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Renal nutcracker syndrome

MedGen UID:
465238
Concept ID:
C3178770
Disease or Syndrome
Synonyms: Nutcracker Syndrome, Renal; Nutcracker Syndromes, Renal; Renal Nutcracker Syndrome; Renal Nutcracker Syndromes; Renal Vein Entrapment Syndrome
SNOMED CT: Left renal vein entrapment syndrome (717267005); Renal nutcracker syndrome (717267005); Left renal vein (LRV) entrapment syndrome (717267005); NCS - nutcracker syndrome (717267005); Mesoaortic compression of left renal vein (717267005)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
Monarch Initiative: MONDO:0019105
Orphanet: ORPHA71273

Definition

Compression of the left renal vein between the superior mesenteric artery and the abdominal aorta causing an increase in the pressure gradient between the left renal vein and the inferior vena cava. The thin septae between the veins and the collecting system in the renal fornices rupture, with resultant left sided haematuria. Most symptomatic cases present in the third or fourth decade of life, with women being more commonly affected than men. Three types of renal nutcracker syndrome have been defined: anterior nutcracker syndrome, posterior nutcracker syndrome and combined nutcracker syndrome. [from SNOMEDCT_US]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRenal nutcracker syndrome
Follow this link to review classifications for Renal nutcracker syndrome in Orphanet.

Professional guidelines

PubMed

Charondo LDB, Hamouche F, Stoller M
Urology 2022 Nov;169:250-255. Epub 2022 Aug 18 doi: 10.1016/j.urology.2022.08.013. PMID: 35987378
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209
O'Brien MT, Gillespie DL
J Vasc Surg Venous Lymphat Disord 2015 Jan;3(1):96-106. Epub 2014 Jun 25 doi: 10.1016/j.jvsv.2014.05.007. PMID: 26993690

Recent clinical studies

Etiology

Dieleman F, Hamming JF, Erben Y, van der Vorst JR
Ann Vasc Surg 2023 Aug;94:178-185. Epub 2023 Apr 5 doi: 10.1016/j.avsg.2023.03.030. PMID: 37023926
Charondo LDB, Hamouche F, Stoller M
Urology 2022 Nov;169:250-255. Epub 2022 Aug 18 doi: 10.1016/j.urology.2022.08.013. PMID: 35987378
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Park JH, Lee GH, Lee SM, Eisenhut M, Kronbichler A, Lee KH, Shin JI
Vasa 2018 Jan;47(1):23-29. Epub 2017 Nov 22 doi: 10.1024/0301-1526/a000670. PMID: 29165061
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209

Diagnosis

Nastasi DR, Fraser AR, Williams AB, Bhamidi V
J Vasc Surg Venous Lymphat Disord 2022 Nov;10(6):1410-1416. Epub 2022 Aug 23 doi: 10.1016/j.jvsv.2022.08.003. PMID: 36007798
Franco-Mesa C, Gloviczki P, Erben Y
J Cardiovasc Surg (Torino) 2021 Oct;62(5):467-471. Epub 2021 Jun 9 doi: 10.23736/S0021-9509.21.11923-8. PMID: 34105927
Kim SH
Korean J Radiol 2019 Dec;20(12):1627-1637. doi: 10.3348/kjr.2019.0084. PMID: 31854150Free PMC Article
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209
Venkatachalam S, Bumpus K, Kapadia SR, Gray B, Lyden S, Shishehbor MH
Ann Vasc Surg 2011 Nov;25(8):1154-64. Epub 2011 Mar 25 doi: 10.1016/j.avsg.2011.01.002. PMID: 21439772

Therapy

Chait J, Sen I, Kalra M
Tech Vasc Interv Radiol 2021 Mar;24(1):100734. Epub 2021 Apr 16 doi: 10.1016/j.tvir.2021.100734. PMID: 34147193
Franco-Mesa C, Gloviczki P, Erben Y
J Cardiovasc Surg (Torino) 2021 Oct;62(5):467-471. Epub 2021 Jun 9 doi: 10.23736/S0021-9509.21.11923-8. PMID: 34105927
Avgerinos ED, Saadeddin Z, Humar R, Salem K, Singh M, Hager E, Makaroun M, Chaer RA
J Vasc Surg Venous Lymphat Disord 2019 Nov;7(6):853-859. Epub 2019 Aug 27 doi: 10.1016/j.jvsv.2019.06.016. PMID: 31471277
Velasquez CA, Saeyeldin A, Zafar MA, Brownstein AJ, Erben Y
J Vasc Surg Venous Lymphat Disord 2018 Mar;6(2):271-278. Epub 2017 Dec 29 doi: 10.1016/j.jvsv.2017.11.005. PMID: 29292117
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209

