U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Myocardial disorder

MedGen UID:
469033
•Concept ID:
C3241958
•
Disease or Syndrome
Synonyms: disease of myocardium; disease or disorder of myocardium; disorder of heart muscle; disorder of myocardium; myocardial disease; Myocardial Disorder; myocardial disorder; myocardium disease; myocardium disease or disorder
 
Monarch Initiative: MONDO:0024643

Definition

A disorder that affects the muscle tissue of the heart. Representative examples include myocardial infarction, myocarditis, and cardiomyopathy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMyocardial disorder

Professional guidelines

PubMed

A Validation Study of the Mayo Clinic Phenotype-Based Genetic Test Prediction Score for Japanese Patients With Hypertrophic Cardiomyopathy.
Moriki T, Kubo T, Sugiura K, Ochi Y, Baba Y, Hirota T, Yamasaki N, Kimura A, Doi YL, Kitaoka H
Circ J 2021 Apr 23;85(5):669-674. Epub 2021 Jan 23 doi: 10.1253/circj.CJ-20-0826. PMID: 33487615
Guidelines for the diagnosis and management of familial dilated cardiomyopathy.
Fatkin D; members of the CSANZ Cardiac Genetic Diseases Council Writing Group
Heart Lung Circ 2011 Nov;20(11):691-3. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.008. PMID: 21885340
Narrative review: harnessing molecular genetics for the diagnosis and management of hypertrophic cardiomyopathy.
Wang L, Seidman JG, Seidman CE
Ann Intern Med 2010 Apr 20;152(8):513-20, W181. doi: 10.7326/0003-4819-152-8-201004200-00008. PMID: 20404382Free PMC Article

Recent clinical studies

Etiology

Hypertrophic Cardiomyopathy: New Concepts and Therapies.
Maron BJ, Rowin EJ, Maron MS
Annu Rev Med 2022 Jan 27;73:363-375. doi: 10.1146/annurev-med-042220-021539. PMID: 35084989
Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy.
Desai MY, Wolski K, Owens A, Naidu SS, Geske JB, Smedira NG, Schaff H, Lampl K, McErlean E, Sewell C, Zhang D, Edelberg JM, Sehnert AJ, Nissen SE
Am Heart J 2021 Sep;239:80-89. Epub 2021 May 24 doi: 10.1016/j.ahj.2021.05.007. PMID: 34038706
The evolution of scuba divers pulmonary edema.
Edmonds C
Undersea Hyperb Med 2016 Mar-Apr;43(2):83-91. PMID: 27265985
Nomenclature and systems of classification for cardiomyopathy in children.
Konta L, Franklin RC, Kaski JP
Cardiol Young 2015 Aug;25 Suppl 2:31-42. doi: 10.1017/S1047951115001201. PMID: 26377708
Genetics of restrictive cardiomyopathy.
Sen-Chowdhry S, Syrris P, McKenna WJ
Heart Fail Clin 2010 Apr;6(2):179-86. doi: 10.1016/j.hfc.2009.11.005. PMID: 20347786

Diagnosis

Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy.
Desai MY, Wolski K, Owens A, Naidu SS, Geske JB, Smedira NG, Schaff H, Lampl K, McErlean E, Sewell C, Zhang D, Edelberg JM, Sehnert AJ, Nissen SE
Am Heart J 2021 Sep;239:80-89. Epub 2021 May 24 doi: 10.1016/j.ahj.2021.05.007. PMID: 34038706
A review of fibroblast growth factor 21 in diabetic cardiomyopathy.
Zhang X, Yang L, Xu X, Tang F, Yi P, Qiu B, Hao Y
Heart Fail Rev 2019 Nov;24(6):1005-1017. doi: 10.1007/s10741-019-09809-x. PMID: 31175491
Nomenclature and systems of classification for cardiomyopathy in children.
Konta L, Franklin RC, Kaski JP
Cardiol Young 2015 Aug;25 Suppl 2:31-42. doi: 10.1017/S1047951115001201. PMID: 26377708
Guidelines for the diagnosis and management of familial dilated cardiomyopathy.
Fatkin D; members of the CSANZ Cardiac Genetic Diseases Council Writing Group
Heart Lung Circ 2011 Nov;20(11):691-3. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.008. PMID: 21885340
Left ventricular noncompaction.
Pantazis AA, Elliott PM
Curr Opin Cardiol 2009 May;24(3):209-13. doi: 10.1097/HCO.0b013e32832a11e7. PMID: 19318934

