U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Malignant Gastrointestinal Stromal Tumor

MedGen UID:
465816
•Concept ID:
C3179349
•
Neoplastic Process
Synonym: Gastrointestinal Stromal Sarcoma
SNOMED CT: Gastrointestinal stromal tumor, malignant (128756002); Gastrointestinal stromal sarcoma (128756002); Gastrointestinal stromal sarcoma (420120006); Malignant GIST (gastrointestinal stromal tumor) (128756002)

Definition

A gastrointestinal stromal tumor that is characterized by large size (diameter greater than 10 cm for gastric localization and greater than 5 cm for intestinal localization) or more than 5 mitotic figures per 50 high power fields. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Gastrointestinal Stromal Tumor

Professional guidelines

PubMed

Giant malignant gastrointestinal stromal tumors: recurrence and effects of treatment with STI-571.
Chen TW, Liu HD, Shyu RY, Yu JC, Shih ML, Chang TM, Hsieh CB
World J Gastroenterol 2005 Jan 14;11(2):260-3. doi: 10.3748/wjg.v11.i2.260. PMID: 15633227Free PMC Article

Recent clinical studies

Etiology

Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
Diagnosis by endoscopic ultrasound of a large aberrant pancreas mimicking malignant gastrointestinal stromal tumor of the stomach.
Akaraviputh T, Manuyakorn A, Lohsiriwat V
Endoscopy 2009;41 Suppl 2:E63-4. Epub 2009 Mar 24 doi: 10.1055/s-0028-1119457. PMID: 19319784
The radiology of gastrointestinal stromal tumours (GIST).
King DM
Cancer Imaging 2005 Dec 15;5(1):150-6. doi: 10.1102/1470-7330.2005.0109. PMID: 16361144Free PMC Article
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462
Malignant gastrointestinal stromal tumor: distribution, imaging features, and pattern of metastatic spread.
Burkill GJ, Badran M, Al-Muderis O, Meirion Thomas J, Judson IR, Fisher C, Moskovic EC
Radiology 2003 Feb;226(2):527-32. doi: 10.1148/radiol.2262011880. PMID: 12563150

Diagnosis

Pancreatic Malignant Gastrointestinal Stromal Tumor: a Case Report.
Pandit N, Yadav TN, Lacoul R, Dongol R, Awale L, Adhikary S
J Gastrointest Cancer 2020 Mar;51(1):314-316. doi: 10.1007/s12029-019-00253-6. PMID: 31102170
Supraclavicular lymph node metastases from malignant gastrointestinal stromal tumor of the jejunum: A case report with review of the literature.
Ma C, Hao SL, Liu XC, Nin JY, Wu GC, Jiang LX, Fancellu A, Porcu A, Zheng HT
World J Gastroenterol 2017 Mar 14;23(10):1920-1924. doi: 10.3748/wjg.v23.i10.1920. PMID: 28348499Free PMC Article
Diagnosis by endoscopic ultrasound of a large aberrant pancreas mimicking malignant gastrointestinal stromal tumor of the stomach.
Akaraviputh T, Manuyakorn A, Lohsiriwat V
Endoscopy 2009;41 Suppl 2:E63-4. Epub 2009 Mar 24 doi: 10.1055/s-0028-1119457. PMID: 19319784
Long-term control for a retroperitoneal metastasis of malignant gastrointestinal stromal tumor after chemoradiotherapy and immunotherapy.
Shioyama Y, Yakeishi Y, Watanabe T, Nakamura K, Kunitake N, Kimura M, Sasaki M, Honda H, Terashima H, Masuda K
Acta Oncol 2001;40(1):102-4. doi: 10.1080/028418601750071154. PMID: 11321651
Image of the Month. Malignant gastrointestinal stromal tumor of the stomach, uncommitted type.
Kokubun N, Hiraishi H, Terano A
Gastroenterology 1998 Oct;115(4):812, 1037. PMID: 9786736

