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Metabolic dysfunction-associated steatohepatitis

MedGen UID:
469032
Concept ID:
C3241937
Disease or Syndrome
Synonym: Non-alcoholic steatohepatitis
SNOMED CT: NASH - Nonalcoholic steatohepatitis (442685003); Nonalcoholic steatohepatitis (442685003); Non-alcoholic steatohepatitis (442685003)
 
Monarch Initiative: MONDO:0007027

Definition

Fatty replacement and damage to the hepatocytes not related to alcohol use. It may lead to cirrhosis and liver failure. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetabolic dysfunction-associated steatohepatitis

Professional guidelines

PubMed

European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Zeng J, Fan JG, Francque SM
United European Gastroenterol J 2024 Mar;12(2):177-186. Epub 2024 Jan 9 doi: 10.1002/ueg2.12525. PMID: 38193865Free PMC Article
Ilagan-Ying YC, Banini BA, Do A, Lam R, Lim JK
Curr Gastroenterol Rep 2023 Oct;25(10):213-224. Epub 2023 Sep 28 doi: 10.1007/s11894-023-00883-8. PMID: 37768417

Recent clinical studies

Etiology

Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E, Yoneda M, Behling C, Cummings OW, Tang Y, Brouwers B, Robins DA, Nikooie A, Bunck MC, Haupt A, Sanyal AJ; SYNERGY-NASH Investigators
N Engl J Med 2024 Jul 25;391(4):299-310. Epub 2024 Jun 8 doi: 10.1056/NEJMoa2401943. PMID: 38856224
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Tincopa MA, Anstee QM, Loomba R
Cell Metab 2024 May 7;36(5):912-926. Epub 2024 Apr 11 doi: 10.1016/j.cmet.2024.03.011. PMID: 38608696
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495
Newsome PN, Ambery P
J Hepatol 2023 Dec;79(6):1557-1565. Epub 2023 Aug 9 doi: 10.1016/j.jhep.2023.07.033. PMID: 37562748

Diagnosis

European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
Obes Facts 2024;17(4):374-444. Epub 2024 Jun 7 doi: 10.1159/000539371. PMID: 38852583Free PMC Article
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Kanwal F, Neuschwander-Tetri BA, Loomba R, Rinella ME
Hepatology 2024 May 1;79(5):1212-1219. Epub 2023 Nov 9 doi: 10.1097/HEP.0000000000000670. PMID: 38445559
Zeng J, Fan JG, Francque SM
United European Gastroenterol J 2024 Mar;12(2):177-186. Epub 2024 Jan 9 doi: 10.1002/ueg2.12525. PMID: 38193865Free PMC Article
Ilagan-Ying YC, Banini BA, Do A, Lam R, Lim JK
Curr Gastroenterol Rep 2023 Oct;25(10):213-224. Epub 2023 Sep 28 doi: 10.1007/s11894-023-00883-8. PMID: 37768417

Therapy

Loomba R, Hartman ML, Lawitz EJ, Vuppalanchi R, Boursier J, Bugianesi E, Yoneda M, Behling C, Cummings OW, Tang Y, Brouwers B, Robins DA, Nikooie A, Bunck MC, Haupt A, Sanyal AJ; SYNERGY-NASH Investigators
N Engl J Med 2024 Jul 25;391(4):299-310. Epub 2024 Jun 8 doi: 10.1056/NEJMoa2401943. PMID: 38856224
Zeng J, Fan JG, Francque SM
United European Gastroenterol J 2024 Mar;12(2):177-186. Epub 2024 Jan 9 doi: 10.1002/ueg2.12525. PMID: 38193865Free PMC Article
Wang K, Zhang Y, Wang G, Hao H, Wang H
Med Res Rev 2024 Mar;44(2):568-586. Epub 2023 Oct 30 doi: 10.1002/med.21991. PMID: 37899676
Pan C, Liu J, Gao Y, Yang M, Hu H, Liu C, Qian M, Yuan HY, Yang S, Zheng MH, Wang L
Cell Metab 2023 Dec 5;35(12):2231-2249.e7. doi: 10.1016/j.cmet.2023.10.018. PMID: 38056431
Newsome PN, Ambery P
J Hepatol 2023 Dec;79(6):1557-1565. Epub 2023 Aug 9 doi: 10.1016/j.jhep.2023.07.033. PMID: 37562748

