U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Breast milk jaundice

MedGen UID:
468560
•Concept ID:
C0270215
•
Pathologic Function
Synonym: BREAST MILK JAUNDICE
SNOMED CT: Breast milk inhibitor jaundice (82696006); Breast milk jaundice (82696006); Neonatal jaundice due to delayed conjugation from breast milk inhibitor (82696006); Breast-feeding inhibitor causing neonatal jaundice (82696006)
 
OMIM®: 237900

Definition

Jaundice in an otherwise healthy breast-fed newborn. It appears four to seven days after birth, lasts longer than the physiologic jaundice, and there are no identifiable causes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast milk jaundice

Professional guidelines

PubMed

Impact of a standardized protocol for the Management of Prolonged Neonatal Jaundice in a regional setting: an interventional quasi-experimental study.
Tan HS, Balasubramaniam IS, Hss AS, Yeong ML, Chew CC, Singh RP, Leow AY, Damanhuri FM, Verasingam S
BMC Pediatr 2019 May 29;19(1):174. doi: 10.1186/s12887-019-1550-3. PMID: 31142302Free PMC Article
Interruption of breast-feeding versus phototherapy as treatment of hyperbilirubinemia in full-term infants.
Amato M, Howald H, von Muralt G
Helv Paediatr Acta 1985 Jul;40(2-3):127-31. PMID: 3843244

Recent clinical studies

Etiology

Effect of Epidermal Growth Factor in Human Milk and Maternal Diet on Late-Onset Breast Milk Jaundice: A Case-Control Study in Beijing.
Guo Q, Cui M, Liu X, Zhao S, Liu P, Wang L
Nutrients 2022 Nov 1;14(21) doi: 10.3390/nu14214587. PMID: 36364849Free PMC Article
Breastfeeding during breast milk jaundice - a pathophysiological perspective.
Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480
Breast milk jaundice: effect of bacteria present in breast milk and infant feces.
Tuzun F, Kumral A, Duman N, Ozkan H
J Pediatr Gastroenterol Nutr 2013 Mar;56(3):328-32. doi: 10.1097/MPG.0b013e31827a964b. PMID: 23132163
Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599

Diagnosis

Inherited disorders of bilirubin clearance.
Memon N, Weinberger BI, Hegyi T, Aleksunes LM
Pediatr Res 2016 Mar;79(3):378-86. Epub 2015 Nov 23 doi: 10.1038/pr.2015.247. PMID: 26595536Free PMC Article
Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Breastfeeding and breast milk jaundice.
Leung AK, Sauve RS
J R Soc Health 1989 Dec;109(6):213-7. doi: 10.1177/146642408910900615. PMID: 2513410
Breastfeeding and human milk: their association with jaundice in the neonate.
Auerbach KG, Gartner LM
Clin Perinatol 1987 Mar;14(1):89-107. PMID: 3549117

Therapy

Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Neonatal jaundice, animal-induced injuries, and immunizations.
Koh AY, Bernstein HH
Curr Opin Pediatr 2000 Aug;12(4):413-25. doi: 10.1097/00008480-200008000-00023. PMID: 10943826
Breast-milk jaundice and oral contraceptives.
Wong YK, Wood BS
Br Med J 1971 Nov 13;4(5784):403-4. doi: 10.1136/bmj.4.5784.403. PMID: 5166361Free PMC Article

Prognosis

Characterization of gut microbiota and short-chain fatty acid in breastfed infants with or without breast milk jaundice.
Duan M, Han ZH, Huang T, Yang Y, Huang B
Lett Appl Microbiol 2021 Jan;72(1):60-67. Epub 2020 Oct 7 doi: 10.1111/lam.13382. PMID: 32893879
Cytokines in human milk and late-onset breast milk jaundice.
Apaydin K, Ermis B, Arasli M, Tekin I, Ankarali H
Pediatr Int 2012 Dec;54(6):801-5. Epub 2012 Sep 11 doi: 10.1111/j.1442-200X.2012.03680.x. PMID: 22672115
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Neonatal jaundice, animal-induced injuries, and immunizations.
Koh AY, Bernstein HH
Curr Opin Pediatr 2000 Aug;12(4):413-25. doi: 10.1097/00008480-200008000-00023. PMID: 10943826
Breast milk jaundice in preterm infants.
Sirota L, Nussinovitch M, Landman J, Dulitzky F
Clin Pediatr (Phila) 1988 Apr;27(4):195-7. doi: 10.1177/000992288802700404. PMID: 3349728

Clinical prediction guides

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review.
Gao C, Guo Y, Huang M, He J, Qiu X
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102261. PMID: 37242142Free PMC Article
Characterization of gut microbiota and short-chain fatty acid in breastfed infants with or without breast milk jaundice.
Duan M, Han ZH, Huang T, Yang Y, Huang B
Lett Appl Microbiol 2021 Jan;72(1):60-67. Epub 2020 Oct 7 doi: 10.1111/lam.13382. PMID: 32893879
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Neonatal jaundice, animal-induced injuries, and immunizations.
Koh AY, Bernstein HH
Curr Opin Pediatr 2000 Aug;12(4):413-25. doi: 10.1097/00008480-200008000-00023. PMID: 10943826
Human milk in disease: lipid composition.
Hamosh M, Bitman J
Lipids 1992 Nov;27(11):848-57. doi: 10.1007/BF02535863. PMID: 1491602

Recent systematic reviews

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review.
Gao C, Guo Y, Huang M, He J, Qiu X
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102261. PMID: 37242142Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • OMIM
      Related records in OMIM
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed
    • PubMed (OMIM)
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...