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Breast milk jaundice

MedGen UID:
468560
•Concept ID:
C0270215
•
Pathologic Function
Synonym: BREAST MILK JAUNDICE
SNOMED CT: Breast milk inhibitor jaundice (82696006); Breast milk jaundice (82696006); Neonatal jaundice due to delayed conjugation from breast milk inhibitor (82696006); Breast-feeding inhibitor causing neonatal jaundice (82696006)
 
OMIM®: 237900

Definition

Jaundice in an otherwise healthy breast-fed newborn. It appears four to seven days after birth, lasts longer than the physiologic jaundice, and there are no identifiable causes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast milk jaundice

Professional guidelines

PubMed

Impact of a standardized protocol for the Management of Prolonged Neonatal Jaundice in a regional setting: an interventional quasi-experimental study.
Tan HS, Balasubramaniam IS, Hss AS, Yeong ML, Chew CC, Singh RP, Leow AY, Damanhuri FM, Verasingam S
BMC Pediatr 2019 May 29;19(1):174. doi: 10.1186/s12887-019-1550-3. PMID: 31142302Free PMC Article
Interruption of breast-feeding versus phototherapy as treatment of hyperbilirubinemia in full-term infants.
Amato M, Howald H, von Muralt G
Helv Paediatr Acta 1985 Jul;40(2-3):127-31. PMID: 3843244

Recent clinical studies

Etiology

Breastfeeding during breast milk jaundice - a pathophysiological perspective.
Prameela KK
Med J Malaysia 2019 Dec;74(6):527-533. PMID: 31929480
Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Cytokines in human milk and late-onset breast milk jaundice.
Apaydin K, Ermis B, Arasli M, Tekin I, Ankarali H
Pediatr Int 2012 Dec;54(6):801-5. Epub 2012 Sep 11 doi: 10.1111/j.1442-200X.2012.03680.x. PMID: 22672115
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
The hereditary hyperbilirubinaemias.
Nowicki MJ, Poley JR
Baillieres Clin Gastroenterol 1998 Jun;12(2):355-67. doi: 10.1016/s0950-3528(98)90139-7. PMID: 9890077

Diagnosis

Inherited disorders of bilirubin clearance.
Memon N, Weinberger BI, Hegyi T, Aleksunes LM
Pediatr Res 2016 Mar;79(3):378-86. Epub 2015 Nov 23 doi: 10.1038/pr.2015.247. PMID: 26595536Free PMC Article
Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Breastfeeding and breast milk jaundice.
Leung AK, Sauve RS
J R Soc Health 1989 Dec;109(6):213-7. doi: 10.1177/146642408910900615. PMID: 2513410
Breastfeeding and human milk: their association with jaundice in the neonate.
Auerbach KG, Gartner LM
Clin Perinatol 1987 Mar;14(1):89-107. PMID: 3549117

Therapy

Hyperbilirubinemia and management of breastfeeding.
Soldi A, Tonetto P, Chiale F, Varalda A, Peila C, Sabatino G, Occhi L, Giuliani F, Perathoner C, Prandi G
J Biol Regul Homeost Agents 2012 Jul-Sep;26(3 Suppl):25-9. PMID: 23158510
Neonatal jaundice and human milk.
Soldi A, Tonetto P, Varalda A, Bertino E
J Matern Fetal Neonatal Med 2011 Oct;24 Suppl 1:85-7. doi: 10.3109/14767058.2011.607612. PMID: 21942599
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Breast-milk jaundice and the pill.
Wood BS, Wong YK
Br Med J 1972 May 27;2(5812):531. doi: 10.1136/bmj.2.5812.531-a. PMID: 5031234Free PMC Article
Breast-milk jaundice and oral contraceptives.
Wong YK, Wood BS
Br Med J 1971 Nov 13;4(5784):403-4. doi: 10.1136/bmj.4.5784.403. PMID: 5166361Free PMC Article

Prognosis

Characterization of gut microbiota and short-chain fatty acid in breastfed infants with or without breast milk jaundice.
Duan M, Han ZH, Huang T, Yang Y, Huang B
Lett Appl Microbiol 2021 Jan;72(1):60-67. Epub 2020 Oct 7 doi: 10.1111/lam.13382. PMID: 32893879
Cytokines in human milk and late-onset breast milk jaundice.
Apaydin K, Ermis B, Arasli M, Tekin I, Ankarali H
Pediatr Int 2012 Dec;54(6):801-5. Epub 2012 Sep 11 doi: 10.1111/j.1442-200X.2012.03680.x. PMID: 22672115
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Neonatal jaundice, animal-induced injuries, and immunizations.
Koh AY, Bernstein HH
Curr Opin Pediatr 2000 Aug;12(4):413-25. doi: 10.1097/00008480-200008000-00023. PMID: 10943826
Breast milk jaundice in preterm infants.
Sirota L, Nussinovitch M, Landman J, Dulitzky F
Clin Pediatr (Phila) 1988 Apr;27(4):195-7. doi: 10.1177/000992288802700404. PMID: 3349728

Clinical prediction guides

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review.
Gao C, Guo Y, Huang M, He J, Qiu X
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102261. PMID: 37242142Free PMC Article
Characterization of gut microbiota and short-chain fatty acid in breastfed infants with or without breast milk jaundice.
Duan M, Han ZH, Huang T, Yang Y, Huang B
Lett Appl Microbiol 2021 Jan;72(1):60-67. Epub 2020 Oct 7 doi: 10.1111/lam.13382. PMID: 32893879
Understanding and managing breast milk jaundice.
Preer GL, Philipp BL
Arch Dis Child Fetal Neonatal Ed 2011 Nov;96(6):F461-6. Epub 2010 Aug 5 doi: 10.1136/adc.2010.184416. PMID: 20688866
Neonatal jaundice, animal-induced injuries, and immunizations.
Koh AY, Bernstein HH
Curr Opin Pediatr 2000 Aug;12(4):413-25. doi: 10.1097/00008480-200008000-00023. PMID: 10943826
Breast mild jaundice: natural history, familial incidence and late neurodevelopmental outcome of the infant.
Grunebaum E, Amir J, Merlob P, Mimouni M, Varsano I
Eur J Pediatr 1991 Feb;150(4):267-70. doi: 10.1007/BF01955528. PMID: 2029918

Recent systematic reviews

Breast Milk Constituents and the Development of Breast Milk Jaundice in Neonates: A Systematic Review.
Gao C, Guo Y, Huang M, He J, Qiu X
Nutrients 2023 May 10;15(10) doi: 10.3390/nu15102261. PMID: 37242142Free PMC Article

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