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Pancreatic Intraepithelial Neoplasia

MedGen UID:
468983
Concept ID:
C1301034
Neoplastic Process
Synonyms: Pancreatic Dysplasia; Pancreatic intraepithelial neoplasia; Pancreatic intraepithelial neoplasia (PanIN)
SNOMED CT: Pancreatic intraepithelial neoplasia (PanIN) (396871009); Pancreatic intraepithelial neoplasia (396871009)

Definition

A pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts. It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter. [from NCI]

Professional guidelines

PubMed

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Benzel J, Fendrich V
Digestion 2018;97(4):275-287. Epub 2018 Mar 27 doi: 10.1159/000485741. PMID: 29587290
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Recent clinical studies

Etiology

Wang L, Xie D, Wei D
Methods Mol Biol 2019;1882:299-308. doi: 10.1007/978-1-4939-8879-2_26. PMID: 30378064
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Benzel J, Fendrich V
Oncol Res Treat 2018;41(10):611-618. Epub 2018 Sep 28 doi: 10.1159/000493473. PMID: 30269130
Lindquist CM, Miller FH, Hammond NA, Nikolaidis P
Abdom Radiol (NY) 2018 Feb;43(2):264-272. doi: 10.1007/s00261-017-1308-z. PMID: 28840303
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Diagnosis

Takahashi K, Takeda Y, Ono Y, Isomoto H, Mizukami Y
J Gastroenterol 2023 Sep;58(9):834-847. Epub 2023 Jul 20 doi: 10.1007/s00535-023-02024-4. PMID: 37470859Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Benzel J, Fendrich V
Oncol Res Treat 2018;41(10):611-618. Epub 2018 Sep 28 doi: 10.1159/000493473. PMID: 30269130
Storz P
Nat Rev Gastroenterol Hepatol 2017 May;14(5):296-304. Epub 2017 Mar 8 doi: 10.1038/nrgastro.2017.12. PMID: 28270694Free PMC Article
Mitchell RM, Byrne MF, Baillie J
Lancet 2003 Apr 26;361(9367):1447-55. doi: 10.1016/s0140-6736(03)13139-x. PMID: 12727412

Therapy

Zhang Z, Cheng L, Li J, Qiao Q, Karki A, Allison DB, Shaker N, Li K, Utturkar SM, Atallah Lanman NM, Rao X, Rychahou P, He D, Konieczny SF, Wang C, Shao Q, Evers BM, Liu X
Cancer Res 2022 Oct 4;82(19):3532-3548. doi: 10.1158/0008-5472.CAN-22-0018. PMID: 35950917Free PMC Article
Hanada K, Shimizu A, Kurihara K, Ikeda M, Yamamoto T, Okuda Y, Tazuma S
Dig Endosc 2022 Jul;34(5):927-937. Epub 2022 Feb 14 doi: 10.1111/den.14240. PMID: 35165942
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Benzel J, Fendrich V
Digestion 2018;97(4):275-287. Epub 2018 Mar 27 doi: 10.1159/000485741. PMID: 29587290
Mitchell RM, Byrne MF, Baillie J
Lancet 2003 Apr 26;361(9367):1447-55. doi: 10.1016/s0140-6736(03)13139-x. PMID: 12727412

Prognosis

Takahashi K, Takeda Y, Ono Y, Isomoto H, Mizukami Y
J Gastroenterol 2023 Sep;58(9):834-847. Epub 2023 Jul 20 doi: 10.1007/s00535-023-02024-4. PMID: 37470859Free PMC Article
Jiang SH, Zhu LL, Zhang M, Li RK, Yang Q, Yan JY, Zhang C, Yang JY, Dong FY, Dai M, Hu LP, Li J, Li Q, Wang YH, Yang XM, Zhang YL, Nie HZ, Zhu L, Zhang XL, Tian GA, Zhang XX, Cao XY, Tao LY, Huang S, Jiang YS, Hua R, Qian Luo K, Gu JR, Sun YW, Hou S, Zhang ZG
Gut 2019 Nov;68(11):1994-2006. Epub 2019 Mar 2 doi: 10.1136/gutjnl-2018-317479. PMID: 30826748
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Benzel J, Fendrich V
Digestion 2018;97(4):275-287. Epub 2018 Mar 27 doi: 10.1159/000485741. PMID: 29587290
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article

Clinical prediction guides

Faur AC, Lazar DC, Ghenciu LA
World J Gastroenterol 2023 Mar 28;29(12):1811-1823. doi: 10.3748/wjg.v29.i12.1811. PMID: 37032728Free PMC Article
Carpenter ES, Elhossiny AM, Kadiyala P, Li J, McGue J, Griffith BD, Zhang Y, Edwards J, Nelson S, Lima F, Donahue KL, Du W, Bischoff AC, Alomari D, Watkoske HR, Mattea M, The S, Espinoza CE, Barrett M, Sonnenday CJ, Olden N, Chen CT, Peterson N, Gunchick V, Sahai V, Rao A, Bednar F, Shi J, Frankel TL, Pasca di Magliano M
Cancer Discov 2023 Jun 2;13(6):1324-1345. doi: 10.1158/2159-8290.CD-23-0013. PMID: 37021392Free PMC Article
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Basturk O, Hong SM, Wood LD, Adsay NV, Albores-Saavedra J, Biankin AV, Brosens LA, Fukushima N, Goggins M, Hruban RH, Kato Y, Klimstra DS, Klöppel G, Krasinskas A, Longnecker DS, Matthaei H, Offerhaus GJ, Shimizu M, Takaori K, Terris B, Yachida S, Esposito I, Furukawa T; Baltimore Consensus Meeting
Am J Surg Pathol 2015 Dec;39(12):1730-41. doi: 10.1097/PAS.0000000000000533. PMID: 26559377Free PMC Article
Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R
Cancer Cell 2014 Jun 16;25(6):719-34. Epub 2014 May 22 doi: 10.1016/j.ccr.2014.04.005. PMID: 24856586Free PMC Article

Recent systematic reviews

Mattiolo P, Wang H, Basturk O, Brosens LAA, Hong SM, Adsay V, Scarpa A, Luchini C
J Clin Pathol 2023 Nov;76(11):740-746. Epub 2023 Aug 29 doi: 10.1136/jcp-2023-209103. PMID: 37643836
Corral JE, Mareth KF, Riegert-Johnson DL, Das A, Wallace MB
Clin Gastroenterol Hepatol 2019 Jan;17(1):41-53. Epub 2018 Jun 30 doi: 10.1016/j.cgh.2018.04.065. PMID: 29775792

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