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Paraneoplastic Syndromes, Ocular

MedGen UID:
465285
Concept ID:
C3178817
Disease or Syndrome
Synonyms: Disease, Ocular Paraneoplastic; Diseases, Ocular Paraneoplastic; Ocular Paraneoplastic Disease; Ocular Paraneoplastic Diseases; Ocular Paraneoplastic Syndrome; Ocular Paraneoplastic Syndromes; Paraneoplastic Disease, Ocular; Paraneoplastic Diseases, Ocular; Paraneoplastic Syndrome, Ocular; Syndrome, Ocular Paraneoplastic; Syndromes, Ocular Paraneoplastic

Definition

Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Syndromes, Ocular

Professional guidelines

PubMed

Bardazzi F, Loi C, Chessa Marco A, Di Altobrando A, Filippi F, Lacava R, Viviani F, Balestri R, Leuzzi M, Sacchelli L
Dermatol Ther 2021 Sep;34(5):e15032. Epub 2021 Jul 14 doi: 10.1111/dth.15032. PMID: 34145701
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019
Glantz MJ, Biran H, Myers ME, Gockerman JP, Friedberg MH
Cancer 1994 Jan 1;73(1):168-75. doi: 10.1002/1097-0142(19940101)73:1<168::aid-cncr2820730129>3.0.co;2-z. PMID: 8275420

Recent clinical studies

Etiology

Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019

Diagnosis

Tajfirouz D, Chen JJ
Handb Clin Neurol 2024;200:203-210. doi: 10.1016/B978-0-12-823912-4.00003-7. PMID: 38494278
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Therapy

Brossard-Barbosa N, Dezard V, Margolin E
Ophthalmol Retina 2023 Sep;7(9):819-828. Epub 2023 May 7 doi: 10.1016/j.oret.2023.05.002. PMID: 37160190
Weppelmann TA, Khalil S, Zafrullah N, Amir S, Margo CE
Cancer Control 2022 Jan-Dec;29:10732748221144458. doi: 10.1177/10732748221144458. PMID: 36473045Free PMC Article
Cohen DA, Bhatti MT, Pulido JS, Lennon VA, Dubey D, Flanagan EP, Pittock SJ, Klein CJ, Chen JJ
Ophthalmology 2020 Feb;127(2):221-229. Epub 2019 Sep 20 doi: 10.1016/j.ophtha.2019.09.012. PMID: 31676123
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
Tyagi P, Santiago C
BMC Ophthalmol 2018 Sep 14;18(Suppl 1):221. doi: 10.1186/s12886-018-0861-8. PMID: 30255823Free PMC Article

Prognosis

Janetos TM, Volpe NJ, Simon SS
Chin Clin Oncol 2022 Jun;11(3):25. doi: 10.21037/cco-21-137. PMID: 35818857
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Clinical prediction guides

Gougoulakis LS, Rothermundt C, Flynn MC, Jörger M, Todorova MG
Klin Monbl Augenheilkd 2024 Apr;241(4):510-524. Epub 2024 Apr 23 doi: 10.1055/a-2227-3970. PMID: 38653300
Drača N, Orešković EG, Lazić R, Vukojević M, Radolović Bertetić A, Vukojević N
Medicina (Kaunas) 2023 Dec 13;59(12) doi: 10.3390/medicina59122158. PMID: 38138261Free PMC Article
Gyoten D, Ueno S, Okado S, Chaya T, Yasuda S, Morimoto T, Kondo M, Kimura K, Hayashi T, Leroy BP, Woo SJ, Mukai R, Joo K, Furukawa T
Exp Eye Res 2021 Nov;212:108770. Epub 2021 Sep 22 doi: 10.1016/j.exer.2021.108770. PMID: 34562437
Ray TA, Cochran KJ, Kay JN
Adv Exp Med Biol 2019;1185:251-255. doi: 10.1007/978-3-030-27378-1_41. PMID: 31884620
Hoogewoud F, Butori P, Blanche P, Brézin AP
BMC Ophthalmol 2018 Nov 3;18(1):285. doi: 10.1186/s12886-018-0948-2. PMID: 30390655Free PMC Article

Recent systematic reviews

Brossard-Barbosa N, Dezard V, Margolin E
Ophthalmol Retina 2023 Sep;7(9):819-828. Epub 2023 May 7 doi: 10.1016/j.oret.2023.05.002. PMID: 37160190
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M
Gynecol Oncol 2017 Sep;146(3):661-671. Epub 2017 Jun 24 doi: 10.1016/j.ygyno.2017.06.025. PMID: 28655412

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