Disease or Syndrome
Difficulty in swallowing.
See: Feature record | Search on this feature
Esophagitis
MedGen UID:
4549
•Concept ID:
C0014868
•
Disease or Syndrome
Inflammation of the esophagus.
See: Feature record | Search on this feature
Vomiting
MedGen UID:
12124
•Concept ID:
C0042963
•
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
See: Feature record | Search on this feature
Eosinophilia
MedGen UID:
41824
•Concept ID:
C0014457
•
Disease or Syndrome
Increased count of eosinophils in the blood.
See: Feature record | Search on this feature
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Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

IgE in the diagnosis and treatment of allergic disease.
Platts-Mills TAE, Schuyler AJ, Erwin EA, Commins SP, Woodfolk JA
J Allergy Clin Immunol 2016 Jun;137(6):1662-1670. Epub 2016 Apr 27 doi: 10.1016/j.jaci.2016.04.010. PMID: 27264001Free PMC Article

Recent clinical studies

Etiology

Efficacy of Elimination Diets in Eosinophilic Esophagitis: A Systematic Review and Meta-analysis.
Mayerhofer C, Kavallar AM, Aldrian D, Lindner AK, Müller T, Vogel GF
Clin Gastroenterol Hepatol 2023 Aug;21(9):2197-2210.e3. Epub 2023 Jan 31 doi: 10.1016/j.cgh.2023.01.019. PMID: 36731591
Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A
N Engl J Med 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624
Eosinophilic esophagitis.
Watts MM, Saltoun C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):462-464. doi: 10.2500/aap.2019.40.4272. PMID: 31690395
Eosinophilic Gastrointestinal Disorders.
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article

Diagnosis

Medical treatment of eosinophilic esophagitis.
Franciosi JP, Gordon M, Sinopoulou V, Dellon ES, Gupta SK, Reed CC, Gutiérrez-Junquera C, Venkatesh RD, Erwin EA, Egiz A, Elleithy A, Mougey EB
Cochrane Database Syst Rev 2023 Jul 20;7(7):CD004065. doi: 10.1002/14651858.CD004065.pub4. PMID: 37470293Free PMC Article
Diagnosis and treatment of eosinophilic esophagitis.
Gonsalves NP, Aceves SS
J Allergy Clin Immunol 2020 Jan;145(1):1-7. doi: 10.1016/j.jaci.2019.11.011. PMID: 31910983Free PMC Article
Eosinophilic esophagitis.
Watts MM, Saltoun C, Greenberger PA
Allergy Asthma Proc 2019 Nov 1;40(6):462-464. doi: 10.2500/aap.2019.40.4272. PMID: 31690395
Eosinophilic esophagitis: Current concepts in diagnosis and treatment.
Gómez-Aldana A, Jaramillo-Santos M, Delgado A, Jaramillo C, Lúquez-Mindiola A
World J Gastroenterol 2019 Aug 28;25(32):4598-4613. doi: 10.3748/wjg.v25.i32.4598. PMID: 31528089Free PMC Article
Eosinophilic Gastrointestinal Disorders.
Gonsalves N
Clin Rev Allergy Immunol 2019 Oct;57(2):272-285. doi: 10.1007/s12016-019-08732-1. PMID: 30903439

Therapy

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A
N Engl J Med 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624
Dupilumab: A Review of Present Indications and Off-Label Uses.
Muñoz-Bellido FJ, Moreno E, Dávila I
J Investig Allergol Clin Immunol 2022 Apr 19;32(2):97-115. Epub 2021 Mar 3 doi: 10.18176/jiaci.0682. PMID: 33661102
Diagnosis and treatment of eosinophilic esophagitis.
Gonsalves NP, Aceves SS
J Allergy Clin Immunol 2020 Jan;145(1):1-7. doi: 10.1016/j.jaci.2019.11.011. PMID: 31910983Free PMC Article
Mechanisms of Dupilumab.
Harb H, Chatila TA
Clin Exp Allergy 2020 Jan;50(1):5-14. Epub 2019 Sep 30 doi: 10.1111/cea.13491. PMID: 31505066Free PMC Article
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article

Prognosis

Eosinophilic Gastrointestinal Diseases in Children: A Practical Review.
Licari A, Votto M, D'Auria E, Castagnoli R, Caimmi SME, Marseglia GL
Curr Pediatr Rev 2020;16(2):106-114. doi: 10.2174/1573396315666191022154432. PMID: 31642786
Conjunctivitis in dupilumab clinical trials.
Akinlade B, Guttman-Yassky E, de Bruin-Weller M, Simpson EL, Blauvelt A, Cork MJ, Prens E, Asbell P, Akpek E, Corren J, Bachert C, Hirano I, Weyne J, Korotzer A, Chen Z, Hultsch T, Zhu X, Davis JD, Mannent L, Hamilton JD, Teper A, Staudinger H, Rizova E, Pirozzi G, Graham NMH, Shumel B, Ardeleanu M, Wollenberg A
Br J Dermatol 2019 Sep;181(3):459-473. Epub 2019 May 7 doi: 10.1111/bjd.17869. PMID: 30851191Free PMC Article
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ
Gastroenterology 2018 Oct;155(4):1022-1033.e10. Epub 2018 Sep 6 doi: 10.1053/j.gastro.2018.07.009. PMID: 30009819Free PMC Article
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Clinical prediction guides

Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis.
Dellon ES, Rothenberg ME, Collins MH, Hirano I, Chehade M, Bredenoord AJ, Lucendo AJ, Spergel JM, Aceves S, Sun X, Kosloski MP, Kamal MA, Hamilton JD, Beazley B, McCann E, Patel K, Mannent LP, Laws E, Akinlade B, Amin N, Lim WK, Wipperman MF, Ruddy M, Patel N, Weinreich DR, Yancopoulos GD, Shumel B, Maloney J, Giannelou A, Shabbir A
N Engl J Med 2022 Dec 22;387(25):2317-2330. doi: 10.1056/NEJMoa2205982. PMID: 36546624
STAT6: A review of a signaling pathway implicated in various diseases with a special emphasis in its usefulness in pathology.
Karpathiou G, Papoudou-Bai A, Ferrand E, Dumollard JM, Peoc'h M
Pathol Res Pract 2021 Jul;223:153477. Epub 2021 May 11 doi: 10.1016/j.prp.2021.153477. PMID: 33991851
Updated International Consensus Diagnostic Criteria for Eosinophilic Esophagitis: Proceedings of the AGREE Conference.
Dellon ES, Liacouras CA, Molina-Infante J, Furuta GT, Spergel JM, Zevit N, Spechler SJ, Attwood SE, Straumann A, Aceves SS, Alexander JA, Atkins D, Arva NC, Blanchard C, Bonis PA, Book WM, Capocelli KE, Chehade M, Cheng E, Collins MH, Davis CM, Dias JA, Di Lorenzo C, Dohil R, Dupont C, Falk GW, Ferreira CT, Fox A, Gonsalves NP, Gupta SK, Katzka DA, Kinoshita Y, Menard-Katcher C, Kodroff E, Metz DC, Miehlke S, Muir AB, Mukkada VA, Murch S, Nurko S, Ohtsuka Y, Orel R, Papadopoulou A, Peterson KA, Philpott H, Putnam PE, Richter JE, Rosen R, Rothenberg ME, Schoepfer A, Scott MM, Shah N, Sheikh J, Souza RF, Strobel MJ, Talley NJ, Vaezi MF, Vandenplas Y, Vieira MC, Walker MM, Wechsler JB, Wershil BK, Wen T, Yang GY, Hirano I, Bredenoord AJ
Gastroenterology 2018 Oct;155(4):1022-1033.e10. Epub 2018 Sep 6 doi: 10.1053/j.gastro.2018.07.009. PMID: 30009819Free PMC Article
Epidemiology and Natural History of Eosinophilic Esophagitis.
Dellon ES, Hirano I
Gastroenterology 2018 Jan;154(2):319-332.e3. Epub 2017 Aug 1 doi: 10.1053/j.gastro.2017.06.067. PMID: 28774845Free PMC Article
Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment.
Sicherer SH, Sampson HA
J Allergy Clin Immunol 2014 Feb;133(2):291-307; quiz 308. Epub 2013 Dec 31 doi: 10.1016/j.jaci.2013.11.020. PMID: 24388012

Recent systematic reviews

Medical treatment of eosinophilic esophagitis.
Franciosi JP, Gordon M, Sinopoulou V, Dellon ES, Gupta SK, Reed CC, Gutiérrez-Junquera C, Venkatesh RD, Erwin EA, Egiz A, Elleithy A, Mougey EB
Cochrane Database Syst Rev 2023 Jul 20;7(7):CD004065. doi: 10.1002/14651858.CD004065.pub4. PMID: 37470293Free PMC Article
Efficacy of Elimination Diets in Eosinophilic Esophagitis: A Systematic Review and Meta-analysis.
Mayerhofer C, Kavallar AM, Aldrian D, Lindner AK, Müller T, Vogel GF
Clin Gastroenterol Hepatol 2023 Aug;21(9):2197-2210.e3. Epub 2023 Jan 31 doi: 10.1016/j.cgh.2023.01.019. PMID: 36731591
Association between eosinophilic esophagitis and esophageal dysmotility: A systematic review and meta-analysis.
Reddy SB, Ketchem CJ, Dougherty MK, Eluri S, Dellon ES
Neurogastroenterol Motil 2023 Feb;35(2):e14475. Epub 2022 Sep 27 doi: 10.1111/nmo.14475. PMID: 36168184
Treatment Trends for Eosinophilic Esophagitis and the Other Eosinophilic Gastrointestinal Diseases: Systematic Review of Clinical Trials.
Visaggi P, Ghisa M, Barberio B, Maniero D, Greco E, Savarino V, Black CJ, Ford AC, de Bortoli N, Savarino E
Dig Liver Dis 2023 Feb;55(2):208-222. Epub 2022 May 30 doi: 10.1016/j.dld.2022.05.004. PMID: 35654734
Steroids therapy for eosinophilic esophagitis: Systematic review and meta-analysis.
Tan ND, Xiao YL, Chen MH
J Dig Dis 2015 Aug;16(8):431-42. doi: 10.1111/1751-2980.12265. PMID: 26058809

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