U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Torsade-de-pointes syndrome with short coupling interval

MedGen UID:
462201
Concept ID:
C3150851
Disease or Syndrome
Synonym: Torsade de pointes, short-coupled variant
SNOMED CT: Torsade de pointes with short coupling interval syndrome (718104007); Torsade de pointes short coupled variant (718104007)
 
Monarch Initiative: MONDO:0013317
OMIM®: 613600
Orphanet: ORPHA51084

Definition

Torsade de pointes is characterized by an electrocardiographic (ECG) pattern of nonuniform but still-organized electrical activity with progressive changes in morphology, amplitude, and polarity of the QRS complexes, the peaks of which twist around the isoelectric baseline before ending spontaneously. In classic torsade de pointes, the coupling interval of the first beat is long (see LQT1, 192500), whereas in this short-coupled variant, the coupling interval of the first beat is very short (summary by Leenhardt et al., 1994). [from OMIM]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTorsade-de-pointes syndrome with short coupling interval
Follow this link to review classifications for Torsade-de-pointes syndrome with short coupling interval in Orphanet.

Professional guidelines

PubMed

Rosso R, Hochstadt A, Viskin D, Chorin E, Schwartz AL, Tovia-Brodie O, Laish-Farkash A, Havakuk O, Gepstein L, Banai S, Viskin S
Eur Heart J 2021 Oct 7;42(38):3965-3975. doi: 10.1093/eurheartj/ehab138. PMID: 33693589

Recent clinical studies

Etiology

Rosso R, Hochstadt A, Viskin D, Chorin E, Schwartz AL, Tovia-Brodie O, Laish-Farkash A, Havakuk O, Gepstein L, Banai S, Viskin S
Eur Heart J 2021 Oct 7;42(38):3965-3975. doi: 10.1093/eurheartj/ehab138. PMID: 33693589
Lester RM, Paglialunga S, Johnson IA
Int J Mol Sci 2019 Mar 15;20(6) doi: 10.3390/ijms20061324. PMID: 30884748Free PMC Article
Viskin S, Chorin E, Viskin D, Hochstadt A, Halkin A, Tovia-Brodie O, Lee JK, Asher E, Laish-Farkash A, Amit G, Havakuk O, Belhassen B, Rosso R
Circulation 2019 May 14;139(20):2304-2314. doi: 10.1161/CIRCULATIONAHA.118.038036. PMID: 30696267
Kukla P, Jastrzębski M, Fijorek K, Stec S, Bryniarski L, Czarnecka D, Baranchuk A
Ann Noninvasive Electrocardiol 2016 Nov;21(6):572-579. Epub 2016 Mar 28 doi: 10.1111/anec.12355. PMID: 27018992Free PMC Article
Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P
Circulation 1994 Jan;89(1):206-15. doi: 10.1161/01.cir.89.1.206. PMID: 8281648

Diagnosis

Lester RM, Paglialunga S, Johnson IA
Int J Mol Sci 2019 Mar 15;20(6) doi: 10.3390/ijms20061324. PMID: 30884748Free PMC Article
Cuneo BF, Strasburger JF, Wakai RT
J Electrocardiol 2016 Nov-Dec;49(6):807-813. Epub 2016 Jul 28 doi: 10.1016/j.jelectrocard.2016.07.023. PMID: 27539165Free PMC Article
Oksuz F, Sensoy B, Sahan E, Sen F, Baser K, Cetin H, Unal S, Ozeke O, Topaloglu S, Aras D
Indian Heart J 2015 Jul-Aug;67(4):392-4. Epub 2015 Apr 27 doi: 10.1016/j.ihj.2015.02.030. PMID: 26304578Free PMC Article
Van den Branden B, Wever E, Boersma L
Acta Cardiol 2010 Jun;65(3):345-6. doi: 10.2143/AC.65.3.2050353. PMID: 20666275
Sánchez Muñoz JJ, García-Alberola A, Martínez-Sánchez J, Peñafiel-Verdú P, Caro-Martínez C, Manzano-Fernández S, Valdés Chávarri M
Rev Esp Cardiol 2010 Jul;63(7):798-801. doi: 10.1016/s1885-5857(10)70164-x. PMID: 20609313