Therapy

Supraclavicular lymph node metastases from malignant gastrointestinal stromal tumor of the jejunum: A case report with review of the literature.
Ma C, Hao SL, Liu XC, Nin JY, Wu GC, Jiang LX, Fancellu A, Porcu A, Zheng HT
World J Gastroenterol 2017 Mar 14;23(10):1920-1924. doi: 10.3748/wjg.v23.i10.1920. PMID: 28348499Free PMC Article
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
Imaging characteristics of liver metastasis from gastrointestinal stromal tumor before and after imatinib mesylate treatment.
Ulusan S, Koç Z, Kayaselçuk F
Turk J Gastroenterol 2008 Jun;19(2):129-32. PMID: 19110671
Malignant gastrointestinal stromal tumor of the small intestine complicated with pulmonary tuberculosis during treatment with imatinib mesylate.
Takashima M, Igaki N, Matsuda T, Ohyama M, Kanda S, Tamada F, Goto T
Intern Med 2005 Feb;44(2):114-9. doi: 10.2169/internalmedicine.44.114. PMID: 15750270
Long-term control for a retroperitoneal metastasis of malignant gastrointestinal stromal tumor after chemoradiotherapy and immunotherapy.
Shioyama Y, Yakeishi Y, Watanabe T, Nakamura K, Kunitake N, Kimura M, Sasaki M, Honda H, Terashima H, Masuda K
Acta Oncol 2001;40(1):102-4. doi: 10.1080/028418601750071154. PMID: 11321651

Prognosis

Primary Malignant Gastrointestinal Stromal Tumor (GIST) of the Gallbladder: Report of a Case.
Bolanaki H, Delladetsima I, Argyropoulou P, Kapranou A, Kakolyris S, Simopoulos C, Karayiannakis AJ
J Gastrointest Cancer 2012 Sep;43 Suppl 1:S151-5. doi: 10.1007/s12029-011-9346-1. PMID: 22086710
Malignant gastrointestinal stromal tumor presenting with hemoperitoneum in puerperium: report of a case with review of the literature.
Varras M, Vlachakos N, Akrivis C, Vasilakaki T, Skafida E
World J Surg Oncol 2010 Nov 7;8:95. doi: 10.1186/1477-7819-8-95. PMID: 21054898Free PMC Article
Imaging characteristics of liver metastasis from gastrointestinal stromal tumor before and after imatinib mesylate treatment.
Ulusan S, Koç Z, Kayaselçuk F
Turk J Gastroenterol 2008 Jun;19(2):129-32. PMID: 19110671
Malignant gastrointestinal stromal tumor of the small intestine complicated with pulmonary tuberculosis during treatment with imatinib mesylate.
Takashima M, Igaki N, Matsuda T, Ohyama M, Kanda S, Tamada F, Goto T
Intern Med 2005 Feb;44(2):114-9. doi: 10.2169/internalmedicine.44.114. PMID: 15750270
Malignant gastrointestinal leiomyosarcoma and gastrointestinal stromal tumor with prominent osteoclast-like giant cells.
Insabato L, Di Vizio D, Ciancia G, Pettinato G, Tornillo L, Terracciano L
Arch Pathol Lab Med 2004 Apr;128(4):440-3. doi: 10.5858/2004-128-440-MGLAGS. PMID: 15043462

Clinical prediction guides

ACRIN 6665/RTOG 0132 phase II trial of neoadjuvant imatinib mesylate for operable malignant gastrointestinal stromal tumor: monitoring with 18F-FDG PET and correlation with genotype and GLUT4 expression.
Van den Abbeele AD, Gatsonis C, de Vries DJ, Melenevsky Y, Szot-Barnes A, Yap JT, Godwin AK, Rink L, Huang M, Blevins M, Sicks J, Eisenberg B, Siegel BA
J Nucl Med 2012 Apr;53(4):567-74. Epub 2012 Mar 1 doi: 10.2967/jnumed.111.094425. PMID: 22381410Free PMC Article
Loss of chromosome 9p21 and decreased p16 expression correlate with malignant gastrointestinal stromal tumor.
Zhang Y, Cao H, Wang M, Zhao WY, Shen ZY, Shen DP, Ni XZ, Wu ZY, Shen YY, Song YY
World J Gastroenterol 2010 Oct 7;16(37):4716-24. doi: 10.3748/wjg.v16.i37.4716. PMID: 20872974Free PMC Article
Antiangiogenic drugs in oncology: a focus on drug safety and the elderly - a mini-review.
Boehm S, Rothermundt C, Hess D, Joerger M
Gerontology 2010;56(3):303-9. Epub 2009 Nov 26 doi: 10.1159/000262450. PMID: 19940466
The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000.
Tran T, Davila JA, El-Serag HB
Am J Gastroenterol 2005 Jan;100(1):162-8. doi: 10.1111/j.1572-0241.2005.40709.x. PMID: 15654796
Clinicopathologic study of primary malignant gastrointestinal stromal tumor of the stomach, with special reference to prognostic factors: analysis of results in 140 surgically resected patients.
Fujimoto Y, Nakanishi Y, Yoshimura K, Shimoda T
Gastric Cancer 2003;6(1):39-48. doi: 10.1007/s101200300005. PMID: 12673425

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...