Prognosis

Franco-Mesa C, Gloviczki P, Erben Y
J Cardiovasc Surg (Torino) 2021 Oct;62(5):467-471. Epub 2021 Jun 9 doi: 10.23736/S0021-9509.21.11923-8. PMID: 34105927
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209
Avgerinos ED, McEnaney R, Chaer RA
Semin Vasc Surg 2013 Dec;26(4):170-7. Epub 2014 Jun 25 doi: 10.1053/j.semvascsurg.2014.06.014. PMID: 25220323
Venkatachalam S, Bumpus K, Kapadia SR, Gray B, Lyden S, Shishehbor MH
Ann Vasc Surg 2011 Nov;25(8):1154-64. Epub 2011 Mar 25 doi: 10.1016/j.avsg.2011.01.002. PMID: 21439772

Clinical prediction guides

Nastasi DR, Fraser AR, Williams AB, Bhamidi V
J Vasc Surg Venous Lymphat Disord 2022 Nov;10(6):1410-1416. Epub 2022 Aug 23 doi: 10.1016/j.jvsv.2022.08.003. PMID: 36007798
Meyer J, Rother U, Stehr M, Meyer A
J Pediatr Surg 2022 Nov;57(11):716-722. Epub 2022 Jan 1 doi: 10.1016/j.jpedsurg.2021.12.019. PMID: 35065803
Meissner MH, Khilnani NM, Labropoulos N, Gasparis AP, Gibson K, Greiner M, Learman LA, Atashroo D, Lurie F, Passman MA, Basile A, Lazarshvilli Z, Lohr J, Kim MD, Nicolini PH, Pabon-Ramos WM, Rosenblatt M
J Vasc Surg Venous Lymphat Disord 2021 May;9(3):568-584. Epub 2021 Jan 30 doi: 10.1016/j.jvsv.2020.12.084. PMID: 33529720
Ananthan K, Onida S, Davies AH
Eur J Vasc Endovasc Surg 2017 Jun;53(6):886-894. Epub 2017 Mar 27 doi: 10.1016/j.ejvs.2017.02.015. PMID: 28356209
Venkatachalam S, Bumpus K, Kapadia SR, Gray B, Lyden S, Shishehbor MH
Ann Vasc Surg 2011 Nov;25(8):1154-64. Epub 2011 Mar 25 doi: 10.1016/j.avsg.2011.01.002. PMID: 21439772

Recent systematic reviews

Fuentes-Perez A, Bush RL, Kalra M, Shortell C, Gloviczki P, Brigham TJ, Li Y, Erben Y
J Vasc Surg Venous Lymphat Disord 2023 Mar;11(2):433-441. Epub 2022 Oct 29 doi: 10.1016/j.jvsv.2022.10.001. PMID: 36404475
Nastasi DR, Fraser AR, Williams AB, Bhamidi V
J Vasc Surg Venous Lymphat Disord 2022 Nov;10(6):1410-1416. Epub 2022 Aug 23 doi: 10.1016/j.jvsv.2022.08.003. PMID: 36007798
Meyer J, Rother U, Stehr M, Meyer A
J Pediatr Surg 2022 Nov;57(11):716-722. Epub 2022 Jan 1 doi: 10.1016/j.jpedsurg.2021.12.019. PMID: 35065803
Velasquez CA, Saeyeldin A, Zafar MA, Brownstein AJ, Erben Y
J Vasc Surg Venous Lymphat Disord 2018 Mar;6(2):271-278. Epub 2017 Dec 29 doi: 10.1016/j.jvsv.2017.11.005. PMID: 29292117
Park JH, Lee GH, Lee SM, Eisenhut M, Kronbichler A, Lee KH, Shin JI
Vasa 2018 Jan;47(1):23-29. Epub 2017 Nov 22 doi: 10.1024/0301-1526/a000670. PMID: 29165061

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