Prognosis

Tao L, Yang X, Ge C, Zhang P, He W, Xu X, Li X, Chen W, Yu Y, Zhang H, Chen SD, Pan XY, Su Y, Xu C, Yu Y, Zheng MH, Min J, Wang F
Cell Metab 2024 Oct 1;36(10):2190-2206.e5. Epub 2024 Aug 13 doi: 10.1016/j.cmet.2024.07.013. PMID: 39142286
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO)
Obes Facts 2024;17(4):374-444. Epub 2024 Jun 7 doi: 10.1159/000539371. PMID: 38852583Free PMC Article
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Miao L, Targher G, Byrne CD, Cao YY, Zheng MH
Trends Endocrinol Metab 2024 Aug;35(8):697-707. Epub 2024 Feb 29 doi: 10.1016/j.tem.2024.02.007. PMID: 38429161
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495

Clinical prediction guides

Wei X, Wu D, Li J, Wu M, Li Q, Che Z, Cheng X, Cheng Q, Yin F, Zhang H, Wang X, Abtahi S, Zuo L, Hang L, Ma L, Kuo WT, Liu X, Turner JR, Wang H, Xiao J, Wang F
Cell Metab 2024 Oct 1;36(10):2281-2297.e7. Epub 2024 Sep 20 doi: 10.1016/j.cmet.2024.08.010. PMID: 39305895
Tao L, Yang X, Ge C, Zhang P, He W, Xu X, Li X, Chen W, Yu Y, Zhang H, Chen SD, Pan XY, Su Y, Xu C, Yu Y, Zheng MH, Min J, Wang F
Cell Metab 2024 Oct 1;36(10):2190-2206.e5. Epub 2024 Aug 13 doi: 10.1016/j.cmet.2024.07.013. PMID: 39142286
European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Yashaswini CN, Qin T, Bhattacharya D, Amor C, Lowe S, Lujambio A, Wang S, Friedman SL
J Hepatol 2024 Aug;81(2):207-217. Epub 2024 Mar 18 doi: 10.1016/j.jhep.2024.03.014. PMID: 38508241Free PMC Article
Lekakis V, Papatheodoridis GV
Eur J Intern Med 2024 Apr;122:3-10. Epub 2023 Nov 7 doi: 10.1016/j.ejim.2023.11.005. PMID: 37940495

Recent systematic reviews

Hwang J, Hwang H, Shin H, Kim BH, Kang SH, Yoo JJ, Choi MY, Lee DE, Jun DW, Cho Y
Clin Mol Hepatol 2024 Jul;30(3):561-576. Epub 2024 Jun 3 doi: 10.3350/cmh.2023.0384. PMID: 38830642Free PMC Article
Mantovani A, Csermely A, Bilson J, Borella N, Enrico S, Pecoraro B, Shtembari E, Morandin R, Polyzos SA, Valenti L, Tilg H, Byrne CD, Targher G
Gut 2024 Aug 8;73(9):1554-1561. doi: 10.1136/gutjnl-2024-332491. PMID: 38782564
Jeong C, Han N, Jeon N, Rhee SJ, Staatz CE, Kim MS, Baek IH
Clin Pharmacol Ther 2024 Jul;116(1):72-81. Epub 2024 Apr 26 doi: 10.1002/cpt.3278. PMID: 38666606
Jang H, Han N, Staatz CE, Kwak JH, Baek IH
Clin Res Hepatol Gastroenterol 2023 Dec;47(10):102227. Epub 2023 Oct 24 doi: 10.1016/j.clinre.2023.102227. PMID: 37884091
Lai J, Luo L, Zhou T, Feng X, Ye J, Zhong B
Biomolecules 2023 Sep 6;13(9) doi: 10.3390/biom13091356. PMID: 37759756Free PMC Article

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