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Renal hypomagnesemia 6(HOMG6)

MedGen UID:
462645
•Concept ID:
C3151295
•
Disease or Syndrome
Synonyms: HOMG6; HYPOMAGNESEMIA 6, RENAL
 
Gene (location): CNNM2 (10q24.32)
 
Monarch Initiative: MONDO:0013480
OMIM®: 613882

Clinical features

From HPO
Impaired renal tubular reabsorption of magnesium
MedGen UID:
1778245
•Concept ID:
C5539797
•
Finding
Decreased renal tubular reabsorption of magnesium.
See: Feature record | Search on this feature
Vertigo
MedGen UID:
53006
•Concept ID:
C0042571
•
Sign or Symptom
An abnormal sensation of spinning while the body is actually stationary.
See: Feature record | Search on this feature
Headache
MedGen UID:
9149
•Concept ID:
C0018681
•
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
See: Feature record | Search on this feature
Muscle weakness
MedGen UID:
57735
•Concept ID:
C0151786
•
Finding
Reduced strength of muscles.
See: Feature record | Search on this feature
Hypomagnesemia
MedGen UID:
57481
•Concept ID:
C0151723
•
Disease or Syndrome
An abnormally decreased magnesium concentration in the blood.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies.
Hamed SA
Expert Rev Clin Pharmacol 2019 Jan;12(1):61-90. Epub 2019 Jan 11 doi: 10.1080/17512433.2019.1555468. PMID: 30501441
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Obesity and hypomagnesemia.
Guerrero-Romero F, Flores-García A, Saldaña-Guerrero S, Simental-Mendía LE, Rodríguez-Morán M
Eur J Intern Med 2016 Oct;34:29-33. Epub 2016 Jun 25 doi: 10.1016/j.ejim.2016.06.015. PMID: 27353277
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Diagnosis

Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head.
Gadoth A, Nisnboym M, Alcalay Y, Zubkov A, Schwartz I, Schwartz D, Abboud M, Rubinek T, Yossepowitch O, Weinstein T
Neurol Neuroimmunol Neuroinflamm 2023 Nov;10(6) Epub 2023 Aug 17 doi: 10.1212/NXI.0000000000200155. PMID: 37591767Free PMC Article
AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Pathophysiologic approach in genetic hypokalemia: An update.
Blanchard A
Ann Endocrinol (Paris) 2023 Apr;84(2):298-307. Epub 2023 Jan 10 doi: 10.1016/j.ando.2022.11.005. PMID: 36639120
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia in Type 2 Diabetes: A Vicious Circle?
Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH
Diabetes 2016 Jan;65(1):3-13. doi: 10.2337/db15-1028. PMID: 26696633

Therapy

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Carboplatin and hypomagnesemia: Is it really a problem?
Gaughran G, Qayyum K, Smyth L, Davis A
Asia Pac J Clin Oncol 2021 Dec;17(6):478-485. Epub 2020 Oct 13 doi: 10.1111/ajco.13481. PMID: 33052033
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Prognosis

Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head.
Gadoth A, Nisnboym M, Alcalay Y, Zubkov A, Schwartz I, Schwartz D, Abboud M, Rubinek T, Yossepowitch O, Weinstein T
Neurol Neuroimmunol Neuroinflamm 2023 Nov;10(6) Epub 2023 Aug 17 doi: 10.1212/NXI.0000000000200155. PMID: 37591767Free PMC Article
Subcutaneous Fat Necrosis of the Newborn.
Soua Y, Hamouda H, Njima M, Ghanmi S, Soua H, Zili J
Skinmed 2021;19(5):392-394. Epub 2021 Oct 1 PMID: 34861924
Hypocalcaemia of malignancy.
Schattner A, Dubin I, Huber R, Gelber M
Neth J Med 2016 Jul;74(6):231-9. PMID: 27571720
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536

Clinical prediction guides

Subcutaneous Fat Necrosis of the Newborn.
Soua Y, Hamouda H, Njima M, Ghanmi S, Soua H, Zili J
Skinmed 2021;19(5):392-394. Epub 2021 Oct 1 PMID: 34861924
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article
Hypomagnesemia and the risk of death and GFR decline in chronic kidney disease.
Van Laecke S, Nagler EV, Verbeke F, Van Biesen W, Vanholder R
Am J Med 2013 Sep;126(9):825-31. Epub 2013 Jul 24 doi: 10.1016/j.amjmed.2013.02.036. PMID: 23891286

Recent systematic reviews

Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review.
Vanoni FO, Milani GP, Agostoni C, Treglia G, Faré PB, Camozzi P, Lava SAG, Bianchetti MG, Janett S
Nutrients 2021 Jun 7;13(6) doi: 10.3390/nu13061959. PMID: 34200366Free PMC Article
Serum Magnesium after Kidney Transplantation: A Systematic Review.
Garnier AS, Duveau A, Planchais M, Subra JF, Sayegh J, Augusto JF
Nutrients 2018 Jun 6;10(6) doi: 10.3390/nu10060729. PMID: 29882768Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536
Early and late renal adverse effects after potentially nephrotoxic treatment for childhood cancer.
Knijnenburg SL, Mulder RL, Schouten-Van Meeteren AY, Bökenkamp A, Blufpand H, van Dulmen-den Broeder E, Veening MA, Kremer LC, Jaspers MW
Cochrane Database Syst Rev 2013 Oct 8;(10):CD008944. doi: 10.1002/14651858.CD008944.pub2. PMID: 24101439

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