Therapy

Mavacamten, a precision medicine for hypertrophic cardiomyopathy: From a motor protein to patients.
Nag S, Gollapudi SK, Del Rio CL, Spudich JA, McDowell R
Sci Adv 2023 Jul 28;9(30):eabo7622. doi: 10.1126/sciadv.abo7622. PMID: 37506209
Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy.
Desai MY, Wolski K, Owens A, Naidu SS, Geske JB, Smedira NG, Schaff H, Lampl K, McErlean E, Sewell C, Zhang D, Edelberg JM, Sehnert AJ, Nissen SE
Am Heart J 2021 Sep;239:80-89. Epub 2021 May 24 doi: 10.1016/j.ahj.2021.05.007. PMID: 34038706
Guidelines for the diagnosis and management of arrhythmogenic right ventricular cardiomyopathy.
Smith W; Members of CSANZ Cardiovascular Genetics Working Group
Heart Lung Circ 2011 Dec;20(12):757-60. Epub 2011 Aug 31 doi: 10.1016/j.hlc.2011.07.019. PMID: 21885338
Genetic screening and double mutation in Japanese patients with hypertrophic cardiomyopathy.
Kubo T, Kitaoka H, Okawa M, Baba Y, Hirota T, Hayato K, Yamasaki N, Matsumura Y, Otsuka H, Arimura T, Kimura A, Doi YL
Circ J 2011;75(11):2654-9. Epub 2011 Jul 29 doi: 10.1253/circj.cj-10-1314. PMID: 21799269
New treatment strategies for hypertrophic obstructive cardiomyopathy: alcohol ablation of the septum: the new gold standard?
Hess OM, Sigwart U
J Am Coll Cardiol 2004 Nov 16;44(10):2054-5. doi: 10.1016/j.jacc.2004.08.047. PMID: 15542291

Prognosis

Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy.
Desai MY, Wolski K, Owens A, Naidu SS, Geske JB, Smedira NG, Schaff H, Lampl K, McErlean E, Sewell C, Zhang D, Edelberg JM, Sehnert AJ, Nissen SE
Am Heart J 2021 Sep;239:80-89. Epub 2021 May 24 doi: 10.1016/j.ahj.2021.05.007. PMID: 34038706
Neonatal Non-compacted Cardiomyopathy: Predictors of Poor Outcome.
Rodriguez-Fanjul J, Tubio-Gómez S, Carretero Bellón JM, Bautista-Rodríguez C, Sanchez-de-Toledo J
Pediatr Cardiol 2020 Jan;41(1):175-180. Epub 2019 Nov 23 doi: 10.1007/s00246-019-02241-w. PMID: 31758211
When rare illuminates common: how cardiocutaneous syndromes transformed our perspective on arrhythmogenic cardiomyopathy.
Sen-Chowdhry S, McKenna WJ
Cell Commun Adhes 2014 Feb;21(1):3-11. doi: 10.3109/15419061.2013.876415. PMID: 24460197
Isolated left ventricular noncompaction: what do we really know?
Peters F, Khandheria BK
Curr Cardiol Rep 2012 Jun;14(3):381-8. doi: 10.1007/s11886-012-0255-0. PMID: 22415394
Risk stratification in hypertrophic cardiomyopathy.
Vassalli G, Seiler C, Hess OM
Curr Opin Cardiol 1994 May;9(3):330-6. doi: 10.1097/00001573-199405000-00011. PMID: 8049590

Clinical prediction guides

Study design and rationale of VALOR-HCM: evaluation of mavacamten in adults with symptomatic obstructive hypertrophic cardiomyopathy who are eligible for septal reduction therapy.
Desai MY, Wolski K, Owens A, Naidu SS, Geske JB, Smedira NG, Schaff H, Lampl K, McErlean E, Sewell C, Zhang D, Edelberg JM, Sehnert AJ, Nissen SE
Am Heart J 2021 Sep;239:80-89. Epub 2021 May 24 doi: 10.1016/j.ahj.2021.05.007. PMID: 34038706
Evolution of risk stratification and sudden death prevention in hypertrophic cardiomyopathy: Twenty years with the implantable cardioverter-defibrillator.
Maron BJ, Rowin EJ, Maron MS
Heart Rhythm 2021 Jun;18(6):1012-1023. Epub 2021 Jan 26 doi: 10.1016/j.hrthm.2021.01.019. PMID: 33508516
Impaired calcium handling and mitochondrial metabolic dysfunction as early markers of hypertrophic cardiomyopathy.
Viola HM, Hool LC
Arch Biochem Biophys 2019 Apr 15;665:166-174. Epub 2019 Mar 16 doi: 10.1016/j.abb.2019.03.006. PMID: 30885674
Nomenclature and systems of classification for cardiomyopathy in children.
Konta L, Franklin RC, Kaski JP
Cardiol Young 2015 Aug;25 Suppl 2:31-42. doi: 10.1017/S1047951115001201. PMID: 26377708
Genetics of restrictive cardiomyopathy.
Sen-Chowdhry S, Syrris P, McKenna WJ
Heart Fail Clin 2010 Apr;6(2):179-86. doi: 10.1016/j.hfc.2009.11.005. PMID: 20347786

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...