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Paraneoplastic Syndromes, Ocular

MedGen UID:
465285
•Concept ID:
C3178817
•
Disease or Syndrome
Synonyms: Disease, Ocular Paraneoplastic; Diseases, Ocular Paraneoplastic; Ocular Paraneoplastic Disease; Ocular Paraneoplastic Diseases; Ocular Paraneoplastic Syndrome; Ocular Paraneoplastic Syndromes; Paraneoplastic Disease, Ocular; Paraneoplastic Diseases, Ocular; Paraneoplastic Syndrome, Ocular; Syndrome, Ocular Paraneoplastic; Syndromes, Ocular Paraneoplastic

Definition

Ocular manifestations secondary to various NEOPLASMS in which antibodies to antigens of the primary tumor cross-react with ocular antigens. This autoimmune response often leads to visual loss and other ocular dysfunctions. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVParaneoplastic Syndromes, Ocular

Professional guidelines

PubMed

Therapeutic approaches and targets for treatment of autoimmune bullous diseases.
Bardazzi F, Loi C, Chessa Marco A, Di Altobrando A, Filippi F, Lacava R, Viviani F, Balestri R, Leuzzi M, Sacchelli L
Dermatol Ther 2021 Sep;34(5):e15032. Epub 2021 Jul 14 doi: 10.1111/dth.15032. PMID: 34145701
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management.
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019
The radiographic diagnosis and treatment of paraneoplastic central nervous system disease.
Glantz MJ, Biran H, Myers ME, Gockerman JP, Friedberg MH
Cancer 1994 Jan 1;73(1):168-75. doi: 10.1002/1097-0142(19940101)73:1<168::aid-cncr2820730129>3.0.co;2-z. PMID: 8275420

Recent clinical studies

Etiology

Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Neoplastic lymphomatous submaculopathy.
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
Paraneoplastic syndromes in ophthalmology.
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239
Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: evaluation and management.
Rahimy E, Sarraf D
Surv Ophthalmol 2013 Sep-Oct;58(5):430-58. doi: 10.1016/j.survophthal.2012.09.001. PMID: 23969019

Diagnosis

Paraneoplastic syndromes in ophthalmology.
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Paraneoplastic syndromes in ophthalmology.
Bussat A, Langner-Lemercier S, Salmon A, Mouriaux F
J Fr Ophtalmol 2018 May;41(5):e181-e185. Epub 2018 May 18 doi: 10.1016/j.jfo.2018.03.002. PMID: 29784239
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Autoimmune retinopathy.
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Therapy

Ocular Paraneoplastic Syndromes: A Critical Review of Diffuse Uveal Melanocytic Proliferation and Autoimmune Retinopathy.
Weppelmann TA, Khalil S, Zafrullah N, Amir S, Margo CE
Cancer Control 2022 Jan-Dec;29:10732748221144458. doi: 10.1177/10732748221144458. PMID: 36473045Free PMC Article
Collapsin Response-Mediator Protein 5-Associated Retinitis, Vitritis, and Optic Disc Edema.
Cohen DA, Bhatti MT, Pulido JS, Lennon VA, Dubey D, Flanagan EP, Pittock SJ, Klein CJ, Chen JJ
Ophthalmology 2020 Feb;127(2):221-229. Epub 2019 Sep 20 doi: 10.1016/j.ophtha.2019.09.012. PMID: 31676123
Neoplastic lymphomatous submaculopathy.
Testi I, Agarwal A, Gupta V; PGI Ocular Lymphoma Study Group
Indian J Ophthalmol 2019 Dec;67(12):2051-2052. doi: 10.4103/ijo.IJO_1697_19. PMID: 31755451Free PMC Article
New features in MEK retinopathy.
Tyagi P, Santiago C
BMC Ophthalmol 2018 Sep 14;18(Suppl 1):221. doi: 10.1186/s12886-018-0861-8. PMID: 30255823Free PMC Article
Ophthalmology manifestations of pediatric cancer treatment.
Salvin JH, Hendricks D
Curr Opin Ophthalmol 2012 Sep;23(5):394-9. doi: 10.1097/ICU.0b013e328356230f. PMID: 22729184

