U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pulmonary eosinophilia

MedGen UID:
46208
•Concept ID:
C0034068
•
Disease or Syndrome
Synonyms: Eosinophilia, Pulmonary; Eosinophilias, Pulmonary; Pulmonary Eosinophilia; Pulmonary Eosinophilias
SNOMED CT: PIE - Pulmonary infiltrates with eosinophilia (367542003); Pulmonary infiltrates with eosinophilia (367542003); Andrews syndrome (367542003); Pulmonary eosinophilia (367542003)
 
Monarch Initiative: MONDO:0004802

Definition

A condition characterized by infiltration of the lung with eosinophils due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPulmonary eosinophilia

Professional guidelines

PubMed

Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia.
Zimmermann N, Wikenheiser-Brokamp KA
Ann Allergy Asthma Immunol 2018 Aug;121(2):179-185. Epub 2018 May 24 doi: 10.1016/j.anai.2018.05.014. PMID: 29803709
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Recent clinical studies

Etiology

Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study.
Pavord I, Gardiner F, Heaney LG, Domingo C, Price RG, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P
Front Immunol 2023;14:1150162. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1150162. PMID: 37122713Free PMC Article
Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Nopsopon T, Lassiter G, Chen ML, Alexander GC, Keet C, Hong H, Akenroye A
J Allergy Clin Immunol 2023 Mar;151(3):747-755. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.11.021. PMID: 36538979Free PMC Article
Drug-Related Pneumonitis Induced by Osimertinib as First-Line Treatment for Epidermal Growth Factor Receptor Mutation-Positive Non-Small Cell Lung Cancer: A Real-World Setting.
Sato Y, Sumikawa H, Shibaki R, Morimoto T, Sakata Y, Oya Y, Tamiya M, Suzuki H, Matsumoto H, Yokoi T, Hashimoto K, Kobe H, Hino A, Inaba M, Tsukita Y, Ikeda H, Arai D, Maruyama H, Hara S, Tsumura S, Sakata S, Fujimoto D
Chest 2022 Nov;162(5):1188-1198. Epub 2022 Jun 1 doi: 10.1016/j.chest.2022.05.035. PMID: 35661746
Smoking-associated interstitial lung disease: update and review.
Dawod YT, Cook NE, Graham WB, Madhani-Lovely F, Thao C
Expert Rev Respir Med 2020 Aug;14(8):825-834. Epub 2020 May 22 doi: 10.1080/17476348.2020.1766971. PMID: 32379511
Pulmonary eosinophilia.
Campos LE, Pereira LF
J Bras Pneumol 2009 Jun;35(6):561-73. doi: 10.1590/s1806-37132009000600010. PMID: 19618037

Diagnosis

Eosinophilic Lung Diseases.
Cottin V
Immunol Allergy Clin North Am 2023 May;43(2):289-322. doi: 10.1016/j.iac.2023.01.002. PMID: 37055090
Approach to Eosinophilia Presenting With Pulmonary Symptoms.
Rosenberg CE, Khoury P
Chest 2021 Feb;159(2):507-516. Epub 2020 Sep 28 doi: 10.1016/j.chest.2020.09.247. PMID: 33002503Free PMC Article
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477
Eosinophilic Lung Diseases.
Cottin V
Clin Chest Med 2016 Sep;37(3):535-56. Epub 2016 Jun 25 doi: 10.1016/j.ccm.2016.04.015. PMID: 27514599

Therapy

Daptomycin-induced eosinophilic pneumonia.
Hassett MR
JAAPA 2024 Apr 1;37(4):1-4. Epub 2024 Mar 26 doi: 10.1097/01.JAA.0001005632.20281.96. PMID: 38531037
Reduction of daily maintenance inhaled corticosteroids in patients with severe eosinophilic asthma treated with benralizumab (SHAMAL): a randomised, multicentre, open-label, phase 4 study.
Jackson DJ, Heaney LG, Humbert M, Kent BD, Shavit A, Hiljemark L, Olinger L, Cohen D, Menzies-Gow A, Korn S; SHAMAL Investigators
Lancet 2024 Jan 20;403(10423):271-281. Epub 2023 Dec 7 doi: 10.1016/S0140-6736(23)02284-5. PMID: 38071986
Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial.
Pavord ID, Korn S, Howarth P, Bleecker ER, Buhl R, Keene ON, Ortega H, Chanez P
Lancet 2012 Aug 18;380(9842):651-9. doi: 10.1016/S0140-6736(12)60988-X. PMID: 22901886
Pulmonary eosinophilia.
Katz U, Shoenfeld Y
Clin Rev Allergy Immunol 2008 Jun;34(3):367-71. doi: 10.1007/s12016-007-8053-y. PMID: 18197481
Parasitic pulmonary eosinophilia.
Chitkara RK, Krishna G
Semin Respir Crit Care Med 2006 Apr;27(2):171-84. doi: 10.1055/s-2006-939520. PMID: 16612768

