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Candidiasis, familial, 6(CANDF6)

MedGen UID:
462755
Concept ID:
C3151405
Disease or Syndrome
Synonyms: CANDF6; Candidiasis, familial, 6, autosomal dominant
 
Gene (location): IL17F (6p12.2)
 
Monarch Initiative: MONDO:0013503
OMIM®: 613956

Definition

Any familial chronic mucocutaneous candidiasis in which the cause of the disease is a mutation in the IL17F gene. [from MONDO]

Clinical features

From HPO
Chronic mucocutaneous candidiasis
MedGen UID:
2426
Concept ID:
C0006845
Disease or Syndrome
Recurrent or persistent superficial Candida infections of the skin, mucous membranes, and nails.

Professional guidelines

PubMed

He X, Tang Q, Zhan F, Mao Y, Ye F, Weng Z, Jiang X, Swidsinski A
J Obstet Gynaecol Res 2023 May;49(5):1443-1451. Epub 2023 Feb 11 doi: 10.1111/jog.15577. PMID: 36772906
Benedict K, Moret R, Molinari NAM, Jackson BR
PLoS One 2022;17(12):e0278630. Epub 2022 Dec 30 doi: 10.1371/journal.pone.0278630. PMID: 36584109Free PMC Article
Pintye J, Drake AL, Kinuthia J, Unger JA, Matemo D, Heffron RA, Barnabas RV, Kohler P, McClelland RS, John-Stewart G
Clin Infect Dis 2017 Mar 15;64(6):751-758. doi: 10.1093/cid/ciw850. PMID: 28034882Free PMC Article

Recent clinical studies

Etiology

Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Diagnosis

Cheng C, Guo B, Li R, Wu W, Mi C, Li X
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Nov 28;47(11):1608-1614. doi: 10.11817/j.issn.1672-7347.2022.220100. PMID: 36481640
Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Bitew A, Abebaw Y
BMC Womens Health 2018 Jun 15;18(1):94. doi: 10.1186/s12905-018-0607-z. PMID: 29902998Free PMC Article
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Therapy

Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Belayneh M, Sehn E, Korownyk C
Can Fam Physician 2017 Jun;63(6):455. PMID: 28615397Free PMC Article
Guidry CA, Mansfield SA, Sawyer RG, Cook CH
Surg Clin North Am 2014 Dec;94(6):1195-218. Epub 2014 Oct 3 doi: 10.1016/j.suc.2014.08.010. PMID: 25440119Free PMC Article
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267
Maccato ML, Kaufman RH
Curr Opin Obstet Gynecol 1991 Dec;3(6):849-52. PMID: 1818723

Prognosis

Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Alkhars N, Zeng Y, Alomeir N, Al Jallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J
J Dent Res 2022 Jan;101(1):54-62. Epub 2021 May 21 doi: 10.1177/00220345211012385. PMID: 34018817Free PMC Article
Gernez Y, Freeman AF, Holland SM, Garabedian E, Patel NC, Puck JM, Sullivan KE, Akhter J, Secord E, Chen K, Buckley R, Haddad E, Ochs HD, Fuleihan R, Routes J, Muskat M, Lugar P, Mancini J, Cunningham-Rundles C
J Allergy Clin Immunol Pract 2018 May-Jun;6(3):996-1001. Epub 2017 Sep 19 doi: 10.1016/j.jaip.2017.06.041. PMID: 28939137Free PMC Article
Loh KY, Sivalingam N
Med J Malaysia 2003 Dec;58(5):788-92. PMID: 15190674
Pflugfelder SC, Flynn HW Jr
Infect Dis Clin North Am 1992 Dec;6(4):859-73. PMID: 1460267

Clinical prediction guides

Fisher BT, Boge CLK, Xiao R, Shuster S, Chin-Quee D, Allen J, Shaheen S, Hayden R, Suganda S, Zaoutis TE, Chang YC, Yin DE, Huppler AR, Danziger-Isakov L, Muller WJ, Roilides E, Romero J, Sue PK, Berman D, Wattier RL, Halasa N, Pong A, Maron G, Soler-Palacin P, Hutto SC, Gonzalez BE, Salvatore CM, Rajan S, Green M, Doby Knackstedt E, Hauger SB, Steinbach WJ
Clin Infect Dis 2022 Aug 25;75(2):248-259. doi: 10.1093/cid/ciab928. PMID: 35134165Free PMC Article
Alkhars N, Zeng Y, Alomeir N, Al Jallad N, Wu TT, Aboelmagd S, Youssef M, Jang H, Fogarty C, Xiao J
J Dent Res 2022 Jan;101(1):54-62. Epub 2021 May 21 doi: 10.1177/00220345211012385. PMID: 34018817Free PMC Article
Bitew A, Abebaw Y
BMC Womens Health 2018 Jun 15;18(1):94. doi: 10.1186/s12905-018-0607-z. PMID: 29902998Free PMC Article
Winthrop KL, Mariette X, Silva JT, Benamu E, Calabrese LH, Dumusc A, Smolen JS, Aguado JM, Fernández-Ruiz M
Clin Microbiol Infect 2018 Jun;24 Suppl 2:S21-S40. Epub 2018 Feb 12 doi: 10.1016/j.cmi.2018.02.002. PMID: 29447987
Stiehm ER
Pediatr Res 1993 Jan;33(1 Suppl):S2-7; discussion S7-8. doi: 10.1203/00006450-199305001-00007. PMID: 8433870

Recent systematic reviews

Kahwati LC, Clark R, Berkman N, Urrutia R, Patel SV, Zeng J, Viswanathan M
JAMA 2020 Apr 7;323(13):1293-1309. doi: 10.1001/jama.2020.0233. PMID: 32259235

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