Joint pain.

Severe distention of the kidney with dilation of the renal pelvis and calices.

Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children.

Hematuria that is visible upon inspection of the urine.

An abnormal increase in the size of the kidney.

A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine.

Extracellular meangial accumulation of finely granular material corresponding to immunoglobulin and/or complement by immunofluorescence/immunohistochemistry; most typically electron-dense although this may decrease with resorption of the deposit.

Abnormally increased size of the liver.

An increased susceptibility to respiratory infections as manifested by a history of recurrent respiratory infections.

Inflammation of the renal glomeruli.

The presence of thrombocytopenia in combination with detection of antiplatelet antibodies.

Increased susceptibility to bacterial infections, as manifested by recurrent episodes of bacterial infection.

A deviation from the normal count of T cells.

A deviation from the normal count of B cells, i.e., the cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells.

The presence of normal overall immunoglobulin levels with deficiency of specific immunoglobulins directed against pneumococci.

A lasting reduction beneath the normal level of total immunoglobulin G (IgG) in the blood.

The inability to synthesize postvaccination antibodies against a tetanus antigen, as measured by antibody titer determination following vaccination.

Purpura (from Latin