Therapy

Viskin S, Chorin E, Viskin D, Hochstadt A, Halkin A, Tovia-Brodie O, Lee JK, Asher E, Laish-Farkash A, Amit G, Havakuk O, Belhassen B, Rosso R
Circulation 2019 May 14;139(20):2304-2314. doi: 10.1161/CIRCULATIONAHA.118.038036. PMID: 30696267
Cuneo BF, Strasburger JF, Yu S, Horigome H, Hosono T, Kandori A, Wakai RT
Circulation 2013 Nov 12;128(20):2183-91. doi: 10.1161/CIRCULATIONAHA.113.004840. PMID: 24218437Free PMC Article
Lu LX, Zhou W, Zhang X, Cao Q, Yu K, Zhu C
Resuscitation 2006 Oct;71(1):115-21. Epub 2006 Aug 30 doi: 10.1016/j.resuscitation.2006.03.011. PMID: 16942825
Chiladakis J, Karapanos G, Manolis AS
Int J Cardiol 1998 Mar 13;64(1):93-5. doi: 10.1016/s0167-5273(97)00331-8. PMID: 9579821
Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P
Circulation 1994 Jan;89(1):206-15. doi: 10.1161/01.cir.89.1.206. PMID: 8281648

Prognosis

Lester RM, Paglialunga S, Johnson IA
Int J Mol Sci 2019 Mar 15;20(6) doi: 10.3390/ijms20061324. PMID: 30884748Free PMC Article
Viskin S, Chorin E, Viskin D, Hochstadt A, Halkin A, Tovia-Brodie O, Lee JK, Asher E, Laish-Farkash A, Amit G, Havakuk O, Belhassen B, Rosso R
Circulation 2019 May 14;139(20):2304-2314. doi: 10.1161/CIRCULATIONAHA.118.038036. PMID: 30696267
Kukla P, Jastrzębski M, Fijorek K, Stec S, Bryniarski L, Czarnecka D, Baranchuk A
Ann Noninvasive Electrocardiol 2016 Nov;21(6):572-579. Epub 2016 Mar 28 doi: 10.1111/anec.12355. PMID: 27018992Free PMC Article
Cuneo BF, Strasburger JF, Yu S, Horigome H, Hosono T, Kandori A, Wakai RT
Circulation 2013 Nov 12;128(20):2183-91. doi: 10.1161/CIRCULATIONAHA.113.004840. PMID: 24218437Free PMC Article
Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P
Circulation 1994 Jan;89(1):206-15. doi: 10.1161/01.cir.89.1.206. PMID: 8281648

Clinical prediction guides

Lester RM, Paglialunga S, Johnson IA
Int J Mol Sci 2019 Mar 15;20(6) doi: 10.3390/ijms20061324. PMID: 30884748Free PMC Article
Kukla P, Jastrzębski M, Fijorek K, Stec S, Bryniarski L, Czarnecka D, Baranchuk A
Ann Noninvasive Electrocardiol 2016 Nov;21(6):572-579. Epub 2016 Mar 28 doi: 10.1111/anec.12355. PMID: 27018992Free PMC Article
Sánchez Muñoz JJ, García-Alberola A, Martínez-Sánchez J, Peñafiel-Verdú P, Caro-Martínez C, Manzano-Fernández S, Valdés Chávarri M
Rev Esp Cardiol 2010 Jul;63(7):798-801. doi: 10.1016/s1885-5857(10)70164-x. PMID: 20609313
Noda T, Shimizu W, Satomi K, Suyama K, Kurita T, Aihara N, Kamakura S
Eur Heart J 2004 Dec;25(23):2149-54. doi: 10.1016/j.ehj.2004.08.020. PMID: 15571831
Leenhardt A, Glaser E, Burguera M, Nürnberg M, Maison-Blanche P, Coumel P
Circulation 1994 Jan;89(1):206-15. doi: 10.1161/01.cir.89.1.206. PMID: 8281648

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...