Prognosis

Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study.
Pavord I, Gardiner F, Heaney LG, Domingo C, Price RG, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P
Front Immunol 2023;14:1150162. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1150162. PMID: 37122713Free PMC Article
Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions.
Oppenheimer J, Hoyte FCL, Phipatanakul W, Silver J, Howarth P, Lugogo NL
Ann Allergy Asthma Immunol 2022 Aug;129(2):169-180. Epub 2022 Mar 7 doi: 10.1016/j.anai.2022.02.021. PMID: 35272048
Eosinophilic pneumonia: A review of the previous literature, causes, diagnosis, and management.
Suzuki Y, Suda T
Allergol Int 2019 Oct;68(4):413-419. Epub 2019 Jun 25 doi: 10.1016/j.alit.2019.05.006. PMID: 31253537
Eosinophilic Pneumonias.
Allen J, Wert M
J Allergy Clin Immunol Pract 2018 Sep-Oct;6(5):1455-1461. Epub 2018 May 4 doi: 10.1016/j.jaip.2018.03.011. PMID: 29735405
Acute Eosinophilic Pneumonia. Causes, Diagnosis, and Management.
De Giacomi F, Vassallo R, Yi ES, Ryu JH
Am J Respir Crit Care Med 2018 Mar 15;197(6):728-736. doi: 10.1164/rccm.201710-1967CI. PMID: 29206477

Clinical prediction guides

Blood CD62L(low) inflammatory eosinophils are related to the severity of asthma and reduced by mepolizumab.
Vultaggio A, Accinno M, Vivarelli E, Mecheri V, Maggiore G, Cosmi L, Parronchi P, Rossi O, Maggi E, Gallo O, Matucci A
Allergy 2023 Dec;78(12):3154-3165. Epub 2023 Oct 4 doi: 10.1111/all.15909. PMID: 37792721
Remission outcomes in severe eosinophilic asthma with mepolizumab therapy: Analysis of the REDES study.
Pavord I, Gardiner F, Heaney LG, Domingo C, Price RG, Pullan A, Oppenheimer J, Brusselle G, Nagase H, Chupp G, Pizzichini E, Bañas-Conejero D, Howarth P
Front Immunol 2023;14:1150162. Epub 2023 Apr 12 doi: 10.3389/fimmu.2023.1150162. PMID: 37122713Free PMC Article
Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Nopsopon T, Lassiter G, Chen ML, Alexander GC, Keet C, Hong H, Akenroye A
J Allergy Clin Immunol 2023 Mar;151(3):747-755. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.11.021. PMID: 36538979Free PMC Article
Allergic and eosinophilic asthma in the era of biomarkers and biologics: similarities, differences and misconceptions.
Oppenheimer J, Hoyte FCL, Phipatanakul W, Silver J, Howarth P, Lugogo NL
Ann Allergy Asthma Immunol 2022 Aug;129(2):169-180. Epub 2022 Mar 7 doi: 10.1016/j.anai.2022.02.021. PMID: 35272048
From DREAM to REALITI-A and beyond: Mepolizumab for the treatment of eosinophil-driven diseases.
Pavord ID, Bel EH, Bourdin A, Chan R, Han JK, Keene ON, Liu MC, Martin N, Papi A, Roufosse F, Steinfeld J, Wechsler ME, Yancey SW
Allergy 2022 Mar;77(3):778-797. Epub 2021 Sep 16 doi: 10.1111/all.15056. PMID: 34402066Free PMC Article

Recent systematic reviews

Effect of obesity on airway and systemic inflammation in adults with asthma: a systematic review and meta-analysis.
Scott HA, Ng SH, McLoughlin RF, Valkenborghs SR, Nair P, Brown AC, Carroll OR, Horvat JC, Wood LG
Thorax 2023 Oct;78(10):957-965. Epub 2023 Mar 22 doi: 10.1136/thorax-2022-219268. PMID: 36948588
Comparative efficacy of tezepelumab to mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Nopsopon T, Lassiter G, Chen ML, Alexander GC, Keet C, Hong H, Akenroye A
J Allergy Clin Immunol 2023 Mar;151(3):747-755. Epub 2022 Dec 17 doi: 10.1016/j.jaci.2022.11.021. PMID: 36538979Free PMC Article
Comparative efficacy of mepolizumab, benralizumab, and dupilumab in eosinophilic asthma: A Bayesian network meta-analysis.
Akenroye A, Lassiter G, Jackson JW, Keet C, Segal J, Alexander GC, Hong H
J Allergy Clin Immunol 2022 Nov;150(5):1097-1105.e12. Epub 2022 Jun 27 doi: 10.1016/j.jaci.2022.05.024. PMID: 35772597Free PMC Article
COVID-19 mimics on chest CT: a pictorial review and radiologic guide.
Hochhegger B, Zanon M, Altmayer S, Mandelli NS, Stüker G, Mohammed TL, Verma N, Meirelles GSP, Marchiori E
Br J Radiol 2021 Feb 1;94(1118):20200703. Epub 2020 Dec 9 doi: 10.1259/bjr.20200703. PMID: 33296607Free PMC Article
Diagnostic accuracy of minimally invasive markers for detection of airway eosinophilia in asthma: a systematic review and meta-analysis.
Korevaar DA, Westerhof GA, Wang J, Cohen JF, Spijker R, Sterk PJ, Bel EH, Bossuyt PM
Lancet Respir Med 2015 Apr;3(4):290-300. Epub 2015 Mar 20 doi: 10.1016/S2213-2600(15)00050-8. PMID: 25801413

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...