Prognosis

Neuro-ophthalmic manifestations of cancer: a narrative review.
Janetos TM, Volpe NJ, Simon SS
Chin Clin Oncol 2022 Jun;11(3):25. doi: 10.21037/cco-21-137. PMID: 35818857
Paraneoplastic syndromes in ophthalmology.
Parrado-Carrillo A, Alcubierre R, Camós-Carreras A, Sanchez-Dalmau BF
Arch Soc Esp Oftalmol (Engl Ed) 2022 Jun;97(6):350-357. Epub 2022 Mar 12 doi: 10.1016/j.oftale.2022.03.006. PMID: 35292226
Melanoma-associated retinopathy.
Elsheikh S, Gurney SP, Burdon MA
Clin Exp Dermatol 2020 Mar;45(2):147-152. Epub 2019 Nov 19 doi: 10.1111/ced.14095. PMID: 31742740
Autoimmune retinopathy.
Grange L, Dalal M, Nussenblatt RB, Sen HN
Am J Ophthalmol 2014 Feb;157(2):266-272.e1. Epub 2013 Sep 29 doi: 10.1016/j.ajo.2013.09.019. PMID: 24315290Free PMC Article
Autoimmune retinopathy.
Braithwaite T, Vugler A, Tufail A
Ophthalmologica 2012;228(3):131-42. Epub 2012 Jul 28 doi: 10.1159/000338240. PMID: 22846442

Clinical prediction guides

Broad locations of antigenic regions for anti-TRPM1 autoantibodies in paraneoplastic retinopathy with retinal ON bipolar cell dysfunction.
Gyoten D, Ueno S, Okado S, Chaya T, Yasuda S, Morimoto T, Kondo M, Kimura K, Hayashi T, Leroy BP, Woo SJ, Mukai R, Joo K, Furukawa T
Exp Eye Res 2021 Nov;212:108770. Epub 2021 Sep 22 doi: 10.1016/j.exer.2021.108770. PMID: 34562437
The Enigma of CRB1 and CRB1 Retinopathies.
Ray TA, Cochran KJ, Kay JN
Adv Exp Med Biol 2019;1185:251-255. doi: 10.1007/978-3-030-27378-1_41. PMID: 31884620
Giraffe or leopard spot chorioretinopathy as an outstanding finding: case report and literature review.
Jabbarpoor Bonyadi MH, Ownagh V, Rahimy E, Soheilian M
Int Ophthalmol 2019 Jun;39(6):1405-1412. Epub 2018 Jun 8 doi: 10.1007/s10792-018-0948-5. PMID: 29948498
Cancer-associated retinopathy preceding the diagnosis of cancer.
Hoogewoud F, Butori P, Blanche P, Brézin AP
BMC Ophthalmol 2018 Nov 3;18(1):285. doi: 10.1186/s12886-018-0948-2. PMID: 30390655Free PMC Article
Bilateral diffuse uveal melanocytic proliferation with multiple iris cysts.
Joseph A, Rahimy E, Sarraf D
JAMA Ophthalmol 2014 Jun;132(6):756-60. doi: 10.1001/jamaophthalmol.2014.311. PMID: 24763691

Recent systematic reviews

Treatment of Cancer-Associated Retinopathy: A Systematic Literature Review.
Brossard-Barbosa N, Dezard V, Margolin E
Ophthalmol Retina 2023 Sep;7(9):819-828. Epub 2023 May 7 doi: 10.1016/j.oret.2023.05.002. PMID: 37160190
Paraneoplastic ocular syndrome: a pandora's box of underlying malignancies.
Sarkar P, Mehtani A, Gandhi HC, Bhalla JS, Tapariya S
Eye (Lond) 2022 Jul;36(7):1355-1367. Epub 2021 Aug 3 doi: 10.1038/s41433-021-01676-x. PMID: 34345027Free PMC Article
Paraneoplastic syndromes associated with gynecological cancers: A systematic review.
Viau M, Renaud MC, Grégoire J, Sebastianelli A, Plante M
Gynecol Oncol 2017 Sep;146(3):661-671. Epub 2017 Jun 24 doi: 10.1016/j.ygyno.2017.06.025. PMID: 28655412

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